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The map label for this gene is alsR [H]

Identifier: 77459646

GI number: 77459646

Start: 3904428

End: 3905318

Strand: Reverse

Name: alsR [H]

Synonym: Pfl01_3424

Alternate gene names: 77459646

Gene position: 3905318-3904428 (Counterclockwise)

Preceding gene: 77459647

Following gene: 77459645

Centisome position: 60.66

GC content: 64.31

Gene sequence:

>891_bases
ATGGACCTGCGTTTGCTGCGGTACTTCATGGCCCTGGCCGATGAGCTGCACTTTGGCCGCGCCGCCGAACGGCTGCACAT
CTGCCAGCCGCCGCTGAGCCAGCAGATCCGTTTGCTGGAGGAAGAACTCGGCACGCCGCTGTTCGAGCGCAGCCATCACC
GGGTCGAGCTGACAGCGGCGGGGCAGATGCTCAAAGAGCAGGCGCCGCTGGTGTTCGAGCAACTCGAGCGGGCGCTGGAC
CTGACCCGCCAGACCGGGCGCGGGCAACTCGGCGAGCTGGAAATCGGCATGATCAGTTCGGTGATGGTCGGCGTGCTGCC
CAAGGCGCTGCACCTGTTTCGCGAGCGCTATCCACAGGTGACCTGGCGTCTGCATGAGATGACCCCGGCGGCGCAGGTCA
AGGCGTTGAAGGAAAAACGCATCGACGCCTGCGTATTCCGCGTCGGCTATGACGACCCGCAGTTGCGCAATGAATTGCTG
ATCCATGAGCCGATCCATGTGGTAATGCCGCAGGATCATCCGCTGGCCCGGCGCGAGGTGCTGGCGCCCGCAGACCTCGC
GCAGGAACCGTTCGTGGCGCTGGAATTGAAGCAGTCGCGGTTCGCCAATTTTCTCTATCAGTGCTGCATTCAGGCCGGGT
TCACCCCGCAGATCCGCCAGCAGGTGATCGAGGTGCAGACCTTGCTCAGTCTGGTTCGCGCCGGGTTTGGCGTGGCGCTG
TTACCCGCATCGATCGAGCAGTTGGCTCCCGCGGGACTGGTGTTCCGGCGCCTGACCCCGGCGTTGCCGCAAGTGCCGCT
GTACGCGACGTATCGGGCCGACGATGCCTCGCCGGTGCTCAAGCTGTTTCTCGATACGCTGCGCGAGCTGGTCGATCACT
CATCGCGGTAA

Upstream 100 bases:

>100_bases
ACTGGGCAGTCCTTCGGTGGTCCCGGCGATTGCCAATGCGCTATTCAGCCTGACCGGGGTGCGTCAGCGTTCCACGCCAC
TGAACCTGGGGTAAGCCGCC

Downstream 100 bases:

>100_bases
TCAGGGACAAAGTTGCCCGGCACGATCACAACCGCCTGCGGTCGTAAACTTCACATGCGCGAACTTGTGGAGAACCAATG
AGCCGGGACGTCCTGACCAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MDLRLLRYFMALADELHFGRAAERLHICQPPLSQQIRLLEEELGTPLFERSHHRVELTAAGQMLKEQAPLVFEQLERALD
LTRQTGRGQLGELEIGMISSVMVGVLPKALHLFRERYPQVTWRLHEMTPAAQVKALKEKRIDACVFRVGYDDPQLRNELL
IHEPIHVVMPQDHPLARREVLAPADLAQEPFVALELKQSRFANFLYQCCIQAGFTPQIRQQVIEVQTLLSLVRAGFGVAL
LPASIEQLAPAGLVFRRLTPALPQVPLYATYRADDASPVLKLFLDTLRELVDHSSR

Sequences:

>Translated_296_residues
MDLRLLRYFMALADELHFGRAAERLHICQPPLSQQIRLLEEELGTPLFERSHHRVELTAAGQMLKEQAPLVFEQLERALD
LTRQTGRGQLGELEIGMISSVMVGVLPKALHLFRERYPQVTWRLHEMTPAAQVKALKEKRIDACVFRVGYDDPQLRNELL
IHEPIHVVMPQDHPLARREVLAPADLAQEPFVALELKQSRFANFLYQCCIQAGFTPQIRQQVIEVQTLLSLVRAGFGVAL
LPASIEQLAPAGLVFRRLTPALPQVPLYATYRADDASPVLKLFLDTLRELVDHSSR
>Mature_296_residues
MDLRLLRYFMALADELHFGRAAERLHICQPPLSQQIRLLEEELGTPLFERSHHRVELTAAGQMLKEQAPLVFEQLERALD
LTRQTGRGQLGELEIGMISSVMVGVLPKALHLFRERYPQVTWRLHEMTPAAQVKALKEKRIDACVFRVGYDDPQLRNELL
IHEPIHVVMPQDHPLARREVLAPADLAQEPFVALELKQSRFANFLYQCCIQAGFTPQIRQQVIEVQTLLSLVRAGFGVAL
LPASIEQLAPAGLVFRRLTPALPQVPLYATYRADDASPVLKLFLDTLRELVDHSSR

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=289, Percent_Identity=35.6401384083045, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=38.3399209486166, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=33.1034482758621, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI157672245, Length=247, Percent_Identity=34.0080971659919, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787530, Length=261, Percent_Identity=27.9693486590038, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693105, Length=244, Percent_Identity=25.8196721311475, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788297, Length=272, Percent_Identity=26.8382352941176, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1789204, Length=275, Percent_Identity=28, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788748, Length=289, Percent_Identity=24.2214532871972, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790208, Length=276, Percent_Identity=27.536231884058, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI87081904, Length=183, Percent_Identity=30.6010928961749, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787601, Length=276, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87082132, Length=246, Percent_Identity=28.4552845528455, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790262, Length=297, Percent_Identity=26.5993265993266, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787806, Length=252, Percent_Identity=23.4126984126984, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786713, Length=283, Percent_Identity=27.5618374558304, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI48994962, Length=110, Percent_Identity=36.3636363636364, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789173, Length=190, Percent_Identity=32.1052631578947, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786401, Length=310, Percent_Identity=26.4516129032258, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33642; Mature: 33642

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRLLRYFMALADELHFGRAAERLHICQPPLSQQIRLLEEELGTPLFERSHHRVELTAA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCEEEEHHH
GQMLKEQAPLVFEQLERALDLTRQTGRGQLGELEIGMISSVMVGVLPKALHLFRERYPQV
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
TWRLHEMTPAAQVKALKEKRIDACVFRVGYDDPQLRNELLIHEPIHVVMPQDHPLARREV
HHHHHHCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCEEEECCCCCCHHHHHH
LAPADLAQEPFVALELKQSRFANFLYQCCIQAGFTPQIRQQVIEVQTLLSLVRAGFGVAL
CCCHHHCCCCHHEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
LPASIEQLAPAGLVFRRLTPALPQVPLYATYRADDASPVLKLFLDTLRELVDHSSR
HHHHHHHHCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDLRLLRYFMALADELHFGRAAERLHICQPPLSQQIRLLEEELGTPLFERSHHRVELTAA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCEEEEHHH
GQMLKEQAPLVFEQLERALDLTRQTGRGQLGELEIGMISSVMVGVLPKALHLFRERYPQV
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
TWRLHEMTPAAQVKALKEKRIDACVFRVGYDDPQLRNELLIHEPIHVVMPQDHPLARREV
HHHHHHCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCEEEECCCCCCHHHHHH
LAPADLAQEPFVALELKQSRFANFLYQCCIQAGFTPQIRQQVIEVQTLLSLVRAGFGVAL
CCCHHHCCCCHHEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
LPASIEQLAPAGLVFRRLTPALPQVPLYATYRADDASPVLKLFLDTLRELVDHSSR
HHHHHHHHCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]