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The map label for this gene is ppiC [H]

Identifier: 77459294

GI number: 77459294

Start: 3514797

End: 3515078

Strand: Direct

Name: ppiC [H]

Synonym: Pfl01_3072

Alternate gene names: 77459294

Gene position: 3514797-3515078 (Clockwise)

Preceding gene: 77459293

Following gene: 77459295

Centisome position: 54.59

GC content: 61.35

Gene sequence:

>282_bases
ATGGCTAAAGCCACTGCCCGCCACATCCTGGTTTCCAGCGAAGCCAAGTGCAACGAACTCAAGGCCCAGATCGAAGGTGG
CGCCGATTTCGCCGAAGTGGCCAAGGCCAACTCCACCTGCCCGTCCAGCCGTCAGGGTGGCGACCTGGGTTCGTTCGGTC
CTGGCCAGATGGTCAAGGAATTCGACACCGTAGTGTTCAGCGCGCCGATCAACGTCGTGCAAGGCCCGGTGAAGACCCAG
TTCGGCTACCACCTGCTGGAAGTCACCAGCCGTCAGGACTGA

Upstream 100 bases:

>100_bases
TAGCGACCGGCATCAGACGAGCGAATGGAACTTTGCCGAGAAATCGGCCACTGAATCCGGTAGGCTCACCCCTTTACTGA
TTTGATTGGAGAGTTTCACC

Downstream 100 bases:

>100_bases
TTTTCAGCCCGACCTGCTGTGCAACGGCCCGCCTGATGGCGGGCCGTTTTGTTTTGGTTACACCACACCGCTGGCGAACG
GCGCGCCGCTCGCGTACAAA

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase C; Parvulin; Rotamase C [H]

Number of amino acids: Translated: 93; Mature: 92

Protein sequence:

>93_residues
MAKATARHILVSSEAKCNELKAQIEGGADFAEVAKANSTCPSSRQGGDLGSFGPGQMVKEFDTVVFSAPINVVQGPVKTQ
FGYHLLEVTSRQD

Sequences:

>Translated_93_residues
MAKATARHILVSSEAKCNELKAQIEGGADFAEVAKANSTCPSSRQGGDLGSFGPGQMVKEFDTVVFSAPINVVQGPVKTQ
FGYHLLEVTSRQD
>Mature_92_residues
AKATARHILVSSEAKCNELKAQIEGGADFAEVAKANSTCPSSRQGGDLGSFGPGQMVKEFDTVVFSAPINVVQGPVKTQF
GYHLLEVTSRQD

Specific function: PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1790211, Length=92, Percent_Identity=54.3478260869565, Blast_Score=100, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21356303, Length=92, Percent_Identity=40.2173913043478, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 9856; Mature: 9725

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKATARHILVSSEAKCNELKAQIEGGADFAEVAKANSTCPSSRQGGDLGSFGPGQMVKE
CCCCCCCEEEECCCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
FDTVVFSAPINVVQGPVKTQFGYHLLEVTSRQD
HHHHHHCCCHHHHCCCCCCCCCHHEEHCCCCCC
>Mature Secondary Structure 
AKATARHILVSSEAKCNELKAQIEGGADFAEVAKANSTCPSSRQGGDLGSFGPGQMVKE
CCCCCCEEEECCCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
FDTVVFSAPINVVQGPVKTQFGYHLLEVTSRQD
HHHHHHCCCHHHHCCCCCCCCCHHEEHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]