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The map label for this gene is mtaD [H]

Identifier: 77460301

GI number: 77460301

Start: 4611958

End: 4613292

Strand: Direct

Name: mtaD [H]

Synonym: Pfl01_4080

Alternate gene names: 77460301

Gene position: 4611958-4613292 (Clockwise)

Preceding gene: 77460292

Following gene: 77460302

Centisome position: 71.63

GC content: 64.49

Gene sequence:

>1335_bases
ATGCCGAAACCTGCCATTGCGCTCGACTTATTATTGCTGCCGACCTGGCTGGTACCCGTCGAACCCGCAGGCGTTGTGCT
CAAGGAGCACGGCCTGGGCATCCGCGACGGGCGCATCGTGTTCATCGGCCCGCGTGCCGAAGCGCTGAAGTGTAACGCCG
CCGAAGTCCGCGATCTGCCGGACGTGCTGCTCAGCCCCGGCCTGATCAACGCCCACGGCCACGCCGCGATGACGCTGTTC
CGTGGTCTGGCCGACGATTTGCCGCTGATGACCTGGCTGGAAAACCACATCTGGCCGGCCGAGGGCAAATGGGTCGATGA
AGATTTTGTGCGTGACGGCACCGATCTGGCCATCGCCGAGCAGATAAAAGGTGGCATCACCTGTTTCTCGGACATGTACT
TCTTCCCCAAGGTTGCCAGCGAGCGCGTGCACAACAGCGGAATCCGTGCGCAGATCGCGATTCCGATCCTCGACTTCCCG
ATTCCGGGTGCCGCCAGCGCCGATGAAGCCATTCGTCAGGGCGTCGAACTGTTCGGCGACCTGAAGCATCACGAGCGCAT
CAAGATCACCTTCGGCCCTCATGCACCCTACACCGTGGGCGACGAGAACCTGGAAAAAATCCGCGTGATCGCCGAAGAAC
TGGACGCCTCGATCCACATGCACGTCCACGAAACCGCTTTCGAAGTGCAGCAAGCGCTCGAACAGCACGGCGAACGCCCG
CTGGCCCGCCTCGGTCGTCTCGGCCTGCTCGGCCCGCGCTTCCAGGCCGTGCACATGACCCAGATCAGCGATGACGACCT
GGCGTTGCTGGTAGAAAGCAACACCAGCGTGATCCATTGCCCGGAGTCGAACCTGAAGCTGGCCAGCGGCTTCTGCCCGG
TGGAGCGCCTGTGGCAGGCCGGGGTCAACGTCGCGGTCGGCACCGATGGCGCCGCGAGCAACAATGACCTGGATCTGCTG
GGCGAAACCCGCACCGCCGCCCTGCTGGCCAAAGCCGTCGCCGGCTCGGCCACCGCGCTGGACGCCCACCGGGCACTGCG
CATGGCCACGCTCAATGGCGCGCGAGCCTTGGGAATCGAAGCCGAGACCGGCTCGCTGGAGCTCGGCAAGGCCGCAGACA
TTGTCGCCTTCGACTTGTCCGGTCTGGCGCAACAACCGGTCTATGACCCGGTCTCGCAGCTTATATACGCCACCGGTCGC
GACTGCGTGAAACACCTGTGGGTCGCCGGCAAGCAGTTGCTCGACGACCGCCGCCTGACCCGACTGGACGAACAACAGCT
CGGCGAAACCGCCCGGGCCTGGGGCCGACGCATCAGCGGCCACACCGAATCGTAA

Upstream 100 bases:

>100_bases
CCGCACTCATGAACAAAAGCCGCCGATTATAGCGATCCCCCCGCGAAGACGCTCGGGTATACTTCGCCATCCTTCACAAA
AGCACTGGAACCGACCCTCG

Downstream 100 bases:

>100_bases
ACACCCCGGGGCAAACTCCGGGGCTACAGCCTTTTTCAAGTTTTAGAGGATTGAATCATGAGCAACGTCGACCACGCCGA
AATCGCCAAATTCGAAGCCC

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MPKPAIALDLLLLPTWLVPVEPAGVVLKEHGLGIRDGRIVFIGPRAEALKCNAAEVRDLPDVLLSPGLINAHGHAAMTLF
RGLADDLPLMTWLENHIWPAEGKWVDEDFVRDGTDLAIAEQIKGGITCFSDMYFFPKVASERVHNSGIRAQIAIPILDFP
IPGAASADEAIRQGVELFGDLKHHERIKITFGPHAPYTVGDENLEKIRVIAEELDASIHMHVHETAFEVQQALEQHGERP
LARLGRLGLLGPRFQAVHMTQISDDDLALLVESNTSVIHCPESNLKLASGFCPVERLWQAGVNVAVGTDGAASNNDLDLL
GETRTAALLAKAVAGSATALDAHRALRMATLNGARALGIEAETGSLELGKAADIVAFDLSGLAQQPVYDPVSQLIYATGR
DCVKHLWVAGKQLLDDRRLTRLDEQQLGETARAWGRRISGHTES

Sequences:

>Translated_444_residues
MPKPAIALDLLLLPTWLVPVEPAGVVLKEHGLGIRDGRIVFIGPRAEALKCNAAEVRDLPDVLLSPGLINAHGHAAMTLF
RGLADDLPLMTWLENHIWPAEGKWVDEDFVRDGTDLAIAEQIKGGITCFSDMYFFPKVASERVHNSGIRAQIAIPILDFP
IPGAASADEAIRQGVELFGDLKHHERIKITFGPHAPYTVGDENLEKIRVIAEELDASIHMHVHETAFEVQQALEQHGERP
LARLGRLGLLGPRFQAVHMTQISDDDLALLVESNTSVIHCPESNLKLASGFCPVERLWQAGVNVAVGTDGAASNNDLDLL
GETRTAALLAKAVAGSATALDAHRALRMATLNGARALGIEAETGSLELGKAADIVAFDLSGLAQQPVYDPVSQLIYATGR
DCVKHLWVAGKQLLDDRRLTRLDEQQLGETARAWGRRISGHTES
>Mature_443_residues
PKPAIALDLLLLPTWLVPVEPAGVVLKEHGLGIRDGRIVFIGPRAEALKCNAAEVRDLPDVLLSPGLINAHGHAAMTLFR
GLADDLPLMTWLENHIWPAEGKWVDEDFVRDGTDLAIAEQIKGGITCFSDMYFFPKVASERVHNSGIRAQIAIPILDFPI
PGAASADEAIRQGVELFGDLKHHERIKITFGPHAPYTVGDENLEKIRVIAEELDASIHMHVHETAFEVQQALEQHGERPL
ARLGRLGLLGPRFQAVHMTQISDDDLALLVESNTSVIHCPESNLKLASGFCPVERLWQAGVNVAVGTDGAASNNDLDLLG
ETRTAALLAKAVAGSATALDAHRALRMATLNGARALGIEAETGSLELGKAADIVAFDLSGLAQQPVYDPVSQLIYATGRD
CVKHLWVAGKQLLDDRRLTRLDEQQLGETARAWGRRISGHTES

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=436, Percent_Identity=24.7706422018349, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1789249, Length=405, Percent_Identity=25.9259259259259, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082177, Length=431, Percent_Identity=22.737819025522, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17540282, Length=388, Percent_Identity=26.8041237113402, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319963, Length=332, Percent_Identity=21.6867469879518, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24643849, Length=419, Percent_Identity=27.4463007159904, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 48126; Mature: 47994

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKPAIALDLLLLPTWLVPVEPAGVVLKEHGLGIRDGRIVFIGPRAEALKCNAAEVRDLP
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEECCEEEEECCCCCEEECCHHHHHCCH
DVLLSPGLINAHGHAAMTLFRGLADDLPLMTWLENHIWPAEGKWVDEDFVRDGTDLAIAE
HHHHCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHH
QIKGGITCFSDMYFFPKVASERVHNSGIRAQIAIPILDFPIPGAASADEAIRQGVELFGD
HHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHC
LKHHERIKITFGPHAPYTVGDENLEKIRVIAEELDASIHMHVHETAFEVQQALEQHGERP
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHCCCH
LARLGRLGLLGPRFQAVHMTQISDDDLALLVESNTSVIHCPESNLKLASGFCPVERLWQA
HHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCEEECCCCCCEEECCCCCHHHHHHC
GVNVAVGTDGAASNNDLDLLGETRTAALLAKAVAGSATALDAHRALRMATLNGARALGIE
CCEEEECCCCCCCCCCCEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEE
AETGSLELGKAADIVAFDLSGLAQQPVYDPVSQLIYATGRDCVKHLWVAGKQLLDDRRLT
CCCCCEECCCCCCEEEEEHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RLDEQQLGETARAWGRRISGHTES
HCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PKPAIALDLLLLPTWLVPVEPAGVVLKEHGLGIRDGRIVFIGPRAEALKCNAAEVRDLP
CCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEECCEEEEECCCCCEEECCHHHHHCCH
DVLLSPGLINAHGHAAMTLFRGLADDLPLMTWLENHIWPAEGKWVDEDFVRDGTDLAIAE
HHHHCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHH
QIKGGITCFSDMYFFPKVASERVHNSGIRAQIAIPILDFPIPGAASADEAIRQGVELFGD
HHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHC
LKHHERIKITFGPHAPYTVGDENLEKIRVIAEELDASIHMHVHETAFEVQQALEQHGERP
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHCCCH
LARLGRLGLLGPRFQAVHMTQISDDDLALLVESNTSVIHCPESNLKLASGFCPVERLWQA
HHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCEEECCCCCCEEECCCCCHHHHHHC
GVNVAVGTDGAASNNDLDLLGETRTAALLAKAVAGSATALDAHRALRMATLNGARALGIE
CCEEEECCCCCCCCCCCEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEE
AETGSLELGKAADIVAFDLSGLAQQPVYDPVSQLIYATGRDCVKHLWVAGKQLLDDRRLT
CCCCCEECCCCCCEEEEEHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RLDEQQLGETARAWGRRISGHTES
HCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA