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The map label for this gene is acsA [H]

Identifier: 77459095

GI number: 77459095

Start: 3310279

End: 3311943

Strand: Reverse

Name: acsA [H]

Synonym: Pfl01_2870

Alternate gene names: 77459095

Gene position: 3311943-3310279 (Counterclockwise)

Preceding gene: 77459096

Following gene: 77459094

Centisome position: 51.44

GC content: 63.12

Gene sequence:

>1665_bases
ATGCGCGATTACTTGTCTGCCACCGCACAGTTTGATTATCAGCACACCGTGGACGCCGCACTCAGCGGCACGCTCGAGGC
GCTCAACGCCTGCGTCGAATGTTGTGACCGGCACGCGCTGCCGGGGCGCATTGCGCTGTTCTGGGAAGGCCGCGACGGCG
CCAGTGCGACGTACACCTTCAGCGACCTGCAGGACAAAGCCGCGCGTTTCGCCAATTTCCTTCTCGCCCAAGGCGTGCAG
AAGGGCGACAAGGTCGCCGGCCTGCTGCCGCGCAATATCGAATTGCTGATCACCGTGTTCGCCACCTGGCGCATCGGCGC
GGTGTATCAACCGCTGTTCACCGCGTTCGGCCCCAAGGCCCTCGAACATCGCCTGAACAGCTCCGGCGCCAAGGTTGTAG
TCACTGATGCAGTCAATCGGCCAAAACTCAGCGAAGTCGCCGATTGCCCGACGCTGGTCACTGTCGGTGGTCCGAAAGGC
CAGGGCATCGTCCGTGGCGATTTCAGTTTCTGGGCCGAGCTGCCCAACCATTCCAGTGTCTGCGAGCCGCTGATGCTGAC
CGGCGAAGACCCGTTCCTGCTGATGTTCACCTCGGGTACTACCGGCCCGTCGAAGGCGCTGTCGGTGCCGCTCAAGGCCA
TCGTCGCGTTCCAGAGCTACACCCGCGATGCCGTGGATCTGCGCCCGGAAGATGCGTTCTGGAACGTTGCCGATCCGGGC
TGGGCCTACGGCATTTATTTCGGCGTCACCGGCCCGTTGTCGATGGGCCATCCGATCACGTTCTACGATGGCCCGTTCAC
CCTCGAAAGCACCTGCCGGGTGATCAACAAGTACGGGATCACCAACCTCACCGGTTCGCCCACCGCGTATCGCCTGCTGA
TTGCCGGTGGCGATGAGTTCGCCAAGTCGATCAAGGGCAAGCTGCGCATCGTCAGCAGCGCCGGCGAGCCGTTGAATCCG
GAAGTGATCCGCTGGTTCGCCGACAACCTCGGCGTGGCCATTCACGACCACTACGGCCAAACCGAACTGGGCATGGTCCT
GTGCAACCACCACGGCCTCGAACACCCGATCCACCTCGGCGCCGCCGGTTTCGCCTCGCCGGGCCATCGCATCGTGGTGC
TTGACGAGCAGAACAACGAACTCGGCGTCGGCCAGCCCGGCATCCTCGCCATCGACCGCACACAGTCGCCGATGTGCTGG
TTCGCCGGCTATGAAGGCGTGCCGACCAAGGCCTTCGTCGGCGATTACTACCTGAGCGGCGACACCGTCGAGTGGAACCC
GGACGGCAGCATCAGCTTCGTCGGCCGCAGCGATGACGTGATCACCACTTCCGGCTATCGCGTCGGCCCGTTCGACGTGG
AGAGCGCACTGATCGAACACCCGGCCGTTGTCGAAGCCGCCGTGGTCGGCAAGCCCGATCCTGAGCGCACCGAACTGGTC
AAAGCCTTCGTCGTGCTCAACCCGCAATACCGCGCCGAGCCTGCGCTGGCCGAAGAACTGCGGCAACACGTGCGCAAACG
TCTGGCCGCGCATTCGTACCCCCGTGAAATCGAATTTGTCAGCGAGTTGCCGAAAACCCCGAGCGGCAAATTGCAGCGCT
TTATCTTGCGCAACCAGGAAATCGCCAAGGCTCAAGAGGCTGCGGCGCACAACGTTTCAGCTTGA

Upstream 100 bases:

>100_bases
ACTTTGAGGGCTTTGACCATTGCCGCAGCCGGCGTGCGGCGCGAGTATTCCTCTGTTGTTTACGGTTCCCCAACCTAATA
AGAACAGAGGGATTCTGGCA

Downstream 100 bases:

>100_bases
ACCCAAGGAAACAGTCATGCAGATCGAGAACAAGGTTTTTATCGTCACCGGCGGTGCGTCCGGGCTGGGTGCAGCCACCG
CTGAGCTGTTGGTTGCCGCC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MRDYLSATAQFDYQHTVDAALSGTLEALNACVECCDRHALPGRIALFWEGRDGASATYTFSDLQDKAARFANFLLAQGVQ
KGDKVAGLLPRNIELLITVFATWRIGAVYQPLFTAFGPKALEHRLNSSGAKVVVTDAVNRPKLSEVADCPTLVTVGGPKG
QGIVRGDFSFWAELPNHSSVCEPLMLTGEDPFLLMFTSGTTGPSKALSVPLKAIVAFQSYTRDAVDLRPEDAFWNVADPG
WAYGIYFGVTGPLSMGHPITFYDGPFTLESTCRVINKYGITNLTGSPTAYRLLIAGGDEFAKSIKGKLRIVSSAGEPLNP
EVIRWFADNLGVAIHDHYGQTELGMVLCNHHGLEHPIHLGAAGFASPGHRIVVLDEQNNELGVGQPGILAIDRTQSPMCW
FAGYEGVPTKAFVGDYYLSGDTVEWNPDGSISFVGRSDDVITTSGYRVGPFDVESALIEHPAVVEAAVVGKPDPERTELV
KAFVVLNPQYRAEPALAEELRQHVRKRLAAHSYPREIEFVSELPKTPSGKLQRFILRNQEIAKAQEAAAHNVSA

Sequences:

>Translated_554_residues
MRDYLSATAQFDYQHTVDAALSGTLEALNACVECCDRHALPGRIALFWEGRDGASATYTFSDLQDKAARFANFLLAQGVQ
KGDKVAGLLPRNIELLITVFATWRIGAVYQPLFTAFGPKALEHRLNSSGAKVVVTDAVNRPKLSEVADCPTLVTVGGPKG
QGIVRGDFSFWAELPNHSSVCEPLMLTGEDPFLLMFTSGTTGPSKALSVPLKAIVAFQSYTRDAVDLRPEDAFWNVADPG
WAYGIYFGVTGPLSMGHPITFYDGPFTLESTCRVINKYGITNLTGSPTAYRLLIAGGDEFAKSIKGKLRIVSSAGEPLNP
EVIRWFADNLGVAIHDHYGQTELGMVLCNHHGLEHPIHLGAAGFASPGHRIVVLDEQNNELGVGQPGILAIDRTQSPMCW
FAGYEGVPTKAFVGDYYLSGDTVEWNPDGSISFVGRSDDVITTSGYRVGPFDVESALIEHPAVVEAAVVGKPDPERTELV
KAFVVLNPQYRAEPALAEELRQHVRKRLAAHSYPREIEFVSELPKTPSGKLQRFILRNQEIAKAQEAAAHNVSA
>Mature_554_residues
MRDYLSATAQFDYQHTVDAALSGTLEALNACVECCDRHALPGRIALFWEGRDGASATYTFSDLQDKAARFANFLLAQGVQ
KGDKVAGLLPRNIELLITVFATWRIGAVYQPLFTAFGPKALEHRLNSSGAKVVVTDAVNRPKLSEVADCPTLVTVGGPKG
QGIVRGDFSFWAELPNHSSVCEPLMLTGEDPFLLMFTSGTTGPSKALSVPLKAIVAFQSYTRDAVDLRPEDAFWNVADPG
WAYGIYFGVTGPLSMGHPITFYDGPFTLESTCRVINKYGITNLTGSPTAYRLLIAGGDEFAKSIKGKLRIVSSAGEPLNP
EVIRWFADNLGVAIHDHYGQTELGMVLCNHHGLEHPIHLGAAGFASPGHRIVVLDEQNNELGVGQPGILAIDRTQSPMCW
FAGYEGVPTKAFVGDYYLSGDTVEWNPDGSISFVGRSDDVITTSGYRVGPFDVESALIEHPAVVEAAVVGKPDPERTELV
KAFVVLNPQYRAEPALAEELRQHVRKRLAAHSYPREIEFVSELPKTPSGKLQRFILRNQEIAKAQEAAAHNVSA

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=517, Percent_Identity=36.5570599613153, Blast_Score=285, Evalue=1e-76,
Organism=Homo sapiens, GI42544132, Length=516, Percent_Identity=36.046511627907, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI122937307, Length=513, Percent_Identity=36.8421052631579, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI115511026, Length=512, Percent_Identity=33.59375, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI58082049, Length=520, Percent_Identity=32.6923076923077, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI157311624, Length=520, Percent_Identity=32.3076923076923, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI157311622, Length=520, Percent_Identity=32.3076923076923, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI8923896, Length=571, Percent_Identity=31.6987740805604, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI253970489, Length=582, Percent_Identity=31.2714776632302, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI28416953, Length=561, Percent_Identity=31.0160427807487, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI13375727, Length=553, Percent_Identity=27.124773960217, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI42544134, Length=343, Percent_Identity=30.6122448979592, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI195947378, Length=430, Percent_Identity=24.4186046511628, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI156151445, Length=550, Percent_Identity=24.5454545454545, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI187761345, Length=522, Percent_Identity=23.7547892720307, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI187761343, Length=522, Percent_Identity=23.7547892720307, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1790505, Length=548, Percent_Identity=31.3868613138686, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI145693145, Length=530, Percent_Identity=26.9811320754717, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1786529, Length=515, Percent_Identity=27.9611650485437, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1788107, Length=525, Percent_Identity=26.6666666666667, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI221142682, Length=522, Percent_Identity=23.7547892720307, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786801, Length=441, Percent_Identity=24.4897959183673, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786810, Length=547, Percent_Identity=25.0457038391225, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789201, Length=355, Percent_Identity=25.9154929577465, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983001, Length=566, Percent_Identity=31.095406360424, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71982997, Length=566, Percent_Identity=31.095406360424, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17558820, Length=536, Percent_Identity=24.4402985074627, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=503, Percent_Identity=24.4532803180915, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17557194, Length=544, Percent_Identity=22.2426470588235, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=536, Percent_Identity=22.3880597014925, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71994694, Length=536, Percent_Identity=22.3880597014925, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994690, Length=536, Percent_Identity=22.3880597014925, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17559526, Length=541, Percent_Identity=26.2476894639556, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=548, Percent_Identity=22.992700729927, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=362, Percent_Identity=25.9668508287293, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71996755, Length=496, Percent_Identity=23.3870967741935, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=507, Percent_Identity=23.2741617357002, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560308, Length=524, Percent_Identity=22.7099236641221, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=496, Percent_Identity=21.3709677419355, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319264, Length=556, Percent_Identity=32.9136690647482, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323182, Length=565, Percent_Identity=30.4424778761062, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319699, Length=381, Percent_Identity=23.8845144356955, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667955, Length=560, Percent_Identity=30.3571428571429, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI62472339, Length=537, Percent_Identity=30.3538175046555, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24667959, Length=493, Percent_Identity=29.6146044624746, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21355225, Length=567, Percent_Identity=24.6913580246914, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI18859661, Length=524, Percent_Identity=26.1450381679389, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24581924, Length=521, Percent_Identity=24.1842610364683, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356947, Length=508, Percent_Identity=24.0157480314961, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355181, Length=505, Percent_Identity=25.3465346534653, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922652, Length=501, Percent_Identity=23.9520958083832, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648260, Length=485, Percent_Identity=24.9484536082474, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20130357, Length=500, Percent_Identity=23.4, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356441, Length=491, Percent_Identity=23.4215885947047, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24656500, Length=512, Percent_Identity=22.65625, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24653035, Length=376, Percent_Identity=22.8723404255319, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281365686, Length=470, Percent_Identity=25.3191489361702, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 60186; Mature: 60186

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDYLSATAQFDYQHTVDAALSGTLEALNACVECCDRHALPGRIALFWEGRDGASATYTF
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEH
SDLQDKAARFANFLLAQGVQKGDKVAGLLPRNIELLITVFATWRIGAVYQPLFTAFGPKA
HHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHH
LEHRLNSSGAKVVVTDAVNRPKLSEVADCPTLVTVGGPKGQGIVRGDFSFWAELPNHSSV
HHHHHCCCCCEEEEECCCCCCCHHHHHCCCEEEEECCCCCCCEEECCHHHHHCCCCCCCC
CEPLMLTGEDPFLLMFTSGTTGPSKALSVPLKAIVAFQSYTRDAVDLRPEDAFWNVADPG
CCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCEECCCCCC
WAYGIYFGVTGPLSMGHPITFYDGPFTLESTCRVINKYGITNLTGSPTAYRLLIAGGDEF
EEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHH
AKSIKGKLRIVSSAGEPLNPEVIRWFADNLGVAIHDHYGQTELGMVLCNHHGLEHPIHLG
HHHHCCEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHEEEECCCCCCCCEEEC
AAGFASPGHRIVVLDEQNNELGVGQPGILAIDRTQSPMCWFAGYEGVPTKAFVGDYYLSG
CCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCEEEECCEEECC
DTVEWNPDGSISFVGRSDDVITTSGYRVGPFDVESALIEHPAVVEAAVVGKPDPERTELV
CEEEECCCCCEEEEECCCCEEEECCEEECCCCHHHHHHCCCCCEEEEECCCCCCHHHHHH
KAFVVLNPQYRAEPALAEELRQHVRKRLAAHSYPREIEFVSELPKTPSGKLQRFILRNQE
EEHEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHCCHH
IAKAQEAAAHNVSA
HHHHHHHHHCCCCC
>Mature Secondary Structure
MRDYLSATAQFDYQHTVDAALSGTLEALNACVECCDRHALPGRIALFWEGRDGASATYTF
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEH
SDLQDKAARFANFLLAQGVQKGDKVAGLLPRNIELLITVFATWRIGAVYQPLFTAFGPKA
HHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHH
LEHRLNSSGAKVVVTDAVNRPKLSEVADCPTLVTVGGPKGQGIVRGDFSFWAELPNHSSV
HHHHHCCCCCEEEEECCCCCCCHHHHHCCCEEEEECCCCCCCEEECCHHHHHCCCCCCCC
CEPLMLTGEDPFLLMFTSGTTGPSKALSVPLKAIVAFQSYTRDAVDLRPEDAFWNVADPG
CCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCEECCCCCC
WAYGIYFGVTGPLSMGHPITFYDGPFTLESTCRVINKYGITNLTGSPTAYRLLIAGGDEF
EEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHH
AKSIKGKLRIVSSAGEPLNPEVIRWFADNLGVAIHDHYGQTELGMVLCNHHGLEHPIHLG
HHHHCCEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHEEEECCCCCCCCEEEC
AAGFASPGHRIVVLDEQNNELGVGQPGILAIDRTQSPMCWFAGYEGVPTKAFVGDYYLSG
CCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCEEEECCEEECC
DTVEWNPDGSISFVGRSDDVITTSGYRVGPFDVESALIEHPAVVEAAVVGKPDPERTELV
CEEEECCCCCEEEEECCCCEEEECCEEECCCCHHHHHHCCCCCEEEEECCCCCCHHHHHH
KAFVVLNPQYRAEPALAEELRQHVRKRLAAHSYPREIEFVSELPKTPSGKLQRFILRNQE
EEHEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHCCHH
IAKAQEAAAHNVSA
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]