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The map label for this gene is alsR [H]

Identifier: 77459507

GI number: 77459507

Start: 3771258

End: 3772163

Strand: Direct

Name: alsR [H]

Synonym: Pfl01_3285

Alternate gene names: 77459507

Gene position: 3771258-3772163 (Clockwise)

Preceding gene: 77459504

Following gene: 77459509

Centisome position: 58.57

GC content: 62.36

Gene sequence:

>906_bases
ATGTTCGAATTGACCCAACTGCGCTGCTTCACCACTGTCGCCACCGAACTCAACTTCCGCCGCGCCGCCGAGCGGTTGAA
CATGACCCAGCCGCCACTCAGCCGGCAGATCCAGTTACTGGAACATCATCTGGGCGTCGAACTGTTTACCCGCAGCACGC
GCAGTGTCGCGCTCACCGCCGCCGGCCGGGCGTTTTTCATCGAGGCGCAGAATCTGCTCGAACGCGCGCAACAGGCTGCC
GTCACCGCCCGGCGCTTTGCCGAGGGCGATATCGGTTCGGTGAACATCAGTTTTGTCGGCAGCGCGGTGTACGAATTTCT
GCCCAAGGTCATCGCCGAGGCGCGCCTCAAGCAGCCGCAGGTGAAGATCGACCTGACTGAAATGAACACCTATCAGCAAC
ACGAAGCCCTGCGTGCCCGTCGCATCGATCTGGGCATCGTCCGCGCGCCGTTGCTCGAACCTGGTTACGCCACCGAATGC
CTGGTGCGCGAGCCCTTTGTGCTGGCGGTACCGAGCGGCCATCGACTGGCGGAGGCAGACGACGTTTCAGTGAAGGACCT
GGATGGGCAGCCCTTCCTGATGTATTCCCACGCCGCCTATCCGCCGTTCAACGAATTGCTCACCGGCATGCTGCGCTCGG
CCCGGGTCGCTCCGGATTACGTGCAGTGGCTGGGATCTTCCTTGACGATTCTGGCGCTGGTCAACGCAGGCATGGGCCTG
GCGCTGGTGCCGCGTTGCGCGACCAGTGTGGTGTTCAGGAATGTGGTGTTTCGCGAGATCGATCTGGGCGAAGGGGTGCA
GAGCGAGCTGCATCTGATCTGGCGGGAGAACAACGACAACCCGGCGTTTGCGATGTTGCTGGAGGGCATTCGCCGGGCGG
TGAAGGATGGATGGGGTCAGGAATGA

Upstream 100 bases:

>100_bases
TTTTGTAGGGAAGGCCTGTTCAGGCGTAGAGCGATCATGGACGGGGCAATTGATCCCGTCTAATCTAACCTGGCATTCGA
TTGATACCTGGATTAGATCA

Downstream 100 bases:

>100_bases
GCTTGCGGATATGGAGGGTATTTCGGCGGAGGAGGTGCCTTTGATGCCTCGATCAATGGTTTCTCCAGCCGCTTTCCGTC
CGGCCCTACAAAAAGACGCT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MFELTQLRCFTTVATELNFRRAAERLNMTQPPLSRQIQLLEHHLGVELFTRSTRSVALTAAGRAFFIEAQNLLERAQQAA
VTARRFAEGDIGSVNISFVGSAVYEFLPKVIAEARLKQPQVKIDLTEMNTYQQHEALRARRIDLGIVRAPLLEPGYATEC
LVREPFVLAVPSGHRLAEADDVSVKDLDGQPFLMYSHAAYPPFNELLTGMLRSARVAPDYVQWLGSSLTILALVNAGMGL
ALVPRCATSVVFRNVVFREIDLGEGVQSELHLIWRENNDNPAFAMLLEGIRRAVKDGWGQE

Sequences:

>Translated_301_residues
MFELTQLRCFTTVATELNFRRAAERLNMTQPPLSRQIQLLEHHLGVELFTRSTRSVALTAAGRAFFIEAQNLLERAQQAA
VTARRFAEGDIGSVNISFVGSAVYEFLPKVIAEARLKQPQVKIDLTEMNTYQQHEALRARRIDLGIVRAPLLEPGYATEC
LVREPFVLAVPSGHRLAEADDVSVKDLDGQPFLMYSHAAYPPFNELLTGMLRSARVAPDYVQWLGSSLTILALVNAGMGL
ALVPRCATSVVFRNVVFREIDLGEGVQSELHLIWRENNDNPAFAMLLEGIRRAVKDGWGQE
>Mature_301_residues
MFELTQLRCFTTVATELNFRRAAERLNMTQPPLSRQIQLLEHHLGVELFTRSTRSVALTAAGRAFFIEAQNLLERAQQAA
VTARRFAEGDIGSVNISFVGSAVYEFLPKVIAEARLKQPQVKIDLTEMNTYQQHEALRARRIDLGIVRAPLLEPGYATEC
LVREPFVLAVPSGHRLAEADDVSVKDLDGQPFLMYSHAAYPPFNELLTGMLRSARVAPDYVQWLGSSLTILALVNAGMGL
ALVPRCATSVVFRNVVFREIDLGEGVQSELHLIWRENNDNPAFAMLLEGIRRAVKDGWGQE

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=284, Percent_Identity=34.1549295774648, Blast_Score=161, Evalue=4e-41,
Organism=Escherichia coli, GI1788887, Length=286, Percent_Identity=36.3636363636364, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI2367136, Length=292, Percent_Identity=29.7945205479452, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=30.6122448979592, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788748, Length=246, Percent_Identity=28.8617886178862, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787601, Length=220, Percent_Identity=30, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI157672245, Length=187, Percent_Identity=30.4812834224599, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=27.9835390946502, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790208, Length=246, Percent_Identity=28.0487804878049, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789204, Length=264, Percent_Identity=25, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081904, Length=181, Percent_Identity=29.2817679558011, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788297, Length=243, Percent_Identity=23.8683127572016, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786713, Length=299, Percent_Identity=28.0936454849498, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787806, Length=248, Percent_Identity=22.9838709677419, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788481, Length=248, Percent_Identity=27.0161290322581, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787530, Length=257, Percent_Identity=25.6809338521401, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789173, Length=169, Percent_Identity=30.1775147928994, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790262, Length=280, Percent_Identity=23.5714285714286, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789639, Length=295, Percent_Identity=24.7457627118644, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33604; Mature: 33604

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFELTQLRCFTTVATELNFRRAAERLNMTQPPLSRQIQLLEHHLGVELFTRSTRSVALTA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHEECCCCEEEEEE
AGRAFFIEAQNLLERAQQAAVTARRFAEGDIGSVNISFVGSAVYEFLPKVIAEARLKQPQ
CCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCC
VKIDLTEMNTYQQHEALRARRIDLGIVRAPLLEPGYATECLVREPFVLAVPSGHRLAEAD
EEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEECCCCCCCCCCC
DVSVKDLDGQPFLMYSHAAYPPFNELLTGMLRSARVAPDYVQWLGSSLTILALVNAGMGL
CCCEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHCCCCH
ALVPRCATSVVFRNVVFREIDLGEGVQSELHLIWRENNDNPAFAMLLEGIRRAVKDGWGQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
E
C
>Mature Secondary Structure
MFELTQLRCFTTVATELNFRRAAERLNMTQPPLSRQIQLLEHHLGVELFTRSTRSVALTA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHEECCCCEEEEEE
AGRAFFIEAQNLLERAQQAAVTARRFAEGDIGSVNISFVGSAVYEFLPKVIAEARLKQPQ
CCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCC
VKIDLTEMNTYQQHEALRARRIDLGIVRAPLLEPGYATECLVREPFVLAVPSGHRLAEAD
EEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEECCCCCCCCCCC
DVSVKDLDGQPFLMYSHAAYPPFNELLTGMLRSARVAPDYVQWLGSSLTILALVNAGMGL
CCCEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHCCCCH
ALVPRCATSVVFRNVVFREIDLGEGVQSELHLIWRENNDNPAFAMLLEGIRRAVKDGWGQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]