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The map label for this gene is tpm

Identifier: 77460206

GI number: 77460206

Start: 4514194

End: 4514847

Strand: Reverse

Name: tpm

Synonym: Pfl01_3985

Alternate gene names: 77460206

Gene position: 4514847-4514194 (Counterclockwise)

Preceding gene: 77460208

Following gene: 77460203

Centisome position: 70.12

GC content: 60.4

Gene sequence:

>654_bases
ATGCAGCCGGAGTTTTGGCACAAGAAGTGGGAATCGAACCAGATCGGCTTTCACCAGCTTGAGGTGAACCCGTATTTGCA
GCGGCACTGGCCCGATCTGGCCATCCCGGTGCAGGCGCGTGTGTTGGTGCCGTTGTGCGGTAAAAGTCTGGATCTGCTGT
GGCTCGCCGGCCGTGGTCATCAGGTGCTGGGCGTCGAGCTTTCGGAAAAGGCAGTGGAAGACTTTTTCCATGAGCAGCAA
TTGCAGCCGCAGGTGAGCGAGCAGGGCGACTTCAAGGTTTATCGCGCCGACGCGGTCGAGTTGTGGTGCGGGGATTTCTT
CTCGCTGACGATGGCTGACGTGGCGGGTTGCACCGCGTTGTATGACCGTGCGGCAGTGATTGCCTTGCCGCCAGCGATGC
GCGAGCGTTATGCGGCGCATCTGCAGAGCATTCTGCCGGCGTGTCGAGGGCTGTTGGTGACGCTGGATTATGACCAGTCG
CAGATGCCAGGGCCGCCATTTTCCGTAGACGATGCCGAAGTGCAGCGTTTGCTGGGCAGTGTCTGGCGCGTCGAGATGCT
GGAGCAGCAGGATGTACTCGGTGACAGCTGGAAGTTCGTGCAGGCCGGCGTAACCCGGCTTGAGGAACGGGTTTACCGGA
TTCGCGGGGTGTAA

Upstream 100 bases:

>100_bases
AAGGGTTCCTGAGCGTTAAGATGGCTCATCTTCAGTCAGTTCATTGATCTAATTCCAATATAAGTTTTAACGCCTTTTGA
TCGAATTCCTGGGAGGATGC

Downstream 100 bases:

>100_bases
ACGACAGGCAAAAAAAGGCCCGCATCACTGCGGGCCTTTTCATTGGTGCGCCGGTTTGATCAACCGCGACGACGCAGGGC
GTCGATACGCTCTTCCAGCG

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MQPEFWHKKWESNQIGFHQLEVNPYLQRHWPDLAIPVQARVLVPLCGKSLDLLWLAGRGHQVLGVELSEKAVEDFFHEQQ
LQPQVSEQGDFKVYRADAVELWCGDFFSLTMADVAGCTALYDRAAVIALPPAMRERYAAHLQSILPACRGLLVTLDYDQS
QMPGPPFSVDDAEVQRLLGSVWRVEMLEQQDVLGDSWKFVQAGVTRLEERVYRIRGV

Sequences:

>Translated_217_residues
MQPEFWHKKWESNQIGFHQLEVNPYLQRHWPDLAIPVQARVLVPLCGKSLDLLWLAGRGHQVLGVELSEKAVEDFFHEQQ
LQPQVSEQGDFKVYRADAVELWCGDFFSLTMADVAGCTALYDRAAVIALPPAMRERYAAHLQSILPACRGLLVTLDYDQS
QMPGPPFSVDDAEVQRLLGSVWRVEMLEQQDVLGDSWKFVQAGVTRLEERVYRIRGV
>Mature_217_residues
MQPEFWHKKWESNQIGFHQLEVNPYLQRHWPDLAIPVQARVLVPLCGKSLDLLWLAGRGHQVLGVELSEKAVEDFFHEQQ
LQPQVSEQGDFKVYRADAVELWCGDFFSLTMADVAGCTALYDRAAVIALPPAMRERYAAHLQSILPACRGLLVTLDYDQS
QMPGPPFSVDDAEVQRLLGSVWRVEMLEQQDVLGDSWKFVQAGVTRLEERVYRIRGV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=216, Percent_Identity=34.2592592592593, Blast_Score=131, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_PSEPF (Q3K932)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_349713.1
- ProteinModelPortal:   Q3K932
- SMR:   Q3K932
- STRING:   Q3K932
- GeneID:   3714011
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_3985
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- BioCyc:   PFLU205922:PFL_3985-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24763; Mature: 24763

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPEFWHKKWESNQIGFHQLEVNPYLQRHWPDLAIPVQARVLVPLCGKSLDLLWLAGRGH
CCCCHHHHHCCCCCCCEEEEECCHHHHHCCCCEECCCHHEEEEECCCCCEEEEEEECCCC
QVLGVELSEKAVEDFFHEQQLQPQVSEQGDFKVYRADAVELWCGDFFSLTMADVAGCTAL
EEEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHHHH
YDRAAVIALPPAMRERYAAHLQSILPACRGLLVTLDYDQSQMPGPPFSVDDAEVQRLLGS
HHCCEEEECCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
VWRVEMLEQQDVLGDSWKFVQAGVTRLEERVYRIRGV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQPEFWHKKWESNQIGFHQLEVNPYLQRHWPDLAIPVQARVLVPLCGKSLDLLWLAGRGH
CCCCHHHHHCCCCCCCEEEEECCHHHHHCCCCEECCCHHEEEEECCCCCEEEEEEECCCC
QVLGVELSEKAVEDFFHEQQLQPQVSEQGDFKVYRADAVELWCGDFFSLTMADVAGCTAL
EEEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHHHH
YDRAAVIALPPAMRERYAAHLQSILPACRGLLVTLDYDQSQMPGPPFSVDDAEVQRLLGS
HHCCEEEECCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
VWRVEMLEQQDVLGDSWKFVQAGVTRLEERVYRIRGV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA