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The map label for this gene is mutT [H]

Identifier: 77460646

GI number: 77460646

Start: 4982575

End: 4983519

Strand: Reverse

Name: mutT [H]

Synonym: Pfl01_4425

Alternate gene names: 77460646

Gene position: 4983519-4982575 (Counterclockwise)

Preceding gene: 77460647

Following gene: 77460642

Centisome position: 77.4

GC content: 64.66

Gene sequence:

>945_bases
GTGAAACGTGTACACGTCGCCGCCGCCGTCATTCGTGACGGCAGTGGCAAGATTCTGATCGCCCGTCGTGCCGATACCCA
GCATCAAGGCGGCCTCTGGGAATTTCCCGGTGGCAAGGTCGAGGCCGATGAGTCGGTGCAAACCGCGCTGGCCCGAGAGC
TGCACGAAGAGTTGGGCATTGTCGTTGGCGCCGCTCGGCCGCTGATCAAGGTGCGTCATGACTACCCGGACAAGCAGGTG
TTGCTGGATGTCTGGGAAGTTTCGAGTTTTACCGGTGAGCCCCACGGCGCTGAAGGTCAGCCCTTGGCCTGGGTGTCGGC
CAGGGAGCTGACGGATTACGAATTCCCGGCGGCCAACCAGCCGATCGTGGCGGCGGCGCGTCTGCCTGCCGAATACCTGA
TCACCCCGGAAGACCTGGAAACCCCGGCCTTGCTGCGCGGTATCCAGAAGGCAATCGCCGGTGGCATCAAGCTGATCCAG
CTGCGTGCGCCCAATGGTTATGATCCGAAGTACCGCGATCTGGCGGTCGATGCGGTCGGCCTGTGCGCCGGCAAGGCGCA
GTTGATGATCAAGGGCCCGTTCGAGTGGCTGGGGGATTTCCCGGCGGCCGGCTGGCACATCACCTCGGCGCAGTTGCGCA
AATACGCCGCTGCGGGGCGTCCGTTACCGGCGGAGCGCTGGTTGGCAGCGTCCTGCCACAACGCTGAAGAACTGGCACTG
GCCGAGCAGATGGGCGTGGATTTCGTCACTCTGTCGCCGGTGCAGCCGACCCTGACTCACCCGGATGCACAGCCGTTGGG
CTGGGAGCAGGCGTCGACGCTGATCGAAGGCTTCAGCAAACCGGTGTTCCTGTTGGGCGGAGTCGGCCCGGCGGAGCGCG
AAAAAGCATGGAATGCCGGGGCTCAGGGTGTCGCGGGGATTCGGGCGTTCTGGCCTGAGGCCTGA

Upstream 100 bases:

>100_bases
AGGTGAAGCTGCCGGCCGACGATCAAGCCTATGTTGAAACCGTCTACCAATGGCCGGCCTTCAAGGCCTGGCAAAAGGCT
GGACTGGAGGAATTGCAGTC

Downstream 100 bases:

>100_bases
ATTAGCATTGATGCGACTGCCCCCTTCGCGAGCGGGCTCGCGAAGGGGGCCTGACTGGCGCTACTGATCTGAAGGTTTCG
CCGCCGGTTGCCACAGAATC

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKRVHVAAAVIRDGSGKILIARRADTQHQGGLWEFPGGKVEADESVQTALARELHEELGIVVGAARPLIKVRHDYPDKQV
LLDVWEVSSFTGEPHGAEGQPLAWVSARELTDYEFPAANQPIVAAARLPAEYLITPEDLETPALLRGIQKAIAGGIKLIQ
LRAPNGYDPKYRDLAVDAVGLCAGKAQLMIKGPFEWLGDFPAAGWHITSAQLRKYAAAGRPLPAERWLAASCHNAEELAL
AEQMGVDFVTLSPVQPTLTHPDAQPLGWEQASTLIEGFSKPVFLLGGVGPAEREKAWNAGAQGVAGIRAFWPEA

Sequences:

>Translated_314_residues
MKRVHVAAAVIRDGSGKILIARRADTQHQGGLWEFPGGKVEADESVQTALARELHEELGIVVGAARPLIKVRHDYPDKQV
LLDVWEVSSFTGEPHGAEGQPLAWVSARELTDYEFPAANQPIVAAARLPAEYLITPEDLETPALLRGIQKAIAGGIKLIQ
LRAPNGYDPKYRDLAVDAVGLCAGKAQLMIKGPFEWLGDFPAAGWHITSAQLRKYAAAGRPLPAERWLAASCHNAEELAL
AEQMGVDFVTLSPVQPTLTHPDAQPLGWEQASTLIEGFSKPVFLLGGVGPAEREKAWNAGAQGVAGIRAFWPEA
>Mature_314_residues
MKRVHVAAAVIRDGSGKILIARRADTQHQGGLWEFPGGKVEADESVQTALARELHEELGIVVGAARPLIKVRHDYPDKQV
LLDVWEVSSFTGEPHGAEGQPLAWVSARELTDYEFPAANQPIVAAARLPAEYLITPEDLETPALLRGIQKAIAGGIKLIQ
LRAPNGYDPKYRDLAVDAVGLCAGKAQLMIKGPFEWLGDFPAAGWHITSAQLRKYAAAGRPLPAERWLAASCHNAEELAL
AEQMGVDFVTLSPVQPTLTHPDAQPLGWEQASTLIEGFSKPVFLLGGVGPAEREKAWNAGAQGVAGIRAFWPEA

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=127, Percent_Identity=39.3700787401575, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788056, Length=125, Percent_Identity=40.8, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-; 2.5.1.3

Molecular weight: Translated: 33845; Mature: 33845

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVHVAAAVIRDGSGKILIARRADTQHQGGLWEFPGGKVEADESVQTALARELHEELGI
CCCEEEEEEEEECCCCCEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCE
VVGAARPLIKVRHDYPDKQVLLDVWEVSSFTGEPHGAEGQPLAWVSARELTDYEFPAANQ
EEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCC
PIVAAARLPAEYLITPEDLETPALLRGIQKAIAGGIKLIQLRAPNGYDPKYRDLAVDAVG
CEEEEECCCHHHEECCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHH
LCAGKAQLMIKGPFEWLGDFPAAGWHITSAQLRKYAAAGRPLPAERWLAASCHNAEELAL
HCCCCEEEEEECCHHHHCCCCCCCEEECHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHH
AEQMGVDFVTLSPVQPTLTHPDAQPLGWEQASTLIEGFSKPVFLLGGVGPAEREKAWNAG
HHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCC
AQGVAGIRAFWPEA
CCCCCHHHHCCCCC
>Mature Secondary Structure
MKRVHVAAAVIRDGSGKILIARRADTQHQGGLWEFPGGKVEADESVQTALARELHEELGI
CCCEEEEEEEEECCCCCEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCE
VVGAARPLIKVRHDYPDKQVLLDVWEVSSFTGEPHGAEGQPLAWVSARELTDYEFPAANQ
EEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCC
PIVAAARLPAEYLITPEDLETPALLRGIQKAIAGGIKLIQLRAPNGYDPKYRDLAVDAVG
CEEEEECCCHHHEECCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHH
LCAGKAQLMIKGPFEWLGDFPAAGWHITSAQLRKYAAAGRPLPAERWLAASCHNAEELAL
HCCCCEEEEEECCHHHHCCCCCCCEEECHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHH
AEQMGVDFVTLSPVQPTLTHPDAQPLGWEQASTLIEGFSKPVFLLGGVGPAEREKAWNAG
HHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCC
AQGVAGIRAFWPEA
CCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3033442; 1630901; 9278503; 2841285; 8202364; 3288626; 1851162; 1309939; 7578113; 9063868 [H]