Click here to switch to the map view.

The map label for this gene is qor [C]

Identifier: 77459559

GI number: 77459559

Start: 3813081

End: 3814076

Strand: Reverse

Name: qor [C]

Synonym: Pfl01_3337

Alternate gene names: 77459559

Gene position: 3814076-3813081 (Counterclockwise)

Preceding gene: 77459560

Following gene: 77459558

Centisome position: 59.24

GC content: 61.75

Gene sequence:

>996_bases
ATGAAAGCGATGCTGCTTGAATCATTTGGCAACCCGGAATCGTTCACACTCTGCGACGTGCCCAAGCCTGTGCCGGAAAC
GGGACAAGTGCTGGTCCGGGTACACGCCACCTCGATCAATCCATTGGATTATCAAGTCCGACGCGGCGACTATCAGGATC
TGGTGCAACTGCCGGTCATCACCGGACATGACGTCTCCGGCGTAGTCGAGGCGGTTGGCCCCGGCGTGACGGCTTTCGCC
CCCGGAGACGAAGTCTGGTACACGCCGCAAATTTTCGACGGCCCCGGCAGCTATGCCGAGTATCACGTAGCGTCCGCCAG
CATCATCGGCAAAAAACCTTCTTCGCTGAGCCATCTCGAAGCGGCCAGCCTGAGCCTGGTCGGCGGGACGGCGTGGGAAG
CGCTGATCGTGCGGGCGGCGCTCAGAGTGGGGGAGAGCATTCTGATCCACGGCGGCGCGGGAGGCGTCGGACATGTCGCC
ATCCAGCTCGCCAAAGCGATGGGCGCCAAAGTGTTCACCACCGCACGCGAAGCAAACGCCGAGTTCGTCCGTCGCATGGG
CGCCGATGTGATCATCGACTACGAAAAGGACGACTACGTCGACGCCATCCTGCGAGAAACCAATGGCCTCGGAGTGGACG
TGGTGTTCGACACCATCGGCGGCGACACCCTGTCGCGCAGCCCCGACGCACTCGCGCAACTTGGCCGCGTGGTCTCGATC
GTCGACATCGCCCGGCCACAAAACCTCGTTCAGGCGTGGGGCAAGAACGCGAGCTATCACTTCGTTTTCACCCGCCAGAA
CCGCGGCAAGCTCGATGAATTGAGTGCCCTGGTGGAACGCGGTCAACTGCGGCCACATGTTGGCGCGGTGTATTCGCTTG
CGGAGATTGCGCTGGCGCATGCGCGGCTGGAAAGTCCCAACAATGGTCTTCAGGGGAAGATTGCGATTGCGGTCGTGCCG
GCGCTTCGTTCGGGTTCTGTGGAGGATGCATCATGA

Upstream 100 bases:

>100_bases
CAGCGCCTTGGCCGAGGTCATAGGGAAAGAGCTGTAAAAAAATTTACCGCAATTTATCGAGATATCTCGATATCCCTTAT
TGTCGATACGAGGATTCACC

Downstream 100 bases:

>100_bases
TTTATGAGATCGCTTTGCTGCCTGTTCACGCAGAACGTGTTGATGAGTTCCGACGTGCATTTGCCGAGGTTGCGCCTTTG
CTCCGCCGCGCGAACGGGTA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKAMLLESFGNPESFTLCDVPKPVPETGQVLVRVHATSINPLDYQVRRGDYQDLVQLPVITGHDVSGVVEAVGPGVTAFA
PGDEVWYTPQIFDGPGSYAEYHVASASIIGKKPSSLSHLEAASLSLVGGTAWEALIVRAALRVGESILIHGGAGGVGHVA
IQLAKAMGAKVFTTAREANAEFVRRMGADVIIDYEKDDYVDAILRETNGLGVDVVFDTIGGDTLSRSPDALAQLGRVVSI
VDIARPQNLVQAWGKNASYHFVFTRQNRGKLDELSALVERGQLRPHVGAVYSLAEIALAHARLESPNNGLQGKIAIAVVP
ALRSGSVEDAS

Sequences:

>Translated_331_residues
MKAMLLESFGNPESFTLCDVPKPVPETGQVLVRVHATSINPLDYQVRRGDYQDLVQLPVITGHDVSGVVEAVGPGVTAFA
PGDEVWYTPQIFDGPGSYAEYHVASASIIGKKPSSLSHLEAASLSLVGGTAWEALIVRAALRVGESILIHGGAGGVGHVA
IQLAKAMGAKVFTTAREANAEFVRRMGADVIIDYEKDDYVDAILRETNGLGVDVVFDTIGGDTLSRSPDALAQLGRVVSI
VDIARPQNLVQAWGKNASYHFVFTRQNRGKLDELSALVERGQLRPHVGAVYSLAEIALAHARLESPNNGLQGKIAIAVVP
ALRSGSVEDAS
>Mature_331_residues
MKAMLLESFGNPESFTLCDVPKPVPETGQVLVRVHATSINPLDYQVRRGDYQDLVQLPVITGHDVSGVVEAVGPGVTAFA
PGDEVWYTPQIFDGPGSYAEYHVASASIIGKKPSSLSHLEAASLSLVGGTAWEALIVRAALRVGESILIHGGAGGVGHVA
IQLAKAMGAKVFTTAREANAEFVRRMGADVIIDYEKDDYVDAILRETNGLGVDVVFDTIGGDTLSRSPDALAQLGRVVSI
VDIARPQNLVQAWGKNASYHFVFTRQNRGKLDELSALVERGQLRPHVGAVYSLAEIALAHARLESPNNGLQGKIAIAVVP
ALRSGSVEDAS

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=311, Percent_Identity=32.7974276527331, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI13236495, Length=311, Percent_Identity=32.7974276527331, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI194239676, Length=307, Percent_Identity=31.5960912052117, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI47519420, Length=362, Percent_Identity=30.1104972375691, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI22538446, Length=339, Percent_Identity=29.2035398230088, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI22538444, Length=339, Percent_Identity=29.2035398230088, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI18379349, Length=307, Percent_Identity=29.3159609120521, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI24308257, Length=339, Percent_Identity=26.5486725663717, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI28557745, Length=231, Percent_Identity=34.1991341991342, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI41872631, Length=208, Percent_Identity=32.2115384615385, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI197927207, Length=176, Percent_Identity=28.4090909090909, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI90669511, Length=226, Percent_Identity=30.0884955752212, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI67078404, Length=172, Percent_Identity=30.2325581395349, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI67078406, Length=166, Percent_Identity=30.1204819277108, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1790485, Length=232, Percent_Identity=33.6206896551724, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=25.8720930232558, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788073, Length=248, Percent_Identity=26.6129032258064, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=327, Percent_Identity=29.3577981651376, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71987554, Length=375, Percent_Identity=31.2, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17556000, Length=203, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319520, Length=325, Percent_Identity=28.9230769230769, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=232, Percent_Identity=29.3103448275862, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=217, Percent_Identity=29.4930875576037, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=217, Percent_Identity=29.9539170506912, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24581339, Length=364, Percent_Identity=25.2747252747253, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24581341, Length=366, Percent_Identity=24.0437158469945, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221330659, Length=172, Percent_Identity=33.7209302325581, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19920632, Length=172, Percent_Identity=33.7209302325581, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24581345, Length=238, Percent_Identity=28.9915966386555, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35125; Mature: 35125

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMLLESFGNPESFTLCDVPKPVPETGQVLVRVHATSINPLDYQVRRGDYQDLVQLPVI
CCCEEEHHCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCEEECCCCHHHHHHCCCC
TGHDVSGVVEAVGPGVTAFAPGDEVWYTPQIFDGPGSYAEYHVASASIIGKKPSSLSHLE
CCCCHHHHHHHHCCCEEEECCCCCEEECCEEECCCCCCCEEEEEEHEEECCCCCCHHHHH
AASLSLVGGTAWEALIVRAALRVGESILIHGGAGGVGHVAIQLAKAMGAKVFTTAREANA
HHHEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEHHHHCCH
EFVRRMGADVIIDYEKDDYVDAILRETNGLGVDVVFDTIGGDTLSRSPDALAQLGRVVSI
HHHHHCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
VDIARPQNLVQAWGKNASYHFVFTRQNRGKLDELSALVERGQLRPHVGAVYSLAEIALAH
HHHHCHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ARLESPNNGLQGKIAIAVVPALRSGSVEDAS
HHHCCCCCCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKAMLLESFGNPESFTLCDVPKPVPETGQVLVRVHATSINPLDYQVRRGDYQDLVQLPVI
CCCEEEHHCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCEEECCCCHHHHHHCCCC
TGHDVSGVVEAVGPGVTAFAPGDEVWYTPQIFDGPGSYAEYHVASASIIGKKPSSLSHLE
CCCCHHHHHHHHCCCEEEECCCCCEEECCEEECCCCCCCEEEEEEHEEECCCCCCHHHHH
AASLSLVGGTAWEALIVRAALRVGESILIHGGAGGVGHVAIQLAKAMGAKVFTTAREANA
HHHEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEHHHHCCH
EFVRRMGADVIIDYEKDDYVDAILRETNGLGVDVVFDTIGGDTLSRSPDALAQLGRVVSI
HHHHHCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
VDIARPQNLVQAWGKNASYHFVFTRQNRGKLDELSALVERGQLRPHVGAVYSLAEIALAH
HHHHCHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ARLESPNNGLQGKIAIAVVPALRSGSVEDAS
HHHCCCCCCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]