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The map label for this gene is moaA [H]

Identifier: 77460368

GI number: 77460368

Start: 4685475

End: 4686443

Strand: Reverse

Name: moaA [H]

Synonym: Pfl01_4147

Alternate gene names: 77460368

Gene position: 4686443-4685475 (Counterclockwise)

Preceding gene: 77460369

Following gene: 77460367

Centisome position: 72.79

GC content: 62.95

Gene sequence:

>969_bases
ATGATCGTTGACCGTCAAGGCAGGCGTTTTCGCAATTTGCGGATCAGTCTGACTTCAGCCTGCAATTACGCCTGTACCTA
CTGCGTGCCCAACGGCAAGCGGCTGGTGGCTGCGCAGGATGAACTGTCGGCCGAGGCCATGGCGCGCGGCGTGGCTTATC
TGATCGAAGCCGCCGGCATCGAGCGCCTGCGCATCACCGGCGGCGAGCCGCTGGTCAGCCCCAAACTCGAATCGTTCATG
AGCGCCGTCGGCAAGATGGGGCTGGAAGACATCAGCCTGACCACCAACGGCCAGCTCCTGGCGAAAAAGCTCCCGTTGCT
GGTCGATGCCGGCCTGCGACGCATCAACGTTTCCCTCGATACCCTGGACGCCGGCGCGTTCCGCAGCATTGCCCGTGGCG
GTGATCTGGCCACCGTGCTGGATGGCATGGATCAGGCGGCCGCGGCGGGGATGAAGATCAAGGTCAACATGGTGCCGTTG
CGCGGGCAGAACCTCGACCAGGTGATGCCACTGCTCGATTACTGCCTCGAGCGCGGTTTTGAGCTGCGCTTCATCGAGCT
GATGCGCATGGGCCACCTGGCCACCGATTCCAACGCCTTCCTGCAACAGTTCGTCAGCCTGCAACAGTTGCTGAGTCTGA
TCGGTGAACATTACGAGTACGCGCAAACCGATGCGCCAGTGGATGCCACGGCAGTTCGCTATGCGATTCCCGGTCGGGGC
AACTTCGGCGTGATCGCCAACGAAAGCGTACCGTTCTGCCGAACCTGCTCGCGCCTGCGCCTGTCCTCCACCGGATGGCT
GCATGGCTGCCTGTCGTCGAGCAACCGCCACTACGTCGGTGATCTGCTCGACAAGCCGCGTCACGAGGCGCTGCCAGCGT
TGCAGCGGTTGCTGGTCAAGGCGCTGGGCGACAAGCAGGAAGTCGCGTTCTCCGGCGGTGCGACCGTCATGAAGATCATC
GGCGGCTGA

Upstream 100 bases:

>100_bases
TGGCGCAGTACCGCAGGAATATACTCAGGCATAGGGCTTGCTAAAACTTGAATTGTGAGTCAAGTTTTAGCCGCTCGATT
TTCCATCGCCGGAGTGCTTC

Downstream 100 bases:

>100_bases
ACCCGGTTTAGCCACGAAGTCTTATTTCAAAGCGGATACCTGCACATTTTCAAGGACTGGCGCAAAAGCTGCATCTTACG
GCCATTCGCCGGTTTTCCGT

Product: molybdenum cofactor synthesis-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MIVDRQGRRFRNLRISLTSACNYACTYCVPNGKRLVAAQDELSAEAMARGVAYLIEAAGIERLRITGGEPLVSPKLESFM
SAVGKMGLEDISLTTNGQLLAKKLPLLVDAGLRRINVSLDTLDAGAFRSIARGGDLATVLDGMDQAAAAGMKIKVNMVPL
RGQNLDQVMPLLDYCLERGFELRFIELMRMGHLATDSNAFLQQFVSLQQLLSLIGEHYEYAQTDAPVDATAVRYAIPGRG
NFGVIANESVPFCRTCSRLRLSSTGWLHGCLSSSNRHYVGDLLDKPRHEALPALQRLLVKALGDKQEVAFSGGATVMKII
GG

Sequences:

>Translated_322_residues
MIVDRQGRRFRNLRISLTSACNYACTYCVPNGKRLVAAQDELSAEAMARGVAYLIEAAGIERLRITGGEPLVSPKLESFM
SAVGKMGLEDISLTTNGQLLAKKLPLLVDAGLRRINVSLDTLDAGAFRSIARGGDLATVLDGMDQAAAAGMKIKVNMVPL
RGQNLDQVMPLLDYCLERGFELRFIELMRMGHLATDSNAFLQQFVSLQQLLSLIGEHYEYAQTDAPVDATAVRYAIPGRG
NFGVIANESVPFCRTCSRLRLSSTGWLHGCLSSSNRHYVGDLLDKPRHEALPALQRLLVKALGDKQEVAFSGGATVMKII
GG
>Mature_322_residues
MIVDRQGRRFRNLRISLTSACNYACTYCVPNGKRLVAAQDELSAEAMARGVAYLIEAAGIERLRITGGEPLVSPKLESFM
SAVGKMGLEDISLTTNGQLLAKKLPLLVDAGLRRINVSLDTLDAGAFRSIARGGDLATVLDGMDQAAAAGMKIKVNMVPL
RGQNLDQVMPLLDYCLERGFELRFIELMRMGHLATDSNAFLQQFVSLQQLLSLIGEHYEYAQTDAPVDATAVRYAIPGRG
NFGVIANESVPFCRTCSRLRLSSTGWLHGCLSSSNRHYVGDLLDKPRHEALPALQRLLVKALGDKQEVAFSGGATVMKII
GG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=315, Percent_Identity=35.5555555555556, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI22027536, Length=315, Percent_Identity=35.5555555555556, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1786999, Length=331, Percent_Identity=33.5347432024169, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI32566331, Length=270, Percent_Identity=33.7037037037037, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI32566329, Length=270, Percent_Identity=33.7037037037037, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17561210, Length=275, Percent_Identity=33.8181818181818, Blast_Score=157, Evalue=6e-39,
Organism=Drosophila melanogaster, GI28574490, Length=275, Percent_Identity=34.1818181818182, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI28574488, Length=307, Percent_Identity=33.5504885993485, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 34972; Mature: 34972

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVDRQGRRFRNLRISLTSACNYACTYCVPNGKRLVAAQDELSAEAMARGVAYLIEAAGI
CCCCCCCCHHHHEEEEEECCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCCC
ERLRITGGEPLVSPKLESFMSAVGKMGLEDISLTTNGQLLAKKLPLLVDAGLRRINVSLD
CEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHCCHHHHCCCEEEEEEEE
TLDAGAFRSIARGGDLATVLDGMDQAAAAGMKIKVNMVPLRGQNLDQVMPLLDYCLERGF
CCCHHHHHHHHCCCCHHHHHHCHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCC
ELRFIELMRMGHLATDSNAFLQQFVSLQQLLSLIGEHYEYAQTDAPVDATAVRYAIPGRG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEECCCCC
NFGVIANESVPFCRTCSRLRLSSTGWLHGCLSSSNRHYVGDLLDKPRHEALPALQRLLVK
CEEEEECCCCCHHHHHHHHCCCCCCHHHHHHCCCCCEEEHHHHCCCHHHHHHHHHHHHHH
ALGDKQEVAFSGGATVMKIIGG
HHCCCHHEEECCCCEEEEEECC
>Mature Secondary Structure
MIVDRQGRRFRNLRISLTSACNYACTYCVPNGKRLVAAQDELSAEAMARGVAYLIEAAGI
CCCCCCCCHHHHEEEEEECCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCCC
ERLRITGGEPLVSPKLESFMSAVGKMGLEDISLTTNGQLLAKKLPLLVDAGLRRINVSLD
CEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHCCHHHHCCCEEEEEEEE
TLDAGAFRSIARGGDLATVLDGMDQAAAAGMKIKVNMVPLRGQNLDQVMPLLDYCLERGF
CCCHHHHHHHHCCCCHHHHHHCHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCC
ELRFIELMRMGHLATDSNAFLQQFVSLQQLLSLIGEHYEYAQTDAPVDATAVRYAIPGRG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEECCCCC
NFGVIANESVPFCRTCSRLRLSSTGWLHGCLSSSNRHYVGDLLDKPRHEALPALQRLLVK
CEEEEECCCCCHHHHHHHHCCCCCCHHHHHHCCCCCEEEHHHHCCCHHHHHHHHHHHHHH
ALGDKQEVAFSGGATVMKIIGG
HHCCCHHEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA