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The map label for this gene is ilvC [H]

Identifier: 77461007

GI number: 77461007

Start: 5401533

End: 5402549

Strand: Reverse

Name: ilvC [H]

Synonym: Pfl01_4786

Alternate gene names: 77461007

Gene position: 5402549-5401533 (Counterclockwise)

Preceding gene: 77461008

Following gene: 77461006

Centisome position: 83.91

GC content: 57.52

Gene sequence:

>1017_bases
ATGAAAGTTTTCTACGATAAAGACTGCGACCTGTCGATCATCCAGGGCAAGAAAGTTGCCATTATCGGTTACGGCTCCCA
AGGCCACGCCCAGGCGTGCAACCTGAAAGATTCCGGTGTCGACGTTACCGTCGGTCTGCGTAAAGGTTCGGCTACCGTTG
CCAAGGCTGAAGCCCACGGCCTGAAAGTGACCGATGTAGCTGCCGCTGTTGCCGGTGCCGACCTGGTCATGATCCTGACC
CCGGACGAGTTCCAGTCCCAGCTGTACAAGAACGAAATCGAGCCGAACATCAAGAAAGGCGCCACCCTGGCCTTCTCCCA
CGGCTTCGCGATCCACTACAACCAGGTTGTTCCGCGTGCCGACCTCGACGTGATCATGATCGCGCCGAAAGCCCCGGGCC
ACACCGTGCGTTCCGAGTTCGTGAAAGGCGGCGGTATCCCTGACCTGATCGCGATCTACCAGGACGCCTCGGGCAACGCC
AAGAACGTTGCGCTGTCCTACGCCGCTGGCGTTGGTGGCGGTCGTACCGGCATCATCGAAACTACCTTCAAGGACGAGAC
CGAAACCGACCTGTTCGGCGAACAAGCCGTTCTGTGCGGCGGTACCGTCGAGCTGGTGAAAGCCGGTTTCGAAACCCTGG
TTGAAGCTGGCTACGCGCCGGAAATGGCCTATTTCGAGTGCCTGCACGAACTGAAACTGATCGTTGACCTCATGTACGAA
GGCGGTATCGCCAACATGAACTACTCGATCTCCAACAACGCTGAATACGGCGAGTACGTGACGGGTCCGGAAGTGATCAA
CGCCGAATCCCGTCAGGCCATGCGCAACGCCCTGAAACGTATTCAGGACGGCGAATACGCCAAAATGTTCATCAGCGAAG
GCGCAACCGGCTACCCTTCGATGACTGCCAAGCGTCGTAACAACGCCGCTCACGGTATCGAAATCATCGGCGAGCAACTG
CGCTCCATGATGCCGTGGATCGGTGCCAACAAGATCGTCGACAAAGCCAAAAACTAA

Upstream 100 bases:

>100_bases
CCGCAGTGGCGTCACCGGTATTGCCCGCGGCGACAAAGTACTCAGCATCTAAACCAAATTAGCGAATGGCCTGAACGGCC
TGGATATAAAGGGGAAATTC

Downstream 100 bases:

>100_bases
GTCGTCGAACCTTGTATGAAAAAAACGCGGCCTCGGCCGCGTTTTTTCGTATGGGCGTGCGGTTCTGGTATAAAGCTGCA
TCGTTTGTGGCCGAACCGTC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKVFYDKDCDLSIIQGKKVAIIGYGSQGHAQACNLKDSGVDVTVGLRKGSATVAKAEAHGLKVTDVAAAVAGADLVMILT
PDEFQSQLYKNEIEPNIKKGATLAFSHGFAIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGNA
KNVALSYAAGVGGGRTGIIETTFKDETETDLFGEQAVLCGGTVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGPEVINAESRQAMRNALKRIQDGEYAKMFISEGATGYPSMTAKRRNNAAHGIEIIGEQL
RSMMPWIGANKIVDKAKN

Sequences:

>Translated_338_residues
MKVFYDKDCDLSIIQGKKVAIIGYGSQGHAQACNLKDSGVDVTVGLRKGSATVAKAEAHGLKVTDVAAAVAGADLVMILT
PDEFQSQLYKNEIEPNIKKGATLAFSHGFAIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGNA
KNVALSYAAGVGGGRTGIIETTFKDETETDLFGEQAVLCGGTVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGPEVINAESRQAMRNALKRIQDGEYAKMFISEGATGYPSMTAKRRNNAAHGIEIIGEQL
RSMMPWIGANKIVDKAKN
>Mature_338_residues
MKVFYDKDCDLSIIQGKKVAIIGYGSQGHAQACNLKDSGVDVTVGLRKGSATVAKAEAHGLKVTDVAAAVAGADLVMILT
PDEFQSQLYKNEIEPNIKKGATLAFSHGFAIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGNA
KNVALSYAAGVGGGRTGIIETTFKDETETDLFGEQAVLCGGTVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGPEVINAESRQAMRNALKRIQDGEYAKMFISEGATGYPSMTAKRRNNAAHGIEIIGEQL
RSMMPWIGANKIVDKAKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=261, Percent_Identity=39.8467432950192, Blast_Score=161, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6323387, Length=272, Percent_Identity=34.9264705882353, Blast_Score=125, Evalue=9e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36237; Mature: 36237

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFYDKDCDLSIIQGKKVAIIGYGSQGHAQACNLKDSGVDVTVGLRKGSATVAKAEAHG
CCEEECCCCCEEEECCCEEEEEEECCCCCCEECCCCCCCCEEEEEEECCCCEEEEHHHCC
LKVTDVAAAVAGADLVMILTPDEFQSQLYKNEIEPNIKKGATLAFSHGFAIHYNQVVPRA
CCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCCCCC
DLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGNAKNVALSYAAGVGGGRTGIIE
CCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCEEE
TTFKDETETDLFGEQAVLCGGTVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMYE
ECCCCCCCHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGPEVINAESRQAMRNALKRIQDGEYAKMFISEGATGYPS
CCCCCEEEEECCCCCCCCEECCCHHCCCHHHHHHHHHHHHCCCCCCEEHEECCCCCCCCC
MTAKRRNNAAHGIEIIGEQLRSMMPWIGANKIVDKAKN
CHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCC
>Mature Secondary Structure
MKVFYDKDCDLSIIQGKKVAIIGYGSQGHAQACNLKDSGVDVTVGLRKGSATVAKAEAHG
CCEEECCCCCEEEECCCEEEEEEECCCCCCEECCCCCCCCEEEEEEECCCCEEEEHHHCC
LKVTDVAAAVAGADLVMILTPDEFQSQLYKNEIEPNIKKGATLAFSHGFAIHYNQVVPRA
CCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCCCCC
DLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGNAKNVALSYAAGVGGGRTGIIE
CCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCEEE
TTFKDETETDLFGEQAVLCGGTVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMYE
ECCCCCCCHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGPEVINAESRQAMRNALKRIQDGEYAKMFISEGATGYPS
CCCCCEEEEECCCCCCCCEECCCHHCCCHHHHHHHHHHHHCCCCCCEEHEECCCCCCCCC
MTAKRRNNAAHGIEIIGEQLRSMMPWIGANKIVDKAKN
CHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA