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The map label for this gene is hpmB [H]

Identifier: 77460014

GI number: 77460014

Start: 4292523

End: 4294250

Strand: Reverse

Name: hpmB [H]

Synonym: Pfl01_3792

Alternate gene names: 77460014

Gene position: 4294250-4292523 (Counterclockwise)

Preceding gene: 77460017

Following gene: 77460013

Centisome position: 66.7

GC content: 63.6

Gene sequence:

>1728_bases
GTGCCGTATTCGCTTTGCGTTGTTTCTCGTTGTCGTTCCCTGCCGCGCCCGCTGTTGTCGGCCTTGTTGTTGAGTGTGTG
CGCGCCCAGCGTTCTCGCCGCCGAAACTCCAGCCCCTGGCCAGGAAGTGCTGCGTCAGCAGCAACTGCAACAGCGTGACC
TGCAACAACTGCAACTCGAACAGCGCAAACGCCAACTGGAGCGCGGCGCGTTTGGCCCGACGCCGGTCAATCCGGACATT
CCTGAGTCGATCAAACCTGATGAGCGCTGCTGGCCCTTGAGTGGTACGCGCATCGGCGGTGTGACGCTGATCGATAAAGA
CAAACTCAACGCCCGGATCAAACCGCTGTTGGCGCCGTGCATGGGCGTCGGCCAGATCAACCATTTGCTGGCGACCATCA
CCGCGCTGTACGTGGAGAAGGGCTATATCGCCAGCCGGCCATACCTGAGCAGCGCTCCAGCGGCGGGGCAATCGCTGGAT
ATCCTGATCGACGAAGGCTACATCGAGTCCATCGAGCTGGCCGACCAGAGCCTGCCAGTGTCGCTCGGCGGGGCGTTCCC
CGGAATGCTCGGCAAACCGCTGAACCTGCGGGATCTGGAGCAGGGGCTGGATCAGTTGAACCGTCTGCGTTCGCTCGATC
TGACCGCCGACATCGCCCCCGGCGGCCAGCCCGGTGCGTCAAAAATCATCTTGCGTTCACGTACTTCCGGGCAGTCACGC
TGGGCCCTCGGTGCCGGTTTCGACAACCTAGGCAGTGCCAGCACCGGTCGCGATCGCGACACGCTGAGCCTGACGCTCGA
CAGTCCGCTCGAACTCAACGATCTGCTGAGCCTCAGCGCCAGCGACACCCTCAATCAGGGCGACCGCTACAGCCGCAACG
CCAGCCTCTATTACGCGATTCCCTACGGTTACTGGACGTTCAGCGCTTTCGCCAGCCACGCCGAATACCGCGCGCCGTTC
AAGCTCAGCACGGCGACCCTGTACAGCACCGGCATCACCGATCAGCTCAGCCTGCGCGCCGACCGGGTGTTGTGGCGCGA
CCAGAGCCATCAGCTCAGCGCCAACTTGCAACTGGCGCACAAGGACGTTGACAGTTATCTGGAAAACGTCCGCCTCGGCA
TTCAGAGCCCGACCCTGACCGTGGCCGAAGCCGGGCTCAATCTGTTCTGGCTCGACCGCGCGGTGTGGAACCTCGACGTC
AATTACGCCCAGGGTTTAAGCGGGTTCGGTGCCGACGACGATGCCGATCGCCAGGTCAAAAACCTGCCCAAGGCACAGTT
TCGCAAGTACCGCGCCGGCCTCAGCCAGTGGCGCAACGGCCAGCTCGGCGCGCAAGCCTGGCAATGGCAGAGCCAACTCA
ATTTGCAGTACAGCCCGGATCCGTTGCCGGCCATCGAACAACTGCTCGGCACCGACGATTCCGCCGTGCGCGGTTACCGG
GTCAGCAGCGCGTCCGGCGCCAGCGGCGCGATCTGGCGCAACACCTTGCGCCTGCCGCTGCGCAGCGATTTGCCGGTGCA
GCTCACCCCGCGCGTCGGCCTCGACCACGGCTGGATCAAGGCCGATCACGGCGCTCCGGTTCAACGCCTGAGCGGCGCCA
GCATCGGCCTCAACCTGGGCTGGAAAAACCTGCAGGTGGACGTCGATTACCAACGCAGCCTGAACACCCCGACCGGCCTG
CACCGCGAACCTGAAACCTGGTTGATGCGGGTCGGATTACAGATATGA

Upstream 100 bases:

>100_bases
GTAAGCGCTGTAGGAAGCGTCTTGCATTTGTGTAGGAAGGCTCTGACTATCACCGCAATTGATGGGGTGGCATTACGCCA
GTTGATTGCAAGGATGTTGA

Downstream 100 bases:

>100_bases
ACGTCAGTGAACAACAGCCATCGGACCTGAGCGCGACAGCCGTGGCCTTCAACTTAACGCGCAACGTGATGCCGCACTAC
ATGGAGAGTTTTTTATGCCA

Product: hemolysin activator HlyB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MPYSLCVVSRCRSLPRPLLSALLLSVCAPSVLAAETPAPGQEVLRQQQLQQRDLQQLQLEQRKRQLERGAFGPTPVNPDI
PESIKPDERCWPLSGTRIGGVTLIDKDKLNARIKPLLAPCMGVGQINHLLATITALYVEKGYIASRPYLSSAPAAGQSLD
ILIDEGYIESIELADQSLPVSLGGAFPGMLGKPLNLRDLEQGLDQLNRLRSLDLTADIAPGGQPGASKIILRSRTSGQSR
WALGAGFDNLGSASTGRDRDTLSLTLDSPLELNDLLSLSASDTLNQGDRYSRNASLYYAIPYGYWTFSAFASHAEYRAPF
KLSTATLYSTGITDQLSLRADRVLWRDQSHQLSANLQLAHKDVDSYLENVRLGIQSPTLTVAEAGLNLFWLDRAVWNLDV
NYAQGLSGFGADDDADRQVKNLPKAQFRKYRAGLSQWRNGQLGAQAWQWQSQLNLQYSPDPLPAIEQLLGTDDSAVRGYR
VSSASGASGAIWRNTLRLPLRSDLPVQLTPRVGLDHGWIKADHGAPVQRLSGASIGLNLGWKNLQVDVDYQRSLNTPTGL
HREPETWLMRVGLQI

Sequences:

>Translated_575_residues
MPYSLCVVSRCRSLPRPLLSALLLSVCAPSVLAAETPAPGQEVLRQQQLQQRDLQQLQLEQRKRQLERGAFGPTPVNPDI
PESIKPDERCWPLSGTRIGGVTLIDKDKLNARIKPLLAPCMGVGQINHLLATITALYVEKGYIASRPYLSSAPAAGQSLD
ILIDEGYIESIELADQSLPVSLGGAFPGMLGKPLNLRDLEQGLDQLNRLRSLDLTADIAPGGQPGASKIILRSRTSGQSR
WALGAGFDNLGSASTGRDRDTLSLTLDSPLELNDLLSLSASDTLNQGDRYSRNASLYYAIPYGYWTFSAFASHAEYRAPF
KLSTATLYSTGITDQLSLRADRVLWRDQSHQLSANLQLAHKDVDSYLENVRLGIQSPTLTVAEAGLNLFWLDRAVWNLDV
NYAQGLSGFGADDDADRQVKNLPKAQFRKYRAGLSQWRNGQLGAQAWQWQSQLNLQYSPDPLPAIEQLLGTDDSAVRGYR
VSSASGASGAIWRNTLRLPLRSDLPVQLTPRVGLDHGWIKADHGAPVQRLSGASIGLNLGWKNLQVDVDYQRSLNTPTGL
HREPETWLMRVGLQI
>Mature_574_residues
PYSLCVVSRCRSLPRPLLSALLLSVCAPSVLAAETPAPGQEVLRQQQLQQRDLQQLQLEQRKRQLERGAFGPTPVNPDIP
ESIKPDERCWPLSGTRIGGVTLIDKDKLNARIKPLLAPCMGVGQINHLLATITALYVEKGYIASRPYLSSAPAAGQSLDI
LIDEGYIESIELADQSLPVSLGGAFPGMLGKPLNLRDLEQGLDQLNRLRSLDLTADIAPGGQPGASKIILRSRTSGQSRW
ALGAGFDNLGSASTGRDRDTLSLTLDSPLELNDLLSLSASDTLNQGDRYSRNASLYYAIPYGYWTFSAFASHAEYRAPFK
LSTATLYSTGITDQLSLRADRVLWRDQSHQLSANLQLAHKDVDSYLENVRLGIQSPTLTVAEAGLNLFWLDRAVWNLDVN
YAQGLSGFGADDDADRQVKNLPKAQFRKYRAGLSQWRNGQLGAQAWQWQSQLNLQYSPDPLPAIEQLLGTDDSAVRGYRV
SSASGASGAIWRNTLRLPLRSDLPVQLTPRVGLDHGWIKADHGAPVQRLSGASIGLNLGWKNLQVDVDYQRSLNTPTGLH
REPETWLMRVGLQI

Specific function: Probable member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 63116; Mature: 62985

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYSLCVVSRCRSLPRPLLSALLLSVCAPSVLAAETPAPGQEVLRQQQLQQRDLQQLQLE
CCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QRKRQLERGAFGPTPVNPDIPESIKPDERCWPLSGTRIGGVTLIDKDKLNARIKPLLAPC
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCEEEEECCCCCCHHHHHHHHH
MGVGQINHLLATITALYVEKGYIASRPYLSSAPAAGQSLDILIDEGYIESIELADQSLPV
HCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHCCCCCCE
SLGGAFPGMLGKPLNLRDLEQGLDQLNRLRSLDLTADIAPGGQPGASKIILRSRTSGQSR
EECCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCC
WALGAGFDNLGSASTGRDRDTLSLTLDSPLELNDLLSLSASDTLNQGDRYSRNASLYYAI
EEEECCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
PYGYWTFSAFASHAEYRAPFKLSTATLYSTGITDQLSLRADRVLWRDQSHQLSANLQLAH
CCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEHH
KDVDSYLENVRLGIQSPTLTVAEAGLNLFWLDRAVWNLDVNYAQGLSGFGADDDADRQVK
HHHHHHHHHHHCCCCCCCEEEHHCCCCEEEECHHHEEECCHHHHCCCCCCCCCCHHHHHH
NLPKAQFRKYRAGLSQWRNGQLGAQAWQWQSQLNLQYSPDPLPAIEQLLGTDDSAVRGYR
HCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEECCCCCHHHHHHHCCCCHHHCCEE
VSSASGASGAIWRNTLRLPLRSDLPVQLTPRVGLDHGWIKADHGAPVQRLSGASIGLNLG
ECCCCCCCCCHHHHEEECCCCCCCCEEECCCCCCCCCCEECCCCCCHHHHCCCEEEEECC
WKNLQVDVDYQRSLNTPTGLHREPETWLMRVGLQI
CEEEEEEEEHHHCCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
PYSLCVVSRCRSLPRPLLSALLLSVCAPSVLAAETPAPGQEVLRQQQLQQRDLQQLQLE
CCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QRKRQLERGAFGPTPVNPDIPESIKPDERCWPLSGTRIGGVTLIDKDKLNARIKPLLAPC
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCEEEEECCCCCCHHHHHHHHH
MGVGQINHLLATITALYVEKGYIASRPYLSSAPAAGQSLDILIDEGYIESIELADQSLPV
HCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHCCCCCCE
SLGGAFPGMLGKPLNLRDLEQGLDQLNRLRSLDLTADIAPGGQPGASKIILRSRTSGQSR
EECCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCC
WALGAGFDNLGSASTGRDRDTLSLTLDSPLELNDLLSLSASDTLNQGDRYSRNASLYYAI
EEEECCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
PYGYWTFSAFASHAEYRAPFKLSTATLYSTGITDQLSLRADRVLWRDQSHQLSANLQLAH
CCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEHH
KDVDSYLENVRLGIQSPTLTVAEAGLNLFWLDRAVWNLDVNYAQGLSGFGADDDADRQVK
HHHHHHHHHHHCCCCCCCEEEHHCCCCEEEECHHHEEECCHHHHCCCCCCCCCCHHHHHH
NLPKAQFRKYRAGLSQWRNGQLGAQAWQWQSQLNLQYSPDPLPAIEQLLGTDDSAVRGYR
HCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEECCCCCHHHHHHHCCCCHHHCCEE
VSSASGASGAIWRNTLRLPLRSDLPVQLTPRVGLDHGWIKADHGAPVQRLSGASIGLNLG
ECCCCCCCCCHHHHEEECCCCCCCCEEECCCCCCCCCCEECCCCCCHHHHCCCEEEEECC
WKNLQVDVDYQRSLNTPTGLHREPETWLMRVGLQI
CEEEEEEEEHHHCCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2407716 [H]