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The map label for this gene is gor [H]

Identifier: 77459153

GI number: 77459153

Start: 3373671

End: 3375029

Strand: Reverse

Name: gor [H]

Synonym: Pfl01_2928

Alternate gene names: 77459153

Gene position: 3375029-3373671 (Counterclockwise)

Preceding gene: 77459154

Following gene: 77459151

Centisome position: 52.42

GC content: 59.16

Gene sequence:

>1359_bases
ATGGCCTACGATTTTGACCTTTATGTGATTGGCGCCGGTTCCGGCGGTGTGCGGGCTGCGCGTTTTGCTGCCGGGTTCGG
TGCGAAAGTGGCGGTGGCCGAGAGCCGTTATCTTGGCGGAACCTGCGTCAACGTCGGTTGCGTACCGAAAAAACTGTTGG
TGTACGGCGCCCATTTTGCCGAAGACTTCGAGCAGTCTTCGGGTTTCGGGTGGAATCTGGGTGAGGCGGATTTCGACTGG
GCCACGCTGATTGCCAACAAGGATCGCGAGATCAATCGTCTGAACGGCATTTATCGCAATCTGCTGGTCAACAGCGGCGT
GACCCTGCATGAGGCTCACGCGAAAATCGTTGGTCCGCACGAAGTCGAGGTCAACGGTGAGCGATACACCGCGAAGAATA
TTCTGATCGCCACCGGAGGCTGGCCGCAGATCCCCGAGATTCCGGGGCATGAGCATGCGATCAGCTCGAACCAGGCGTTC
TTCCTGAAAGAGCTGCCCAAGCGCGTGCTGGTCGTCGGCGGCGGTTACATCGCCGTCGAATTTGCCGGGATTTTCCATGG
CCTGGGCGCCAACACGACGTTGTTGTATCGCGGGGATCTGTTCCTCCGTGGTTTCGATGGTTCAGTGCGTAACCATTTGA
AAGAAGAGCTGACCAAACGCGGGATGGATCTGCAATTCAATGCCGACATTGCCCGTATCGACAAGCAGTCGGATGGCAGC
CTGAAAGCGACCCTCAAGGATGGTCGCGTACTGGAGGCGGATTGTGTGTTCTACGCCACCGGCCGACGTCCGATGCTGGA
CAACCTGGGGCTGGAGAACATTGATGTGCAGCTCGACGACAAAGGCTTCATCAAGGTCGATGAGCAATACCAGACCACCG
AGCCATCAATCCTGGCGCTGGGCGATGTCATCGGTCGTGTGCAGCTGACGCCAGTGGCACTGGCCGAAGGCATGGCGGTG
GCGCGACGTCTGTTCAAGCCTGAGCAATATCGTCCGGTGGATTACAAGATGATCCCGACGGCGGTGTTCAGTCTGCCGAA
TATCGGCACCGTCGGCCTGACCGAAGAAGAGGCGCGGGAAGCGGGTCACGACGTCGTGATCTACGAAAGCCGCTTCCGTC
CAATGAAGCTGACTCTGACGGATTGCCAGGAGCGCACGCTGATGAAGCTGGTGGTCGATGGCAAATCTGACAAGGTGTTG
GGCTGTCACATGGTCGGGCCGGATGCCGGCGAGATCGTGCAGGGTCTGGCGATCGCGCTGAAGGCTGGCGCCACCAAGCG
TGACTTCGACGACACCATCGGGGTGCACCCGACGGCGGCCGAAGAGTTTGTCACCATGCGTACGCCGGTCGGCGCTTAA

Upstream 100 bases:

>100_bases
CACCTTCGGGTGGCTTTTTCATTTTCTGCCCCTATATCGGCAGGAGTGCTTGCCCAACGGACGACGGCGGGTATGCTGAT
CGCCTGCCGAGGAGATAGAA

Downstream 100 bases:

>100_bases
GTCTTTTCCGGTTCTGCTGCGTCTGGCGCTGCCACAACGGCAGTGGCCAGGCGCAAGCTGGCTTGAATCTTAGTCAATTC
CTTCTCCAATGACTGATTGA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MAYDFDLYVIGAGSGGVRAARFAAGFGAKVAVAESRYLGGTCVNVGCVPKKLLVYGAHFAEDFEQSSGFGWNLGEADFDW
ATLIANKDREINRLNGIYRNLLVNSGVTLHEAHAKIVGPHEVEVNGERYTAKNILIATGGWPQIPEIPGHEHAISSNQAF
FLKELPKRVLVVGGGYIAVEFAGIFHGLGANTTLLYRGDLFLRGFDGSVRNHLKEELTKRGMDLQFNADIARIDKQSDGS
LKATLKDGRVLEADCVFYATGRRPMLDNLGLENIDVQLDDKGFIKVDEQYQTTEPSILALGDVIGRVQLTPVALAEGMAV
ARRLFKPEQYRPVDYKMIPTAVFSLPNIGTVGLTEEEAREAGHDVVIYESRFRPMKLTLTDCQERTLMKLVVDGKSDKVL
GCHMVGPDAGEIVQGLAIALKAGATKRDFDDTIGVHPTAAEEFVTMRTPVGA

Sequences:

>Translated_452_residues
MAYDFDLYVIGAGSGGVRAARFAAGFGAKVAVAESRYLGGTCVNVGCVPKKLLVYGAHFAEDFEQSSGFGWNLGEADFDW
ATLIANKDREINRLNGIYRNLLVNSGVTLHEAHAKIVGPHEVEVNGERYTAKNILIATGGWPQIPEIPGHEHAISSNQAF
FLKELPKRVLVVGGGYIAVEFAGIFHGLGANTTLLYRGDLFLRGFDGSVRNHLKEELTKRGMDLQFNADIARIDKQSDGS
LKATLKDGRVLEADCVFYATGRRPMLDNLGLENIDVQLDDKGFIKVDEQYQTTEPSILALGDVIGRVQLTPVALAEGMAV
ARRLFKPEQYRPVDYKMIPTAVFSLPNIGTVGLTEEEAREAGHDVVIYESRFRPMKLTLTDCQERTLMKLVVDGKSDKVL
GCHMVGPDAGEIVQGLAIALKAGATKRDFDDTIGVHPTAAEEFVTMRTPVGA
>Mature_451_residues
AYDFDLYVIGAGSGGVRAARFAAGFGAKVAVAESRYLGGTCVNVGCVPKKLLVYGAHFAEDFEQSSGFGWNLGEADFDWA
TLIANKDREINRLNGIYRNLLVNSGVTLHEAHAKIVGPHEVEVNGERYTAKNILIATGGWPQIPEIPGHEHAISSNQAFF
LKELPKRVLVVGGGYIAVEFAGIFHGLGANTTLLYRGDLFLRGFDGSVRNHLKEELTKRGMDLQFNADIARIDKQSDGSL
KATLKDGRVLEADCVFYATGRRPMLDNLGLENIDVQLDDKGFIKVDEQYQTTEPSILALGDVIGRVQLTPVALAEGMAVA
RRLFKPEQYRPVDYKMIPTAVFSLPNIGTVGLTEEEAREAGHDVVIYESRFRPMKLTLTDCQERTLMKLVVDGKSDKVLG
CHMVGPDAGEIVQGLAIALKAGATKRDFDDTIGVHPTAAEEFVTMRTPVGA

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=42.9193899782135, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI148277065, Length=475, Percent_Identity=36.4210526315789, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=36.4210526315789, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=36.4210526315789, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=36.4210526315789, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=36.4210526315789, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=35.2941176470588, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=35.5932203389831, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=30.58568329718, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI291045268, Length=474, Percent_Identity=33.1223628691983, Blast_Score=211, Evalue=2e-54,
Organism=Escherichia coli, GI1789915, Length=430, Percent_Identity=46.5116279069767, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1786307, Length=450, Percent_Identity=31.3333333333333, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=29.0748898678414, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=29.8245614035088, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1789065, Length=238, Percent_Identity=28.9915966386555, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71983429, Length=448, Percent_Identity=44.4196428571429, Blast_Score=328, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI71983419, Length=448, Percent_Identity=44.4196428571429, Blast_Score=328, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=33.6886993603412, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=34.0956340956341, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI32565766, Length=457, Percent_Identity=31.9474835886214, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17559934, Length=188, Percent_Identity=26.063829787234, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=40.1301518438178, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=30.6695464362851, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6325240, Length=467, Percent_Identity=27.6231263383298, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=36.0934182590234, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=36.0934182590234, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=36.0934182590234, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=34.8101265822785, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=30.3030303030303, Blast_Score=209, Evalue=4e-54,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49245; Mature: 49114

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYDFDLYVIGAGSGGVRAARFAAGFGAKVAVAESRYLGGTCVNVGCVPKKLLVYGAHFA
CCEEEEEEEEECCCCCCCHHHHHCCCCCEEEEECCCCCCCEEEECCCCCHHHHEECCHHH
EDFEQSSGFGWNLGEADFDWATLIANKDREINRLNGIYRNLLVNSGVTLHEAHAKIVGPH
HHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEECCEEEECCE
EVEVNGERYTAKNILIATGGWPQIPEIPGHEHAISSNQAFFLKELPKRVLVVGGGYIAVE
EEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCEEEEE
FAGIFHGLGANTTLLYRGDLFLRGFDGSVRNHLKEELTKRGMDLQFNADIARIDKQSDGS
EEHHHHCCCCCEEEEEECCEEEECCCCHHHHHHHHHHHHCCCCEEECCCCEECCCCCCCC
LKATLKDGRVLEADCVFYATGRRPMLDNLGLENIDVQLDDKGFIKVDEQYQTTEPSILAL
EEEEECCCEEEEEEEEEEECCCCCCHHHCCCCEEEEEECCCCCEEECCCCCCCCCCEEEE
GDVIGRVQLTPVALAEGMAVARRLFKPEQYRPVDYKMIPTAVFSLPNIGTVGLTEEEARE
CHHHCCEEECHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHCCCCCCCCCCCHHHHHH
AGHDVVIYESRFRPMKLTLTDCQERTLMKLVVDGKSDKVLGCHMVGPDAGEIVQGLAIAL
CCCEEEEECCCCCEEEEEECCHHHHEEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHH
KAGATKRDFDDTIGVHPTAAEEFVTMRTPVGA
HCCCCCCCCCCCCCCCCCCHHHEEEECCCCCC
>Mature Secondary Structure 
AYDFDLYVIGAGSGGVRAARFAAGFGAKVAVAESRYLGGTCVNVGCVPKKLLVYGAHFA
CEEEEEEEEECCCCCCCHHHHHCCCCCEEEEECCCCCCCEEEECCCCCHHHHEECCHHH
EDFEQSSGFGWNLGEADFDWATLIANKDREINRLNGIYRNLLVNSGVTLHEAHAKIVGPH
HHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEECCEEEECCE
EVEVNGERYTAKNILIATGGWPQIPEIPGHEHAISSNQAFFLKELPKRVLVVGGGYIAVE
EEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCEEEEE
FAGIFHGLGANTTLLYRGDLFLRGFDGSVRNHLKEELTKRGMDLQFNADIARIDKQSDGS
EEHHHHCCCCCEEEEEECCEEEECCCCHHHHHHHHHHHHCCCCEEECCCCEECCCCCCCC
LKATLKDGRVLEADCVFYATGRRPMLDNLGLENIDVQLDDKGFIKVDEQYQTTEPSILAL
EEEEECCCEEEEEEEEEEECCCCCCHHHCCCCEEEEEECCCCCEEECCCCCCCCCCEEEE
GDVIGRVQLTPVALAEGMAVARRLFKPEQYRPVDYKMIPTAVFSLPNIGTVGLTEEEARE
CHHHCCEEECHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHCCCCCCCCCCCHHHHHH
AGHDVVIYESRFRPMKLTLTDCQERTLMKLVVDGKSDKVLGCHMVGPDAGEIVQGLAIAL
CCCEEEEECCCCCEEEEEECCHHHHEEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHH
KAGATKRDFDDTIGVHPTAAEEFVTMRTPVGA
HCCCCCCCCCCCCCCCCCCHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1849605; 10984043 [H]