Click here to switch to the map view.

The map label for this gene is hlyB [H]

Identifier: 77460603

GI number: 77460603

Start: 4938090

End: 4940306

Strand: Direct

Name: hlyB [H]

Synonym: Pfl01_4382

Alternate gene names: 77460603

Gene position: 4938090-4940306 (Clockwise)

Preceding gene: 77460602

Following gene: 77460604

Centisome position: 76.7

GC content: 62.34

Gene sequence:

>2217_bases
ATGGCGCTGAATGGATTTGGCGAACCGGGCACCTTCCTGCCTCTTAGCCAACAGCTCATCCATTCGCGAGAACGTCCCAT
GTTCGACTCTCTGTCCATTCGCCTGAAAATCGTCCTGCTGTCCGGCCTGTGCCTGCTCGGTGTGGTCGCGCTGATCGTTG
GCATCAATATTTACCAGACCAACCAGAACGACGAACTGGTCAGCACTTCCAGCAGCAAGATGCTCACCGCCAGTGTGCAG
GACCTGCTGCAGGCCAAGGCTGCCGAACAGGCGGTGCAAGTGCAGAAAACCTTCGGCGAGAGCCTGCTGGTGATCACCGC
CCTGGCCGACCAGGTCAAGGACATGCGCGTCATGGCTGCCAAGCGTTCGCTGGACGCCGGCGCCCTGCGTGAAGAGTTGA
ACCAGAGCCTGAAAACCGCCTTCGAACGCAACAGCAAGGTGCTCGGCATCTGGCTGGCGTTCGAACCGAACGGACTGGAT
GGCAAGGACAGCGAATTCGCCAACGATGCCGCGCGTCAGTCCAACGAGGCGGGGCGTTTCGCCAGTTACTGGAGCCGTGC
TGCGGGTCCGTCGCTGAACACGATCATGGTCGAAGACGACATGAACAAGACCACCCTCAGCGTCAGCGGCACGCCTTACA
ACAGCTGGTACACCTGCCCTCGCGACAACAAGCGCACCTGCCTGCTTGATCCTTACGCCGATACCGTGGGCGGCAAGGAA
ATGCTCATGACCACCATTTCCGTACCGTTGCTGGTGGACGGCAAGGCCATCGGCGTGGTCGGCATCGACATTGCCCTGGA
TGCGCTGCAAGCGGCGGCCGTCAATTCCCAGCGTGAGCTGTTCAACAGTGCCGGACACATGCTGATCGTCTCCGGCAGCG
GCGTGCTGGGCGCCTACAGCACCGACGCAACCAAAGTCGGCAAAGGCATCACCGAAACCCTCGGTGCCGAAGGCAAGGAC
ATCCTGCAACTGCTGAGCGCCGGCACGCCGAAGATTCTCGAACAGGGCGACCTGATCCGCGCCGTGTACCCGGTCGATCC
GATTGGCAACTCCCGGGCCTGGGGCGTGGTCATCGACCTGCCGAAACAAGTGCTGCTGGCCGACTCGGTCAAGCTCCAGG
CAGTGCTCGACGATGCCCAGCAAACCGGCATGATTACCGCGTTGGCGGTGGCCGTGATCGCCGGCCTGATCGGTCTGCTG
CTGATCTGGCTCACCGCCTCCGGCGTGACCCGCCCGATCAACAGCGTCGCCGAAATGCTGAAGAACATCGCCAGCGGCGA
AGGCGACCTGACCCAGCGCCTGAACTACACCAAGAAAGACGAACTGGGCGAACTGGTGAACTGGTTCAACCGCTTCCTCG
ACAAGCTGCAACCGACCATCGCCCAGATCAAACAGAGCATCACCGAGGCCCGTGGCACCGCCGATCAATCGTCGGAAATC
GCCCGCCAGACCAGCGAAGGCATGCAGGTGCAGTTCCGCGAGATCGATCAGGTGGCAACCGCCTCCAACGAGATGAGCGC
CACCGCCCACGACGTGGCCAACAGCGCCTCGAATGCGGCCAACGCGGCGAAAGGCGCCGACCAGTCGGCCAAGGACGGCA
TGTCGATCATCGAGCGCAGCACCCGCGACATCAATCAACTGGCGGACGAAGTCAGCAAAGCGGTGACCGAAGTCGAAGAG
CTGGCAGTCAACAGCGAGCAGATCGGTTCGGTGCTGGAAGTGATCCGCAGCATCGCTGAACAGACCAACCTGCTGGCACT
GAACGCCGCGATCGAAGCGGCCCGTGCCGGTGAAAGCGGTCGTGGTTTTGCGGTGGTGGCCGACGAAGTCCGTAACCTCG
CCAAGCGCACTCAGGATTCGGTGGAAGAAATCCGCGTGGTCATCGAACGCATCCAGACCGGCACCCGTGGCGTGGTCGCG
ACCATGCACTCGAGCCAGACCCAGGCTCACAACAACGCCGGGCAGATCCGCCAGGCCGTGGACGCCCTCGGCAAGATCAG
CGACGCGGTCACCGTGATCAGCGACATGAACCTGCAGATCGCCAGCGCCGCCGAACAGCAGAGCGCGGTGGCCGAAGAGG
TCAACCGCAACGTCTCGGCGATCCGCACCGTCACCGAAACCCTGACCGAACAGGCCACCGAATCGGCGGCGATCAGCAGC
CAGCTCAACGCCCTGGCCAGCCAGCAGATGAAATTGATGGATCAGTTCCGCGTCTGA

Upstream 100 bases:

>100_bases
TTCCCCTTGTTTTCAGGGTATTTACCCGCGCAAACGTTTAGCCGCGACCGCTCGTCGGCTTGTGATTCATGCCTGTCCGC
CCCGCGCCGATGAGCATTGA

Downstream 100 bases:

>100_bases
TTTGATCTATGATCAGGCCCTCTTCCGGAGGGCCTTCGATGACTGATCTGCTCACGTCCATTCAAGCCGCACTCGGCTTG
TCCCCCACGCCGATTCCGTT

Product: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 738; Mature: 737

Protein sequence:

>738_residues
MALNGFGEPGTFLPLSQQLIHSRERPMFDSLSIRLKIVLLSGLCLLGVVALIVGINIYQTNQNDELVSTSSSKMLTASVQ
DLLQAKAAEQAVQVQKTFGESLLVITALADQVKDMRVMAAKRSLDAGALREELNQSLKTAFERNSKVLGIWLAFEPNGLD
GKDSEFANDAARQSNEAGRFASYWSRAAGPSLNTIMVEDDMNKTTLSVSGTPYNSWYTCPRDNKRTCLLDPYADTVGGKE
MLMTTISVPLLVDGKAIGVVGIDIALDALQAAAVNSQRELFNSAGHMLIVSGSGVLGAYSTDATKVGKGITETLGAEGKD
ILQLLSAGTPKILEQGDLIRAVYPVDPIGNSRAWGVVIDLPKQVLLADSVKLQAVLDDAQQTGMITALAVAVIAGLIGLL
LIWLTASGVTRPINSVAEMLKNIASGEGDLTQRLNYTKKDELGELVNWFNRFLDKLQPTIAQIKQSITEARGTADQSSEI
ARQTSEGMQVQFREIDQVATASNEMSATAHDVANSASNAANAAKGADQSAKDGMSIIERSTRDINQLADEVSKAVTEVEE
LAVNSEQIGSVLEVIRSIAEQTNLLALNAAIEAARAGESGRGFAVVADEVRNLAKRTQDSVEEIRVVIERIQTGTRGVVA
TMHSSQTQAHNNAGQIRQAVDALGKISDAVTVISDMNLQIASAAEQQSAVAEEVNRNVSAIRTVTETLTEQATESAAISS
QLNALASQQMKLMDQFRV

Sequences:

>Translated_738_residues
MALNGFGEPGTFLPLSQQLIHSRERPMFDSLSIRLKIVLLSGLCLLGVVALIVGINIYQTNQNDELVSTSSSKMLTASVQ
DLLQAKAAEQAVQVQKTFGESLLVITALADQVKDMRVMAAKRSLDAGALREELNQSLKTAFERNSKVLGIWLAFEPNGLD
GKDSEFANDAARQSNEAGRFASYWSRAAGPSLNTIMVEDDMNKTTLSVSGTPYNSWYTCPRDNKRTCLLDPYADTVGGKE
MLMTTISVPLLVDGKAIGVVGIDIALDALQAAAVNSQRELFNSAGHMLIVSGSGVLGAYSTDATKVGKGITETLGAEGKD
ILQLLSAGTPKILEQGDLIRAVYPVDPIGNSRAWGVVIDLPKQVLLADSVKLQAVLDDAQQTGMITALAVAVIAGLIGLL
LIWLTASGVTRPINSVAEMLKNIASGEGDLTQRLNYTKKDELGELVNWFNRFLDKLQPTIAQIKQSITEARGTADQSSEI
ARQTSEGMQVQFREIDQVATASNEMSATAHDVANSASNAANAAKGADQSAKDGMSIIERSTRDINQLADEVSKAVTEVEE
LAVNSEQIGSVLEVIRSIAEQTNLLALNAAIEAARAGESGRGFAVVADEVRNLAKRTQDSVEEIRVVIERIQTGTRGVVA
TMHSSQTQAHNNAGQIRQAVDALGKISDAVTVISDMNLQIASAAEQQSAVAEEVNRNVSAIRTVTETLTEQATESAAISS
QLNALASQQMKLMDQFRV
>Mature_737_residues
ALNGFGEPGTFLPLSQQLIHSRERPMFDSLSIRLKIVLLSGLCLLGVVALIVGINIYQTNQNDELVSTSSSKMLTASVQD
LLQAKAAEQAVQVQKTFGESLLVITALADQVKDMRVMAAKRSLDAGALREELNQSLKTAFERNSKVLGIWLAFEPNGLDG
KDSEFANDAARQSNEAGRFASYWSRAAGPSLNTIMVEDDMNKTTLSVSGTPYNSWYTCPRDNKRTCLLDPYADTVGGKEM
LMTTISVPLLVDGKAIGVVGIDIALDALQAAAVNSQRELFNSAGHMLIVSGSGVLGAYSTDATKVGKGITETLGAEGKDI
LQLLSAGTPKILEQGDLIRAVYPVDPIGNSRAWGVVIDLPKQVLLADSVKLQAVLDDAQQTGMITALAVAVIAGLIGLLL
IWLTASGVTRPINSVAEMLKNIASGEGDLTQRLNYTKKDELGELVNWFNRFLDKLQPTIAQIKQSITEARGTADQSSEIA
RQTSEGMQVQFREIDQVATASNEMSATAHDVANSASNAANAAKGADQSAKDGMSIIERSTRDINQLADEVSKAVTEVEEL
AVNSEQIGSVLEVIRSIAEQTNLLALNAAIEAARAGESGRGFAVVADEVRNLAKRTQDSVEEIRVVIERIQTGTRGVVAT
MHSSQTQAHNNAGQIRQAVDALGKISDAVTVISDMNLQIASAAEQQSAVAEEVNRNVSAIRTVTETLTEQATESAAISSQ
LNALASQQMKLMDQFRV

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=360, Percent_Identity=30.5555555555556, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1788194, Length=366, Percent_Identity=29.5081967213115, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI2367378, Length=327, Percent_Identity=29.3577981651376, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1788195, Length=307, Percent_Identity=30.2931596091205, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1789453, Length=363, Percent_Identity=27.5482093663912, Blast_Score=109, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 78842; Mature: 78711

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNGFGEPGTFLPLSQQLIHSRERPMFDSLSIRLKIVLLSGLCLLGVVALIVGINIYQT
CCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
NQNDELVSTSSSKMLTASVQDLLQAKAAEQAVQVQKTFGESLLVITALADQVKDMRVMAA
CCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KRSLDAGALREELNQSLKTAFERNSKVLGIWLAFEPNGLDGKDSEFANDAARQSNEAGRF
HHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCHH
ASYWSRAAGPSLNTIMVEDDMNKTTLSVSGTPYNSWYTCPRDNKRTCLLDPYADTVGGKE
HHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCHHHCCCHH
MLMTTISVPLLVDGKAIGVVGIDIALDALQAAAVNSQRELFNSAGHMLIVSGSGVLGAYS
HHHHHHCCCEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECC
TDATKVGKGITETLGAEGKDILQLLSAGTPKILEQGDLIRAVYPVDPIGNSRAWGVVIDL
CCHHHHCCCHHHHHCCCCHHHHHHHHCCCCHHHCCCCEEEEEECCCCCCCCCCCEEEEEC
PKQVLLADSVKLQAVLDDAQQTGMITALAVAVIAGLIGLLLIWLTASGVTRPINSVAEML
CHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KNIASGEGDLTQRLNYTKKDELGELVNWFNRFLDKLQPTIAQIKQSITEARGTADQSSEI
HHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ARQTSEGMQVQFREIDQVATASNEMSATAHDVANSASNAANAAKGADQSAKDGMSIIERS
HHHHHCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TRDINQLADEVSKAVTEVEELAVNSEQIGSVLEVIRSIAEQTNLLALNAAIEAARAGESG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCC
RGFAVVADEVRNLAKRTQDSVEEIRVVIERIQTGTRGVVATMHSSQTQAHNNAGQIRQAV
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHCCCHHHHHHHH
DALGKISDAVTVISDMNLQIASAAEQQSAVAEEVNRNVSAIRTVTETLTEQATESAAISS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
QLNALASQQMKLMDQFRV
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALNGFGEPGTFLPLSQQLIHSRERPMFDSLSIRLKIVLLSGLCLLGVVALIVGINIYQT
CCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
NQNDELVSTSSSKMLTASVQDLLQAKAAEQAVQVQKTFGESLLVITALADQVKDMRVMAA
CCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KRSLDAGALREELNQSLKTAFERNSKVLGIWLAFEPNGLDGKDSEFANDAARQSNEAGRF
HHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCHH
ASYWSRAAGPSLNTIMVEDDMNKTTLSVSGTPYNSWYTCPRDNKRTCLLDPYADTVGGKE
HHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCHHHCCCHH
MLMTTISVPLLVDGKAIGVVGIDIALDALQAAAVNSQRELFNSAGHMLIVSGSGVLGAYS
HHHHHHCCCEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECC
TDATKVGKGITETLGAEGKDILQLLSAGTPKILEQGDLIRAVYPVDPIGNSRAWGVVIDL
CCHHHHCCCHHHHHCCCCHHHHHHHHCCCCHHHCCCCEEEEEECCCCCCCCCCCEEEEEC
PKQVLLADSVKLQAVLDDAQQTGMITALAVAVIAGLIGLLLIWLTASGVTRPINSVAEML
CHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KNIASGEGDLTQRLNYTKKDELGELVNWFNRFLDKLQPTIAQIKQSITEARGTADQSSEI
HHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ARQTSEGMQVQFREIDQVATASNEMSATAHDVANSASNAANAAKGADQSAKDGMSIIERS
HHHHHCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TRDINQLADEVSKAVTEVEELAVNSEQIGSVLEVIRSIAEQTNLLALNAAIEAARAGESG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCC
RGFAVVADEVRNLAKRTQDSVEEIRVVIERIQTGTRGVVATMHSSQTQAHNNAGQIRQAV
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHCCCHHHHHHHH
DALGKISDAVTVISDMNLQIASAAEQQSAVAEEVNRNVSAIRTVTETLTEQATESAAISS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
QLNALASQQMKLMDQFRV
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]