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The map label for this gene is hlyB [H]

Identifier: 77460487

GI number: 77460487

Start: 4814381

End: 4816021

Strand: Direct

Name: hlyB [H]

Synonym: Pfl01_4266

Alternate gene names: 77460487

Gene position: 4814381-4816021 (Clockwise)

Preceding gene: 77460483

Following gene: 77460488

Centisome position: 74.78

GC content: 59.84

Gene sequence:

>1641_bases
ATGAGTTGGTTGAATGACGCAAGACTTTCCACGAAATTGATCACCGCCTTCGCGGCGTGCGCCTTCATCACCCTGGGGGT
GGGCCTGCTGGGAAGCCGGGGAGTGACCGAGCTCTCGACAAGCCTCAGATCGGTGTTCGGCAACAACCTCGTCGCCGTCG
CCAACATCGCGCAGACCAAAATCAAGGCTGTCGGACAGACCCGTGACATGTATCGGCTTTACGTCGCCACTGCCGCCAAC
CTGCCACAGAGCACCAAAGACGAATTCCTCGCCTCGATGAGCGCGAACCAGTTGGCGAGTGAAAAAGCCTTTGCCGAATA
TCGAAAAACCAAGCTTGCCGACGACGAACGTGCAGCAGGCGACCGAATGGAAAAAGCCTGGCCCGTTTACCAGGCGATCG
TGCAAAAGTATCTGGCCCTGATGAAGGCCGGCGACCTGGAAAACGGCCGCGAACTGCTGCTCGGCGACCTGCAAAAGAAC
TACCGCGTCGTCATGGACGAATTGACCATCATGACCAACTCCAACGATATGCAAGTCAGCGAAGCCGCAAAGCGATCGGT
TCTGACGGAGTCGTCCGCCAAGACGTCGCTGTACATCGGCATCGTGCTGGCCTTCGTCGCTGCGATTTTGCTCGGCCTGT
TCATCAGCCGACTGATCAGCCGCCCCATCTCAAAAGCCGTTGAAAGCGCCCGAAGCATCGCTGGGGGAGACCTGACTCAA
AACATCGTCAGCACCGGCCGCGACGAGGCCGGTCAGTTGCTCACGACCCTGGCCGAGATGCAGGGCAGCCTGAAAGGCAC
TATTCAGCAGATCGCCAACGCGGCAGATCAACTGGCTTCAGCTGCCGAAGAACTCACCGCCGTCACCGACAACGGAAGCC
GTGGTCTGATCCGTCAGAACGACGAGATCCAGCAGGCAGCGACCGCTGTCACGGAAATGACCTCCGCCGTGGAGGAAGTC
GCGCGCAATGCGGTATCCACCTCCGAGGCCTCCCAAGCCACCAGCCGGGAAGCCGGCAATGGACGCGATCAAGCGCGAAG
CGCCGTCGCCGCGATCAACCATGCAACCACGGAAATCGCCACCTCCACCACCATGGTCAAAGACCTGGCGGAGAAGGTTC
GAGACATCGGCAAGGTGCTGGATGTGATCCGGGGGATTGCCGAGCAAACCAATCTGCTGGCGCTTAACGCCGCTATCGAG
GCTGCACGCGCGGGTGAGCAAGGTCGAGGTTTTGCCGTGGTCGCCGACGAGGTACGAGCCCTGGCGGCAAGAACCCAAGC
CTCGACAGGGGAAATCGAAGGTATGATCAACGACGTTCGCAACAGTGCAGACGAAGCCGTTGGCGCCATGGGGAAAAGCC
AGGCGCTGGTCAGCGAAACCCAGTCACTGGCGCAAGCGACCGGCCAGGCATTGGAGCTGATTGCCGACGGCATCTCGCAG
ATCAACGATCGCAACCTCGTCATCGCCACTGCTTCGGAAGAACAGGCACACGTCGCTCGCGAAGTGGATCGTAATCTGGT
CAACATCCAGGATCTGTCCACCCAAACGGCGGCAGGTGCGCATCAGACCAGCGCCTCGACCCAGGAACTTTCCAACCTGG
CGGCGTCGTTCAACACCATGGTCAGTCGCTTCCGCTTATAA

Upstream 100 bases:

>100_bases
GTTGTGGACTCAGCAGCCGAAAGATGTACGACGACATACCGTTTTCTTACGAGCTGCACTCGATATTGTCCCGACCCCAC
ATGTCAGCAGGATGCCCCTT

Downstream 100 bases:

>100_bases
AATGGCGACAACAAAAAGCCCCGCCAGATTACCTGCGCGGGGCTTTTCAATGGATGGTGTCCCAGGGCAGGTTCGAACTG
CCAACCTTCCCCTTAGGAGG

Product: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MSWLNDARLSTKLITAFAACAFITLGVGLLGSRGVTELSTSLRSVFGNNLVAVANIAQTKIKAVGQTRDMYRLYVATAAN
LPQSTKDEFLASMSANQLASEKAFAEYRKTKLADDERAAGDRMEKAWPVYQAIVQKYLALMKAGDLENGRELLLGDLQKN
YRVVMDELTIMTNSNDMQVSEAAKRSVLTESSAKTSLYIGIVLAFVAAILLGLFISRLISRPISKAVESARSIAGGDLTQ
NIVSTGRDEAGQLLTTLAEMQGSLKGTIQQIANAADQLASAAEELTAVTDNGSRGLIRQNDEIQQAATAVTEMTSAVEEV
ARNAVSTSEASQATSREAGNGRDQARSAVAAINHATTEIATSTTMVKDLAEKVRDIGKVLDVIRGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRALAARTQASTGEIEGMINDVRNSADEAVGAMGKSQALVSETQSLAQATGQALELIADGISQ
INDRNLVIATASEEQAHVAREVDRNLVNIQDLSTQTAAGAHQTSASTQELSNLAASFNTMVSRFRL

Sequences:

>Translated_546_residues
MSWLNDARLSTKLITAFAACAFITLGVGLLGSRGVTELSTSLRSVFGNNLVAVANIAQTKIKAVGQTRDMYRLYVATAAN
LPQSTKDEFLASMSANQLASEKAFAEYRKTKLADDERAAGDRMEKAWPVYQAIVQKYLALMKAGDLENGRELLLGDLQKN
YRVVMDELTIMTNSNDMQVSEAAKRSVLTESSAKTSLYIGIVLAFVAAILLGLFISRLISRPISKAVESARSIAGGDLTQ
NIVSTGRDEAGQLLTTLAEMQGSLKGTIQQIANAADQLASAAEELTAVTDNGSRGLIRQNDEIQQAATAVTEMTSAVEEV
ARNAVSTSEASQATSREAGNGRDQARSAVAAINHATTEIATSTTMVKDLAEKVRDIGKVLDVIRGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRALAARTQASTGEIEGMINDVRNSADEAVGAMGKSQALVSETQSLAQATGQALELIADGISQ
INDRNLVIATASEEQAHVAREVDRNLVNIQDLSTQTAAGAHQTSASTQELSNLAASFNTMVSRFRL
>Mature_545_residues
SWLNDARLSTKLITAFAACAFITLGVGLLGSRGVTELSTSLRSVFGNNLVAVANIAQTKIKAVGQTRDMYRLYVATAANL
PQSTKDEFLASMSANQLASEKAFAEYRKTKLADDERAAGDRMEKAWPVYQAIVQKYLALMKAGDLENGRELLLGDLQKNY
RVVMDELTIMTNSNDMQVSEAAKRSVLTESSAKTSLYIGIVLAFVAAILLGLFISRLISRPISKAVESARSIAGGDLTQN
IVSTGRDEAGQLLTTLAEMQGSLKGTIQQIANAADQLASAAEELTAVTDNGSRGLIRQNDEIQQAATAVTEMTSAVEEVA
RNAVSTSEASQATSREAGNGRDQARSAVAAINHATTEIATSTTMVKDLAEKVRDIGKVLDVIRGIAEQTNLLALNAAIEA
ARAGEQGRGFAVVADEVRALAARTQASTGEIEGMINDVRNSADEAVGAMGKSQALVSETQSLAQATGQALELIADGISQI
NDRNLVIATASEEQAHVAREVDRNLVNIQDLSTQTAAGAHQTSASTQELSNLAASFNTMVSRFRL

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=425, Percent_Identity=29.6470588235294, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787690, Length=454, Percent_Identity=29.7356828193833, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788194, Length=374, Percent_Identity=31.5508021390374, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788195, Length=282, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1789453, Length=342, Percent_Identity=29.8245614035088, Blast_Score=99, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 57891; Mature: 57760

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWLNDARLSTKLITAFAACAFITLGVGLLGSRGVTELSTSLRSVFGNNLVAVANIAQTK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEHHHHHHH
IKAVGQTRDMYRLYVATAANLPQSTKDEFLASMSANQLASEKAFAEYRKTKLADDERAAG
HHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DRMEKAWPVYQAIVQKYLALMKAGDLENGRELLLGDLQKNYRVVMDELTIMTNSNDMQVS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHH
EAAKRSVLTESSAKTSLYIGIVLAFVAAILLGLFISRLISRPISKAVESARSIAGGDLTQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
NIVSTGRDEAGQLLTTLAEMQGSLKGTIQQIANAADQLASAAEELTAVTDNGSRGLIRQN
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DEIQQAATAVTEMTSAVEEVARNAVSTSEASQATSREAGNGRDQARSAVAAINHATTEIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TSTTMVKDLAEKVRDIGKVLDVIRGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
LAARTQASTGEIEGMINDVRNSADEAVGAMGKSQALVSETQSLAQATGQALELIADGISQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INDRNLVIATASEEQAHVAREVDRNLVNIQDLSTQTAAGAHQTSASTQELSNLAASFNTM
CCCCCEEEEECCHHHHHHHHHHHHHHCCHHHCCHHHHCCCHHCCCHHHHHHHHHHHHHHH
VSRFRL
HHHHCC
>Mature Secondary Structure 
SWLNDARLSTKLITAFAACAFITLGVGLLGSRGVTELSTSLRSVFGNNLVAVANIAQTK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEHHHHHHH
IKAVGQTRDMYRLYVATAANLPQSTKDEFLASMSANQLASEKAFAEYRKTKLADDERAAG
HHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DRMEKAWPVYQAIVQKYLALMKAGDLENGRELLLGDLQKNYRVVMDELTIMTNSNDMQVS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHH
EAAKRSVLTESSAKTSLYIGIVLAFVAAILLGLFISRLISRPISKAVESARSIAGGDLTQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
NIVSTGRDEAGQLLTTLAEMQGSLKGTIQQIANAADQLASAAEELTAVTDNGSRGLIRQN
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DEIQQAATAVTEMTSAVEEVARNAVSTSEASQATSREAGNGRDQARSAVAAINHATTEIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TSTTMVKDLAEKVRDIGKVLDVIRGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
LAARTQASTGEIEGMINDVRNSADEAVGAMGKSQALVSETQSLAQATGQALELIADGISQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INDRNLVIATASEEQAHVAREVDRNLVNIQDLSTQTAAGAHQTSASTQELSNLAASFNTM
CCCCCEEEEECCHHHHHHHHHHHHHHCCHHHCCHHHHCCCHHCCCHHHHHHHHHHHHHHH
VSRFRL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]