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The map label for this gene is lip2 [H]

Identifier: 77460219

GI number: 77460219

Start: 4526491

End: 4527504

Strand: Direct

Name: lip2 [H]

Synonym: Pfl01_3998

Alternate gene names: 77460219

Gene position: 4526491-4527504 (Clockwise)

Preceding gene: 77460218

Following gene: 77460222

Centisome position: 70.3

GC content: 61.93

Gene sequence:

>1014_bases
ATGAACACTTTCAGCAAAGTCTTGACCGGTACCCTTCTCGCCCTGTCCATCCACAGCGCATTTGCCGGGGAGGTTGAACA
CAACACTCAGGCGTTTCTCGATGTGCTGAATGCCGGCACCGGCAAACCGATGGAACAGCTGACACCCAAGGAGGCCCGCG
CCGTGCTGACGGGCGCGCAGTCCGGGGTCAAACTGACGCTGCCCAAGGCGGACGTCAGCGAGAAAACCATCCAGGTCGAT
GGCCAACCGTTGAGCCTGACCATCGTCCGGCCGGCCGGGGTCAAGGGCGAGCTGCCGGTGTTCATGTTCTTCCACGGCGG
CGGCTGGGTGCTGGGGGATTTCCCGACTCACGAACGTCTGGTGCGGGATCTGGTGGTCGGCTCGGGTGCGGCGGCGGTGT
TCGTCAATTACACCCCTTCACCGGAAGCGCATTACCCGGTGGCGATCAACCAGGCTTATGCCGCTACCAAATGGGTGGCC
GAACACGGCAAAGAAATCAACGTCGACGGCAAGCGTCTGGCGGTGGCGGGCAACAGCGTCGGCGGCAACATGGCGGCAGT
CGTCGCCTTGATGGCCAAAGACAAAGGCACTCCGGCGATCAAATTCCAGGTGCTGCTGTGGCCGGTGACCGATGCCAATT
TCGACACTGGTTCGTATAACCAGTACGCCGAGGGGCACTTCCTCACTCGCAATATGATGAAGTGGTTCTGGGACAACTAC
ACCACCGACGCCAACCAGCGGAACGAGATCTACGCCTCGCCGCTGCGGGCAACCACCGCGCAATTGAAAGGTCTGCCGCC
CGCGCTGGTGCAGACTGCGGGGGCTGACGTGCTGCGTGACGAAGGTGAAGCCTACGCCCGCAAACTCGACGAAGCCGGGG
TGCCGGTGACCTCGGTGCGCTACAACGGCATGATCCACGACTACGGTTTGCTCAACGTGGTCAGCCAGGTGCCGGCAGTG
CGCTCGGCGATGCTGCAGGCCTCGGAAGAACTGAAGCAGCACCTGAAGAAGTAA

Upstream 100 bases:

>100_bases
CCAGGTCTGCCCGTACTCCAACGCCACCCGTGGCAACGTCGATGTGCGTCTGCACGTCACCGTGTAATCACTGACGCTCA
AGCCCGTACAGGAAATGAAC

Downstream 100 bases:

>100_bases
TTTTCATCAGGCACAAAAAAGCCCGACTCGATGGTCGGGCTTTTTCTTTCCACAAAAAGCAGTGCTTATTTGGCACGGCC
TTTGTAGGAACCGCCTTCGC

Product: esterase/lipase/thioesterase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MNTFSKVLTGTLLALSIHSAFAGEVEHNTQAFLDVLNAGTGKPMEQLTPKEARAVLTGAQSGVKLTLPKADVSEKTIQVD
GQPLSLTIVRPAGVKGELPVFMFFHGGGWVLGDFPTHERLVRDLVVGSGAAAVFVNYTPSPEAHYPVAINQAYAATKWVA
EHGKEINVDGKRLAVAGNSVGGNMAAVVALMAKDKGTPAIKFQVLLWPVTDANFDTGSYNQYAEGHFLTRNMMKWFWDNY
TTDANQRNEIYASPLRATTAQLKGLPPALVQTAGADVLRDEGEAYARKLDEAGVPVTSVRYNGMIHDYGLLNVVSQVPAV
RSAMLQASEELKQHLKK

Sequences:

>Translated_337_residues
MNTFSKVLTGTLLALSIHSAFAGEVEHNTQAFLDVLNAGTGKPMEQLTPKEARAVLTGAQSGVKLTLPKADVSEKTIQVD
GQPLSLTIVRPAGVKGELPVFMFFHGGGWVLGDFPTHERLVRDLVVGSGAAAVFVNYTPSPEAHYPVAINQAYAATKWVA
EHGKEINVDGKRLAVAGNSVGGNMAAVVALMAKDKGTPAIKFQVLLWPVTDANFDTGSYNQYAEGHFLTRNMMKWFWDNY
TTDANQRNEIYASPLRATTAQLKGLPPALVQTAGADVLRDEGEAYARKLDEAGVPVTSVRYNGMIHDYGLLNVVSQVPAV
RSAMLQASEELKQHLKK
>Mature_337_residues
MNTFSKVLTGTLLALSIHSAFAGEVEHNTQAFLDVLNAGTGKPMEQLTPKEARAVLTGAQSGVKLTLPKADVSEKTIQVD
GQPLSLTIVRPAGVKGELPVFMFFHGGGWVLGDFPTHERLVRDLVVGSGAAAVFVNYTPSPEAHYPVAINQAYAATKWVA
EHGKEINVDGKRLAVAGNSVGGNMAAVVALMAKDKGTPAIKFQVLLWPVTDANFDTGSYNQYAEGHFLTRNMMKWFWDNY
TTDANQRNEIYASPLRATTAQLKGLPPALVQTAGADVLRDEGEAYARKLDEAGVPVTSVRYNGMIHDYGLLNVVSQVPAV
RSAMLQASEELKQHLKK

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=262, Percent_Identity=25.9541984732824, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI157041239, Length=256, Percent_Identity=23.828125, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI21328446, Length=107, Percent_Identity=31.7757009345794, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI68051721, Length=269, Percent_Identity=26.0223048327138, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786682, Length=220, Percent_Identity=27.7272727272727, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17567059, Length=349, Percent_Identity=26.3610315186246, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71996133, Length=124, Percent_Identity=31.4516129032258, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 36361; Mature: 36361

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFSKVLTGTLLALSIHSAFAGEVEHNTQAFLDVLNAGTGKPMEQLTPKEARAVLTGAQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHCCHHHHHHHHCCCC
SGVKLTLPKADVSEKTIQVDGQPLSLTIVRPAGVKGELPVFMFFHGGGWVLGDFPTHERL
CCEEEEECCCCCCCCEEEECCCEEEEEEECCCCCCCCCCEEEEEECCCEEECCCCCHHHH
VRDLVVGSGAAAVFVNYTPSPEAHYPVAINQAYAATKWVAEHGKEINVDGKRLAVAGNSV
HHHHHHCCCCEEEEEEECCCCCCCCCEEECCHHHHHHHHHHCCCEECCCCCEEEEECCCC
GGNMAAVVALMAKDKGTPAIKFQVLLWPVTDANFDTGSYNQYAEGHFLTRNMMKWFWDNY
CCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
TTDANQRNEIYASPLRATTAQLKGLPPALVQTAGADVLRDEGEAYARKLDEAGVPVTSVR
CCCCCCCCCEEECCHHHHHHHHCCCCHHHHHHCCCHHHHCCHHHHHHHHHHCCCCEEEEE
YNGMIHDYGLLNVVSQVPAVRSAMLQASEELKQHLKK
ECCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTFSKVLTGTLLALSIHSAFAGEVEHNTQAFLDVLNAGTGKPMEQLTPKEARAVLTGAQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHCCHHHHHHHHCCCC
SGVKLTLPKADVSEKTIQVDGQPLSLTIVRPAGVKGELPVFMFFHGGGWVLGDFPTHERL
CCEEEEECCCCCCCCEEEECCCEEEEEEECCCCCCCCCCEEEEEECCCEEECCCCCHHHH
VRDLVVGSGAAAVFVNYTPSPEAHYPVAINQAYAATKWVAEHGKEINVDGKRLAVAGNSV
HHHHHHCCCCEEEEEEECCCCCCCCCEEECCHHHHHHHHHHCCCEECCCCCEEEEECCCC
GGNMAAVVALMAKDKGTPAIKFQVLLWPVTDANFDTGSYNQYAEGHFLTRNMMKWFWDNY
CCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
TTDANQRNEIYASPLRATTAQLKGLPPALVQTAGADVLRDEGEAYARKLDEAGVPVTSVR
CCCCCCCCCEEECCHHHHHHHHCCCCHHHHHHCCCHHHHCCHHHHHHHHHHCCCCEEEEE
YNGMIHDYGLLNVVSQVPAVRSAMLQASEELKQHLKK
ECCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]