Click here to switch to the map view.

The map label for this gene is cyoE2 [H]

Identifier: 77460865

GI number: 77460865

Start: 5242476

End: 5243363

Strand: Reverse

Name: cyoE2 [H]

Synonym: Pfl01_4644

Alternate gene names: 77460865

Gene position: 5243363-5242476 (Counterclockwise)

Preceding gene: 77460866

Following gene: 77460864

Centisome position: 81.44

GC content: 59.35

Gene sequence:

>888_bases
ATGTCGCTCAAGCACTTTATCCAAATCACCAAACCGGGGATCATTTTCGGTAACGTGCTTTCTGTGGCAGGCGGGTTCTT
CCTGGCCTCGAAAGGGCATGTCGATCTGGCCGTGTTTCTGGCAGCCATGATCGGCACTTCCCTGGTTGTGGCCTCCGGTT
GCGTGTTCAACAACTGCATCGACCGCGACATCGACCTGAAGATGGAACGCACCAAGAACCGGGTGCTGGTCCAGGGCTTG
ATCTCCCTGAAACTGGCCCTGGTCTATGCAACCGTCCTGGGTGTCGCCGGCGTAGCGTTGCTGTACAAGGTGGCCAACCC
GTTGGCCGCATTGTTCGCCGTGATCGGCTTCATCATCTACGTCGGCTTCTACAGCCTGTACCTCAAGCGCAAGTCGGTTC
ACGGCACGCTGGTGGGCAGTCTGTCGGGCGCCATGCCGCCGGTGATCGGTTACGTGGCCGTGACCAATAGCTTCGACATG
GCCGCGCTGACCCTGCTGGTGATGTTCAGTCTGTGGCAGATGCCGCATTCCTACGCCATCGCGATCTTCCGCTTCAACGA
TTACCTGGCCGCATCGATTCCGGTGCTGCCAGTGAAGCGCGGAATCCAGGTGGCCAAGAAGCACATCCTGATCTACATCC
TGGCCTTCCTCGTGGCGACCTTGATGCTGACCTTCAGCGGTTACGCCGGCATGAGCTACCTCGCCGTCGCCGCGGCCATG
GGCATGTACTGGCTGTACATGGCCTGGACCGGCTACAAGGCGGTGGATGACACGGTCTGGGCACGCAAGCTGTTCGTCTT
CTCGATCTTCACCATCACCGCGTTGAGCGTCATGATGTCTCTGGACTTCAAGGTGCCGACCGAGCTGCTGCTGACGTACG
CGCCGTAA

Upstream 100 bases:

>100_bases
TTCGTCTTTACGGCCATCGTGATCGTGCTGCTGGTCGGTCTGTCGCTGTGGATCATGTTCAGCATCCACACCTACATGAT
GGCGAAGTGAGGTAAACCCG

Downstream 100 bases:

>100_bases
GGTTCGAACGTTGTACGAGAAACCCCGTTCATCGAGAGATGAGCGGGGTTTTTTGTTGCTCGGATGATGGAGAAACGACG
TCCTTTGTCGTTAACAGACT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase 2; Heme O synthase 2 [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSLKHFIQITKPGIIFGNVLSVAGGFFLASKGHVDLAVFLAAMIGTSLVVASGCVFNNCIDRDIDLKMERTKNRVLVQGL
ISLKLALVYATVLGVAGVALLYKVANPLAALFAVIGFIIYVGFYSLYLKRKSVHGTLVGSLSGAMPPVIGYVAVTNSFDM
AALTLLVMFSLWQMPHSYAIAIFRFNDYLAASIPVLPVKRGIQVAKKHILIYILAFLVATLMLTFSGYAGMSYLAVAAAM
GMYWLYMAWTGYKAVDDTVWARKLFVFSIFTITALSVMMSLDFKVPTELLLTYAP

Sequences:

>Translated_295_residues
MSLKHFIQITKPGIIFGNVLSVAGGFFLASKGHVDLAVFLAAMIGTSLVVASGCVFNNCIDRDIDLKMERTKNRVLVQGL
ISLKLALVYATVLGVAGVALLYKVANPLAALFAVIGFIIYVGFYSLYLKRKSVHGTLVGSLSGAMPPVIGYVAVTNSFDM
AALTLLVMFSLWQMPHSYAIAIFRFNDYLAASIPVLPVKRGIQVAKKHILIYILAFLVATLMLTFSGYAGMSYLAVAAAM
GMYWLYMAWTGYKAVDDTVWARKLFVFSIFTITALSVMMSLDFKVPTELLLTYAP
>Mature_294_residues
SLKHFIQITKPGIIFGNVLSVAGGFFLASKGHVDLAVFLAAMIGTSLVVASGCVFNNCIDRDIDLKMERTKNRVLVQGLI
SLKLALVYATVLGVAGVALLYKVANPLAALFAVIGFIIYVGFYSLYLKRKSVHGTLVGSLSGAMPPVIGYVAVTNSFDMA
ALTLLVMFSLWQMPHSYAIAIFRFNDYLAASIPVLPVKRGIQVAKKHILIYILAFLVATLMLTFSGYAGMSYLAVAAAMG
MYWLYMAWTGYKAVDDTVWARKLFVFSIFTITALSVMMSLDFKVPTELLLTYAP

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=170, Percent_Identity=38.8235294117647, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786631, Length=288, Percent_Identity=68.0555555555556, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71998235, Length=238, Percent_Identity=34.0336134453782, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325085, Length=279, Percent_Identity=25.4480286738351, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921064, Length=268, Percent_Identity=29.8507462686567, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32163; Mature: 32032

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKHFIQITKPGIIFGNVLSVAGGFFLASKGHVDLAVFLAAMIGTSLVVASGCVFNNCI
CCHHHHEEECCCCEEHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHC
DRDIDLKMERTKNRVLVQGLISLKLALVYATVLGVAGVALLYKVANPLAALFAVIGFIIY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGFYSLYLKRKSVHGTLVGSLSGAMPPVIGYVAVTNSFDMAALTLLVMFSLWQMPHSYAI
HHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHEECCCCHHHHHHHHHHHHHHHCCCHHEE
AIFRFNDYLAASIPVLPVKRGIQVAKKHILIYILAFLVATLMLTFSGYAGMSYLAVAAAM
EEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GMYWLYMAWTGYKAVDDTVWARKLFVFSIFTITALSVMMSLDFKVPTELLLTYAP
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECC
>Mature Secondary Structure 
SLKHFIQITKPGIIFGNVLSVAGGFFLASKGHVDLAVFLAAMIGTSLVVASGCVFNNCI
CHHHHEEECCCCEEHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHC
DRDIDLKMERTKNRVLVQGLISLKLALVYATVLGVAGVALLYKVANPLAALFAVIGFIIY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGFYSLYLKRKSVHGTLVGSLSGAMPPVIGYVAVTNSFDMAALTLLVMFSLWQMPHSYAI
HHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHEECCCCHHHHHHHHHHHHHHHCCCHHEE
AIFRFNDYLAASIPVLPVKRGIQVAKKHILIYILAFLVATLMLTFSGYAGMSYLAVAAAM
EEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GMYWLYMAWTGYKAVDDTVWARKLFVFSIFTITALSVMMSLDFKVPTELLLTYAP
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA