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The map label for this gene is acrE [H]

Identifier: 77459118

GI number: 77459118

Start: 3332839

End: 3333996

Strand: Direct

Name: acrE [H]

Synonym: Pfl01_2893

Alternate gene names: 77459118

Gene position: 3332839-3333996 (Clockwise)

Preceding gene: 77459114

Following gene: 77459119

Centisome position: 51.76

GC content: 65.03

Gene sequence:

>1158_bases
ATGTCGAAGAATCTGCTGGCCGGGCTCGGCCTGATCGCATTGGCGCTGACGCTGAGTGCCTGTGATAAATCCTCGAACGC
CGAGGAACAGGCGCCGCCGGCCACCGTGCGGATCGAAACCCTTGAGGCGCGCCCCCTGTCGATCAGCAGCGAACTGAGCG
GGCGGATTGCCGCCCCGCGCATCGCCGAAGTCCGCGCCCGGGTCGCCGGCGTAGTGCTGCAACGCACCTACCGCGAAGGC
AGCGACGTGAAAAAGGGCGACGTGCTGTTCCGTATCGATCCGGCGCCGTTCAAGGCTGACCTCGATAGCGCCGAAGCGGC
CCTGCGCAAGGCCGAGGCAAACGCGTTCCAGGCAAAACTTCAGGAACAGCGCTACGCCCAGTTGATCGACGACAAGGCCA
TCAGCGCTCAGGATTACGACAACGCCCGCGCCAACGCCCGGCAGACCGCCGCCGATGTTGCCGCCAACAAGGCAGCCGTC
GAGCGGGCGAAGCTGAACCTCGGTTACGCCACCGTCACCGCGCCGATTTCCGGGCGCGTCGGGCGTGCCCTGGTGACTGA
AGGTGCGCTGGTCGGCCAGAACGAAACCACGCCCATGGCGCTGATCCAGCAGCTGAACCCGATCCACGCCGACCTCACCC
AGTCGACCCGCGAACTCAACGAGTTGCGCAGGGCATTCCGTTCCGGCCAGTTGCAGCAGGTCGGCCAGGATCAGGTCAAG
GCCACGCTGATCCAGGACGATGGCAGCCTCTATCCGCTGCCGGGCAAATTGCTGTTCAGCGATATCACGGTCGATCCGGG
CACCGGACAAATCATTTTGCGCAGCGAGTTCCCCAATCCGGATCTCGATCTGTTGCCGGGCAGCTACGTTCGCGTGCGTC
TGGAGCAAGGCGTGATCCAGCATGGCCTGACCGTGCCACAACGCGCGGTACAACGTGACAGCGCCGGTGTGGCGCAGGTC
CTGACGGTCGACGACCAGATGCGCGTTGCCCAGCAGCCAGTGCAGCTCGGCGCGGTACAGAACGACCGCTGGATCGTCAC
CGGCGGCCTCAAGGCCGGCGACCGCATTGTCATCGAAGGCCTGCAACACGCCCGTCCGGGCGAAGTGGTGCAGATCGACG
ACACCCCTCTTCCACTTGCCCAGACCTCTGGTCAGTAA

Upstream 100 bases:

>100_bases
GAGCAAAACCCTTACACAATTTCACACAGCACCTACAAAGCTTCACCGCTACCCTCGGCGACTGTCCGTAGGATGCGCAG
ATCAATATTGGGGGTTGTAC

Downstream 100 bases:

>100_bases
GCAGGACGCTCTTCTATGCCGCAGTTCTTTATCGACCGCCCGGTGTTCGCCTGGGTCGTCGCGTTGTTCATCCTGTTGGC
CGGTGCGCTGGCCATCCCGC

Product: secretion protein HlyD

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSKNLLAGLGLIALALTLSACDKSSNAEEQAPPATVRIETLEARPLSISSELSGRIAAPRIAEVRARVAGVVLQRTYREG
SDVKKGDVLFRIDPAPFKADLDSAEAALRKAEANAFQAKLQEQRYAQLIDDKAISAQDYDNARANARQTAADVAANKAAV
ERAKLNLGYATVTAPISGRVGRALVTEGALVGQNETTPMALIQQLNPIHADLTQSTRELNELRRAFRSGQLQQVGQDQVK
ATLIQDDGSLYPLPGKLLFSDITVDPGTGQIILRSEFPNPDLDLLPGSYVRVRLEQGVIQHGLTVPQRAVQRDSAGVAQV
LTVDDQMRVAQQPVQLGAVQNDRWIVTGGLKAGDRIVIEGLQHARPGEVVQIDDTPLPLAQTSGQ

Sequences:

>Translated_385_residues
MSKNLLAGLGLIALALTLSACDKSSNAEEQAPPATVRIETLEARPLSISSELSGRIAAPRIAEVRARVAGVVLQRTYREG
SDVKKGDVLFRIDPAPFKADLDSAEAALRKAEANAFQAKLQEQRYAQLIDDKAISAQDYDNARANARQTAADVAANKAAV
ERAKLNLGYATVTAPISGRVGRALVTEGALVGQNETTPMALIQQLNPIHADLTQSTRELNELRRAFRSGQLQQVGQDQVK
ATLIQDDGSLYPLPGKLLFSDITVDPGTGQIILRSEFPNPDLDLLPGSYVRVRLEQGVIQHGLTVPQRAVQRDSAGVAQV
LTVDDQMRVAQQPVQLGAVQNDRWIVTGGLKAGDRIVIEGLQHARPGEVVQIDDTPLPLAQTSGQ
>Mature_384_residues
SKNLLAGLGLIALALTLSACDKSSNAEEQAPPATVRIETLEARPLSISSELSGRIAAPRIAEVRARVAGVVLQRTYREGS
DVKKGDVLFRIDPAPFKADLDSAEAALRKAEANAFQAKLQEQRYAQLIDDKAISAQDYDNARANARQTAADVAANKAAVE
RAKLNLGYATVTAPISGRVGRALVTEGALVGQNETTPMALIQQLNPIHADLTQSTRELNELRRAFRSGQLQQVGQDQVKA
TLIQDDGSLYPLPGKLLFSDITVDPGTGQIILRSEFPNPDLDLLPGSYVRVRLEQGVIQHGLTVPQRAVQRDSAGVAQVL
TVDDQMRVAQQPVQLGAVQNDRWIVTGGLKAGDRIVIEGLQHARPGEVVQIDDTPLPLAQTSGQ

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=377, Percent_Identity=46.1538461538462, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1786668, Length=372, Percent_Identity=46.505376344086, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1789929, Length=357, Percent_Identity=40.6162464985994, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI87082036, Length=320, Percent_Identity=29.375, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41344; Mature: 41213

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNLLAGLGLIALALTLSACDKSSNAEEQAPPATVRIETLEARPLSISSELSGRIAAPR
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEEEECCCCCEECHHCCCCCCCCH
IAEVRARVAGVVLQRTYREGSDVKKGDVLFRIDPAPFKADLDSAEAALRKAEANAFQAKL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
QEQRYAQLIDDKAISAQDYDNARANARQTAADVAANKAAVERAKLNLGYATVTAPISGRV
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEECCCCCC
GRALVTEGALVGQNETTPMALIQQLNPIHADLTQSTRELNELRRAFRSGQLQQVGQDQVK
CHHHHHCCEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHE
ATLIQDDGSLYPLPGKLLFSDITVDPGTGQIILRSEFPNPDLDLLPGSYVRVRLEQGVIQ
EEEEECCCCEECCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEEHHHHHH
HGLTVPQRAVQRDSAGVAQVLTVDDQMRVAQQPVQLGAVQNDRWIVTGGLKAGDRIVIEG
HCCCCCHHHHHCCCCCEEEEEEECHHHHHHHCCHHHCCCCCCCEEEECCCCCCCCCEEEC
LQHARPGEVVQIDDTPLPLAQTSGQ
CCCCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SKNLLAGLGLIALALTLSACDKSSNAEEQAPPATVRIETLEARPLSISSELSGRIAAPR
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEEEECCCCCEECHHCCCCCCCCH
IAEVRARVAGVVLQRTYREGSDVKKGDVLFRIDPAPFKADLDSAEAALRKAEANAFQAKL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
QEQRYAQLIDDKAISAQDYDNARANARQTAADVAANKAAVERAKLNLGYATVTAPISGRV
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEECCCCCC
GRALVTEGALVGQNETTPMALIQQLNPIHADLTQSTRELNELRRAFRSGQLQQVGQDQVK
CHHHHHCCEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHE
ATLIQDDGSLYPLPGKLLFSDITVDPGTGQIILRSEFPNPDLDLLPGSYVRVRLEQGVIQ
EEEEECCCCEECCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEEHHHHHH
HGLTVPQRAVQRDSAGVAQVLTVDDQMRVAQQPVQLGAVQNDRWIVTGGLKAGDRIVIEG
HCCCCCHHHHHCCCCCEEEEEEECHHHHHHHCCHHHCCCCCCCEEEECCCCCCCCCEEEC
LQHARPGEVVQIDDTPLPLAQTSGQ
CCCCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]