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The map label for this gene is ytnA [H]

Identifier: 77460782

GI number: 77460782

Start: 5146102

End: 5147523

Strand: Reverse

Name: ytnA [H]

Synonym: Pfl01_4561

Alternate gene names: 77460782

Gene position: 5147523-5146102 (Counterclockwise)

Preceding gene: 77460783

Following gene: 77460781

Centisome position: 79.95

GC content: 62.31

Gene sequence:

>1422_bases
ATGCCAGTCGGCAATCACCCGCCCCATGGCGAAACCGCTCAAGGCGGTCCGCTCAAACGCGAACTCGGTGAACGGCATAT
TCGCCTGATGGCGCTCGGCGCCTGCATCGGTGTCGGTCTGTTTCTCGGTTCGGCCAAGGCCATCGAAATGGCCGGCCCGG
CGATCATGCTGTCTTACATCATCGGCGGTCTGGCGATCCTGGTGATCATGCGCGCCCTCGGCGAAATGGCCGTACACAAC
CCGGTCGCCGGCTCCTTCAGCCGTTACGCACAGGATTATCTCGGCCCGCTGGCGGGCTTTCTCACCGGCTGGAACTACTG
GTTCCTGTGGCTGGTGACCTGCGTCGCCGAAATCACGGCGGTGGCGGTGTACATGGGCATCTGGTTCCCCGATGTCCCGC
GCTGGATCTGGGCGCTGGCGGCGCTGGTCAGCATGGGCTCGATCAACCTGATCGCGGTGAAAGCCTTCGGTGAGTTCGAG
TTCTGGTTCGCCCTGATCAAGATCGTCACCATCATCGCCATGGTGCTCGGCGGCATTGGCATCATCGCCTTCGGTTTCGG
CAACGACGGTGTGGCACTGGGGATTTCCAACCTGTGGGCCCACGGCGGCTTCATGCCCAACGGTGTGACGGGCGTGCTGA
TGTCCCTGCAAATGGTGATGTTCGCCTATCTGGGCGTGGAGATGATCGGCCTGACCGCCGGTGAAGCGAAGAACCCGCAG
AAGACCATCCCGAATGCGATCGGCTCGGTGTTCTGGCGGATCCTGCTGTTCTACGTCGGCGCGCTGTTCGTGATCCTGTC
GATCTACCCGTGGAACGAAATCGGCACCCAGGGCAGTCCGTTCGTGATGACCTTTGAGCGTCTGGGCATCAAGACCGCCG
CCGGCATCATCAACTTCGTGGTGATCACTGCAGCGCTGTCGTCGTGCAACGGCGGCATCTTCAGCACCGGTCGCATGCTC
TACAGCCTGGCGCAAAACGGCCAGGCGCCGGCCGGTTTCGCTCGCACCTCGAGCAACGGCGTACCGCGTCGGGCACTGCT
CCTGTCGATCTTCGCGCTGCTGCTGGGCGTGCTGCTCAACTATCTGGTACCGGAAAAAGTCTTCGTCTGGGTGACGTCCA
TCGCCACCTTCGGCGCGATCTGGACCTGGGTGATGATCCTGCTGGCCCAGCTGAAATTCCGCAAAGGCCTGAGCGCCAGC
GAACGGGCGGGCCTGAAGTACAAGATGTGGCTGTTCCCGGTCAGCTCCTATCTGGCGCTGGCGTTCCTGGTGCTGGTGGT
CGGCCTGATGGCGTACTTCCCGGACACTCGCGTGGCGCTGTATGTCGGCCCGGCGTTCCTGGTGCTGCTGACCGTGTTGT
TCTACGTGTTCAAGCTGCAACCGAAGGATTCGGTACAGGGCGCGATGCGTTCGGCTTCGTAA

Upstream 100 bases:

>100_bases
TGCCCACGAAGCAGGGCCGGTATTTACCCAGGCGCAGGCTTATCGGCCGACGCTTGAACACTCGGTGGTCACATCCAATA
ACAAGACGAGGAAGTCCCCC

Downstream 100 bases:

>100_bases
TTCGTTGTCGCTGAAACCTGAAAGCCCCGGTCGAAAGTCCGGGGCTTTTTCATGGGTGTGAGTTGATGCCGCTGGTCTGA
AATCAGCGCAAAAAACGACT

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MPVGNHPPHGETAQGGPLKRELGERHIRLMALGACIGVGLFLGSAKAIEMAGPAIMLSYIIGGLAILVIMRALGEMAVHN
PVAGSFSRYAQDYLGPLAGFLTGWNYWFLWLVTCVAEITAVAVYMGIWFPDVPRWIWALAALVSMGSINLIAVKAFGEFE
FWFALIKIVTIIAMVLGGIGIIAFGFGNDGVALGISNLWAHGGFMPNGVTGVLMSLQMVMFAYLGVEMIGLTAGEAKNPQ
KTIPNAIGSVFWRILLFYVGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVITAALSSCNGGIFSTGRML
YSLAQNGQAPAGFARTSSNGVPRRALLLSIFALLLGVLLNYLVPEKVFVWVTSIATFGAIWTWVMILLAQLKFRKGLSAS
ERAGLKYKMWLFPVSSYLALAFLVLVVGLMAYFPDTRVALYVGPAFLVLLTVLFYVFKLQPKDSVQGAMRSAS

Sequences:

>Translated_473_residues
MPVGNHPPHGETAQGGPLKRELGERHIRLMALGACIGVGLFLGSAKAIEMAGPAIMLSYIIGGLAILVIMRALGEMAVHN
PVAGSFSRYAQDYLGPLAGFLTGWNYWFLWLVTCVAEITAVAVYMGIWFPDVPRWIWALAALVSMGSINLIAVKAFGEFE
FWFALIKIVTIIAMVLGGIGIIAFGFGNDGVALGISNLWAHGGFMPNGVTGVLMSLQMVMFAYLGVEMIGLTAGEAKNPQ
KTIPNAIGSVFWRILLFYVGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVITAALSSCNGGIFSTGRML
YSLAQNGQAPAGFARTSSNGVPRRALLLSIFALLLGVLLNYLVPEKVFVWVTSIATFGAIWTWVMILLAQLKFRKGLSAS
ERAGLKYKMWLFPVSSYLALAFLVLVVGLMAYFPDTRVALYVGPAFLVLLTVLFYVFKLQPKDSVQGAMRSAS
>Mature_472_residues
PVGNHPPHGETAQGGPLKRELGERHIRLMALGACIGVGLFLGSAKAIEMAGPAIMLSYIIGGLAILVIMRALGEMAVHNP
VAGSFSRYAQDYLGPLAGFLTGWNYWFLWLVTCVAEITAVAVYMGIWFPDVPRWIWALAALVSMGSINLIAVKAFGEFEF
WFALIKIVTIIAMVLGGIGIIAFGFGNDGVALGISNLWAHGGFMPNGVTGVLMSLQMVMFAYLGVEMIGLTAGEAKNPQK
TIPNAIGSVFWRILLFYVGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVITAALSSCNGGIFSTGRMLY
SLAQNGQAPAGFARTSSNGVPRRALLLSIFALLLGVLLNYLVPEKVFVWVTSIATFGAIWTWVMILLAQLKFRKGLSASE
RAGLKYKMWLFPVSSYLALAFLVLVVGLMAYFPDTRVALYVGPAFLVLLTVLFYVFKLQPKDSVQGAMRSAS

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=320, Percent_Identity=26.5625, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI258645169, Length=209, Percent_Identity=29.1866028708134, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI114326544, Length=348, Percent_Identity=22.1264367816092, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI114326550, Length=348, Percent_Identity=22.1264367816092, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI258614003, Length=209, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI258614005, Length=209, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI110347453, Length=348, Percent_Identity=24.4252873563218, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI71999149, Length=432, Percent_Identity=24.0740740740741, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786602, Length=435, Percent_Identity=56.0919540229885, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI48994972, Length=451, Percent_Identity=50.3325942350333, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1786789, Length=449, Percent_Identity=44.097995545657, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1786302, Length=455, Percent_Identity=43.2967032967033, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1790653, Length=436, Percent_Identity=43.1192660550459, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI87081915, Length=437, Percent_Identity=41.6475972540046, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI87081708, Length=461, Percent_Identity=39.2624728850325, Blast_Score=318, Evalue=7e-88,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=36.8909512761021, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1788480, Length=460, Percent_Identity=36.304347826087, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI87081869, Length=249, Percent_Identity=22.8915662650602, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367353, Length=359, Percent_Identity=25.9052924791086, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082023, Length=286, Percent_Identity=22.3776223776224, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=390, Percent_Identity=25.1282051282051, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17540018, Length=341, Percent_Identity=24.9266862170088, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=475, Percent_Identity=32.2105263157895, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6320772, Length=446, Percent_Identity=34.0807174887892, Blast_Score=226, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6324924, Length=484, Percent_Identity=32.2314049586777, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6324990, Length=443, Percent_Identity=31.1512415349887, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6324059, Length=439, Percent_Identity=31.8906605922551, Blast_Score=192, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6321629, Length=414, Percent_Identity=27.536231884058, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322892, Length=408, Percent_Identity=31.8627450980392, Blast_Score=186, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6320717, Length=448, Percent_Identity=28.3482142857143, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=393, Percent_Identity=33.0788804071247, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6319824, Length=405, Percent_Identity=28.641975308642, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319542, Length=405, Percent_Identity=28.8888888888889, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319543, Length=404, Percent_Identity=28.7128712871287, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6319608, Length=450, Percent_Identity=27.5555555555556, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322967, Length=399, Percent_Identity=26.8170426065163, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=401, Percent_Identity=27.6807980049875, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6321053, Length=453, Percent_Identity=28.6975717439294, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=399, Percent_Identity=26.0651629072682, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=507, Percent_Identity=27.2189349112426, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24667468, Length=359, Percent_Identity=28.133704735376, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24668806, Length=400, Percent_Identity=25.5, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356285, Length=400, Percent_Identity=25.5, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24668802, Length=400, Percent_Identity=25.5, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI161077963, Length=342, Percent_Identity=25.7309941520468, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281366235, Length=339, Percent_Identity=25.9587020648968, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI116007820, Length=339, Percent_Identity=25.9587020648968, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51080; Mature: 50948

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVGNHPPHGETAQGGPLKRELGERHIRLMALGACIGVGLFLGSAKAIEMAGPAIMLSYI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHH
IGGLAILVIMRALGEMAVHNPVAGSFSRYAQDYLGPLAGFLTGWNYWFLWLVTCVAEITA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVYMGIWFPDVPRWIWALAALVSMGSINLIAVKAFGEFEFWFALIKIVTIIAMVLGGIG
HHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCHH
IIAFGFGNDGVALGISNLWAHGGFMPNGVTGVLMSLQMVMFAYLGVEMIGLTAGEAKNPQ
EEEEEECCCCCEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCH
KTIPNAIGSVFWRILLFYVGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEHHHHCHHHHHHHHHHH
VITAALSSCNGGIFSTGRMLYSLAQNGQAPAGFARTSSNGVPRRALLLSIFALLLGVLLN
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YLVPEKVFVWVTSIATFGAIWTWVMILLAQLKFRKGLSASERAGLKYKMWLFPVSSYLAL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEHHHHHHHHHHH
AFLVLVVGLMAYFPDTRVALYVGPAFLVLLTVLFYVFKLQPKDSVQGAMRSAS
HHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure 
PVGNHPPHGETAQGGPLKRELGERHIRLMALGACIGVGLFLGSAKAIEMAGPAIMLSYI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHH
IGGLAILVIMRALGEMAVHNPVAGSFSRYAQDYLGPLAGFLTGWNYWFLWLVTCVAEITA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVYMGIWFPDVPRWIWALAALVSMGSINLIAVKAFGEFEFWFALIKIVTIIAMVLGGIG
HHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCHH
IIAFGFGNDGVALGISNLWAHGGFMPNGVTGVLMSLQMVMFAYLGVEMIGLTAGEAKNPQ
EEEEEECCCCCEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCH
KTIPNAIGSVFWRILLFYVGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEHHHHCHHHHHHHHHHH
VITAALSSCNGGIFSTGRMLYSLAQNGQAPAGFARTSSNGVPRRALLLSIFALLLGVLLN
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YLVPEKVFVWVTSIATFGAIWTWVMILLAQLKFRKGLSASERAGLKYKMWLFPVSSYLAL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEHHHHHHHHHHH
AFLVLVVGLMAYFPDTRVALYVGPAFLVLLTVLFYVFKLQPKDSVQGAMRSAS
HHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]