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The map label for this gene is fabG [C]

Identifier: 77459138

GI number: 77459138

Start: 3358211

End: 3358915

Strand: Reverse

Name: fabG [C]

Synonym: Pfl01_2913

Alternate gene names: 77459138

Gene position: 3358915-3358211 (Counterclockwise)

Preceding gene: 77459142

Following gene: 77459137

Centisome position: 52.17

GC content: 61.42

Gene sequence:

>705_bases
ATGAAACCATTCGACAACCAGACTGTTGTGGTCATCGGCGGCAGCAGCGGCATTGGCGCCGCCGTCGCGTCGAACGCCGC
TGAACGAGGCGCCCGTGTTTATTCGGTTGGGCGCCGTGTTGAAACGTCAGAAACCCATGACGGTGTCCGCCACGAATCCG
CCGATGTCACCGATGACGCCTCGCTGCGTCAACTGTTCGAACGCATTGGCGCCCTCGATCATCTGGTGATTACCGCCGGG
CCGAGCGTCAGCGCCAAGCTGTTGGCCGACAGCGATCTGCTTCAGGCGCAGCAGGCCTTCGACGTGAAATTCTGGGGCAC
CTTGCGCGCCATTCAAGCGGCACTGCCGTACCTGAGCGAGCGGGCCAGCATCACCCTGACGTCAGGTTTGCTGTCGCGCA
AATTCGTAGCGGGGCAATTCATCAAGACCACGTTGAATGCCGCGCTGGAAGCTCTGGCCAAACAACTGGCCAAGGAGCTG
GCGCCGCGCCGGGTCAACGTGATCAGCCCCGGCGTGACTGACACCGAAGCTTACGCAGGCATGGACGAAAGTCAGCGCAA
TGCAATGTTCGTCCGTACCTCGGCGGCGCTGCCGGTGGGTCGGGTCGGCAAGCCGCAGGACCTGGCCGCCGCTTTTATGC
TGGTCATGGAAAACGGCTTTATCAGCGGCAGCATCATCGATGTCGACGGAGGTGGATTGTTATGA

Upstream 100 bases:

>100_bases
TTGGTAAAAATCCTTTAAAGATCCTTCCGATTTACCGGGATTTTTCTGCGATTGGCAACCGGGGAAGATGCAATCTCCTC
AAGCCCACCGGAGAACTCTC

Downstream 100 bases:

>100_bases
CCTGGCACTTCGATCACCTGGCGTTCAATGCGCCGGACGGGCAGCCGATTCAGGACGCCTTCAATGTATTGCTGGGATTG
ACGCCGGGGCGGCGACCGCC

Product: Short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKPFDNQTVVVIGGSSGIGAAVASNAAERGARVYSVGRRVETSETHDGVRHESADVTDDASLRQLFERIGALDHLVITAG
PSVSAKLLADSDLLQAQQAFDVKFWGTLRAIQAALPYLSERASITLTSGLLSRKFVAGQFIKTTLNAALEALAKQLAKEL
APRRVNVISPGVTDTEAYAGMDESQRNAMFVRTSAALPVGRVGKPQDLAAAFMLVMENGFISGSIIDVDGGGLL

Sequences:

>Translated_234_residues
MKPFDNQTVVVIGGSSGIGAAVASNAAERGARVYSVGRRVETSETHDGVRHESADVTDDASLRQLFERIGALDHLVITAG
PSVSAKLLADSDLLQAQQAFDVKFWGTLRAIQAALPYLSERASITLTSGLLSRKFVAGQFIKTTLNAALEALAKQLAKEL
APRRVNVISPGVTDTEAYAGMDESQRNAMFVRTSAALPVGRVGKPQDLAAAFMLVMENGFISGSIIDVDGGGLL
>Mature_234_residues
MKPFDNQTVVVIGGSSGIGAAVASNAAERGARVYSVGRRVETSETHDGVRHESADVTDDASLRQLFERIGALDHLVITAG
PSVSAKLLADSDLLQAQQAFDVKFWGTLRAIQAALPYLSERASITLTSGLLSRKFVAGQFIKTTLNAALEALAKQLAKEL
APRRVNVISPGVTDTEAYAGMDESQRNAMFVRTSAALPVGRVGKPQDLAAAFMLVMENGFISGSIIDVDGGGLL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=26.7782426778243, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=28.1124497991968, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=26.0162601626016, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI2367365, Length=242, Percent_Identity=27.2727272727273, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=26.5151515151515, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=28.1954887218045, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI23397609, Length=244, Percent_Identity=33.1967213114754, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24643142, Length=236, Percent_Identity=29.2372881355932, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=29.0836653386454, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355319, Length=258, Percent_Identity=29.4573643410853, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24686; Mature: 24686

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFDNQTVVVIGGSSGIGAAVASNAAERGARVYSVGRRVETSETHDGVRHESADVTDDA
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCH
SLRQLFERIGALDHLVITAGPSVSAKLLADSDLLQAQQAFDVKFWGTLRAIQAALPYLSE
HHHHHHHHHCCHHEEEEECCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
RASITLTSGLLSRKFVAGQFIKTTLNAALEALAKQLAKELAPRRVNVISPGVTDTEAYAG
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCC
MDESQRNAMFVRTSAALPVGRVGKPQDLAAAFMLVMENGFISGSIIDVDGGGLL
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MKPFDNQTVVVIGGSSGIGAAVASNAAERGARVYSVGRRVETSETHDGVRHESADVTDDA
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCH
SLRQLFERIGALDHLVITAGPSVSAKLLADSDLLQAQQAFDVKFWGTLRAIQAALPYLSE
HHHHHHHHHCCHHEEEEECCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
RASITLTSGLLSRKFVAGQFIKTTLNAALEALAKQLAKELAPRRVNVISPGVTDTEAYAG
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCC
MDESQRNAMFVRTSAALPVGRVGKPQDLAAAFMLVMENGFISGSIIDVDGGGLL
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]