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The map label for this gene is dsbD [H]

Identifier: 77460157

GI number: 77460157

Start: 4450030

End: 4451763

Strand: Direct

Name: dsbD [H]

Synonym: Pfl01_3936

Alternate gene names: 77460157

Gene position: 4450030-4451763 (Clockwise)

Preceding gene: 77460151

Following gene: 77460158

Centisome position: 69.12

GC content: 63.55

Gene sequence:

>1734_bases
ATGCGTCATTTTTTTCTGTTTTTTGCACTGCTGATTTCGAGTCTGGCCCAGGCGGGGAATGATCCATTTGCGTCAAAACC
GGAGTTCTTGCCGGTCGACAAGGCATTCGTGCTGACCTCGCAACGTCTGGATTCCGGTGAGACCCAGCTGTTCTGGCAAA
TCGCCGATGGCTATTACCTGTATCAGAAGCGTCTGAAGTTCGACGGGCTGACGACACAAAACATCCCGGCCCTGCCCGAA
GGCGAGTCCCACAGCGACGAGTACTTCGGCGAACAACCGGTTTATCGCCAGGGTCTGGAACTGAAGATTCCGGCGGCCGC
CACGGGCCAGATCAAGGTCAGTTATCAGGGCTGTGCCGACGCCGGTCTTTGCTATCCCCCGCAGACGCGAGTGATCGACC
TCGGCGGCAAAGCTGCCGCTGCGGCGACAGATGAAGCGCCGGATCAGGCACTGGCCAGCGGCCTGCAACAGCACTCGCTG
GGCTGGAGTCTGCTGGTGTTCTTCGGTCTCGGTCTGCTGTTGGCGTTTGCGCCGTGCTCGCTGCCGATGCTGCCGATTCT
GGCGGGCATGGTCGTGGGCAGCGGCGCCACGCCGCGTCGCGGTTTCGCGCTGGCCGGCAGCTATGTGGTATGCATGGCGC
TGGTGTATGCGGCGATGGGCGTTATTGCCGCGCTGCTGGGGGCGAACCTGCAGGCGTGGTTGCAGAACCCGTGGCTGCTC
GGGACGTTCGCGGCCGTATTTGTGGTTCTGGCGTTGCCGATGTTCGGCTTCTTCGAACTGCAATTGCCGGTGGCCCTGCG
GGATCGACTGGAACATGCCTCGCGCAGTCAACGCGGTGGCAGTCTGGTCGGCGCGGGCATACTGGGCGCGTTGTCCGGTC
TGCTGGTCGGCCCATGCATGACCGCACCGCTGGCGGGCGCCCTGCTTTACATCGCGCAAAGTGGCAACGCGCTGCACGGC
GGTCTGATTCTGTTTGCCCTCGGGATCGGCATCGGCGTACCGCTATTGTTGCTGGTAACCGTCGGCAATCGCTTCCTGCC
CAAACCCGGCGCGTGGATGAACCTGCTCAAGGGCGTGTTCGGTTTCCTGTTCCTCGCCACCGCGCTGCTGATGCTGCGTC
CGGTGCTGGATCCGTCGCTGTGGCTGGGTCTGTGCGGTGCGCTGCTGTTGATCGCCGCTTACAGCGCATGGAAACAGTCC
GAGGGCTTTGGTCGCGTAGCGCAATTGTTCGGTGCCGGTTCGCTGTTGCTGGGTCTGTGGGGCAGTCTGCTGGTGGTCGG
TGCGGCGGGCGGCAGTGAAGACCCGTATCAGCCGCTGCAGGTATACAGCGCCGGCCGCGTCGGCACGGCGGCCCCGAACG
GCCACGAAGCCTTCACGACGATCAAGGATCCCGCTGCCCTGCAACGCGAGCTCGACACCGCCAAAGCGCAGGGCCAGTGG
GTGCTGCTCGACTACTACGCCGACTGGTGCGTGTCGTGCAAAGTCATGGAGAAACAGGTGTTCGGCCAGGCGCGGGTGAT
GCAGGCCCTGAGTGATGTGCGCTTGCTCCGACTCGATGTCACCGCCGACAATGCCGCCAGCCGCGAACTGCTCGGCCGTT
ATAAAGTGCCGGGGCCACCAAGTTTCGTGTGGATCGGCGCCGACGGCGAAGAGCGCCGCAGCCAGCGCATCACCGGCGAG
GTCGATGCCGATACTTTCCTGCAACGCTGGACCACCACCCGAGACGCCCGTTAA

Upstream 100 bases:

>100_bases
TATGCCCCGAACGCCACCGCGACAAGGGCGTCGCGGTTAATCATCGGTTAATCGCCGCCCGCCACTGTGCCCCTCAATTG
CACAGGGACAAGGCTCCTCC

Downstream 100 bases:

>100_bases
TGCTGACCTTCACCCTCGGCACCTTTGCCATCGCCCTCAACCATCTGCTGCTGATCAGCGCGCTGGCGCTGGCGACCTTC
GTCGGCTGGCGGGTGGCCAA

Product: protein-disulfide reductase

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MRHFFLFFALLISSLAQAGNDPFASKPEFLPVDKAFVLTSQRLDSGETQLFWQIADGYYLYQKRLKFDGLTTQNIPALPE
GESHSDEYFGEQPVYRQGLELKIPAAATGQIKVSYQGCADAGLCYPPQTRVIDLGGKAAAAATDEAPDQALASGLQQHSL
GWSLLVFFGLGLLLAFAPCSLPMLPILAGMVVGSGATPRRGFALAGSYVVCMALVYAAMGVIAALLGANLQAWLQNPWLL
GTFAAVFVVLALPMFGFFELQLPVALRDRLEHASRSQRGGSLVGAGILGALSGLLVGPCMTAPLAGALLYIAQSGNALHG
GLILFALGIGIGVPLLLLVTVGNRFLPKPGAWMNLLKGVFGFLFLATALLMLRPVLDPSLWLGLCGALLLIAAYSAWKQS
EGFGRVAQLFGAGSLLLGLWGSLLVVGAAGGSEDPYQPLQVYSAGRVGTAAPNGHEAFTTIKDPAALQRELDTAKAQGQW
VLLDYYADWCVSCKVMEKQVFGQARVMQALSDVRLLRLDVTADNAASRELLGRYKVPGPPSFVWIGADGEERRSQRITGE
VDADTFLQRWTTTRDAR

Sequences:

>Translated_577_residues
MRHFFLFFALLISSLAQAGNDPFASKPEFLPVDKAFVLTSQRLDSGETQLFWQIADGYYLYQKRLKFDGLTTQNIPALPE
GESHSDEYFGEQPVYRQGLELKIPAAATGQIKVSYQGCADAGLCYPPQTRVIDLGGKAAAAATDEAPDQALASGLQQHSL
GWSLLVFFGLGLLLAFAPCSLPMLPILAGMVVGSGATPRRGFALAGSYVVCMALVYAAMGVIAALLGANLQAWLQNPWLL
GTFAAVFVVLALPMFGFFELQLPVALRDRLEHASRSQRGGSLVGAGILGALSGLLVGPCMTAPLAGALLYIAQSGNALHG
GLILFALGIGIGVPLLLLVTVGNRFLPKPGAWMNLLKGVFGFLFLATALLMLRPVLDPSLWLGLCGALLLIAAYSAWKQS
EGFGRVAQLFGAGSLLLGLWGSLLVVGAAGGSEDPYQPLQVYSAGRVGTAAPNGHEAFTTIKDPAALQRELDTAKAQGQW
VLLDYYADWCVSCKVMEKQVFGQARVMQALSDVRLLRLDVTADNAASRELLGRYKVPGPPSFVWIGADGEERRSQRITGE
VDADTFLQRWTTTRDAR
>Mature_577_residues
MRHFFLFFALLISSLAQAGNDPFASKPEFLPVDKAFVLTSQRLDSGETQLFWQIADGYYLYQKRLKFDGLTTQNIPALPE
GESHSDEYFGEQPVYRQGLELKIPAAATGQIKVSYQGCADAGLCYPPQTRVIDLGGKAAAAATDEAPDQALASGLQQHSL
GWSLLVFFGLGLLLAFAPCSLPMLPILAGMVVGSGATPRRGFALAGSYVVCMALVYAAMGVIAALLGANLQAWLQNPWLL
GTFAAVFVVLALPMFGFFELQLPVALRDRLEHASRSQRGGSLVGAGILGALSGLLVGPCMTAPLAGALLYIAQSGNALHG
GLILFALGIGIGVPLLLLVTVGNRFLPKPGAWMNLLKGVFGFLFLATALLMLRPVLDPSLWLGLCGALLLIAAYSAWKQS
EGFGRVAQLFGAGSLLLGLWGSLLVVGAAGGSEDPYQPLQVYSAGRVGTAAPNGHEAFTTIKDPAALQRELDTAKAQGQW
VLLDYYADWCVSCKVMEKQVFGQARVMQALSDVRLLRLDVTADNAASRELLGRYKVPGPPSFVWIGADGEERRSQRITGE
VDADTFLQRWTTTRDAR

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=578, Percent_Identity=37.5432525951557, Blast_Score=355, Evalue=3e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 61671; Mature: 61671

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHFFLFFALLISSLAQAGNDPFASKPEFLPVDKAFVLTSQRLDSGETQLFWQIADGYYL
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEEHHHCCCCCCEEEEEECCCCHH
YQKRLKFDGLTTQNIPALPEGESHSDEYFGEQPVYRQGLELKIPAAATGQIKVSYQGCAD
HHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHCCCCEEECCCCCCEEEEEECCCCC
AGLCYPPQTRVIDLGGKAAAAATDEAPDQALASGLQQHSLGWSLLVFFGLGLLLAFAPCS
CCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
LPMLPILAGMVVGSGATPRRGFALAGSYVVCMALVYAAMGVIAALLGANLQAWLQNPWLL
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHH
GTFAAVFVVLALPMFGFFELQLPVALRDRLEHASRSQRGGSLVGAGILGALSGLLVGPCM
HHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
TAPLAGALLYIAQSGNALHGGLILFALGIGIGVPLLLLVTVGNRFLPKPGAWMNLLKGVF
HHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
GFLFLATALLMLRPVLDPSLWLGLCGALLLIAAYSAWKQSEGFGRVAQLFGAGSLLLGLW
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHH
GSLLVVGAAGGSEDPYQPLQVYSAGRVGTAAPNGHEAFTTIKDPAALQRELDTAKAQGQW
HHHHEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCCE
VLLDYYADWCVSCKVMEKQVFGQARVMQALSDVRLLRLDVTADNAASRELLGRYKVPGPP
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHCCCCCCCC
SFVWIGADGEERRSQRITGEVDADTFLQRWTTTRDAR
CEEEEECCCHHHHHHCCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRHFFLFFALLISSLAQAGNDPFASKPEFLPVDKAFVLTSQRLDSGETQLFWQIADGYYL
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEEHHHCCCCCCEEEEEECCCCHH
YQKRLKFDGLTTQNIPALPEGESHSDEYFGEQPVYRQGLELKIPAAATGQIKVSYQGCAD
HHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHCCCCEEECCCCCCEEEEEECCCCC
AGLCYPPQTRVIDLGGKAAAAATDEAPDQALASGLQQHSLGWSLLVFFGLGLLLAFAPCS
CCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
LPMLPILAGMVVGSGATPRRGFALAGSYVVCMALVYAAMGVIAALLGANLQAWLQNPWLL
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHH
GTFAAVFVVLALPMFGFFELQLPVALRDRLEHASRSQRGGSLVGAGILGALSGLLVGPCM
HHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
TAPLAGALLYIAQSGNALHGGLILFALGIGIGVPLLLLVTVGNRFLPKPGAWMNLLKGVF
HHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
GFLFLATALLMLRPVLDPSLWLGLCGALLLIAAYSAWKQSEGFGRVAQLFGAGSLLLGLW
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHH
GSLLVVGAAGGSEDPYQPLQVYSAGRVGTAAPNGHEAFTTIKDPAALQRELDTAKAQGQW
HHHHEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCCE
VLLDYYADWCVSCKVMEKQVFGQARVMQALSDVRLLRLDVTADNAASRELLGRYKVPGPP
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHCCCCCCCC
SFVWIGADGEERRSQRITGEVDADTFLQRWTTTRDAR
CEEEEECCCHHHHHHCCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA