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The map label for this gene is moaB [H]

Identifier: 77460182

GI number: 77460182

Start: 4488165

End: 4488704

Strand: Reverse

Name: moaB [H]

Synonym: Pfl01_3961

Alternate gene names: 77460182

Gene position: 4488704-4488165 (Counterclockwise)

Preceding gene: 77460185

Following gene: 77460181

Centisome position: 69.72

GC content: 61.48

Gene sequence:

>540_bases
ATGAAAGCCAAGGCTGATGTACCTTTCGTGCCGCTCAATATCGCGGTGTTGACGGTCAGCGACACCCGCACCCTGGAAAC
CGACACCTCCGGCCAGGTCTTCGTCGACCGGCTGACAGCCGCGGGCCACCATCTGGCGCAGCGGGTGCTGCTCAAAGATG
ACCTGTACAAGATTCGTGCGCAAGTCGCCCACTGGATTGCCGAAGACGTCGTGCAAGTGGTGCTGATTACCGGCGGAACC
GGTTTTACCGGTCGCGATAGCACCCCGGAAGCGGTCGCTTGCCTGCTGGACAAACAGGTCGACGGTTTTGGTGAGCTGTT
TCGCCAGATCTCGGTGCCTGACATCGGCACCTCCTCCGTGCAATCCCGGGCTTTGGCGGGACTGGCCAATGGCACGCTGG
TCTGCTGCCTGCCTGGCTCGACCAACGCAGTGCGCACCGGTTGGGATGGCATCCTCGCCGAGCAACTGGACTCACGCCAC
CGCCCGTGCAATTTCGTCACTCATTTGAAACAGGCGGCGCCTTGTGAATCCCGTGGGTAA

Upstream 100 bases:

>100_bases
ATGGCGTGTTCGAAGTCATGGCAGCTCTCCGCAGGGGCGGCGAAAAAAGGGGGCGCTGTGATATAACACCAGGCTGTTTC
TCATACAACTGGACGAGCCT

Downstream 100 bases:

>100_bases
GCCGGGCAAGACTGGCAGCCTGATGCCTGTCGAAGCAGCATTGACGCGGTTGCTGGAAATGGCCGAGGGCTCGCGGATTG
TCGAGAGTGAGTTTTTGCCT

Product: molybdenum cofactor biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MKAKADVPFVPLNIAVLTVSDTRTLETDTSGQVFVDRLTAAGHHLAQRVLLKDDLYKIRAQVAHWIAEDVVQVVLITGGT
GFTGRDSTPEAVACLLDKQVDGFGELFRQISVPDIGTSSVQSRALAGLANGTLVCCLPGSTNAVRTGWDGILAEQLDSRH
RPCNFVTHLKQAAPCESRG

Sequences:

>Translated_179_residues
MKAKADVPFVPLNIAVLTVSDTRTLETDTSGQVFVDRLTAAGHHLAQRVLLKDDLYKIRAQVAHWIAEDVVQVVLITGGT
GFTGRDSTPEAVACLLDKQVDGFGELFRQISVPDIGTSSVQSRALAGLANGTLVCCLPGSTNAVRTGWDGILAEQLDSRH
RPCNFVTHLKQAAPCESRG
>Mature_179_residues
MKAKADVPFVPLNIAVLTVSDTRTLETDTSGQVFVDRLTAAGHHLAQRVLLKDDLYKIRAQVAHWIAEDVVQVVLITGGT
GFTGRDSTPEAVACLLDKQVDGFGELFRQISVPDIGTSSVQSRALAGLANGTLVCCLPGSTNAVRTGWDGILAEQLDSRH
RPCNFVTHLKQAAPCESRG

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=148, Percent_Identity=30.4054054054054, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI10880983, Length=148, Percent_Identity=30.4054054054054, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1787000, Length=169, Percent_Identity=54.4378698224852, Blast_Score=196, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17564954, Length=145, Percent_Identity=32.4137931034483, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136978, Length=146, Percent_Identity=34.2465753424658, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24638841, Length=146, Percent_Identity=34.2465753424658, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 19165; Mature: 19165

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKADVPFVPLNIAVLTVSDTRTLETDTSGQVFVDRLTAAGHHLAQRVLLKDDLYKIRA
CCCCCCCCEEEEEEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVAHWIAEDVVQVVLITGGTGFTGRDSTPEAVACLLDKQVDGFGELFRQISVPDIGTSSV
HHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHH
QSRALAGLANGTLVCCLPGSTNAVRTGWDGILAEQLDSRHRPCNFVTHLKQAAPCESRG
HHHHHHHCCCCEEEEEECCCCCCEECCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKAKADVPFVPLNIAVLTVSDTRTLETDTSGQVFVDRLTAAGHHLAQRVLLKDDLYKIRA
CCCCCCCCEEEEEEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVAHWIAEDVVQVVLITGGTGFTGRDSTPEAVACLLDKQVDGFGELFRQISVPDIGTSSV
HHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHH
QSRALAGLANGTLVCCLPGSTNAVRTGWDGILAEQLDSRHRPCNFVTHLKQAAPCESRG
HHHHHHHCCCCEEEEEECCCCCCEECCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]