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The map label for this gene is tyrR [H]

Identifier: 77460611

GI number: 77460611

Start: 4949149

End: 4950657

Strand: Direct

Name: tyrR [H]

Synonym: Pfl01_4390

Alternate gene names: 77460611

Gene position: 4949149-4950657 (Clockwise)

Preceding gene: 77460610

Following gene: 77460612

Centisome position: 76.87

GC content: 64.68

Gene sequence:

>1509_bases
ATGCGTATCCACGTCAGCTTCATCGACCGCGTCGGCATCACCCAGGAAGTCCTGGCTATCCTCGGCGGGCGCAATCTCAA
TCTGGATGCGGTGGAAATGATCCCGCCCAACGTCTACATCGACGCCCCGACCTTGAGCCCGCAAGTGCTCGAAGAACTGA
AAGATGCGCTGTTTCGCGTGCGTGGTGTAGAAGCAGTAACCGTGGTCGACATCCTCCCCGGCCAGCGTCGGCACTTGCAG
CTCGACGCATTGCTCGCGGCGATGACCGACCCGGTGCTGGCACTGGACAGCGCCGGCAAGGTGCTGCTGGCCAACCCGGC
ACTGATCGCCCTGTACGGCCGCGAGCCGGCTGGCGAAAGCGTTTCGGAACTGTTCAACGATCCGGGCCTGCTCGAAACCC
TGCTCGAACAAGGCTTCCGCCTGCCGCTGCGGGAAATCACCGTCAACGGCCAGACCCTGTTGCTGGACGCCACGCCGATC
ACCGACGCCGGCGCCCTGCTGACCCTGTATCAACCCAACCGCATCGGCGAACAACTCTCGGCGTTGCACCACGACCATGC
CGAAGGCTTTGATGCGCTGCTCGGTGAATCGCCGCCAATCCGCACCCTCAAGGCTCGCGCCCAACGCGTCGCGGCCCTCG
ACGCGCCGCTGCTGATCCAGGGCGAAACCGGCACCGGCAAGGAACTGGTGGCCCGCGCCTGCCACGCCATCAGCGCCCGG
CACAGTGCGCCATTCCTCGCACTGAACTGCGCGGCCCTGCCGGAGAACCTCGCCGAAAGCGAACTGTTCGGCTACGCCCC
CGGCGCCTTCACCGGCGCACAACGCGGCGGCAAACCGGGGCTGATGGAGCTGGCCAACCAGGGCACGGTGTTCCTCGACG
AAATCGGCGAGATGTCGCCGTACTTGCAGGCCAAACTGCTGCGCTTTCTCAACGACGGCAGCTTCCGTCGGGTTGGCGGT
GACCGAGAGGTAAAGGTCAACGTGCGGATCCTCAGCGCCACCCACCGCGACCTGGAAAAAATGGTCAGCGAAGGCCTGTT
CCGCGAAGACCTGTTCTACCGCCTCAACGTGCTCAACGTCGAAGTGCCGCCACTGCGTGAACGTGGTCAGGACATTCTGT
TGCTGGCGCGCTATTTCATGCAGCAGGCCTGCGCGCAGATCCAGCGCCCGGTCTGCCGCCTGGCCCCGGGCACCTATCCG
GCGCTGCTCGGTAACCGCTGGCCAGGCAACGTGCGGCAATTGCAGAACGTGATCTTCCGCGCCGCCGCCATTTGCGAAAG
CAGCCTGGTGGACATCGGCGACCTCGACATCGCCGGCACCTCCGTGGCACGCCAGACCGACACCGACGTCGACAGCCTGG
AAGAAGCGGTCGAAGCCTTCGAAAAATCGCTGCTGGAAAAGCTCTACGTCAGCTACCCCTCGACCCGCCAACTGGCCAGC
CGCCTGCAGACCTCGCACACCGCAATTGCCCATCGGCTGCGCAAGTACGGGATTCCGGGCAAAGCCTGA

Upstream 100 bases:

>100_bases
GGGGTGGATTTCGAGCACGACGCCATTCTCAAGATTTCACCCCAGTCCCCCATCAAGGCATACTTGCCACCCTCCGCACT
CCAGAACCCAGAACCGCCCC

Downstream 100 bases:

>100_bases
GATCGCGCCAAAAACGACCTCCATCTGTACTGAAAGCGCTACAGCGGAACGATATCGCTACACCCTCCTCCGATCACCGC
TGTGCAAGGCTTTGATCCGG

Product: transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MRIHVSFIDRVGITQEVLAILGGRNLNLDAVEMIPPNVYIDAPTLSPQVLEELKDALFRVRGVEAVTVVDILPGQRRHLQ
LDALLAAMTDPVLALDSAGKVLLANPALIALYGREPAGESVSELFNDPGLLETLLEQGFRLPLREITVNGQTLLLDATPI
TDAGALLTLYQPNRIGEQLSALHHDHAEGFDALLGESPPIRTLKARAQRVAALDAPLLIQGETGTGKELVARACHAISAR
HSAPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLMELANQGTVFLDEIGEMSPYLQAKLLRFLNDGSFRRVGG
DREVKVNVRILSATHRDLEKMVSEGLFREDLFYRLNVLNVEVPPLRERGQDILLLARYFMQQACAQIQRPVCRLAPGTYP
ALLGNRWPGNVRQLQNVIFRAAAICESSLVDIGDLDIAGTSVARQTDTDVDSLEEAVEAFEKSLLEKLYVSYPSTRQLAS
RLQTSHTAIAHRLRKYGIPGKA

Sequences:

>Translated_502_residues
MRIHVSFIDRVGITQEVLAILGGRNLNLDAVEMIPPNVYIDAPTLSPQVLEELKDALFRVRGVEAVTVVDILPGQRRHLQ
LDALLAAMTDPVLALDSAGKVLLANPALIALYGREPAGESVSELFNDPGLLETLLEQGFRLPLREITVNGQTLLLDATPI
TDAGALLTLYQPNRIGEQLSALHHDHAEGFDALLGESPPIRTLKARAQRVAALDAPLLIQGETGTGKELVARACHAISAR
HSAPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLMELANQGTVFLDEIGEMSPYLQAKLLRFLNDGSFRRVGG
DREVKVNVRILSATHRDLEKMVSEGLFREDLFYRLNVLNVEVPPLRERGQDILLLARYFMQQACAQIQRPVCRLAPGTYP
ALLGNRWPGNVRQLQNVIFRAAAICESSLVDIGDLDIAGTSVARQTDTDVDSLEEAVEAFEKSLLEKLYVSYPSTRQLAS
RLQTSHTAIAHRLRKYGIPGKA
>Mature_502_residues
MRIHVSFIDRVGITQEVLAILGGRNLNLDAVEMIPPNVYIDAPTLSPQVLEELKDALFRVRGVEAVTVVDILPGQRRHLQ
LDALLAAMTDPVLALDSAGKVLLANPALIALYGREPAGESVSELFNDPGLLETLLEQGFRLPLREITVNGQTLLLDATPI
TDAGALLTLYQPNRIGEQLSALHHDHAEGFDALLGESPPIRTLKARAQRVAALDAPLLIQGETGTGKELVARACHAISAR
HSAPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLMELANQGTVFLDEIGEMSPYLQAKLLRFLNDGSFRRVGG
DREVKVNVRILSATHRDLEKMVSEGLFREDLFYRLNVLNVEVPPLRERGQDILLLARYFMQQACAQIQRPVCRLAPGTYP
ALLGNRWPGNVRQLQNVIFRAAAICESSLVDIGDLDIAGTSVARQTDTDVDSLEEAVEAFEKSLLEKLYVSYPSTRQLAS
RLQTSHTAIAHRLRKYGIPGKA

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=517, Percent_Identity=41.779497098646, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1788550, Length=313, Percent_Identity=43.4504792332268, Blast_Score=251, Evalue=9e-68,
Organism=Escherichia coli, GI1789233, Length=340, Percent_Identity=39.4117647058824, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=42.9906542056075, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1788905, Length=279, Percent_Identity=45.5197132616487, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1790299, Length=256, Percent_Identity=49.21875, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1790437, Length=277, Percent_Identity=43.3212996389892, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI87082117, Length=244, Percent_Identity=45.4918032786885, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI87081872, Length=255, Percent_Identity=47.4509803921569, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1789087, Length=248, Percent_Identity=43.5483870967742, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1786524, Length=242, Percent_Identity=48.3471074380165, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1789828, Length=241, Percent_Identity=36.9294605809129, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081858, Length=452, Percent_Identity=25.6637168141593, Blast_Score=132, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54785; Mature: 54785

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIHVSFIDRVGITQEVLAILGGRNLNLDAVEMIPPNVYIDAPTLSPQVLEELKDALFRV
CEEEEEEHHHCCCHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHH
RGVEAVTVVDILPGQRRHLQLDALLAAMTDPVLALDSAGKVLLANPALIALYGREPAGES
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCEEEECCCEEEEECCCCCCHH
VSELFNDPGLLETLLEQGFRLPLREITVNGQTLLLDATPITDAGALLTLYQPNRIGEQLS
HHHHHCCCCHHHHHHHCCCCCCHHHEEECCCEEEEECCCCCCCCCEEEEECCHHHHHHHH
ALHHDHAEGFDALLGESPPIRTLKARAQRVAALDAPLLIQGETGTGKELVARACHAISAR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHC
HSAPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLMELANQGTVFLDEIGEMSP
CCCCEEEEEHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCEEEHHHHCCCH
YLQAKLLRFLNDGSFRRVGGDREVKVNVRILSATHRDLEKMVSEGLFREDLFYRLNVLNV
HHHHHHHHHHCCCCEEECCCCCEEEEEEEEEEHHHHHHHHHHHCCCHHHHHHHEEEEEEE
EVPPLRERGQDILLLARYFMQQACAQIQRPVCRLAPGTYPALLGNRWPGNVRQLQNVIFR
CCCCHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHCCCCCCHHHHHHHHHHH
AAAICESSLVDIGDLDIAGTSVARQTDTDVDSLEEAVEAFEKSLLEKLYVSYPSTRQLAS
HHHHHHHCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RLQTSHTAIAHRLRKYGIPGKA
HHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIHVSFIDRVGITQEVLAILGGRNLNLDAVEMIPPNVYIDAPTLSPQVLEELKDALFRV
CEEEEEEHHHCCCHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHH
RGVEAVTVVDILPGQRRHLQLDALLAAMTDPVLALDSAGKVLLANPALIALYGREPAGES
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCEEEECCCEEEEECCCCCCHH
VSELFNDPGLLETLLEQGFRLPLREITVNGQTLLLDATPITDAGALLTLYQPNRIGEQLS
HHHHHCCCCHHHHHHHCCCCCCHHHEEECCCEEEEECCCCCCCCCEEEEECCHHHHHHHH
ALHHDHAEGFDALLGESPPIRTLKARAQRVAALDAPLLIQGETGTGKELVARACHAISAR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHC
HSAPFLALNCAALPENLAESELFGYAPGAFTGAQRGGKPGLMELANQGTVFLDEIGEMSP
CCCCEEEEEHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCEEEHHHHCCCH
YLQAKLLRFLNDGSFRRVGGDREVKVNVRILSATHRDLEKMVSEGLFREDLFYRLNVLNV
HHHHHHHHHHCCCCEEECCCCCEEEEEEEEEEHHHHHHHHHHHCCCHHHHHHHEEEEEEE
EVPPLRERGQDILLLARYFMQQACAQIQRPVCRLAPGTYPALLGNRWPGNVRQLQNVIFR
CCCCHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHCCCCCCHHHHHHHHHHH
AAAICESSLVDIGDLDIAGTSVARQTDTDVDSLEEAVEAFEKSLLEKLYVSYPSTRQLAS
HHHHHHHCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RLQTSHTAIAHRLRKYGIPGKA
HHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]