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The map label for this gene is sdaC [H]

Identifier: 77459618

GI number: 77459618

Start: 3874222

End: 3875502

Strand: Reverse

Name: sdaC [H]

Synonym: Pfl01_3396

Alternate gene names: 77459618

Gene position: 3875502-3874222 (Counterclockwise)

Preceding gene: 77459619

Following gene: 77459616

Centisome position: 60.19

GC content: 61.59

Gene sequence:

>1281_bases
ATGAATGATCAGGCCAATAGCGTCGAACAACGCTTTGAGGCGGCAGCACCAGCCGAACTGTCGAGCTGGAATCGCCATGA
CACTACCTGGATGTTGGGACTGTTTGGGACGGCCATCGGCGCCGGTACCCTGTTTTTGCCGATCAACGCAGGTCTGGGTG
GCTTCTGGCCGCTGGTGATCCTCGCGCTGCTGGCCTTCCCGATGACGTTTTACGCACACCGCGGCCTGACCCGCTTCGTG
CTTTCCGGTCGCGAAGGCGCCGACATCACAGACGTGGTGGAACAGCATTTCGGCATCAAGGCCGGCGCGCTGATCACCCT
GCTGTACTTCTTCGCTATCTTCCCGATCCTGCTGATCTACAGCGTCGGCCTGACCAACACGGTCGCCAGTTTCCTCGAGC
ACCAACTGCACATCACGCAGCCACCGCGCGCGCTGCTGTCGTTCGTGCTGATTCTCGGCCTGCTGGCCGTGGTGCGCTGC
GGCGAGCAAGTGATCGTCAAGGCCATGAGCCTTATGGTGTATCCGTTCATCGTCGCGCTGCTGTTCCTGGCGGTGTATCT
GATTCCGCACTGGAACGGCGGCATCCTGACCACCGCTTCGCAAGTGCCGGCACCGTCGGCGCTGCTGCACACGCTGTGGC
TGGCGATTCCGGTGATGGTGTTCTCGTTCAACCACTCGCCGATCATCTCGGCGTTTGCGGTGGATCAGAAGCGCCGTTAC
GGCGTCCACGCTGACGAGCGCAGCTCGCAGATCCTGTCCCGCGCGCACCTGCTGATGGTGGTGATGGTGCTGTTCTTCGT
CTTCAGTTGCGTGCTGACCCTGTCGCCGGAGCAACTGGCGCAAGCCAAGGCGCAGAACCTGTCGATCCTGTCTTACCTGG
CCAACCACTTCAGCAACCCGACCATCGCGTTCGCGGCGCCGCTGATTGCGTTTGTGGCGATCTCCAAGTCGTTCCTCGGC
CACTACATCGGTGCCAGCGAAGGCCTGAAGGGCTTGATCGTCAAGAGCGGCAAGCGTCCGGGCGCCAAGGCGCTGGACCG
CATCGTGGCGGCGTTCATGCTGGTGGTGTGCTGGATCGTGGCGACCCTGAACCCGAGCATCCTCGGCATGATCGAAACCA
TCGGTGGCCCGGTCATCGCGGCGATCCTGTTCCTGATGCCTATGTACGCGATCCGCAAAGTGCCGGCGATGGCCCGTTAT
CGTGGGCAGATGTCGAACGTGTTTGTCACCGCAGTGGGTCTGGTGGCGATTTCGGCGTTGATCTACTCGCTGACTGCTTA
A

Upstream 100 bases:

>100_bases
CGGAGAATCGCGCCCCTGTTTCGGCCGGAGCATGTCTGTCGGTTTTTTCCGACGCGTCCTGACCGAGTGGCAAGTGACCG
GAATGCGGAGATCCGACCGG

Downstream 100 bases:

>100_bases
GGTTCAGCAACAAGGTCCTAAATGATCTTGTGAAAAAGAAAGGCCGATCTGCCTCGCAGGTCGGCCTTTTTTGTGCCTGT
ATGGTTTGTGATTGATCGTT

Product: aromatic amino acid permease

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNDQANSVEQRFEAAAPAELSSWNRHDTTWMLGLFGTAIGAGTLFLPINAGLGGFWPLVILALLAFPMTFYAHRGLTRFV
LSGREGADITDVVEQHFGIKAGALITLLYFFAIFPILLIYSVGLTNTVASFLEHQLHITQPPRALLSFVLILGLLAVVRC
GEQVIVKAMSLMVYPFIVALLFLAVYLIPHWNGGILTTASQVPAPSALLHTLWLAIPVMVFSFNHSPIISAFAVDQKRRY
GVHADERSSQILSRAHLLMVVMVLFFVFSCVLTLSPEQLAQAKAQNLSILSYLANHFSNPTIAFAAPLIAFVAISKSFLG
HYIGASEGLKGLIVKSGKRPGAKALDRIVAAFMLVVCWIVATLNPSILGMIETIGGPVIAAILFLMPMYAIRKVPAMARY
RGQMSNVFVTAVGLVAISALIYSLTA

Sequences:

>Translated_426_residues
MNDQANSVEQRFEAAAPAELSSWNRHDTTWMLGLFGTAIGAGTLFLPINAGLGGFWPLVILALLAFPMTFYAHRGLTRFV
LSGREGADITDVVEQHFGIKAGALITLLYFFAIFPILLIYSVGLTNTVASFLEHQLHITQPPRALLSFVLILGLLAVVRC
GEQVIVKAMSLMVYPFIVALLFLAVYLIPHWNGGILTTASQVPAPSALLHTLWLAIPVMVFSFNHSPIISAFAVDQKRRY
GVHADERSSQILSRAHLLMVVMVLFFVFSCVLTLSPEQLAQAKAQNLSILSYLANHFSNPTIAFAAPLIAFVAISKSFLG
HYIGASEGLKGLIVKSGKRPGAKALDRIVAAFMLVVCWIVATLNPSILGMIETIGGPVIAAILFLMPMYAIRKVPAMARY
RGQMSNVFVTAVGLVAISALIYSLTA
>Mature_426_residues
MNDQANSVEQRFEAAAPAELSSWNRHDTTWMLGLFGTAIGAGTLFLPINAGLGGFWPLVILALLAFPMTFYAHRGLTRFV
LSGREGADITDVVEQHFGIKAGALITLLYFFAIFPILLIYSVGLTNTVASFLEHQLHITQPPRALLSFVLILGLLAVVRC
GEQVIVKAMSLMVYPFIVALLFLAVYLIPHWNGGILTTASQVPAPSALLHTLWLAIPVMVFSFNHSPIISAFAVDQKRRY
GVHADERSSQILSRAHLLMVVMVLFFVFSCVLTLSPEQLAQAKAQNLSILSYLANHFSNPTIAFAAPLIAFVAISKSFLG
HYIGASEGLKGLIVKSGKRPGAKALDRIVAAFMLVVCWIVATLNPSILGMIETIGGPVIAAILFLMPMYAIRKVPAMARY
RGQMSNVFVTAVGLVAISALIYSLTA

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=423, Percent_Identity=64.7754137115839, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1789504, Length=435, Percent_Identity=46.8965517241379, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI1789211, Length=408, Percent_Identity=38.4803921568627, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI1789961, Length=393, Percent_Identity=26.2086513994911, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI145693183, Length=414, Percent_Identity=24.8792270531401, Blast_Score=121, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46199; Mature: 46199

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDQANSVEQRFEAAAPAELSSWNRHDTTWMLGLFGTAIGAGTLFLPINAGLGGFWPLVI
CCCCHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
LALLAFPMTFYAHRGLTRFVLSGREGADITDVVEQHFGIKAGALITLLYFFAIFPILLIY
HHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
SVGLTNTVASFLEHQLHITQPPRALLSFVLILGLLAVVRCGEQVIVKAMSLMVYPFIVAL
HHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LFLAVYLIPHWNGGILTTASQVPAPSALLHTLWLAIPVMVFSFNHSPIISAFAVDQKRRY
HHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GVHADERSSQILSRAHLLMVVMVLFFVFSCVLTLSPEQLAQAKAQNLSILSYLANHFSNP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
TIAFAAPLIAFVAISKSFLGHYIGASEGLKGLIVKSGKRPGAKALDRIVAAFMLVVCWIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHH
ATLNPSILGMIETIGGPVIAAILFLMPMYAIRKVPAMARYRGQMSNVFVTAVGLVAISAL
HHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYSLTA
HHHHCC
>Mature Secondary Structure
MNDQANSVEQRFEAAAPAELSSWNRHDTTWMLGLFGTAIGAGTLFLPINAGLGGFWPLVI
CCCCHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
LALLAFPMTFYAHRGLTRFVLSGREGADITDVVEQHFGIKAGALITLLYFFAIFPILLIY
HHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
SVGLTNTVASFLEHQLHITQPPRALLSFVLILGLLAVVRCGEQVIVKAMSLMVYPFIVAL
HHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LFLAVYLIPHWNGGILTTASQVPAPSALLHTLWLAIPVMVFSFNHSPIISAFAVDQKRRY
HHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GVHADERSSQILSRAHLLMVVMVLFFVFSCVLTLSPEQLAQAKAQNLSILSYLANHFSNP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
TIAFAAPLIAFVAISKSFLGHYIGASEGLKGLIVKSGKRPGAKALDRIVAAFMLVVCWIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHH
ATLNPSILGMIETIGGPVIAAILFLMPMYAIRKVPAMARYRGQMSNVFVTAVGLVAISAL
HHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYSLTA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]