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The map label for this gene is ghrA [H]

Identifier: 77460120

GI number: 77460120

Start: 4410311

End: 4411240

Strand: Reverse

Name: ghrA [H]

Synonym: Pfl01_3899

Alternate gene names: 77460120

Gene position: 4411240-4410311 (Counterclockwise)

Preceding gene: 77460121

Following gene: 77460118

Centisome position: 68.51

GC content: 62.04

Gene sequence:

>930_bases
ATGAACACCGTTGCACTGATGTCCCGCGATACGCTATTGCTCAAACAATTGCAGGAAGCCTTTGCTCGCCGTGCGCCGCA
GCTTTCGGCGGTGCTGGCTGACGATCCCCGGGCGGTGAATGCGCAGATCGCAGCGTGCTGGTTTCCGTTGTCGGACAGCC
TCGCCGCGTTGCCCAATCTGCAAGTGATTCACTCGGTCGCCGCCGGCATCGATCACCTGGAGCACGATCCGTCATGCCCG
GATCTGCCGGTGTGCCGGGTGGTCGATCCCGGCCACCGCCAAGGTATGACCGAGTACGTACGCTGGGCGGTGATTCATTT
TCATCGCGGCTTCGATCAAGTGCTGGAGCAACAACGCCAACAGCATTGGGAGCGACCGCTGCAACGCCCGGCCCATGAGT
TCCGGATCGGTGTGATGGGGCTCGGCTCGCTCGGCAGCGCGATCGTCCAAGACCTGGCCAGTGCCGGTTACGACGTGCGG
GGCTGGGCGCGGAGTAGCAAGAATTTGCCGGGCGTGCAGACCTACGCCGGCATCGACGCCTTCAATCCGTTCCTCGAAGG
CGTGGAGTTGCTGATCAACCTGTTGCCACTGACTCACGAGACGCGCGGCATCCTTAATCGCCAGACGTTCGAGCGTCTGG
GCAATGGCGCGGCACTGGTCAACGTCGGACGCGGCGGTCATTTGAATATCGACGATCTGCAACAAGCGCTGGCCCGTGGA
AAACTGCGCGGTGCGCTGCTCGATGTCTTCGAACAGGAACCGCTGCCCGCCGATCATCCGTTGTGGAAAACTCCGGGCGT
GACCATCACCCCGCACATGGCTTCGGCGGCGTCTCATGACTGCATTGCGGAGCAGATCGCCGAGAACTTCCGCCGTCTGA
ATGCCGGTGAGCCTTTGCTCAACAGCGCGGATCGGCTACTCGGTTACTGA

Upstream 100 bases:

>100_bases
CCGCCGAACAGTTCGACCGCGATGAGCAGGACAACATCATCGACCTGGCCTGGGAGGCCGCACTGACCCTGATCGAATCC
CAGCGCGAGTCCTATCTGTC

Downstream 100 bases:

>100_bases
TCCGCCAGACAGGCCTGCAAGCGTTCGATGAACAGCGTCTCGGCGCGGCTCATGCGCTGCTCGCGATTCCACAGCAGATG
AATGTCGACATCGGCAATCC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNTVALMSRDTLLLKQLQEAFARRAPQLSAVLADDPRAVNAQIAACWFPLSDSLAALPNLQVIHSVAAGIDHLEHDPSCP
DLPVCRVVDPGHRQGMTEYVRWAVIHFHRGFDQVLEQQRQQHWERPLQRPAHEFRIGVMGLGSLGSAIVQDLASAGYDVR
GWARSSKNLPGVQTYAGIDAFNPFLEGVELLINLLPLTHETRGILNRQTFERLGNGAALVNVGRGGHLNIDDLQQALARG
KLRGALLDVFEQEPLPADHPLWKTPGVTITPHMASAASHDCIAEQIAENFRRLNAGEPLLNSADRLLGY

Sequences:

>Translated_309_residues
MNTVALMSRDTLLLKQLQEAFARRAPQLSAVLADDPRAVNAQIAACWFPLSDSLAALPNLQVIHSVAAGIDHLEHDPSCP
DLPVCRVVDPGHRQGMTEYVRWAVIHFHRGFDQVLEQQRQQHWERPLQRPAHEFRIGVMGLGSLGSAIVQDLASAGYDVR
GWARSSKNLPGVQTYAGIDAFNPFLEGVELLINLLPLTHETRGILNRQTFERLGNGAALVNVGRGGHLNIDDLQQALARG
KLRGALLDVFEQEPLPADHPLWKTPGVTITPHMASAASHDCIAEQIAENFRRLNAGEPLLNSADRLLGY
>Mature_309_residues
MNTVALMSRDTLLLKQLQEAFARRAPQLSAVLADDPRAVNAQIAACWFPLSDSLAALPNLQVIHSVAAGIDHLEHDPSCP
DLPVCRVVDPGHRQGMTEYVRWAVIHFHRGFDQVLEQQRQQHWERPLQRPAHEFRIGVMGLGSLGSAIVQDLASAGYDVR
GWARSSKNLPGVQTYAGIDAFNPFLEGVELLINLLPLTHETRGILNRQTFERLGNGAALVNVGRGGHLNIDDLQQALARG
KLRGALLDVFEQEPLPADHPLWKTPGVTITPHMASAASHDCIAEQIAENFRRLNAGEPLLNSADRLLGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=262, Percent_Identity=28.2442748091603, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI23308577, Length=258, Percent_Identity=26.3565891472868, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI87081824, Length=297, Percent_Identity=38.3838383838384, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI87082289, Length=276, Percent_Identity=25.3623188405797, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=301, Percent_Identity=25.5813953488372, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=164, Percent_Identity=29.8780487804878, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574286, Length=265, Percent_Identity=27.9245283018868, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24585516, Length=301, Percent_Identity=27.906976744186, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551003, Length=265, Percent_Identity=27.1698113207547, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45552429, Length=273, Percent_Identity=26.7399267399267, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585514, Length=265, Percent_Identity=27.1698113207547, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574282, Length=265, Percent_Identity=27.1698113207547, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574284, Length=265, Percent_Identity=27.1698113207547, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571528, Length=237, Percent_Identity=27.0042194092827, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=254, Percent_Identity=24.0157480314961, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33982; Mature: 33982

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVALMSRDTLLLKQLQEAFARRAPQLSAVLADDPRAVNAQIAACWFPLSDSLAALPNL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCHHHHHCCCH
QVIHSVAAGIDHLEHDPSCPDLPVCRVVDPGHRQGMTEYVRWAVIHFHRGFDQVLEQQRQ
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
QHWERPLQRPAHEFRIGVMGLGSLGSAIVQDLASAGYDVRGWARSSKNLPGVQTYAGIDA
HHHHHHHHCCHHHHEEHHHCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHCHHH
FNPFLEGVELLINLLPLTHETRGILNRQTFERLGNGAALVNVGRGGHLNIDDLQQALARG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHH
KLRGALLDVFEQEPLPADHPLWKTPGVTITPHMASAASHDCIAEQIAENFRRLNAGEPLL
HHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
NSADRLLGY
HHHHHHHCC
>Mature Secondary Structure
MNTVALMSRDTLLLKQLQEAFARRAPQLSAVLADDPRAVNAQIAACWFPLSDSLAALPNL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCHHHHHCCCH
QVIHSVAAGIDHLEHDPSCPDLPVCRVVDPGHRQGMTEYVRWAVIHFHRGFDQVLEQQRQ
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
QHWERPLQRPAHEFRIGVMGLGSLGSAIVQDLASAGYDVRGWARSSKNLPGVQTYAGIDA
HHHHHHHHCCHHHHEEHHHCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHCHHH
FNPFLEGVELLINLLPLTHETRGILNRQTFERLGNGAALVNVGRGGHLNIDDLQQALARG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHH
KLRGALLDVFEQEPLPADHPLWKTPGVTITPHMASAASHDCIAEQIAENFRRLNAGEPLL
HHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
NSADRLLGY
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA