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The map label for this gene is dctB [H]

Identifier: 77460760

GI number: 77460760

Start: 5113458

End: 5115371

Strand: Direct

Name: dctB [H]

Synonym: Pfl01_4539

Alternate gene names: 77460760

Gene position: 5113458-5115371 (Clockwise)

Preceding gene: 77460759

Following gene: 77460761

Centisome position: 79.42

GC content: 63.64

Gene sequence:

>1914_bases
ATGAAATGCGACCCCACTCTCTATCGCGCCACGCCGCCATCACTTGCCGTGAAACCCCGTCTGATCCGCCACCTGTTCCT
GCCGCCGCTGGTCATCGCCCTGATGATCGGACTGGGTTACATCGGCTTCTGGACCAGTGAACATTTCGGCATCCGCAGCC
TCGGCGAAAACGGCCAGCGCCAGCTGGAACTGCACGCCCGCGCGGTCGAAAGCGAGATCAGCAAATACACCTACCTGCCC
AGCCTGCTGGAACTCGAGTCGAGCGTTTCGCTGCTGCTGGACGACCCGACCCCGGAACACCGGCAAACGGTCAACGATTA
CCTTGAAGGCCTGAACCGGCGCAGCCGCAGTCGGGCCATCTACGTCATGGACACCACCGGCCGGGTCATGGCCACCAGCA
ACTGGCGCGACGTCGACAGTTATCTCGGTGAAGACCTGTCGTTCCGCGCCTACTTCCAGAACGCCATCCGCGGCCAGCCC
GGACGTTTCTACGGGATCGGCAGCACCAACGGCGAACCCGGTTACTACCTGGCCCACGGCCTCGAAGAACACGGCAAGAT
CATCGGCGTCGCGGTGGTCAAGGTGCGCCTGGAAGCCTTGGAGGAACGCTGGCAGCGGGCGCGCCTCGAAGCGTTCGTCA
GCGATGAAAACGGCATCATCATTCTGTCCAGCGATCCGGCCCGGCGCCTGAAATCGGTGATACCGCTGAGCGACGAGACC
AAGGAAAAACTCGCCCGCAGCCTGCAGTACTACTGGTTCCCGCTGAACGAACTGCAACCGCTGGCCCGGGAAACCCTGTC
CGAAGGCGTGGAAAAGCTCACCTTCCCGGCCAACAGCGAAGTGCCGAGCCAACAGGATGGCGATGAGGAAAACATCAGCT
ATCTGGCGCAAACCCGACCGCTGAGCGATACCCCGTGGAATTTCACCCTGCTCACCCCGTTGCAGGATCTGCGGCGCGAA
GCGATCAATCAGGGGATTCTGGTAGCCGTGGCGTTTGCCCTGGTGGCGTTCCTGCTGATCGCCTGGAACGAACGGCGCAA
GGTCATCGCCACCCGCCTCGCCGCCCGCGAAGCCCTGCAGGAAGCCAACAATCAGCTGGAGCGTCGGATTACCGAACGCA
CCGCCGACCTGCGCGCCAGCAATGACCGGCTCAAGAGCCAGATCCGCGAACGGCGTCAGGCCGAAGAAACCTTGCGCCGC
GCCCAGGACGAACTGGTGCAGGCCGGCAAACTCGCGGCCATCGGCCAGATGTCCACCAGCATCGCCCACGAACTGAACCA
GCCGCTGGCGGCGATGCGCACGCTGTCGGGCAACACCATTCGCTTCCTTGAGCGCGGCCAGCTCGATGTCGCCAGCACCA
ACCTCAAAACCATCAACGACCTGATCGACCGCATGGGCCGGATCACCGCCAGCCTGCGTTCCTTCGCCCGGCGCGGCGAC
GACAAGGGCCGCGCCAGCCTCGGCAAAGCGGTGGATGCCGCACTGCAAGTGCTCGGCGCCCGCGTCGAAAGTGCATCCCT
GCAACTGCATCGCCAATTCGACGATGTGCAGGTGCAGATCGACCAGACCCGCCTGGAACAGATTCTGGTCAACCTGATCG
GCAACGCCCTCGACGCCATGCAGGCGCAACCGCTGCCGGAACTGTGGCTGGAAGGTGAAGAATTCAACGGCAAATATCGC
CTGCGAGTGCGCGACAACGGCCACGGCATCGACGCCGAAGCGCGCAAGCACCTGTTCGAACCGTTCTTCACCACCAAACC
CGGCGAACAGGGCCTGGGCCTCGGCCTGACCCTGTCGGCCAGCCTCGCCGCCGCCACCGGCGGGCATCTGGGTGTCGAGC
ACCCGGCCAGCGGTGGTACCACTTTCGTCCTCAGTTTACCGTTGGTAAGCCCTACTCCTGCCGAGCCAATATGA

Upstream 100 bases:

>100_bases
GCGCAGCATTTCCTCGAGAAAATCCTGCAGCACTAAAAACGGCTGCATTCCCCGACATCCTCTGTCGGGGAATGCAGGTG
GTTGACCCAAGGCATCTGTG

Downstream 100 bases:

>100_bases
ACAACGACCTCAGTGTATTGATCGTCGAAGACGACCCCCATGTCCTGCTCGGCTGCCAGCAGGCGCTGACCCTCGAAGAC
ATCCCCTGCATCGGCGTCGG

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MKCDPTLYRATPPSLAVKPRLIRHLFLPPLVIALMIGLGYIGFWTSEHFGIRSLGENGQRQLELHARAVESEISKYTYLP
SLLELESSVSLLLDDPTPEHRQTVNDYLEGLNRRSRSRAIYVMDTTGRVMATSNWRDVDSYLGEDLSFRAYFQNAIRGQP
GRFYGIGSTNGEPGYYLAHGLEEHGKIIGVAVVKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKSVIPLSDET
KEKLARSLQYYWFPLNELQPLARETLSEGVEKLTFPANSEVPSQQDGDEENISYLAQTRPLSDTPWNFTLLTPLQDLRRE
AINQGILVAVAFALVAFLLIAWNERRKVIATRLAAREALQEANNQLERRITERTADLRASNDRLKSQIRERRQAEETLRR
AQDELVQAGKLAAIGQMSTSIAHELNQPLAAMRTLSGNTIRFLERGQLDVASTNLKTINDLIDRMGRITASLRSFARRGD
DKGRASLGKAVDAALQVLGARVESASLQLHRQFDDVQVQIDQTRLEQILVNLIGNALDAMQAQPLPELWLEGEEFNGKYR
LRVRDNGHGIDAEARKHLFEPFFTTKPGEQGLGLGLTLSASLAAATGGHLGVEHPASGGTTFVLSLPLVSPTPAEPI

Sequences:

>Translated_637_residues
MKCDPTLYRATPPSLAVKPRLIRHLFLPPLVIALMIGLGYIGFWTSEHFGIRSLGENGQRQLELHARAVESEISKYTYLP
SLLELESSVSLLLDDPTPEHRQTVNDYLEGLNRRSRSRAIYVMDTTGRVMATSNWRDVDSYLGEDLSFRAYFQNAIRGQP
GRFYGIGSTNGEPGYYLAHGLEEHGKIIGVAVVKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKSVIPLSDET
KEKLARSLQYYWFPLNELQPLARETLSEGVEKLTFPANSEVPSQQDGDEENISYLAQTRPLSDTPWNFTLLTPLQDLRRE
AINQGILVAVAFALVAFLLIAWNERRKVIATRLAAREALQEANNQLERRITERTADLRASNDRLKSQIRERRQAEETLRR
AQDELVQAGKLAAIGQMSTSIAHELNQPLAAMRTLSGNTIRFLERGQLDVASTNLKTINDLIDRMGRITASLRSFARRGD
DKGRASLGKAVDAALQVLGARVESASLQLHRQFDDVQVQIDQTRLEQILVNLIGNALDAMQAQPLPELWLEGEEFNGKYR
LRVRDNGHGIDAEARKHLFEPFFTTKPGEQGLGLGLTLSASLAAATGGHLGVEHPASGGTTFVLSLPLVSPTPAEPI
>Mature_637_residues
MKCDPTLYRATPPSLAVKPRLIRHLFLPPLVIALMIGLGYIGFWTSEHFGIRSLGENGQRQLELHARAVESEISKYTYLP
SLLELESSVSLLLDDPTPEHRQTVNDYLEGLNRRSRSRAIYVMDTTGRVMATSNWRDVDSYLGEDLSFRAYFQNAIRGQP
GRFYGIGSTNGEPGYYLAHGLEEHGKIIGVAVVKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKSVIPLSDET
KEKLARSLQYYWFPLNELQPLARETLSEGVEKLTFPANSEVPSQQDGDEENISYLAQTRPLSDTPWNFTLLTPLQDLRRE
AINQGILVAVAFALVAFLLIAWNERRKVIATRLAAREALQEANNQLERRITERTADLRASNDRLKSQIRERRQAEETLRR
AQDELVQAGKLAAIGQMSTSIAHELNQPLAAMRTLSGNTIRFLERGQLDVASTNLKTINDLIDRMGRITASLRSFARRGD
DKGRASLGKAVDAALQVLGARVESASLQLHRQFDDVQVQIDQTRLEQILVNLIGNALDAMQAQPLPELWLEGEEFNGKYR
LRVRDNGHGIDAEARKHLFEPFFTTKPGEQGLGLGLTLSASLAAATGGHLGVEHPASGGTTFVLSLPLVSPTPAEPI

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=29.004329004329, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=28.5106382978723, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI87081816, Length=291, Percent_Identity=27.1477663230241, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=27.1551724137931, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71049; Mature: 71049

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCDPTLYRATPPSLAVKPRLIRHLFLPPLVIALMIGLGYIGFWTSEHFGIRSLGENGQR
CCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHH
QLELHARAVESEISKYTYLPSLLELESSVSLLLDDPTPEHRQTVNDYLEGLNRRSRSRAI
HHHHHHHHHHHHHHHHHHCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCEE
YVMDTTGRVMATSNWRDVDSYLGEDLSFRAYFQNAIRGQPGRFYGIGSTNGEPGYYLAHG
EEEECCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHCC
LEEHGKIIGVAVVKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKSVIPLSDET
HHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHHHHHHHCCCCCHH
KEKLARSLQYYWFPLNELQPLARETLSEGVEKLTFPANSEVPSQQDGDEENISYLAQTRP
HHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHCCC
LSDTPWNFTLLTPLQDLRREAINQGILVAVAFALVAFLLIAWNERRKVIATRLAAREALQ
CCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EANNQLERRITERTADLRASNDRLKSQIRERRQAEETLRRAQDELVQAGKLAAIGQMSTS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IAHELNQPLAAMRTLSGNTIRFLERGQLDVASTNLKTINDLIDRMGRITASLRSFARRGD
HHHHHCCHHHHHHHCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DKGRASLGKAVDAALQVLGARVESASLQLHRQFDDVQVQIDQTRLEQILVNLIGNALDAM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
QAQPLPELWLEGEEFNGKYRLRVRDNGHGIDAEARKHLFEPFFTTKPGEQGLGLGLTLSA
HCCCCHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEHH
SLAAATGGHLGVEHPASGGTTFVLSLPLVSPTPAEPI
HHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKCDPTLYRATPPSLAVKPRLIRHLFLPPLVIALMIGLGYIGFWTSEHFGIRSLGENGQR
CCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHH
QLELHARAVESEISKYTYLPSLLELESSVSLLLDDPTPEHRQTVNDYLEGLNRRSRSRAI
HHHHHHHHHHHHHHHHHHCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCEE
YVMDTTGRVMATSNWRDVDSYLGEDLSFRAYFQNAIRGQPGRFYGIGSTNGEPGYYLAHG
EEEECCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHCC
LEEHGKIIGVAVVKVRLEALEERWQRARLEAFVSDENGIIILSSDPARRLKSVIPLSDET
HHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHHHHHHHCCCCCHH
KEKLARSLQYYWFPLNELQPLARETLSEGVEKLTFPANSEVPSQQDGDEENISYLAQTRP
HHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHCCC
LSDTPWNFTLLTPLQDLRREAINQGILVAVAFALVAFLLIAWNERRKVIATRLAAREALQ
CCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EANNQLERRITERTADLRASNDRLKSQIRERRQAEETLRRAQDELVQAGKLAAIGQMSTS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IAHELNQPLAAMRTLSGNTIRFLERGQLDVASTNLKTINDLIDRMGRITASLRSFARRGD
HHHHHCCHHHHHHHCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DKGRASLGKAVDAALQVLGARVESASLQLHRQFDDVQVQIDQTRLEQILVNLIGNALDAM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
QAQPLPELWLEGEEFNGKYRLRVRDNGHGIDAEARKHLFEPFFTTKPGEQGLGLGLTLSA
HCCCCHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEHH
SLAAATGGHLGVEHPASGGTTFVLSLPLVSPTPAEPI
HHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]