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The map label for this gene is lolC [H]

Identifier: 77460078

GI number: 77460078

Start: 4358285

End: 4359529

Strand: Reverse

Name: lolC [H]

Synonym: Pfl01_3857

Alternate gene names: 77460078

Gene position: 4359529-4358285 (Counterclockwise)

Preceding gene: 77460079

Following gene: 77460075

Centisome position: 67.71

GC content: 61.2

Gene sequence:

>1245_bases
ATGTTCAGACCGTTATCGATCTTTATCGGCACGCGCTATACCCGCGCCAAGCGCCGCAATCGCTTTGTTTCGTTCATTTC
GATGACCTCGATGATCGGCCTCGCCCTCGGCGTGCTGGCGATGATCGTGGTCCTGTCGGTGATGAACGGCTTCCAGCGCG
AAATGAGCTCGCGCATCCTTGGCATGGTGCCTCACGCGACCATCGTCGGCGTCAAGCCGATCGACGACTGGCAGCCAGTC
GCTGCCGCCGCGATGAAGAATCCGGAAGTGACCGCCGCCGTGCCGTTCACCGAGATGGAAGGCATGCTGTCCTACAAGGG
CATGATGCAGCCGATCCAGATCAGCGGCGTCGATCCGGCTCAGGAAGGCAAGGTGTCGATCGTTGCCCAACATATTGTTC
AAGGCCGTCTCGATGCCTTGAAACCGGGCGAATTCGGCGTAGTGCTCGGCGAAATCACCGCTCGGCGTTTCCGCCTCAAC
GTCGGCGACAAGATCACCCTGATCGTGCCGGAAGTCAGCACCGCACCGGGCGGCATCACCCCGCGCATGCAGCGTCTGAA
TGTGGTCGGCGTGTTCAAGGTCGGTGCCGAACTCGACGGTTCCATGGGCCTGATCCACGTCTCCGACGCCGCGACCATGC
AGCACTGGGAGCCGAATCAGGTGCAGAGCGTGCGTCTGGCGGTGAAGGATCTGTACGCCGCACCGAAGGTTTCCTCGGAC
ATTGCCTCCGGTCTCGGCGCCGATTTCAAGGCTGACGACTGGACCCACACCCAGGGCAGCCTGTTCAGTGCGATGAAGAT
GGAAAAAACCATGATCGGCCTGTTGCTGCTGATGATCGTCGCGGTGGCGGCGTTCAACATCATCGCGACCCTGATCATGG
TGGTGAACGACAAGGGCGCGGATATCGCGATCCTGCGCACCATCGGCGCCACGCCACGGCAGATCATGGCGATCTTCATG
GTGCAGGGCACGGTGATCGGTATCGTCGGCACCATCATCGGTGGCGTGCTGGGTGTGATTGCCGCGCTGAACGTCAGTGA
GATGGTGGGCTGGGTCGAGCGAGTGACCGGGCAGCACATCTTCAGTTCGGACGTGTATTTCGTCAGCAACCTGCCATCGG
AATTGCAGGGCGGTGACGTGCTGCTGATCTGCTCGGCGGGCTTTATCCTCAGCTTCCTGGCCACGGTTTACCCGGCCTGG
CGGGCGGCGAAGATCGAACCGGCGCACGCATTGCGCTATTCGTAA

Upstream 100 bases:

>100_bases
CCTGCAGCTGCAGGAAGGTTGCCTGACCCCCATCTGACGGCTTGAAACCCGGTGCCTGAAAAGGCATCGGGTCTTTTATT
TTTATACGGTGCCCCAGCGA

Downstream 100 bases:

>100_bases
GTTCCCCATTGAGGCCGGCATTGCCGGCCTCAATCGTTTTTCGGCAACTCAATCACAAACCGCGTCCAGCCCTGAGCCGA
TTCGCAATGAATCTGCCCGC

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MFRPLSIFIGTRYTRAKRRNRFVSFISMTSMIGLALGVLAMIVVLSVMNGFQREMSSRILGMVPHATIVGVKPIDDWQPV
AAAAMKNPEVTAAVPFTEMEGMLSYKGMMQPIQISGVDPAQEGKVSIVAQHIVQGRLDALKPGEFGVVLGEITARRFRLN
VGDKITLIVPEVSTAPGGITPRMQRLNVVGVFKVGAELDGSMGLIHVSDAATMQHWEPNQVQSVRLAVKDLYAAPKVSSD
IASGLGADFKADDWTHTQGSLFSAMKMEKTMIGLLLLMIVAVAAFNIIATLIMVVNDKGADIAILRTIGATPRQIMAIFM
VQGTVIGIVGTIIGGVLGVIAALNVSEMVGWVERVTGQHIFSSDVYFVSNLPSELQGGDVLLICSAGFILSFLATVYPAW
RAAKIEPAHALRYS

Sequences:

>Translated_414_residues
MFRPLSIFIGTRYTRAKRRNRFVSFISMTSMIGLALGVLAMIVVLSVMNGFQREMSSRILGMVPHATIVGVKPIDDWQPV
AAAAMKNPEVTAAVPFTEMEGMLSYKGMMQPIQISGVDPAQEGKVSIVAQHIVQGRLDALKPGEFGVVLGEITARRFRLN
VGDKITLIVPEVSTAPGGITPRMQRLNVVGVFKVGAELDGSMGLIHVSDAATMQHWEPNQVQSVRLAVKDLYAAPKVSSD
IASGLGADFKADDWTHTQGSLFSAMKMEKTMIGLLLLMIVAVAAFNIIATLIMVVNDKGADIAILRTIGATPRQIMAIFM
VQGTVIGIVGTIIGGVLGVIAALNVSEMVGWVERVTGQHIFSSDVYFVSNLPSELQGGDVLLICSAGFILSFLATVYPAW
RAAKIEPAHALRYS
>Mature_414_residues
MFRPLSIFIGTRYTRAKRRNRFVSFISMTSMIGLALGVLAMIVVLSVMNGFQREMSSRILGMVPHATIVGVKPIDDWQPV
AAAAMKNPEVTAAVPFTEMEGMLSYKGMMQPIQISGVDPAQEGKVSIVAQHIVQGRLDALKPGEFGVVLGEITARRFRLN
VGDKITLIVPEVSTAPGGITPRMQRLNVVGVFKVGAELDGSMGLIHVSDAATMQHWEPNQVQSVRLAVKDLYAAPKVSSD
IASGLGADFKADDWTHTQGSLFSAMKMEKTMIGLLLLMIVAVAAFNIIATLIMVVNDKGADIAILRTIGATPRQIMAIFM
VQGTVIGIVGTIIGGVLGVIAALNVSEMVGWVERVTGQHIFSSDVYFVSNLPSELQGGDVLLICSAGFILSFLATVYPAW
RAAKIEPAHALRYS

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=413, Percent_Identity=35.1089588377724, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1787360, Length=415, Percent_Identity=36.6265060240964, Blast_Score=233, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44497; Mature: 44497

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRPLSIFIGTRYTRAKRRNRFVSFISMTSMIGLALGVLAMIVVLSVMNGFQREMSSRIL
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMVPHATIVGVKPIDDWQPVAAAAMKNPEVTAAVPFTEMEGMLSYKGMMQPIQISGVDPA
HCCCCEEEEECCCCCCCCHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCEEECCCCCC
QEGKVSIVAQHIVQGRLDALKPGEFGVVLGEITARRFRLNVGDKITLIVPEVSTAPGGIT
CCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHEEECCCCEEEEEEECCCCCCCCCC
PRMQRLNVVGVFKVGAELDGSMGLIHVSDAATMQHWEPNQVQSVRLAVKDLYAAPKVSSD
CHHHHCCEEEEEEECCCCCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHH
IASGLGADFKADDWTHTQGSLFSAMKMEKTMIGLLLLMIVAVAAFNIIATLIMVVNDKGA
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DIAILRTIGATPRQIMAIFMVQGTVIGIVGTIIGGVLGVIAALNVSEMVGWVERVTGQHI
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHH
FSSDVYFVSNLPSELQGGDVLLICSAGFILSFLATVYPAWRAAKIEPAHALRYS
HCCCEEEEECCCHHCCCCCEEEEECHHHHHHHHHHHCCCHHCCCCCHHHHCCCC
>Mature Secondary Structure
MFRPLSIFIGTRYTRAKRRNRFVSFISMTSMIGLALGVLAMIVVLSVMNGFQREMSSRIL
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMVPHATIVGVKPIDDWQPVAAAAMKNPEVTAAVPFTEMEGMLSYKGMMQPIQISGVDPA
HCCCCEEEEECCCCCCCCHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCEEECCCCCC
QEGKVSIVAQHIVQGRLDALKPGEFGVVLGEITARRFRLNVGDKITLIVPEVSTAPGGIT
CCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHEEECCCCEEEEEEECCCCCCCCCC
PRMQRLNVVGVFKVGAELDGSMGLIHVSDAATMQHWEPNQVQSVRLAVKDLYAAPKVSSD
CHHHHCCEEEEEEECCCCCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHH
IASGLGADFKADDWTHTQGSLFSAMKMEKTMIGLLLLMIVAVAAFNIIATLIMVVNDKGA
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DIAILRTIGATPRQIMAIFMVQGTVIGIVGTIIGGVLGVIAALNVSEMVGWVERVTGQHI
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHH
FSSDVYFVSNLPSELQGGDVLLICSAGFILSFLATVYPAWRAAKIEPAHALRYS
HCCCEEEEECCCHHCCCCCEEEEECHHHHHHHHHHHCCCHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]