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The map label for this gene is zwf [H]

Identifier: 77460584

GI number: 77460584

Start: 4914970

End: 4916436

Strand: Reverse

Name: zwf [H]

Synonym: Pfl01_4363

Alternate gene names: 77460584

Gene position: 4916436-4914970 (Counterclockwise)

Preceding gene: 77460586

Following gene: 77460583

Centisome position: 76.36

GC content: 61.35

Gene sequence:

>1467_bases
ATGCCTTCGATTACGGTTGAACCGTGCACCTTCGCCTTGTTCGGCGCCTTGGGCGATCTGGCCCTGCGCAAGCTGTTTCC
TGCCCTTTATCACCTTGATGGCGCCGGCCTGCTGCACGAGGACACGCGCATTATTGCACTGGCCCGTGAGGCGGGCACCG
AGCAGCAGCACCTGGCGTTCATCGCCGCCGAGCTGCGTCGTTATGTGGGCAAGGAGCTGGACGAGGCCGTGGCCGAGCGC
TTTCTGGCGCGCCTGACCTACCTGCACGTCGACTTCCTCAAGGCTGAAGATTATGTGGCGCTGGCCGAACTGGCCGGCAG
CACGCAACGCATGATTGCCTACTTCGCCACCCCGGCGGCGGTGTACGGAGCGATCTGCGAGAACCTGGCGAACGTCGGTC
TGGCGGAAAACACCCGCGTGGTACTGGAAAAACCGATCGGCTCCGACCTCGAATCCTCGCGCAAGGTCAACGACGCCGTG
GCGCAGTTCTTCCCGGAGAACCGCACCTACCGCATCGACCACTACCTCGGCAAAGAAACCGTCCAGAACCTGATCGCCCT
GCGTTTCGCCAACAGCCTGTTCGAAACCCAGTGGAACCAGAACTACATCTCCCACGTGGAAATCACCGTGGCCGAGAAGG
TCGGTATCGAAGGCCGCTGGGGTTACTTCGACAAGGCTGGTCAGCTGCGGGACATGATCCAGAACCACCTGCTGCAACTG
CTCTGCCTGATCGCCATGGATCCGCCGGCCGACCTGTCCGCCGACAGCATCCGCGACGAGAAGGTCAAGGTGCTCAAGGC
CCTGGCGCCGATCAGTCCGGAAGGTCTGACCACGCAAGTGGTGCGCGGCCAATACATCGCCGGGCACAGCGAAGGCAAGT
CCGTGCCGGGCTACCTCGAAGAGCCGAATTCCAACGCCCAGAGCGACACCGAAACCTTCGTCGCCCTGCGTGCCGACATC
CGCAACTGGCGTTGGGCCGGCGTGCCGTTCTACCTGCGCACCGGCAAGCGCATGCCGCAGAAACTGTCGCAGATCGTCAT
CCACTTCAAGGAGCCGTCGCACTATATCTTCGCCCCCGAGCAGCGCCTGCAGATCAGCAACAAACTGATCATCCGCCTGC
AACCGGACGAAGGTATTTCCTTGCGCGTGATGACCAAGGAGCAAGGTCTGGACAAGGGCATGCAACTGCGCAGCGGCCCG
CTGCAACTGAATTTTTCCGACACCTGGCGCAGCGCTCGAATTCCCGATGCCTACGAGCGGTTGTTGCTGGAAGTGATGAA
CGGCAATCAGAACCTGTTTGTCCGTAAAGATGAAATCGAAGCCGCGTGGAAATGGTGTGACCAACTGATCGCCGGGTGGA
AAAAATCCGGTGACGCGCCCAAGCCGTATGCGGCCGGGTCGTGGGGGCCGATGAGCTCCATTGCATTGATCACGCGGGAC
GGGAGGTCGTGGTATGGCGATATCTGA

Upstream 100 bases:

>100_bases
CTGTATTTTGCGAAAATGTTGTGGTTATTACTACATTTTCCCTTGAGTGATGCCTTGAAAAAAGGTATTTGTAGCTTAAC
TTGATAAAAGAACAAACATC

Downstream 100 bases:

>100_bases
TGTGAAACTGCCCGAGGGCGTGAATGCCCATGAATTCAAGAGCCCGGTGCTGCTCGCCGAAGGCCTGGCGCTGAATGTCG
CCAAGCAATTGAGCGAAGCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MPSITVEPCTFALFGALGDLALRKLFPALYHLDGAGLLHEDTRIIALAREAGTEQQHLAFIAAELRRYVGKELDEAVAER
FLARLTYLHVDFLKAEDYVALAELAGSTQRMIAYFATPAAVYGAICENLANVGLAENTRVVLEKPIGSDLESSRKVNDAV
AQFFPENRTYRIDHYLGKETVQNLIALRFANSLFETQWNQNYISHVEITVAEKVGIEGRWGYFDKAGQLRDMIQNHLLQL
LCLIAMDPPADLSADSIRDEKVKVLKALAPISPEGLTTQVVRGQYIAGHSEGKSVPGYLEEPNSNAQSDTETFVALRADI
RNWRWAGVPFYLRTGKRMPQKLSQIVIHFKEPSHYIFAPEQRLQISNKLIIRLQPDEGISLRVMTKEQGLDKGMQLRSGP
LQLNFSDTWRSARIPDAYERLLLEVMNGNQNLFVRKDEIEAAWKWCDQLIAGWKKSGDAPKPYAAGSWGPMSSIALITRD
GRSWYGDI

Sequences:

>Translated_488_residues
MPSITVEPCTFALFGALGDLALRKLFPALYHLDGAGLLHEDTRIIALAREAGTEQQHLAFIAAELRRYVGKELDEAVAER
FLARLTYLHVDFLKAEDYVALAELAGSTQRMIAYFATPAAVYGAICENLANVGLAENTRVVLEKPIGSDLESSRKVNDAV
AQFFPENRTYRIDHYLGKETVQNLIALRFANSLFETQWNQNYISHVEITVAEKVGIEGRWGYFDKAGQLRDMIQNHLLQL
LCLIAMDPPADLSADSIRDEKVKVLKALAPISPEGLTTQVVRGQYIAGHSEGKSVPGYLEEPNSNAQSDTETFVALRADI
RNWRWAGVPFYLRTGKRMPQKLSQIVIHFKEPSHYIFAPEQRLQISNKLIIRLQPDEGISLRVMTKEQGLDKGMQLRSGP
LQLNFSDTWRSARIPDAYERLLLEVMNGNQNLFVRKDEIEAAWKWCDQLIAGWKKSGDAPKPYAAGSWGPMSSIALITRD
GRSWYGDI
>Mature_487_residues
PSITVEPCTFALFGALGDLALRKLFPALYHLDGAGLLHEDTRIIALAREAGTEQQHLAFIAAELRRYVGKELDEAVAERF
LARLTYLHVDFLKAEDYVALAELAGSTQRMIAYFATPAAVYGAICENLANVGLAENTRVVLEKPIGSDLESSRKVNDAVA
QFFPENRTYRIDHYLGKETVQNLIALRFANSLFETQWNQNYISHVEITVAEKVGIEGRWGYFDKAGQLRDMIQNHLLQLL
CLIAMDPPADLSADSIRDEKVKVLKALAPISPEGLTTQVVRGQYIAGHSEGKSVPGYLEEPNSNAQSDTETFVALRADIR
NWRWAGVPFYLRTGKRMPQKLSQIVIHFKEPSHYIFAPEQRLQISNKLIIRLQPDEGISLRVMTKEQGLDKGMQLRSGPL
QLNFSDTWRSARIPDAYERLLLEVMNGNQNLFVRKDEIEAAWKWCDQLIAGWKKSGDAPKPYAAGSWGPMSSIALITRDG
RSWYGDI

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=37.9381443298969, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=37.9381443298969, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI52145310, Length=495, Percent_Identity=30.3030303030303, Blast_Score=166, Evalue=6e-41,
Organism=Escherichia coli, GI1788158, Length=482, Percent_Identity=54.149377593361, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17538218, Length=499, Percent_Identity=37.2745490981964, Blast_Score=309, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6324088, Length=474, Percent_Identity=35.8649789029536, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24643350, Length=476, Percent_Identity=36.1344537815126, Blast_Score=288, Evalue=8e-78,
Organism=Drosophila melanogaster, GI24643352, Length=476, Percent_Identity=36.1344537815126, Blast_Score=287, Evalue=9e-78,
Organism=Drosophila melanogaster, GI221513548, Length=495, Percent_Identity=29.0909090909091, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54837; Mature: 54706

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00069 G6P_DEHYDROGENASE ; PS00256 AKH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSITVEPCTFALFGALGDLALRKLFPALYHLDGAGLLHEDTRIIALAREAGTEQQHLAF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEHHCCCCHHHHHH
IAAELRRYVGKELDEAVAERFLARLTYLHVDFLKAEDYVALAELAGSTQRMIAYFATPAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHCCCHHHHHHHHHHHHH
VYGAICENLANVGLAENTRVVLEKPIGSDLESSRKVNDAVAQFFPENRTYRIDHYLGKET
HHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHCHHH
VQNLIALRFANSLFETQWNQNYISHVEITVAEKVGIEGRWGYFDKAGQLRDMIQNHLLQL
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LCLIAMDPPADLSADSIRDEKVKVLKALAPISPEGLTTQVVRGQYIAGHSEGKSVPGYLE
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCCCCCCCCC
EPNSNAQSDTETFVALRADIRNWRWAGVPFYLRTGKRMPQKLSQIVIHFKEPSHYIFAPE
CCCCCCCCCHHHHHHHHHHHCCCEECCCCCEECCCCHHHHHHHHHEEEEECCCCEEECCH
QRLQISNKLIIRLQPDEGISLRVMTKEQGLDKGMQLRSGPLQLNFSDTWRSARIPDAYER
HHHCCCCEEEEEECCCCCCEEEEEEHHCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHH
LLLEVMNGNQNLFVRKDEIEAAWKWCDQLIAGWKKSGDAPKPYAAGSWGPMSSIALITRD
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEC
GRSWYGDI
CCCCCCCC
>Mature Secondary Structure 
PSITVEPCTFALFGALGDLALRKLFPALYHLDGAGLLHEDTRIIALAREAGTEQQHLAF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEHHCCCCHHHHHH
IAAELRRYVGKELDEAVAERFLARLTYLHVDFLKAEDYVALAELAGSTQRMIAYFATPAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHCCCHHHHHHHHHHHHH
VYGAICENLANVGLAENTRVVLEKPIGSDLESSRKVNDAVAQFFPENRTYRIDHYLGKET
HHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHCHHH
VQNLIALRFANSLFETQWNQNYISHVEITVAEKVGIEGRWGYFDKAGQLRDMIQNHLLQL
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LCLIAMDPPADLSADSIRDEKVKVLKALAPISPEGLTTQVVRGQYIAGHSEGKSVPGYLE
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCCCCCCCCC
EPNSNAQSDTETFVALRADIRNWRWAGVPFYLRTGKRMPQKLSQIVIHFKEPSHYIFAPE
CCCCCCCCCHHHHHHHHHHHCCCEECCCCCEECCCCHHHHHHHHHEEEEECCCCEEECCH
QRLQISNKLIIRLQPDEGISLRVMTKEQGLDKGMQLRSGPLQLNFSDTWRSARIPDAYER
HHHCCCCEEEEEECCCCCCEEEEEEHHCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHH
LLLEVMNGNQNLFVRKDEIEAAWKWCDQLIAGWKKSGDAPKPYAAGSWGPMSSIALITRD
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEC
GRSWYGDI
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537370; 10984043 [H]