Click here to switch to the map view.

The map label for this gene is czcR [H]

Identifier: 77459601

GI number: 77459601

Start: 3853084

End: 3853755

Strand: Direct

Name: czcR [H]

Synonym: Pfl01_3379

Alternate gene names: 77459601

Gene position: 3853084-3853755 (Clockwise)

Preceding gene: 77459600

Following gene: 77459602

Centisome position: 59.85

GC content: 61.9

Gene sequence:

>672_bases
ATGAATATCCTTGTTGTCGAAGACGAACCCAAGGCCGGCAATTATTTGCTCAACGGCTTGCAGGAACTGGGCTACAGCGT
GAGCCTGGCCCGGGACGGCGCCGACGGTCTGCACCTGGCGCTGGAGTTCGACTTCGACGTGATCGTGCTGGACGTGATGA
TGCCGAAAATGGATGGCTGGGAAGTCCTGCGCCGGCTGCGTAAGGAAACCGACACCCCGGTGCTGTTTCTCACCGCCCGC
GATGACATCGCCGACCGGGTCAAGGGGCTTGAACTGGGCGCTGACGACTACCTGATCAAGCCGTTTTCCTTCGCCGAACT
GGTGGCGCGCCTGCGCACCCTGACCCGGCGCGGGCCGATCCATGAAGAAGAGCAATTGCAGGTGGCCGATCTGCAGATCG
ATGTGCTCAAGCGTCGGGTCACCCGGGCCGGCAACCGGATCACCCTGACCAACAAGGAATTCGCCCTGCTGCAACTGTTT
GCCGCCCACACCGGGCAAGTGCTGTCGCGTTCGCTGATCGCCTCGCGGGTGTGGGACATGAATTTCGACAGTGACACCAA
TGTGGTCGATGTCGCCGTGCGCCGCCTGCGGGCGAAGATCGACGATCCGTTCCCGCTCAAGCTGATCCACAGCGTGCGCG
GCATCGGCTACCGCTTCGATACCCAACCATGA

Upstream 100 bases:

>100_bases
CGCGCAGCTCGACTACCTCGACCACCAGGGCCGTGAACATGTGCTGGACTACCAAGTGCAAGGCAGCGGCTGCACCAACG
ACCATTGAGGCGCAGTAGCC

Downstream 100 bases:

>100_bases
AAATCGCCGGCACGTATTCCCTGACCTTGCGTCTGGCGCTGGTCTTCGCCGTGCTCGCCTTTGCCGCGCTGGGAGGCCTG
GGCGCGGCGCTGTACAACCA

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MNILVVEDEPKAGNYLLNGLQELGYSVSLARDGADGLHLALEFDFDVIVLDVMMPKMDGWEVLRRLRKETDTPVLFLTAR
DDIADRVKGLELGADDYLIKPFSFAELVARLRTLTRRGPIHEEEQLQVADLQIDVLKRRVTRAGNRITLTNKEFALLQLF
AAHTGQVLSRSLIASRVWDMNFDSDTNVVDVAVRRLRAKIDDPFPLKLIHSVRGIGYRFDTQP

Sequences:

>Translated_223_residues
MNILVVEDEPKAGNYLLNGLQELGYSVSLARDGADGLHLALEFDFDVIVLDVMMPKMDGWEVLRRLRKETDTPVLFLTAR
DDIADRVKGLELGADDYLIKPFSFAELVARLRTLTRRGPIHEEEQLQVADLQIDVLKRRVTRAGNRITLTNKEFALLQLF
AAHTGQVLSRSLIASRVWDMNFDSDTNVVDVAVRRLRAKIDDPFPLKLIHSVRGIGYRFDTQP
>Mature_223_residues
MNILVVEDEPKAGNYLLNGLQELGYSVSLARDGADGLHLALEFDFDVIVLDVMMPKMDGWEVLRRLRKETDTPVLFLTAR
DDIADRVKGLELGADDYLIKPFSFAELVARLRTLTRRGPIHEEEQLQVADLQIDVLKRRVTRAGNRITLTNKEFALLQLF
AAHTGQVLSRSLIASRVWDMNFDSDTNVVDVAVRRLRAKIDDPFPLKLIHSVRGIGYRFDTQP

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=59.4594594594595, Blast_Score=269, Evalue=1e-73,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=51.131221719457, Blast_Score=238, Evalue=3e-64,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=41.743119266055, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=37.5, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=36.6515837104072, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=35.2941176470588, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=32.0175438596491, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.5991189427313, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=31.2217194570136, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=34.3891402714932, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=35.4545454545455, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.1578947368421, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=211, Percent_Identity=33.6492890995261, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=32.2033898305085, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=38.6792452830189, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1787487, Length=100, Percent_Identity=41, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790437, Length=112, Percent_Identity=38.3928571428571, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=138, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=105, Percent_Identity=37.1428571428571, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=133, Percent_Identity=31.5789473684211, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25315; Mature: 25315

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILVVEDEPKAGNYLLNGLQELGYSVSLARDGADGLHLALEFDFDVIVLDVMMPKMDGW
CEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCEEEEEHHCCCCCHH
EVLRRLRKETDTPVLFLTARDDIADRVKGLELGADDYLIKPFSFAELVARLRTLTRRGPI
HHHHHHHHCCCCCEEEEEECHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCC
HEEEQLQVADLQIDVLKRRVTRAGNRITLTNKEFALLQLFAAHTGQVLSRSLIASRVWDM
CCCCCEEHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NFDSDTNVVDVAVRRLRAKIDDPFPLKLIHSVRGIGYRFDTQP
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCC
>Mature Secondary Structure
MNILVVEDEPKAGNYLLNGLQELGYSVSLARDGADGLHLALEFDFDVIVLDVMMPKMDGW
CEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCEEEEEHHCCCCCHH
EVLRRLRKETDTPVLFLTARDDIADRVKGLELGADDYLIKPFSFAELVARLRTLTRRGPI
HHHHHHHHCCCCCEEEEEECHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCC
HEEEQLQVADLQIDVLKRRVTRAGNRITLTNKEFALLQLFAAHTGQVLSRSLIASRVWDM
CCCCCEEHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NFDSDTNVVDVAVRRLRAKIDDPFPLKLIHSVRGIGYRFDTQP
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]