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The map label for this gene is adh [H]

Identifier: 77459568

GI number: 77459568

Start: 3820876

End: 3821949

Strand: Reverse

Name: adh [H]

Synonym: Pfl01_3346

Alternate gene names: 77459568

Gene position: 3821949-3820876 (Counterclockwise)

Preceding gene: 77459570

Following gene: 77459566

Centisome position: 59.36

GC content: 61.27

Gene sequence:

>1074_bases
ATGGCCACCATGAAAGCTGCCATTTTTGTCGAAAAAAATCGCATCGTGCTGGATGACAAACCGATCCCGGAAGTCGGCCC
GCTGGACGCTTTGATCCGGATAACCACCACGACAATTTGCGGTACGGATGTGCACATCCTGCGCGGCGAATACCCGGTGG
CGAAGGGTTTGACGGTCGGTCACGAACCGGTGGGGATCATCGAACGTCTGGGATCACAGGTGCGCGGGTTTGTAGAGGGG
CAGCGCGTGATTGCCGGCGCCATCACTCCCAGTGGGCAAAGTTATGCGTGCCTGTGTGGCTGTGGTTCCCAGGACGGGCC
GGACACTCGCCATGGTTTCCGGGCCATCGGCGGGTGGAAGTTCGGCAACACCATCGATGGCTGCCAGGCCGAATACGTAC
TGGTGCCCGATGCCTTGGCCAATCTTTGTCCGATTCCTGATGGCCTCAGTGATGAGCAGGTACTCATGTGTCCGGACATC
ATGTCCACCGGTTTTTCCGGTGCCGAACGGGGCGAGGTGAGCATCGGCGACAGCGTCGCTGTATTCGCCCTCGGCCCCAT
TGGTCTGTGTGCAGTCGCCGGTGCCCGGCTCAAAGGCGCCAGCACGATCATCGGTGTCGATGCGGTGGCCGAGCGCATGA
CGGTAGCACGTCGATTGGGCGCCACCCATGTCGTCAATTTTCGCGAGGGCGACGTGGTCGAGCAGATCATGGCCCTCACC
GATGGGCGCGGTGTCGATGTCGCGATCGAGGCACTGGGCACGCAAGGCACCTTTGAATCGGCGTTGCGCGTGCTGCGTCC
GGGCGGCCGCTTGTCGAGCCTGGGCGTGTATTCGAGCGACCTGCGCATTCCGCTCGACGCCTTTGCGGCCGGGTTGGGCG
ATTACAGCATCGTCACCACCCTGTGCCCCGGCGGGAAAGAGCGTATGCGGCGTTTGATGGCGGTCGTGCAGAGCGGCATG
GTTGACCTTTCACCGTTGGTGACCCACCGGTTCAAACTGGATGACATTGAAGCAGCCTACGATTTGTTTGCACACCAGCG
TGACGGTGTGATGAAGGTGGCGATTACCCCGTGA

Upstream 100 bases:

>100_bases
TCAATCGTCGCGGATGTCGTCGATTGTTGATCATTATCAAGTGCCGGTCTGGCAGCGCGGCGCAGGCTGACTACGAGTCG
AATCCTTCAGGAGAATGCTC

Downstream 100 bases:

>100_bases
AGGCGCGTCCGGCCCGTCGGCACGCTCACTGCGGGTGACGATGGCAGCCGACGATCAACTGCTTGAGGCCGTCCATGTTC
TGAATGGTGACGTCGCGGCC

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MATMKAAIFVEKNRIVLDDKPIPEVGPLDALIRITTTTICGTDVHILRGEYPVAKGLTVGHEPVGIIERLGSQVRGFVEG
QRVIAGAITPSGQSYACLCGCGSQDGPDTRHGFRAIGGWKFGNTIDGCQAEYVLVPDALANLCPIPDGLSDEQVLMCPDI
MSTGFSGAERGEVSIGDSVAVFALGPIGLCAVAGARLKGASTIIGVDAVAERMTVARRLGATHVVNFREGDVVEQIMALT
DGRGVDVAIEALGTQGTFESALRVLRPGGRLSSLGVYSSDLRIPLDAFAAGLGDYSIVTTLCPGGKERMRRLMAVVQSGM
VDLSPLVTHRFKLDDIEAAYDLFAHQRDGVMKVAITP

Sequences:

>Translated_357_residues
MATMKAAIFVEKNRIVLDDKPIPEVGPLDALIRITTTTICGTDVHILRGEYPVAKGLTVGHEPVGIIERLGSQVRGFVEG
QRVIAGAITPSGQSYACLCGCGSQDGPDTRHGFRAIGGWKFGNTIDGCQAEYVLVPDALANLCPIPDGLSDEQVLMCPDI
MSTGFSGAERGEVSIGDSVAVFALGPIGLCAVAGARLKGASTIIGVDAVAERMTVARRLGATHVVNFREGDVVEQIMALT
DGRGVDVAIEALGTQGTFESALRVLRPGGRLSSLGVYSSDLRIPLDAFAAGLGDYSIVTTLCPGGKERMRRLMAVVQSGM
VDLSPLVTHRFKLDDIEAAYDLFAHQRDGVMKVAITP
>Mature_356_residues
ATMKAAIFVEKNRIVLDDKPIPEVGPLDALIRITTTTICGTDVHILRGEYPVAKGLTVGHEPVGIIERLGSQVRGFVEGQ
RVIAGAITPSGQSYACLCGCGSQDGPDTRHGFRAIGGWKFGNTIDGCQAEYVLVPDALANLCPIPDGLSDEQVLMCPDIM
STGFSGAERGEVSIGDSVAVFALGPIGLCAVAGARLKGASTIIGVDAVAERMTVARRLGATHVVNFREGDVVEQIMALTD
GRGVDVAIEALGTQGTFESALRVLRPGGRLSSLGVYSSDLRIPLDAFAAGLGDYSIVTTLCPGGKERMRRLMAVVQSGMV
DLSPLVTHRFKLDDIEAAYDLFAHQRDGVMKVAITP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=346, Percent_Identity=28.3236994219653, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4501939, Length=355, Percent_Identity=30.1408450704225, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI156523966, Length=355, Percent_Identity=30.1408450704225, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI71565152, Length=368, Percent_Identity=29.3478260869565, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=25.6064690026954, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71565154, Length=350, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI34577061, Length=367, Percent_Identity=26.158038147139, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI71743840, Length=357, Percent_Identity=26.0504201680672, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI262073058, Length=357, Percent_Identity=26.0504201680672, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=24.2587601078167, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI22538446, Length=208, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI22538444, Length=208, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=32.5513196480938, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786825, Length=398, Percent_Identity=29.8994974874372, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87082125, Length=377, Percent_Identity=30.2387267904509, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788075, Length=337, Percent_Identity=29.3768545994065, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787863, Length=358, Percent_Identity=24.8603351955307, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788073, Length=349, Percent_Identity=25.5014326647564, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786552, Length=352, Percent_Identity=29.2613636363636, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI226510992, Length=342, Percent_Identity=27.1929824561404, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788407, Length=335, Percent_Identity=25.6716417910448, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790718, Length=341, Percent_Identity=21.4076246334311, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081918, Length=285, Percent_Identity=23.5087719298246, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787572, Length=134, Percent_Identity=39.5522388059701, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562878, Length=364, Percent_Identity=29.6703296703297, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562876, Length=365, Percent_Identity=28.7671232876712, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=348, Percent_Identity=27.8735632183908, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71997431, Length=357, Percent_Identity=27.4509803921569, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17565904, Length=339, Percent_Identity=28.9085545722714, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=378, Percent_Identity=28.042328042328, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=378, Percent_Identity=28.042328042328, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6323099, Length=369, Percent_Identity=26.2872628726287, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320033, Length=334, Percent_Identity=29.0419161676647, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=349, Percent_Identity=25.5014326647564, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319520, Length=266, Percent_Identity=25.187969924812, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=358, Percent_Identity=25.9776536312849, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=387, Percent_Identity=24.5478036175711, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=332, Percent_Identity=25.9036144578313, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=332, Percent_Identity=25.6024096385542, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137530, Length=351, Percent_Identity=29.6296296296296, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17737897, Length=349, Percent_Identity=28.6532951289398, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17737895, Length=375, Percent_Identity=27.7333333333333, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37609; Mature: 37478

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATMKAAIFVEKNRIVLDDKPIPEVGPLDALIRITTTTICGTDVHILRGEYPVAKGLTVG
CCCCEEEEEEECCEEEECCCCCCCCCCHHHEEEEEEEEECCCCEEEEECCCCCCCCCCCC
HEPVGIIERLGSQVRGFVEGQRVIAGAITPSGQSYACLCGCGSQDGPDTRHGFRAIGGWK
CCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
FGNTIDGCQAEYVLVPDALANLCPIPDGLSDEQVLMCPDIMSTGFSGAERGEVSIGDSVA
CCCCCCCCCEEEEECCHHHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCEECCCCEE
VFALGPIGLCAVAGARLKGASTIIGVDAVAERMTVARRLGATHVVNFREGDVVEQIMALT
EEEECHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHC
DGRGVDVAIEALGTQGTFESALRVLRPGGRLSSLGVYSSDLRIPLDAFAAGLGDYSIVTT
CCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEECCEECCCCCCCHHHHHHCCCCCEEEEE
LCPGGKERMRRLMAVVQSGMVDLSPLVTHRFKLDDIEAAYDLFAHQRDGVMKVAITP
ECCCCHHHHHHHHHHHHHCCCCCCHHHHHEECCCHHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure 
ATMKAAIFVEKNRIVLDDKPIPEVGPLDALIRITTTTICGTDVHILRGEYPVAKGLTVG
CCCEEEEEEECCEEEECCCCCCCCCCHHHEEEEEEEEECCCCEEEEECCCCCCCCCCCC
HEPVGIIERLGSQVRGFVEGQRVIAGAITPSGQSYACLCGCGSQDGPDTRHGFRAIGGWK
CCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
FGNTIDGCQAEYVLVPDALANLCPIPDGLSDEQVLMCPDIMSTGFSGAERGEVSIGDSVA
CCCCCCCCCEEEEECCHHHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCEECCCCEE
VFALGPIGLCAVAGARLKGASTIIGVDAVAERMTVARRLGATHVVNFREGDVVEQIMALT
EEEECHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHC
DGRGVDVAIEALGTQGTFESALRVLRPGGRLSSLGVYSSDLRIPLDAFAAGLGDYSIVTT
CCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEECCEECCCCCCCHHHHHHCCCCCEEEEE
LCPGGKERMRRLMAVVQSGMVDLSPLVTHRFKLDDIEAAYDLFAHQRDGVMKVAITP
ECCCCHHHHHHHHHHHHHCCCCCCHHHHHEECCCHHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]