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The map label for this gene is ggt [H]

Identifier: 77460985

GI number: 77460985

Start: 5369312

End: 5371144

Strand: Direct

Name: ggt [H]

Synonym: Pfl01_4764

Alternate gene names: 77460985

Gene position: 5369312-5371144 (Clockwise)

Preceding gene: 77460983

Following gene: 77460989

Centisome position: 83.4

GC content: 64.7

Gene sequence:

>1833_bases
GTGCTTCCAGCCCTTTCCCTGAACCGCTTTCGTCTGCCCGCCCTGACACTGATCGTCAGCGCCATTGCCCTTACGGCCTG
CAACGCACCGCCCTCCTCGACCCTGCCAGTGGCACCGGAAGCCGCCTCCGGCTACCGCACCGGCCTGCAAGCCAGCCACG
CCGAAAAACACATGGCCGCCGCAGCCAATCCGCTGGCCGCCGAAGCCGGTCGCGAAATGTTGCGTCAGGGTGGTTCCGCC
ATCGATGCCGCCATCGCGATGCAAGCCGTGTTGACCCTGGTCGAACCGCAGTCCTCGGGGATCGGTGGTGGCGCGATGAT
CGTGCTGTGGGATGGCAAACAGGTGCGCACCTACGACGGTCGCGAAACCGCACCGGCCGGCGCGACCGAGAAGCTGTTTC
TACAGGCAGACGGCAAACCGATGCCGTTCCCGCAGGCGCAGATCGGCGGACGCTCCGTCGGCACGCCGGGCGTGATGCGA
GCGCTGGAACTGGCGCACAAAAAGCACGGCCGCTTGCCGTGGGCCAAGCTGTTCGAACCGGCGATCAAACTCGCCGAGCA
GGGCTTTGCAATCTCTCCGCGCCTGCATTCACTGCTGGAATCCGATCCGGAGATACGCCGCTCGCCAGACATGGCCAAGT
ACTTTCTGAACAGCGACGGCAGCGTCAAAGCCGTCGGCACTCGCTTGCAGAACCCGGCGCTGGCCGCCGTGCTCAAGCGC
ATCGCCAACGAAGGCGCAGACACTCTGTACAAAGGCCCGATCGCCGAAGAGATCGTGGACAAGGTTCAGGGCCACGCCAA
CCCCGGCAGCCTGTCGCTGACCGACCTTCAGCACTATCAGGCCAAGGAACGCGCGCCCCTGTGCACCGACTACAAGCGCT
GGCAGGTGTGCGGAATGCCGCCACCCTCATCGGGCGGGATTGCGGTGGCGCAGATTCTCGGCACCTTACAGGCGCTGGAA
ACCCGCGATCCGCGTCAGGCCCTGACGCCGCTCAAGCCTGTGAAGACCAATAAGCCCGCCGGCATCGAACCTGCACCGCA
AGCCGTGCACCTGATCGCCGAAGCCGAGCGTCTGGCCTACGCCGACCGCGCGCAATACGTAGCCGATACCGACTTCGTGC
CGGTACCGGTCAAAGGCTTGGTCGATCCGGGTTACCTGGCCAGTCGCGCCAGCCTGATCAGCGAACGCAGCATGGGCAGC
GCCAAACCCGGTACACCGCCGGGCATACAGGTTGCCTATGCGCCGGATCGCTCGCCACTGCGCATTTCCACCTCACAAGT
GGTTGCCGTGGATGACTTCGGTGGCGCCGTGTCGATGACGACCACCATCGAAGCAGCGTTCGGCTCGCACCTGATGGTTC
AGGGCTTCTTGCTCAACAATCAGATGACCGATTTCTCGTTCCTCCCCGAAGAGAACGGCCAGAAAGTCGCCAACCGCGTG
GAACCCGGCAAACGCCCGCGCTCATCGATGGCGCCGACCCTGATCTTCGACCGCAACAGCGGCGAGTTCGTCGCCACCGT
CGGCTCTCCGGGCGGCTCGCAGATCATCGAGTACGTGGCCAAAACCACGGTCGGCCTGCTCGACTGGAACCTCGACCCGC
AAAGCGCCATCAGCCTGCCCAACTTCGGCAGCCGCAACGGCCCCACTGAACTCGAACAGGGCCAGTTCAGCCCGACGCTG
ATCCAGGCACTCAAGGACAAGGGCCACACCGTCAGCGAAATCGACATGACCAGCGGCACCCAGGCCATCGTGCGGGTCAA
GGATGCTGCGGGGAAGGCAACGCTGTCAGGTGGGGCAGATCCTCGGCGCGAAGGAGCAGCGTTGGGGGATTGA

Upstream 100 bases:

>100_bases
TCCGCCAAGGCATGAAGGACGAAGATGCCTGCGGTTTGCGTCGTACGCGGCCGGCCGATACAGTCCGTCAGACTTTTATC
CCACGGACGGAGAGCCCCGC

Downstream 100 bases:

>100_bases
ATCAACGCTGCCAACTGAAAAAGGCTTACCGAGAGGTAAGCCTTTTTTGTATTGCAACATCCGGCCATGACTTGTCATTC
AGCGGCGCTCAAACCTCGAG

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MLPALSLNRFRLPALTLIVSAIALTACNAPPSSTLPVAPEAASGYRTGLQASHAEKHMAAAANPLAAEAGREMLRQGGSA
IDAAIAMQAVLTLVEPQSSGIGGGAMIVLWDGKQVRTYDGRETAPAGATEKLFLQADGKPMPFPQAQIGGRSVGTPGVMR
ALELAHKKHGRLPWAKLFEPAIKLAEQGFAISPRLHSLLESDPEIRRSPDMAKYFLNSDGSVKAVGTRLQNPALAAVLKR
IANEGADTLYKGPIAEEIVDKVQGHANPGSLSLTDLQHYQAKERAPLCTDYKRWQVCGMPPPSSGGIAVAQILGTLQALE
TRDPRQALTPLKPVKTNKPAGIEPAPQAVHLIAEAERLAYADRAQYVADTDFVPVPVKGLVDPGYLASRASLISERSMGS
AKPGTPPGIQVAYAPDRSPLRISTSQVVAVDDFGGAVSMTTTIEAAFGSHLMVQGFLLNNQMTDFSFLPEENGQKVANRV
EPGKRPRSSMAPTLIFDRNSGEFVATVGSPGGSQIIEYVAKTTVGLLDWNLDPQSAISLPNFGSRNGPTELEQGQFSPTL
IQALKDKGHTVSEIDMTSGTQAIVRVKDAAGKATLSGGADPRREGAALGD

Sequences:

>Translated_610_residues
MLPALSLNRFRLPALTLIVSAIALTACNAPPSSTLPVAPEAASGYRTGLQASHAEKHMAAAANPLAAEAGREMLRQGGSA
IDAAIAMQAVLTLVEPQSSGIGGGAMIVLWDGKQVRTYDGRETAPAGATEKLFLQADGKPMPFPQAQIGGRSVGTPGVMR
ALELAHKKHGRLPWAKLFEPAIKLAEQGFAISPRLHSLLESDPEIRRSPDMAKYFLNSDGSVKAVGTRLQNPALAAVLKR
IANEGADTLYKGPIAEEIVDKVQGHANPGSLSLTDLQHYQAKERAPLCTDYKRWQVCGMPPPSSGGIAVAQILGTLQALE
TRDPRQALTPLKPVKTNKPAGIEPAPQAVHLIAEAERLAYADRAQYVADTDFVPVPVKGLVDPGYLASRASLISERSMGS
AKPGTPPGIQVAYAPDRSPLRISTSQVVAVDDFGGAVSMTTTIEAAFGSHLMVQGFLLNNQMTDFSFLPEENGQKVANRV
EPGKRPRSSMAPTLIFDRNSGEFVATVGSPGGSQIIEYVAKTTVGLLDWNLDPQSAISLPNFGSRNGPTELEQGQFSPTL
IQALKDKGHTVSEIDMTSGTQAIVRVKDAAGKATLSGGADPRREGAALGD
>Mature_610_residues
MLPALSLNRFRLPALTLIVSAIALTACNAPPSSTLPVAPEAASGYRTGLQASHAEKHMAAAANPLAAEAGREMLRQGGSA
IDAAIAMQAVLTLVEPQSSGIGGGAMIVLWDGKQVRTYDGRETAPAGATEKLFLQADGKPMPFPQAQIGGRSVGTPGVMR
ALELAHKKHGRLPWAKLFEPAIKLAEQGFAISPRLHSLLESDPEIRRSPDMAKYFLNSDGSVKAVGTRLQNPALAAVLKR
IANEGADTLYKGPIAEEIVDKVQGHANPGSLSLTDLQHYQAKERAPLCTDYKRWQVCGMPPPSSGGIAVAQILGTLQALE
TRDPRQALTPLKPVKTNKPAGIEPAPQAVHLIAEAERLAYADRAQYVADTDFVPVPVKGLVDPGYLASRASLISERSMGS
AKPGTPPGIQVAYAPDRSPLRISTSQVVAVDDFGGAVSMTTTIEAAFGSHLMVQGFLLNNQMTDFSFLPEENGQKVANRV
EPGKRPRSSMAPTLIFDRNSGEFVATVGSPGGSQIIEYVAKTTVGLLDWNLDPQSAISLPNFGSRNGPTELEQGQFSPTL
IQALKDKGHTVSEIDMTSGTQAIVRVKDAAGKATLSGGADPRREGAALGD

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=570, Percent_Identity=32.6315789473684, Blast_Score=203, Evalue=4e-52,
Organism=Homo sapiens, GI73915090, Length=570, Percent_Identity=32.6315789473684, Blast_Score=203, Evalue=4e-52,
Organism=Homo sapiens, GI73915096, Length=570, Percent_Identity=32.6315789473684, Blast_Score=203, Evalue=4e-52,
Organism=Homo sapiens, GI73915094, Length=570, Percent_Identity=32.6315789473684, Blast_Score=203, Evalue=4e-52,
Organism=Homo sapiens, GI113429324, Length=563, Percent_Identity=32.3268206039076, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI113429326, Length=568, Percent_Identity=32.2183098591549, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI153266885, Length=549, Percent_Identity=27.5045537340619, Blast_Score=146, Evalue=7e-35,
Organism=Homo sapiens, GI153266901, Length=550, Percent_Identity=27.4545454545455, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI109148539, Length=543, Percent_Identity=28.3609576427256, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI153266907, Length=546, Percent_Identity=25.6410256410256, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI30581157, Length=207, Percent_Identity=34.2995169082126, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI30581155, Length=207, Percent_Identity=34.2995169082126, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI171543825, Length=174, Percent_Identity=29.3103448275862, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789856, Length=562, Percent_Identity=35.4092526690391, Blast_Score=275, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17542894, Length=539, Percent_Identity=31.3543599257885, Blast_Score=228, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI212646519, Length=528, Percent_Identity=32.5757575757576, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI72000294, Length=528, Percent_Identity=32.5757575757576, Blast_Score=213, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI193208247, Length=589, Percent_Identity=29.7113752122241, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI193208245, Length=589, Percent_Identity=29.7113752122241, Blast_Score=202, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17506189, Length=561, Percent_Identity=28.3422459893048, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17564448, Length=459, Percent_Identity=25.0544662309368, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI72001495, Length=223, Percent_Identity=30.0448430493274, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI72001497, Length=223, Percent_Identity=30.0448430493274, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=532, Percent_Identity=27.0676691729323, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24642670, Length=575, Percent_Identity=29.0434782608696, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24642666, Length=575, Percent_Identity=29.0434782608696, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161077880, Length=573, Percent_Identity=29.3193717277487, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI161077878, Length=573, Percent_Identity=29.3193717277487, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI45551474, Length=575, Percent_Identity=29.0434782608696, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI18859893, Length=528, Percent_Identity=30.1136363636364, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI161077496, Length=483, Percent_Identity=29.6066252587992, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI18859741, Length=533, Percent_Identity=26.8292682926829, Blast_Score=139, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 64364; Mature: 64364

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPALSLNRFRLPALTLIVSAIALTACNAPPSSTLPVAPEAASGYRTGLQASHAEKHMAA
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHH
AANPLAAEAGREMLRQGGSAIDAAIAMQAVLTLVEPQSSGIGGGAMIVLWDGKQVRTYDG
HCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEECCC
RETAPAGATEKLFLQADGKPMPFPQAQIGGRSVGTPGVMRALELAHKKHGRLPWAKLFEP
CCCCCCCCCEEEEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
AIKLAEQGFAISPRLHSLLESDPEIRRSPDMAKYFLNSDGSVKAVGTRLQNPALAAVLKR
HHHHHHCCCEECHHHHHHHCCCCHHHCCCCHHHHHHCCCCCEEEHHHHHCCHHHHHHHHH
IANEGADTLYKGPIAEEIVDKVQGHANPGSLSLTDLQHYQAKERAPLCTDYKRWQVCGMP
HHCCCCCHHCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEECCC
PPSSGGIAVAQILGTLQALETRDPRQALTPLKPVKTNKPAGIEPAPQAVHLIAEAERLAY
CCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ADRAQYVADTDFVPVPVKGLVDPGYLASRASLISERSMGSAKPGTPPGIQVAYAPDRSPL
HHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCE
RISTSQVVAVDDFGGAVSMTTTIEAAFGSHLMVQGFLLNNQMTDFSFLPEENGQKVANRV
EEECCCEEEEECCCCEEEEHEEHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHC
EPGKRPRSSMAPTLIFDRNSGEFVATVGSPGGSQIIEYVAKTTVGLLDWNLDPQSAISLP
CCCCCCHHHCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHEEEECCCCHHHHCCCC
NFGSRNGPTELEQGQFSPTLIQALKDKGHTVSEIDMTSGTQAIVRVKDAAGKATLSGGAD
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCEEECCCCC
PRREGAALGD
CCCCCCCCCC
>Mature Secondary Structure
MLPALSLNRFRLPALTLIVSAIALTACNAPPSSTLPVAPEAASGYRTGLQASHAEKHMAA
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHH
AANPLAAEAGREMLRQGGSAIDAAIAMQAVLTLVEPQSSGIGGGAMIVLWDGKQVRTYDG
HCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEECCC
RETAPAGATEKLFLQADGKPMPFPQAQIGGRSVGTPGVMRALELAHKKHGRLPWAKLFEP
CCCCCCCCCEEEEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
AIKLAEQGFAISPRLHSLLESDPEIRRSPDMAKYFLNSDGSVKAVGTRLQNPALAAVLKR
HHHHHHCCCEECHHHHHHHCCCCHHHCCCCHHHHHHCCCCCEEEHHHHHCCHHHHHHHHH
IANEGADTLYKGPIAEEIVDKVQGHANPGSLSLTDLQHYQAKERAPLCTDYKRWQVCGMP
HHCCCCCHHCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEECCC
PPSSGGIAVAQILGTLQALETRDPRQALTPLKPVKTNKPAGIEPAPQAVHLIAEAERLAY
CCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ADRAQYVADTDFVPVPVKGLVDPGYLASRASLISERSMGSAKPGTPPGIQVAYAPDRSPL
HHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCE
RISTSQVVAVDDFGGAVSMTTTIEAAFGSHLMVQGFLLNNQMTDFSFLPEENGQKVANRV
EEECCCEEEEECCCCEEEEHEEHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHC
EPGKRPRSSMAPTLIFDRNSGEFVATVGSPGGSQIIEYVAKTTVGLLDWNLDPQSAISLP
CCCCCCHHHCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHEEEECCCCHHHHCCCC
NFGSRNGPTELEQGQFSPTLIQALKDKGHTVSEIDMTSGTQAIVRVKDAAGKATLSGGAD
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCEEECCCCC
PRREGAALGD
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA