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The map label for this gene is glpK [H]

Identifier: 77460753

GI number: 77460753

Start: 5105705

End: 5107207

Strand: Direct

Name: glpK [H]

Synonym: Pfl01_4532

Alternate gene names: 77460753

Gene position: 5105705-5107207 (Clockwise)

Preceding gene: 77460752

Following gene: 77460754

Centisome position: 79.3

GC content: 62.01

Gene sequence:

>1503_bases
ATGACCGACATTGAGAATAAGAACTACATCATTGCCCTCGATCAGGGTACGACCAGCTCCCGCGCGATCATTTTCGACCG
CGACGCGAACGTGGTCTGCACCGCACAACGCGAATTCGCCCAGCACTACCCGCAAGCCGGTTGGGTCGAACACGACCCGA
TGGAAATCTTCGCCACCCAGAGCGCGGTGATGGTCGAAGCGCTGGCCCAGGCCGGCCTGCACCATGACCAGGTCGCCGCC
ATCGGCATCACCAACCAGCGCGAAACCACCGTGGTCTGGGACAAGACCACCGGCCGCCCGGTGTACAACGCGATCGTCTG
GCAATGCCGGCGCAGCACCGAGATCTGCCAGCAGCTCAAGCGCGACGGTCATGAAGACTACATCCGCGACACTACGGGAC
TGGTCACCGACCCGTACTTCTCCGGCACCAAACTGAAGTGGATCCTCGACAACGTCGAAGGCAGCCGTGAGCGCGCGCGC
AACGGCGAACTGCTGTTCGGCACCGTCGACAGCTGGCTGATCTGGAAATTCACTGGCGGTAAAGTCCACGTCACCGACTA
CACCAACGCCTCGCGCACCATGCTCTTCAACATCCACACCCTGGAGTGGGACGCGAAGATGCTGGAGATCCTCGACATCC
CGCGCGAGATGCTGCCGGAAGTCAAAGCCTCTTCGGAAATCTACGGCCGTACCAAAAGTGGCATCGCCATCGGCGGTATC
GCCGGCGACCAGCAGGCTGCGCTGTTCGGCCAGATGTGCGTCGAGCCGGGCCAGGCAAAAAACACTTACGGCACCGGTTG
CTTCCTGCTGATGAACACCGGCGACAAAGCGGTGAAATCCCAGCACGGCATGCTCACCACCATCGCCTGCGGCCCGCGCG
GCGAAGTGGCCTACGCCCTGGAAGGTGCCGTGTTCAACGGCGGTTCGACCGTGCAGTGGCTGCGCGATGAACTGAAGATC
GTCAACGACGCCCACGACACCGAATACTTCGCCAATAAAGTGAAGGACAGCAACGGCGTGTATCTGGTGCCAGCCTTCAC
CGGCCTCGGTGCGCCCTACTGGGATCCGTATGCCCGTGGCGCCCTGTTCGGCCTGACCCGTGGCGTGCGCGTGGATCACA
TCATCCGCGCTGCTCTGGAATCGATTGCCTATCAGACCCGCGACGTCCTCGACGCCATGCAACAGGACTCCGGCGAACGC
CTCAAGGCCCTGCGCGTGGACGGCGGCGCGGTGGCAAACAACTTCCTGATGCAGTTCCAGGCCGACATCCTCGGCACCCA
GGTCGAGCGTCCGAAAATGCGCGAAACCACGGCGCTCGGCGCAGCTTATCTGGCCGGTCTGGCGTGCGGATTCTGGGGCA
GCCTGGAAGAACTGCGCGGCAAGGCCGTGATCGAGCGCGAATTCGAACCGAGCCTGGACGAAGTCGAGAAAGAGAAGCTG
TATAAAGGCTGGAAAAAAGCTGTCAGCCGTACCCGTGACTGGGCGCGTGAAGACGCTGAATAA

Upstream 100 bases:

>100_bases
CGGCAAACCAAGAACTTCTTGAAACAGTCGGCGCGGACTCCTGCCCTGATAGAGACCGCGCCACGGCCCACTCTCCCTTA
TTTCGTCCAAGGCAATCGAC

Downstream 100 bases:

>100_bases
GCCAACCTGAGTACTCGTATCCGTATGTAACTGGTAGGGAGCGGATTCCTGCGGCATCATGGGCAAATTTTGCACGGCAG
CCCAAAGGAAGCCCCATGAA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MTDIENKNYIIALDQGTTSSRAIIFDRDANVVCTAQREFAQHYPQAGWVEHDPMEIFATQSAVMVEALAQAGLHHDQVAA
IGITNQRETTVVWDKTTGRPVYNAIVWQCRRSTEICQQLKRDGHEDYIRDTTGLVTDPYFSGTKLKWILDNVEGSRERAR
NGELLFGTVDSWLIWKFTGGKVHVTDYTNASRTMLFNIHTLEWDAKMLEILDIPREMLPEVKASSEIYGRTKSGIAIGGI
AGDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGDKAVKSQHGMLTTIACGPRGEVAYALEGAVFNGGSTVQWLRDELKI
VNDAHDTEYFANKVKDSNGVYLVPAFTGLGAPYWDPYARGALFGLTRGVRVDHIIRAALESIAYQTRDVLDAMQQDSGER
LKALRVDGGAVANNFLMQFQADILGTQVERPKMRETTALGAAYLAGLACGFWGSLEELRGKAVIEREFEPSLDEVEKEKL
YKGWKKAVSRTRDWAREDAE

Sequences:

>Translated_500_residues
MTDIENKNYIIALDQGTTSSRAIIFDRDANVVCTAQREFAQHYPQAGWVEHDPMEIFATQSAVMVEALAQAGLHHDQVAA
IGITNQRETTVVWDKTTGRPVYNAIVWQCRRSTEICQQLKRDGHEDYIRDTTGLVTDPYFSGTKLKWILDNVEGSRERAR
NGELLFGTVDSWLIWKFTGGKVHVTDYTNASRTMLFNIHTLEWDAKMLEILDIPREMLPEVKASSEIYGRTKSGIAIGGI
AGDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGDKAVKSQHGMLTTIACGPRGEVAYALEGAVFNGGSTVQWLRDELKI
VNDAHDTEYFANKVKDSNGVYLVPAFTGLGAPYWDPYARGALFGLTRGVRVDHIIRAALESIAYQTRDVLDAMQQDSGER
LKALRVDGGAVANNFLMQFQADILGTQVERPKMRETTALGAAYLAGLACGFWGSLEELRGKAVIEREFEPSLDEVEKEKL
YKGWKKAVSRTRDWAREDAE
>Mature_499_residues
TDIENKNYIIALDQGTTSSRAIIFDRDANVVCTAQREFAQHYPQAGWVEHDPMEIFATQSAVMVEALAQAGLHHDQVAAI
GITNQRETTVVWDKTTGRPVYNAIVWQCRRSTEICQQLKRDGHEDYIRDTTGLVTDPYFSGTKLKWILDNVEGSRERARN
GELLFGTVDSWLIWKFTGGKVHVTDYTNASRTMLFNIHTLEWDAKMLEILDIPREMLPEVKASSEIYGRTKSGIAIGGIA
GDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGDKAVKSQHGMLTTIACGPRGEVAYALEGAVFNGGSTVQWLRDELKIV
NDAHDTEYFANKVKDSNGVYLVPAFTGLGAPYWDPYARGALFGLTRGVRVDHIIRAALESIAYQTRDVLDAMQQDSGERL
KALRVDGGAVANNFLMQFQADILGTQVERPKMRETTALGAAYLAGLACGFWGSLEELRGKAVIEREFEPSLDEVEKEKLY
KGWKKAVSRTRDWAREDAE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=501, Percent_Identity=48.502994011976, Blast_Score=457, Evalue=1e-129,
Organism=Homo sapiens, GI4504007, Length=501, Percent_Identity=48.502994011976, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI42794763, Length=507, Percent_Identity=47.9289940828402, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI41393575, Length=505, Percent_Identity=46.3366336633663, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI88196792, Length=507, Percent_Identity=33.7278106508876, Blast_Score=311, Evalue=1e-84,
Organism=Escherichia coli, GI1790361, Length=498, Percent_Identity=74.4979919678715, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1789987, Length=479, Percent_Identity=24.6346555323591, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790005, Length=480, Percent_Identity=24.5833333333333, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787789, Length=520, Percent_Identity=24.2307692307692, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789138, Length=459, Percent_Identity=22.8758169934641, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17535599, Length=502, Percent_Identity=41.2350597609562, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71986140, Length=518, Percent_Identity=25.8687258687259, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71986147, Length=295, Percent_Identity=31.5254237288136, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321755, Length=550, Percent_Identity=36.1818181818182, Blast_Score=315, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24655555, Length=509, Percent_Identity=43.2220039292731, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24655560, Length=509, Percent_Identity=43.2220039292731, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24655570, Length=509, Percent_Identity=43.2220039292731, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24655574, Length=509, Percent_Identity=43.2220039292731, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24655565, Length=509, Percent_Identity=43.2220039292731, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI17864214, Length=504, Percent_Identity=43.6507936507937, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24654573, Length=441, Percent_Identity=44.671201814059, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19922058, Length=525, Percent_Identity=33.7142857142857, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24652871, Length=491, Percent_Identity=34.0122199592668, Blast_Score=281, Evalue=8e-76,
Organism=Drosophila melanogaster, GI24656367, Length=519, Percent_Identity=28.131021194605, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21357867, Length=536, Percent_Identity=27.6119402985075, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24656372, Length=349, Percent_Identity=30.0859598853868, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45552909, Length=290, Percent_Identity=27.9310344827586, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55628; Mature: 55497

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIENKNYIIALDQGTTSSRAIIFDRDANVVCTAQREFAQHYPQAGWVEHDPMEIFATQ
CCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEECHHHHHHHCCCCCCCCCCCHHEEECH
SAVMVEALAQAGLHHDQVAAIGITNQRETTVVWDKTTGRPVYNAIVWQCRRSTEICQQLK
HHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHH
RDGHEDYIRDTTGLVTDPYFSGTKLKWILDNVEGSRERARNGELLFGTVDSWLIWKFTGG
HCCCHHHHHHCCCCEECCCCCCCEEEEEEECCCCCHHHCCCCCEEEEECCCEEEEEEECC
KVHVTDYTNASRTMLFNIHTLEWDAKMLEILDIPREMLPEVKASSEIYGRTKSGIAIGGI
EEEEEECCCCCEEEEEEEEEECCCHHHHHHHHCCHHHHHHHHCCHHHCCCCCCCEEEECC
AGDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGDKAVKSQHGMLTTIACGPRGEVAYAL
CCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHCCCCEEEEEECCCCCEEEEE
EGAVFNGGSTVQWLRDELKIVNDAHDTEYFANKVKDSNGVYLVPAFTGLGAPYWDPYARG
ECEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHCC
ALFGLTRGVRVDHIIRAALESIAYQTRDVLDAMQQDSGERLKALRVDGGAVANNFLMQFQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHH
ADILGTQVERPKMRETTALGAAYLAGLACGFWGSLEELRGKAVIEREFEPSLDEVEKEKL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEECCCCCCHHHHHHHHH
YKGWKKAVSRTRDWAREDAE
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDIENKNYIIALDQGTTSSRAIIFDRDANVVCTAQREFAQHYPQAGWVEHDPMEIFATQ
CCCCCCCEEEEEECCCCCCEEEEEECCCCEEEECHHHHHHHCCCCCCCCCCCHHEEECH
SAVMVEALAQAGLHHDQVAAIGITNQRETTVVWDKTTGRPVYNAIVWQCRRSTEICQQLK
HHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHH
RDGHEDYIRDTTGLVTDPYFSGTKLKWILDNVEGSRERARNGELLFGTVDSWLIWKFTGG
HCCCHHHHHHCCCCEECCCCCCCEEEEEEECCCCCHHHCCCCCEEEEECCCEEEEEEECC
KVHVTDYTNASRTMLFNIHTLEWDAKMLEILDIPREMLPEVKASSEIYGRTKSGIAIGGI
EEEEEECCCCCEEEEEEEEEECCCHHHHHHHHCCHHHHHHHHCCHHHCCCCCCCEEEECC
AGDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGDKAVKSQHGMLTTIACGPRGEVAYAL
CCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHCCCCEEEEEECCCCCEEEEE
EGAVFNGGSTVQWLRDELKIVNDAHDTEYFANKVKDSNGVYLVPAFTGLGAPYWDPYARG
ECEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHCC
ALFGLTRGVRVDHIIRAALESIAYQTRDVLDAMQQDSGERLKALRVDGGAVANNFLMQFQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHH
ADILGTQVERPKMRETTALGAAYLAGLACGFWGSLEELRGKAVIEREFEPSLDEVEKEKL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEECCCCCCHHHHHHHHH
YKGWKKAVSRTRDWAREDAE
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA