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The map label for this gene is comA [H]

Identifier: 77460399

GI number: 77460399

Start: 4714320

End: 4716563

Strand: Reverse

Name: comA [H]

Synonym: Pfl01_4178

Alternate gene names: 77460399

Gene position: 4716563-4714320 (Counterclockwise)

Preceding gene: 77460401

Following gene: 77460398

Centisome position: 73.26

GC content: 64.93

Gene sequence:

>2244_bases
ATGCGCACAGGGATGATGGCGCTGGCGGTCGGTCTGCTGGCTCCGGTTTTTTTACCGGCCTTGCCGCCGGTCGGGTTATT
GCTGCTGTTGCCGTGGGTGGCGCTGATGCTGCTGCCGTTTCGCAGCTATCCACTGGCTTTTTTACTGCTTGGATTCACAT
GGGCGAGTTTCAACGCGCAGTTGGCGTTGAATGATCGACTGCCTTCCCGGCTGGATGGAGAAACACGCTGGGTGGAAGGA
CGGGTCGTCGGCTTGCCGCAGAATGCCGAGGGCGTCGTGCGCTTCGAACTGGCCGATGCGCGCTCGCGTCACGAGAAACT
GCCGTCGCTGATGCGTCTGGCGTGGTACGCCGGGCCTGAGATCAAAAGTGGCGAACGCTGGCGACTGGCGGTCAAGCTCA
AGCGTCCCGGCGGCCTGCTCAATCCGGATGCGTTCGATTACGAAGCCTGGCTGCTGGCGCAGCGCATCGGTGCCACCGGG
ACGGTGAAAGATGGCCAGCGTCTGGCGCCGGCGCAGTGGGCCTGGCGCGACAGTATTCGCCAGCGCCTGCTTGCGGTGGA
TGCCCAGGGACGTAACGGCGCCCTGGCTGCGTTGGTCCTCGGTGATGGTTCGGGTCTCGGCCGCGAAGACTGGCAGATAT
TGCAGGACACCGGCACCGTGCATCTGCTGGTGATTTCCGGTCAGCACATCGGGCTGTTGGCTGCGTTGATGTATGCGCTG
GTCGTCGGGCTGGCGCGGGTCGGGATCTGGCCGTTGCGTTGGCCCTGGCTGCCCTGGGCGTGTGGTCTGGCGTTCGCGGC
GGCGCTGGGTTACGGACTGCTGGCCGGGTTCGACGTGCCGGTACGGCGAGCCTGCGTGATGGTTGCGCTGGTGCTGTTGT
GGCGTTTGCGCTTCCGCCACCTCGGTGCATGGTGGCCATTGCTGTTGGCGTTCGACGGCGTGTTGCTGATGGATCCGCTG
GCCAGCCTGCGCCCGGGGTTGTGGCTGTCGTTCGTGGCGGTGGCTGTGTTGATCTTCACCTTCGGCGGCCGTCTGGGGCC
GTGGCGCTGGTGGCAGACCTGGACGCGCGCGCAGTGGCTGATCGCGATTGGTTTGTGCCCGGTGCTGCTGGCGCTGAGCC
TGCCGATCAGTCTCAGCGGGCCGCTGGCCAATCTGCTGGCGGTGCCATGCGTCAGTTTTGCGGTGCTGCCGCCAGCGTTG
CTGGGCACATTGTTGCTGCCGATCCCTTATGTCGGGGAAGGGCTGCTGTGGCTGGCGGGCGGACTGATCGATGGATTGTT
CCGGGCGCTGGCCCTGATTGCCGGGCGGTGGCCGGCGTGGATTGCGGCGTCGATACCGGGATGGGTTCTGGCGCTGGGTT
GCATCGGTGCACTGCTGTTATTGCTGCCCCGAGGCGTACCCCTGCGCCTCTTAGGCTGGCCATTGCTGCTGGTGCTGGCA
TTTCCGCCTCGGGAACGCCTGTCCGAAGGCGTGGCCGATGTCTGGCAACTGGACGTCGGTCAGGGCCTGGCGATTCTGAT
CCGCACCCGGCATCACACCTTGCTGTACGACAGTGGCCCGCGTTTCGGCGACTTCGACCTCGGCGAGCGAGTGGTGCTGC
CGGCATTGCGCAAACTGGGCGTGGAACACCTCGACCTGATGCTGCTCAGCCATGCCGATGCCGATCATGCAGGTGGCGCA
CTCGCGGTGGCGAAAGGATTGCCGGTCAGTCGGGTCATCAGCGGCGATCCGTCGGGGCTAGCCGAAGCGCTGAACGCCGA
GGCTTGTGAAAGTGGTCGGCAATGGCAGTGGGACGGCGTGGCCTTTCATCTATGGCAGTGGACCGACGCCCATGACAGCA
ACCAGCGTTCCTGCGTGTTGCAGATCGAAGCCAATGGCGAACGGTTGCTGCTGAGCGGTGACATCGACAGCGCCGCCGAA
CGGGACCTGCTCAACAGCGCACTGGCAGTTCATACCCAATGGCTACAAGCCCCCCACCATGGCAGCCGCAGTTCTTCGTC
GATGGCCTTGCTCAAGGCTTTGCAGCCACAGGCCGTGCTGATTTCCCGAGGGCAGGGCAATTCGTTCGGCCACCCGCACC
CGACGGTCATCGCCCGCTACCGCAAACAGGGCATACAAATCCATGACAGCGCCGAGCAGGGTGCCATTCATCTGCAACTG
GGGCGGTTTCAGCCGGCCCGGTCGATGCGTCAACAACGCCGGTTCTGGCGCGACCCGCCGTTGCCGGGGGCGGAGTACCG
TTGA

Upstream 100 bases:

>100_bases
GGATTCTACGAACCGCCCATTCAGACTTTGTGACAATTGATAACGACGCCCTTGCCCCGCAACCGCTATGCCTGAGGGTG
GGACTCTCAAGGACGGGCTT

Downstream 100 bases:

>100_bases
GCACGGTCGTCGGGGCGACGAGTCTTTATCGCGAACCGGTATGGTAAAGTGGCGCACTTTTTCGAGGGGGCTGTCACTGT
GTGGGAATTGGTCAAATCCG

Product: DNA internalization-like competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MRTGMMALAVGLLAPVFLPALPPVGLLLLLPWVALMLLPFRSYPLAFLLLGFTWASFNAQLALNDRLPSRLDGETRWVEG
RVVGLPQNAEGVVRFELADARSRHEKLPSLMRLAWYAGPEIKSGERWRLAVKLKRPGGLLNPDAFDYEAWLLAQRIGATG
TVKDGQRLAPAQWAWRDSIRQRLLAVDAQGRNGALAALVLGDGSGLGREDWQILQDTGTVHLLVISGQHIGLLAALMYAL
VVGLARVGIWPLRWPWLPWACGLAFAAALGYGLLAGFDVPVRRACVMVALVLLWRLRFRHLGAWWPLLLAFDGVLLMDPL
ASLRPGLWLSFVAVAVLIFTFGGRLGPWRWWQTWTRAQWLIAIGLCPVLLALSLPISLSGPLANLLAVPCVSFAVLPPAL
LGTLLLPIPYVGEGLLWLAGGLIDGLFRALALIAGRWPAWIAASIPGWVLALGCIGALLLLLPRGVPLRLLGWPLLLVLA
FPPRERLSEGVADVWQLDVGQGLAILIRTRHHTLLYDSGPRFGDFDLGERVVLPALRKLGVEHLDLMLLSHADADHAGGA
LAVAKGLPVSRVISGDPSGLAEALNAEACESGRQWQWDGVAFHLWQWTDAHDSNQRSCVLQIEANGERLLLSGDIDSAAE
RDLLNSALAVHTQWLQAPHHGSRSSSSMALLKALQPQAVLISRGQGNSFGHPHPTVIARYRKQGIQIHDSAEQGAIHLQL
GRFQPARSMRQQRRFWRDPPLPGAEYR

Sequences:

>Translated_747_residues
MRTGMMALAVGLLAPVFLPALPPVGLLLLLPWVALMLLPFRSYPLAFLLLGFTWASFNAQLALNDRLPSRLDGETRWVEG
RVVGLPQNAEGVVRFELADARSRHEKLPSLMRLAWYAGPEIKSGERWRLAVKLKRPGGLLNPDAFDYEAWLLAQRIGATG
TVKDGQRLAPAQWAWRDSIRQRLLAVDAQGRNGALAALVLGDGSGLGREDWQILQDTGTVHLLVISGQHIGLLAALMYAL
VVGLARVGIWPLRWPWLPWACGLAFAAALGYGLLAGFDVPVRRACVMVALVLLWRLRFRHLGAWWPLLLAFDGVLLMDPL
ASLRPGLWLSFVAVAVLIFTFGGRLGPWRWWQTWTRAQWLIAIGLCPVLLALSLPISLSGPLANLLAVPCVSFAVLPPAL
LGTLLLPIPYVGEGLLWLAGGLIDGLFRALALIAGRWPAWIAASIPGWVLALGCIGALLLLLPRGVPLRLLGWPLLLVLA
FPPRERLSEGVADVWQLDVGQGLAILIRTRHHTLLYDSGPRFGDFDLGERVVLPALRKLGVEHLDLMLLSHADADHAGGA
LAVAKGLPVSRVISGDPSGLAEALNAEACESGRQWQWDGVAFHLWQWTDAHDSNQRSCVLQIEANGERLLLSGDIDSAAE
RDLLNSALAVHTQWLQAPHHGSRSSSSMALLKALQPQAVLISRGQGNSFGHPHPTVIARYRKQGIQIHDSAEQGAIHLQL
GRFQPARSMRQQRRFWRDPPLPGAEYR
>Mature_747_residues
MRTGMMALAVGLLAPVFLPALPPVGLLLLLPWVALMLLPFRSYPLAFLLLGFTWASFNAQLALNDRLPSRLDGETRWVEG
RVVGLPQNAEGVVRFELADARSRHEKLPSLMRLAWYAGPEIKSGERWRLAVKLKRPGGLLNPDAFDYEAWLLAQRIGATG
TVKDGQRLAPAQWAWRDSIRQRLLAVDAQGRNGALAALVLGDGSGLGREDWQILQDTGTVHLLVISGQHIGLLAALMYAL
VVGLARVGIWPLRWPWLPWACGLAFAAALGYGLLAGFDVPVRRACVMVALVLLWRLRFRHLGAWWPLLLAFDGVLLMDPL
ASLRPGLWLSFVAVAVLIFTFGGRLGPWRWWQTWTRAQWLIAIGLCPVLLALSLPISLSGPLANLLAVPCVSFAVLPPAL
LGTLLLPIPYVGEGLLWLAGGLIDGLFRALALIAGRWPAWIAASIPGWVLALGCIGALLLLLPRGVPLRLLGWPLLLVLA
FPPRERLSEGVADVWQLDVGQGLAILIRTRHHTLLYDSGPRFGDFDLGERVVLPALRKLGVEHLDLMLLSHADADHAGGA
LAVAKGLPVSRVISGDPSGLAEALNAEACESGRQWQWDGVAFHLWQWTDAHDSNQRSCVLQIEANGERLLLSGDIDSAAE
RDLLNSALAVHTQWLQAPHHGSRSSSSMALLKALQPQAVLISRGQGNSFGHPHPTVIARYRKQGIQIHDSAEQGAIHLQL
GRFQPARSMRQQRRFWRDPPLPGAEYR

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=766, Percent_Identity=28.5900783289817, Blast_Score=195, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 81773; Mature: 81773

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTGMMALAVGLLAPVFLPALPPVGLLLLLPWVALMLLPFRSYPLAFLLLGFTWASFNAQ
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEE
LALNDRLPSRLDGETRWVEGRVVGLPQNAEGVVRFELADARSRHEKLPSLMRLAWYAGPE
EEECCCCCCCCCCCCEEECCEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCC
IKSGERWRLAVKLKRPGGLLNPDAFDYEAWLLAQRIGATGTVKDGQRLAPAQWAWRDSIR
CCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
QRLLAVDAQGRNGALAALVLGDGSGLGREDWQILQDTGTVHLLVISGQHIGLLAALMYAL
HHHHEECCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHH
VVGLARVGIWPLRWPWLPWACGLAFAAALGYGLLAGFDVPVRRACVMVALVLLWRLRFRH
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LGAWWPLLLAFDGVLLMDPLASLRPGLWLSFVAVAVLIFTFGGRLGPWRWWQTWTRAQWL
HCHHHHHHHHHCCHHHHCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IAIGLCPVLLALSLPISLSGPLANLLAVPCVSFAVLPPALLGTLLLPIPYVGEGLLWLAG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
GLIDGLFRALALIAGRWPAWIAASIPGWVLALGCIGALLLLLPRGVPLRLLGWPLLLVLA
HHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
FPPRERLSEGVADVWQLDVGQGLAILIRTRHHTLLYDSGPRFGDFDLGERVVLPALRKLG
CCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHCC
VEHLDLMLLSHADADHAGGALAVAKGLPVSRVISGDPSGLAEALNAEACESGRQWQWDGV
HHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCHHHHHHHCHHHHHCCCCEEECCE
AFHLWQWTDAHDSNQRSCVLQIEANGERLLLSGDIDSAAERDLLNSALAVHTQWLQAPHH
EEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
GSRSSSSMALLKALQPQAVLISRGQGNSFGHPHPTVIARYRKQGIQIHDSAEQGAIHLQL
CCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCEEEEEE
GRFQPARSMRQQRRFWRDPPLPGAEYR
CCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRTGMMALAVGLLAPVFLPALPPVGLLLLLPWVALMLLPFRSYPLAFLLLGFTWASFNAQ
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEE
LALNDRLPSRLDGETRWVEGRVVGLPQNAEGVVRFELADARSRHEKLPSLMRLAWYAGPE
EEECCCCCCCCCCCCEEECCEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCC
IKSGERWRLAVKLKRPGGLLNPDAFDYEAWLLAQRIGATGTVKDGQRLAPAQWAWRDSIR
CCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
QRLLAVDAQGRNGALAALVLGDGSGLGREDWQILQDTGTVHLLVISGQHIGLLAALMYAL
HHHHEECCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHH
VVGLARVGIWPLRWPWLPWACGLAFAAALGYGLLAGFDVPVRRACVMVALVLLWRLRFRH
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LGAWWPLLLAFDGVLLMDPLASLRPGLWLSFVAVAVLIFTFGGRLGPWRWWQTWTRAQWL
HCHHHHHHHHHCCHHHHCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IAIGLCPVLLALSLPISLSGPLANLLAVPCVSFAVLPPALLGTLLLPIPYVGEGLLWLAG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
GLIDGLFRALALIAGRWPAWIAASIPGWVLALGCIGALLLLLPRGVPLRLLGWPLLLVLA
HHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
FPPRERLSEGVADVWQLDVGQGLAILIRTRHHTLLYDSGPRFGDFDLGERVVLPALRKLG
CCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHCC
VEHLDLMLLSHADADHAGGALAVAKGLPVSRVISGDPSGLAEALNAEACESGRQWQWDGV
HHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCHHHHHHHCHHHHHCCCCEEECCE
AFHLWQWTDAHDSNQRSCVLQIEANGERLLLSGDIDSAAERDLLNSALAVHTQWLQAPHH
EEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
GSRSSSSMALLKALQPQAVLISRGQGNSFGHPHPTVIARYRKQGIQIHDSAEQGAIHLQL
CCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCEEEEEE
GRFQPARSMRQQRRFWRDPPLPGAEYR
CCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]