Click here to switch to the map view.

The map label for this gene is fumC-1 [H]

Identifier: 77460314

GI number: 77460314

Start: 4629110

End: 4630504

Strand: Direct

Name: fumC-1 [H]

Synonym: Pfl01_4093

Alternate gene names: 77460314

Gene position: 4629110-4630504 (Clockwise)

Preceding gene: 77460308

Following gene: 77460316

Centisome position: 71.9

GC content: 64.66

Gene sequence:

>1395_bases
ATGAGCCGTATCGAAACCGACAGCCTGGGCCAGATCGAGGTCCCGGACGACGCTTACTGGGGCGCTCAGACGCAACGCTC
GCTGATCAACTTCGCCATCGGTCAGGAACGCATGCCCTTGCCGGTACTGCACGCGCTGGCCCTGATCAAGAAAGCCGCGG
CCCGGGTCAACGACCGCAACGGCGACCTGCCCGCCGACATTGCCCGCCTGATCGAACAGGCCGCCGACGAAGTGCTCGAC
GGCCAGCATGACGACCAGTTCCCGCTGGTGGTCTGGCAGACCGGCAGCGGCACGCAAAGCAACATGAACGTCAACGAAGT
GATTGCCGGGCGCGCCAACGAACTGGCCGGCAACCCGCGCGGCGGCAAGACGCCGGTGCACCCCAACGATCACGTCAACC
GCTCGCAGAGCTCCAACGACTGCTTCCCCACCGCCATGAGTATCGCCACCGCGCAAGCGGTGCAGACCCAACTGCTGCCA
GCGATCGCCGAGCTGTCGGGCGGACTGGCCGAACTTTCGGCGCGACACATGAAGCTGGTGAAGACCGGCCGCACCCACAT
GATGGACGCCACGCCGATCACCTTTGGTCAGGAGCTCTCCGGATTCATAGCGCAGCTGGATTACGCCGAACGGGCGATTC
GCGCGGCGTTGCCGGCGGTCTGCGAACTGGCGCAGGGCGGCACTGCCGTCGGCACCGGGCTCAACTCGCCCCACGGCTTC
GGCGAAGCGATTGCCGCTGAACTGGCGGCGTTGTCCGGCCTGCCGTTCGTCACCGCGCCGAACAAGTTTGCCGCCCTTGC
CGGTCATGAACCATTGACCACCCTTTCCGGCGCCCTGAAAACCCTCGCCGTGGCGCTGATGAAAATTGCAAACGATCTGC
GCCTGCTGGGCTCCGGCCCACGAGCCGGGTTCGCCGAAGTGCGCCTGCCGGCCAACGAACCGGGCAGCTCGATCATGCCC
GGCAAGGTCAACCCTACCCAGTGCGAGGCGTTGTCGATGCTGGCCTGTCAGGTGCTGGGCAACGACGTGGCGATCGGTTT
CGCCGCCAGCCAGGGTCACCTGCAACTGAACGTGTTCAAACCGGTGATCATCCACAACCTGCTGCAATCGATCCGCCTGC
TGGCTGATGGCTGCAGCAACTTCCAGCAGCATTGCATCGCCGGTCTTGAGCCGGATGCCGACGTCATGGCGAAACATCTG
GAACGCGGCCTGATGCTGGTGACGGCGCTCAACCCGCACATCGGCTACGACAAGTCGGCGGAAATCGCCAAGAAAGCCTA
CAGCGAAGGCAAGACCCTGCGCGAAGCGGCGCTGGAGCTGGGTTATCTGACCGATGAAGAGTTCGATGCCTGGGTGCGGC
CGGAGAACATGATCGAAGCCGGCGCCAAGGGCTGA

Upstream 100 bases:

>100_bases
CTTGATTGGCGGGGGCCGGCGGGTCAACAATCGAAGGGATGGAACCACCCGGCGTGAGCCGGGCCTAAACTGCGCAAACA
GACCAACAGGAGTGTGCACG

Downstream 100 bases:

>100_bases
GTCATACCGATCCTTCCCGTGCCCCGCACGGGAAGGTCATCCGACCAACAGTTTTGCCCGCCGGGCCTTGAGCCCGGCAA
TCAACGAAGGCCCCAGCGCC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSRIETDSLGQIEVPDDAYWGAQTQRSLINFAIGQERMPLPVLHALALIKKAAARVNDRNGDLPADIARLIEQAADEVLD
GQHDDQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGNPRGGKTPVHPNDHVNRSQSSNDCFPTAMSIATAQAVQTQLLP
AIAELSGGLAELSARHMKLVKTGRTHMMDATPITFGQELSGFIAQLDYAERAIRAALPAVCELAQGGTAVGTGLNSPHGF
GEAIAAELAALSGLPFVTAPNKFAALAGHEPLTTLSGALKTLAVALMKIANDLRLLGSGPRAGFAEVRLPANEPGSSIMP
GKVNPTQCEALSMLACQVLGNDVAIGFAASQGHLQLNVFKPVIIHNLLQSIRLLADGCSNFQQHCIAGLEPDADVMAKHL
ERGLMLVTALNPHIGYDKSAEIAKKAYSEGKTLREAALELGYLTDEEFDAWVRPENMIEAGAKG

Sequences:

>Translated_464_residues
MSRIETDSLGQIEVPDDAYWGAQTQRSLINFAIGQERMPLPVLHALALIKKAAARVNDRNGDLPADIARLIEQAADEVLD
GQHDDQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGNPRGGKTPVHPNDHVNRSQSSNDCFPTAMSIATAQAVQTQLLP
AIAELSGGLAELSARHMKLVKTGRTHMMDATPITFGQELSGFIAQLDYAERAIRAALPAVCELAQGGTAVGTGLNSPHGF
GEAIAAELAALSGLPFVTAPNKFAALAGHEPLTTLSGALKTLAVALMKIANDLRLLGSGPRAGFAEVRLPANEPGSSIMP
GKVNPTQCEALSMLACQVLGNDVAIGFAASQGHLQLNVFKPVIIHNLLQSIRLLADGCSNFQQHCIAGLEPDADVMAKHL
ERGLMLVTALNPHIGYDKSAEIAKKAYSEGKTLREAALELGYLTDEEFDAWVRPENMIEAGAKG
>Mature_463_residues
SRIETDSLGQIEVPDDAYWGAQTQRSLINFAIGQERMPLPVLHALALIKKAAARVNDRNGDLPADIARLIEQAADEVLDG
QHDDQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGNPRGGKTPVHPNDHVNRSQSSNDCFPTAMSIATAQAVQTQLLPA
IAELSGGLAELSARHMKLVKTGRTHMMDATPITFGQELSGFIAQLDYAERAIRAALPAVCELAQGGTAVGTGLNSPHGFG
EAIAAELAALSGLPFVTAPNKFAALAGHEPLTTLSGALKTLAVALMKIANDLRLLGSGPRAGFAEVRLPANEPGSSIMPG
KVNPTQCEALSMLACQVLGNDVAIGFAASQGHLQLNVFKPVIIHNLLQSIRLLADGCSNFQQHCIAGLEPDADVMAKHLE
RGLMLVTALNPHIGYDKSAEIAKKAYSEGKTLREAALELGYLTDEEFDAWVRPENMIEAGAKG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=458, Percent_Identity=58.7336244541485, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI266458395, Length=84, Percent_Identity=44.047619047619, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=60.0877192982456, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=39.4396551724138, Blast_Score=323, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17553882, Length=458, Percent_Identity=57.8602620087336, Blast_Score=553, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=56.1728395061728, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324993, Length=458, Percent_Identity=55.8951965065502, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24640179, Length=459, Percent_Identity=58.3877995642701, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24640177, Length=459, Percent_Identity=58.3877995642701, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=53.0434782608696, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=54.880694143167, Blast_Score=503, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=47.0715835140998, Blast_Score=429, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49157; Mature: 49025

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIETDSLGQIEVPDDAYWGAQTQRSLINFAIGQERMPLPVLHALALIKKAAARVNDRN
CCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
GDLPADIARLIEQAADEVLDGQHDDQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGNPR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCHHHHCCCCC
GGKTPVHPNDHVNRSQSSNDCFPTAMSIATAQAVQTQLLPAIAELSGGLAELSARHMKLV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KTGRTHMMDATPITFGQELSGFIAQLDYAERAIRAALPAVCELAQGGTAVGTGLNSPHGF
HCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCH
GEAIAAELAALSGLPFVTAPNKFAALAGHEPLTTLSGALKTLAVALMKIANDLRLLGSGP
HHHHHHHHHHHCCCCEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RAGFAEVRLPANEPGSSIMPGKVNPTQCEALSMLACQVLGNDVAIGFAASQGHLQLNVFK
CCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEHHH
PVIIHNLLQSIRLLADGCSNFQQHCIAGLEPDADVMAKHLERGLMLVTALNPHIGYDKSA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCHH
EIAKKAYSEGKTLREAALELGYLTDEEFDAWVRPENMIEAGAKG
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCC
>Mature Secondary Structure 
SRIETDSLGQIEVPDDAYWGAQTQRSLINFAIGQERMPLPVLHALALIKKAAARVNDRN
CCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
GDLPADIARLIEQAADEVLDGQHDDQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGNPR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCHHHHCCCCC
GGKTPVHPNDHVNRSQSSNDCFPTAMSIATAQAVQTQLLPAIAELSGGLAELSARHMKLV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KTGRTHMMDATPITFGQELSGFIAQLDYAERAIRAALPAVCELAQGGTAVGTGLNSPHGF
HCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCH
GEAIAAELAALSGLPFVTAPNKFAALAGHEPLTTLSGALKTLAVALMKIANDLRLLGSGP
HHHHHHHHHHHCCCCEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RAGFAEVRLPANEPGSSIMPGKVNPTQCEALSMLACQVLGNDVAIGFAASQGHLQLNVFK
CCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEHHH
PVIIHNLLQSIRLLADGCSNFQQHCIAGLEPDADVMAKHLERGLMLVTALNPHIGYDKSA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCHH
EIAKKAYSEGKTLREAALELGYLTDEEFDAWVRPENMIEAGAKG
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]