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The map label for this gene is ggt [H]

Identifier: 77459787

GI number: 77459787

Start: 4035147

End: 4036874

Strand: Reverse

Name: ggt [H]

Synonym: Pfl01_3565

Alternate gene names: 77459787

Gene position: 4036874-4035147 (Counterclockwise)

Preceding gene: 77459789

Following gene: 77459786

Centisome position: 62.7

GC content: 61.4

Gene sequence:

>1728_bases
ATGAAGTACGAACCTTTTGCCAAATCGCTGATTGCGACCTCGTTGGCGCTCAGCTGCCTCATGGCGCACGCCGCCTCGGT
TGCCCCGGTTGCTGCCGAAAACGGCATGGTGGTCACCGCCCAGCACCTGGCCACCCACGTGGGTGTCGACGTGTTGAAAA
GTGGCGGCAACGCGGTGGATGCGGCGGTCGCCGTGGGTTATGCACTGGCGGTGGTTTACCCGGCGGCGGGCAACCTCGGT
GGCGGTGGTTTCATGACCATTCAACTGGCGGACGGACGCAAGACCTTCCTCGATTTCCGCGAAAAAGCCCCGCTGGCCGC
GACGGCCAACATGTATCTCGACAAGGACGGCAACGTCATTCCGGATCTGAGTACCCGTGGTCACCTCGCGGTCGGCGTTC
CGGGCACCGTGTCCGGCATGGAGCTGGCGCTGAGCAAGTACGGCACCAAGCCGCGCAAGGACATGATCGCCCCAGCGATC
AAACTGGCGGAAGAAGGTTTCGAGCTGGAACAGGGCGACGTCGAGCTTCTGGAGTACGCGACCGACGTATTCAAGAAGGA
CATCAAGGATTCCGGCGCGATCTTTTTGAGCAACGGCGAGCCGATGCAGGTCGGGCAGAAACTGGTGCAGAAGGATCTGG
GCAAAACCCTGCGCACCATTTCCGAAAAAGGCGCCGACGGCTTCTACAAAGGCTGGGTGGCCGACGCCATCGTCACCTCC
AGTCAGGCCAACAAGGGCATCATCACCCAGGCCGACCTCGACAAGTACAAGACCCGCGAACTGGCCCCGGTGGAGTGCGA
CTATCGCGGTTATCACGTGGTATCGGCACCGCCGCCAAGCTCCGGCGGCGTCGTGATCTGCCAGATCATGAACATTCTCG
AAGGCTATCCGATGAAGGATCTGGGCTTCCATTCTGCCCAGGGCATGCACTACCAGATCGAGGCGATGCGTCACGCATAC
GTGGATCGCAACAGTTATCTGGGCGACCCGGATTTCGTGAAAAACCCGATCGAACACCTGCTGGACAAGAACTACGCGAC
CAAGCTGCGTGACGCGATCCAGCCGCAGAAGGCCGGCGTTTCGGCGGAACTCAAGCCCGGCGTCGCGCCTCATGAAGGCA
GCAACACCACGCACTACTCGATCGTCGACAAATGGGGCAACGCGGTCTCGGTCACCTACACCCTCAACGACTGGTTCGGC
GCCGGTGTGATGGCGAGCAAGACCGGGGTGATCCTCAACGATGAAATGGACGACTTCACCTCCAAGGTCGGCGTGCCGAA
CATGTACGGTCTGGTGCAGGGTGAGGCCAACGCCATTGCTCCGGGCAAGGCGCCGCTGTCCTCGATGAGCCCGACTATCG
TCACCAAGGACGGCAAAGTGGTGATGGTGGTCGGTACGCCGGGCGGCAGTCGCATCATTACCGCGACGTTGCTGACCATG
CTCAACGTCATCGACTACGGCATGGGCCTGCAGGAAGCGGTCGACGCTCCACGTTTCCACCAGCAGTGGATGCCGGAGGA
AACCAACCTCGAAGACTTCGCCGCCAGCCCCGACACCAAGAAGATTCTCGAGAGCTGGGGCCACAAGTTCGCGGGCCCGC
AGGACGCCAACCACATCGCCGCGATTCTGGTTGGTGCACCGTCGTTGGGTGGCAAACCGGTCGGCAAGAACCGCTTCTAC
GGCGCCAACGATCCACGGCGCAACACCGGGTTGTCATTGGGTTACTGA

Upstream 100 bases:

>100_bases
CCAGCATACTGCCGGATCGGGGAGGCGCAAACCGCAATCACGACCATACTGGCTGATGCTCTAAGCGCTTTCCTACCTTA
TAAAAAGAAGAGACCGACTC

Downstream 100 bases:

>100_bases
GCAGAGTAAAAAGGGGGCGGGCACACGTCCGCCCCTGTCTCAAGGACCGATCAAGGAAGGCTCACCATGACCACCGCATT
GCTGATCATCGATGTCCAGC

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MKYEPFAKSLIATSLALSCLMAHAASVAPVAAENGMVVTAQHLATHVGVDVLKSGGNAVDAAVAVGYALAVVYPAAGNLG
GGGFMTIQLADGRKTFLDFREKAPLAATANMYLDKDGNVIPDLSTRGHLAVGVPGTVSGMELALSKYGTKPRKDMIAPAI
KLAEEGFELEQGDVELLEYATDVFKKDIKDSGAIFLSNGEPMQVGQKLVQKDLGKTLRTISEKGADGFYKGWVADAIVTS
SQANKGIITQADLDKYKTRELAPVECDYRGYHVVSAPPPSSGGVVICQIMNILEGYPMKDLGFHSAQGMHYQIEAMRHAY
VDRNSYLGDPDFVKNPIEHLLDKNYATKLRDAIQPQKAGVSAELKPGVAPHEGSNTTHYSIVDKWGNAVSVTYTLNDWFG
AGVMASKTGVILNDEMDDFTSKVGVPNMYGLVQGEANAIAPGKAPLSSMSPTIVTKDGKVVMVVGTPGGSRIITATLLTM
LNVIDYGMGLQEAVDAPRFHQQWMPEETNLEDFAASPDTKKILESWGHKFAGPQDANHIAAILVGAPSLGGKPVGKNRFY
GANDPRRNTGLSLGY

Sequences:

>Translated_575_residues
MKYEPFAKSLIATSLALSCLMAHAASVAPVAAENGMVVTAQHLATHVGVDVLKSGGNAVDAAVAVGYALAVVYPAAGNLG
GGGFMTIQLADGRKTFLDFREKAPLAATANMYLDKDGNVIPDLSTRGHLAVGVPGTVSGMELALSKYGTKPRKDMIAPAI
KLAEEGFELEQGDVELLEYATDVFKKDIKDSGAIFLSNGEPMQVGQKLVQKDLGKTLRTISEKGADGFYKGWVADAIVTS
SQANKGIITQADLDKYKTRELAPVECDYRGYHVVSAPPPSSGGVVICQIMNILEGYPMKDLGFHSAQGMHYQIEAMRHAY
VDRNSYLGDPDFVKNPIEHLLDKNYATKLRDAIQPQKAGVSAELKPGVAPHEGSNTTHYSIVDKWGNAVSVTYTLNDWFG
AGVMASKTGVILNDEMDDFTSKVGVPNMYGLVQGEANAIAPGKAPLSSMSPTIVTKDGKVVMVVGTPGGSRIITATLLTM
LNVIDYGMGLQEAVDAPRFHQQWMPEETNLEDFAASPDTKKILESWGHKFAGPQDANHIAAILVGAPSLGGKPVGKNRFY
GANDPRRNTGLSLGY
>Mature_575_residues
MKYEPFAKSLIATSLALSCLMAHAASVAPVAAENGMVVTAQHLATHVGVDVLKSGGNAVDAAVAVGYALAVVYPAAGNLG
GGGFMTIQLADGRKTFLDFREKAPLAATANMYLDKDGNVIPDLSTRGHLAVGVPGTVSGMELALSKYGTKPRKDMIAPAI
KLAEEGFELEQGDVELLEYATDVFKKDIKDSGAIFLSNGEPMQVGQKLVQKDLGKTLRTISEKGADGFYKGWVADAIVTS
SQANKGIITQADLDKYKTRELAPVECDYRGYHVVSAPPPSSGGVVICQIMNILEGYPMKDLGFHSAQGMHYQIEAMRHAY
VDRNSYLGDPDFVKNPIEHLLDKNYATKLRDAIQPQKAGVSAELKPGVAPHEGSNTTHYSIVDKWGNAVSVTYTLNDWFG
AGVMASKTGVILNDEMDDFTSKVGVPNMYGLVQGEANAIAPGKAPLSSMSPTIVTKDGKVVMVVGTPGGSRIITATLLTM
LNVIDYGMGLQEAVDAPRFHQQWMPEETNLEDFAASPDTKKILESWGHKFAGPQDANHIAAILVGAPSLGGKPVGKNRFY
GANDPRRNTGLSLGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=505, Percent_Identity=34.2574257425743, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI73915090, Length=505, Percent_Identity=34.2574257425743, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI73915096, Length=505, Percent_Identity=34.2574257425743, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI73915094, Length=505, Percent_Identity=34.2574257425743, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI113429324, Length=510, Percent_Identity=31.9607843137255, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI113429326, Length=514, Percent_Identity=31.7120622568093, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI153266885, Length=502, Percent_Identity=27.8884462151394, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI153266901, Length=505, Percent_Identity=27.9207920792079, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI109148539, Length=516, Percent_Identity=29.0697674418605, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI153266907, Length=501, Percent_Identity=26.3473053892216, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI30581157, Length=173, Percent_Identity=39.3063583815029, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI30581155, Length=173, Percent_Identity=39.3063583815029, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI218505805, Length=168, Percent_Identity=35.1190476190476, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI310124095, Length=178, Percent_Identity=29.7752808988764, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789856, Length=549, Percent_Identity=52.8233151183971, Blast_Score=552, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI72000294, Length=563, Percent_Identity=34.1030195381883, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI212646519, Length=563, Percent_Identity=34.1030195381883, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17542894, Length=510, Percent_Identity=36.078431372549, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17506189, Length=509, Percent_Identity=33.9882121807466, Blast_Score=228, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI193208245, Length=559, Percent_Identity=30.5903398926655, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI193208247, Length=559, Percent_Identity=30.5903398926655, Blast_Score=215, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17564448, Length=436, Percent_Identity=26.3761467889908, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI72001497, Length=276, Percent_Identity=25, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72001495, Length=234, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323330, Length=488, Percent_Identity=30.1229508196721, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI161077880, Length=518, Percent_Identity=31.4671814671815, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI161077878, Length=517, Percent_Identity=30.9477756286267, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24642670, Length=517, Percent_Identity=30.9477756286267, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24642666, Length=517, Percent_Identity=30.9477756286267, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI45551474, Length=517, Percent_Identity=30.9477756286267, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI18859893, Length=529, Percent_Identity=31.1909262759924, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161077496, Length=478, Percent_Identity=32.2175732217573, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI18859741, Length=487, Percent_Identity=28.3367556468172, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61265; Mature: 61265

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYEPFAKSLIATSLALSCLMAHAASVAPVAAENGMVVTAQHLATHVGVDVLKSGGNAVD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEHHHHHHHHHHHHHHCCCCHHH
AAVAVGYALAVVYPAAGNLGGGGFMTIQLADGRKTFLDFREKAPLAATANMYLDKDGNVI
HHHHHHHHHHHEECCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCCCC
PDLSTRGHLAVGVPGTVSGMELALSKYGTKPRKDMIAPAIKLAEEGFELEQGDVELLEYA
CCCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
TDVFKKDIKDSGAIFLSNGEPMQVGQKLVQKDLGKTLRTISEKGADGFYKGWVADAIVTS
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
SQANKGIITQADLDKYKTRELAPVECDYRGYHVVSAPPPSSGGVVICQIMNILEGYPMKD
CCCCCCCEEECCHHHHHCCCCCCCEECCCCEEEEECCCCCCCCEEHHHHHHHHCCCCCCC
LGFHSAQGMHYQIEAMRHAYVDRNSYLGDPDFVKNPIEHLLDKNYATKLRDAIQPQKAGV
CCCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHCCC
SAELKPGVAPHEGSNTTHYSIVDKWGNAVSVTYTLNDWFGAGVMASKTGVILNDEMDDFT
CCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCEEECCCCEEECCCHHHHH
SKVGVPNMYGLVQGEANAIAPGKAPLSSMSPTIVTKDGKVVMVVGTPGGSRIITATLLTM
HHCCCCCHHEEEECCCCEECCCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHH
LNVIDYGMGLQEAVDAPRFHQQWMPEETNLEDFAASPDTKKILESWGHKFAGPQDANHIA
HHHHHHCCCHHHHHCCCHHHHHCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEE
AILVGAPSLGGKPVGKNRFYGANDPRRNTGLSLGY
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKYEPFAKSLIATSLALSCLMAHAASVAPVAAENGMVVTAQHLATHVGVDVLKSGGNAVD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEHHHHHHHHHHHHHHCCCCHHH
AAVAVGYALAVVYPAAGNLGGGGFMTIQLADGRKTFLDFREKAPLAATANMYLDKDGNVI
HHHHHHHHHHHEECCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCCCC
PDLSTRGHLAVGVPGTVSGMELALSKYGTKPRKDMIAPAIKLAEEGFELEQGDVELLEYA
CCCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
TDVFKKDIKDSGAIFLSNGEPMQVGQKLVQKDLGKTLRTISEKGADGFYKGWVADAIVTS
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
SQANKGIITQADLDKYKTRELAPVECDYRGYHVVSAPPPSSGGVVICQIMNILEGYPMKD
CCCCCCCEEECCHHHHHCCCCCCCEECCCCEEEEECCCCCCCCEEHHHHHHHHCCCCCCC
LGFHSAQGMHYQIEAMRHAYVDRNSYLGDPDFVKNPIEHLLDKNYATKLRDAIQPQKAGV
CCCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHCCC
SAELKPGVAPHEGSNTTHYSIVDKWGNAVSVTYTLNDWFGAGVMASKTGVILNDEMDDFT
CCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCEEECCCCEEECCCHHHHH
SKVGVPNMYGLVQGEANAIAPGKAPLSSMSPTIVTKDGKVVMVVGTPGGSRIITATLLTM
HHCCCCCHHEEEECCCCEECCCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHH
LNVIDYGMGLQEAVDAPRFHQQWMPEETNLEDFAASPDTKKILESWGHKFAGPQDANHIA
HHHHHHCCCHHHHHCCCHHHHHCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEE
AILVGAPSLGGKPVGKNRFYGANDPRRNTGLSLGY
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]