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The map label for this gene is bvgA [H]

Identifier: 77460195

GI number: 77460195

Start: 4498952

End: 4499578

Strand: Direct

Name: bvgA [H]

Synonym: Pfl01_3974

Alternate gene names: 77460195

Gene position: 4498952-4499578 (Clockwise)

Preceding gene: 77460194

Following gene: 77460196

Centisome position: 69.88

GC content: 49.92

Gene sequence:

>627_bases
ATGAACTCCGTTTTTATTGTCGACGATCACCCGGTCATCCGCCTTGCCGTTCGAATGCTGCTGGAACATGAAGGTTATAA
AGTCGTTGGAGAAACCGATAACGGTGTCGATGCCATGCAGATGGTTCGCGAATGCATGCCCGACCTGATCATTCTCGACA
TCAGCATTCCCAAGCTCGATGGCCTGGAAGTCCTGGCCCGCTTCAACGCCATGAGTTCGCCCTTCAAGACGCTGGTATTG
ACTGCGCAATGCCCGACCTTGTTCGGCATTCGTTGCATGCAGTCAGGTGCATCGGGTTATGTCTGCAAACAGGAAGACCT
GAGCGAACTGGTCAGTGCGATCAAGGCTGTCCTTTCCGGCTACAACTATTTTCCCAGCCAGGCCTTGAACCCTGTTCGTC
ACGATGACGTGCGTTATGCAGAACTGGAACTCTTCAAATCCGTCAATGACCGGGAACTTATGGTCTTGCAACTCTTTGCC
CAGGGCCGCACGAACAAGGAAATTGCAAAAGGCATGTTTCTCAGTAACAAAACTGTAAGCACTTATAAAAAACGACTGAT
GCAAAAACTCAAAGCCAAGTCTCTCGTAGAACTTATCGAAATGGCCAAACGTAACGCACTCGTGTGA

Upstream 100 bases:

>100_bases
ATTTCTCCTAGATTGCCACTACCCCCCCGTCAGTTCATGCGAGCGTTCATTCATCTGAGCTAAGGTTCGCCCTTTATTTG
CGCTCGTATGGGATTTGATT

Downstream 100 bases:

>100_bases
GAGTCAACATGTCCAGCCGTTTAATGAGTTTTCTGATTGCATGGAGTGCATGTCTGGGTTTCTGCACCTCTTCAACCGCT
GCATCACCCGCCTCGCAAGA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNSVFIVDDHPVIRLAVRMLLEHEGYKVVGETDNGVDAMQMVRECMPDLIILDISIPKLDGLEVLARFNAMSSPFKTLVL
TAQCPTLFGIRCMQSGASGYVCKQEDLSELVSAIKAVLSGYNYFPSQALNPVRHDDVRYAELELFKSVNDRELMVLQLFA
QGRTNKEIAKGMFLSNKTVSTYKKRLMQKLKAKSLVELIEMAKRNALV

Sequences:

>Translated_208_residues
MNSVFIVDDHPVIRLAVRMLLEHEGYKVVGETDNGVDAMQMVRECMPDLIILDISIPKLDGLEVLARFNAMSSPFKTLVL
TAQCPTLFGIRCMQSGASGYVCKQEDLSELVSAIKAVLSGYNYFPSQALNPVRHDDVRYAELELFKSVNDRELMVLQLFA
QGRTNKEIAKGMFLSNKTVSTYKKRLMQKLKAKSLVELIEMAKRNALV
>Mature_208_residues
MNSVFIVDDHPVIRLAVRMLLEHEGYKVVGETDNGVDAMQMVRECMPDLIILDISIPKLDGLEVLARFNAMSSPFKTLVL
TAQCPTLFGIRCMQSGASGYVCKQEDLSELVSAIKAVLSGYNYFPSQALNPVRHDDVRYAELELFKSVNDRELMVLQLFA
QGRTNKEIAKGMFLSNKTVSTYKKRLMQKLKAKSLVELIEMAKRNALV

Specific function: Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=36.231884057971, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786747, Length=207, Percent_Identity=35.7487922705314, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=33.9712918660287, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1788521, Length=196, Percent_Identity=33.1632653061224, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790102, Length=202, Percent_Identity=30.6930693069307, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787473, Length=184, Percent_Identity=29.8913043478261, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=27.9411764705882, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23379; Mature: 23379

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSVFIVDDHPVIRLAVRMLLEHEGYKVVGETDNGVDAMQMVRECMPDLIILDISIPKLD
CCCEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCC
GLEVLARFNAMSSPFKTLVLTAQCPTLFGIRCMQSGASGYVCKQEDLSELVSAIKAVLSG
HHHHHHHHHHCCCCHHHEEEEECCCHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHCC
YNYFPSQALNPVRHDDVRYAELELFKSVNDRELMVLQLFAQGRTNKEIAKGMFLSNKTVS
CCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
TYKKRLMQKLKAKSLVELIEMAKRNALV
HHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNSVFIVDDHPVIRLAVRMLLEHEGYKVVGETDNGVDAMQMVRECMPDLIILDISIPKLD
CCCEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCC
GLEVLARFNAMSSPFKTLVLTAQCPTLFGIRCMQSGASGYVCKQEDLSELVSAIKAVLSG
HHHHHHHHHHCCCCHHHEEEEECCCHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHCC
YNYFPSQALNPVRHDDVRYAELELFKSVNDRELMVLQLFAQGRTNKEIAKGMFLSNKTVS
CCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
TYKKRLMQKLKAKSLVELIEMAKRNALV
HHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1791760; 12910271 [H]