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The map label for this gene is lip2 [H]

Identifier: 77459088

GI number: 77459088

Start: 3302868

End: 3303722

Strand: Direct

Name: lip2 [H]

Synonym: Pfl01_2863

Alternate gene names: 77459088

Gene position: 3302868-3303722 (Clockwise)

Preceding gene: 77459087

Following gene: 77459089

Centisome position: 51.3

GC content: 60.0

Gene sequence:

>855_bases
ATGGATGAAACTTCGTTGACTGTAGAGGACGCCAGAACGGCGTTGCGGCAGGCGCAAGTCACCTGTGTTCATGATCTGGC
GATCGAGAGCCATGGCCGTTCACTGCCGCTGCGCCTCTACACACCACCCGGCAAGGGACCGTTTCCCGTGCTGGTTTTCT
TTCATGGCGGGGGCTGGGTCACAGGAGACCTGGACACGCATGACGGGTTCTGTCGGTTGATGTGTGAGTGGGCTGGTTGC
GCCGTGGTCGCCGTTGATTTCGCCCGCCCTCCGGAACACTTGTTTCCGGCAGCCCTGGAAGACTGTTGGACAGCTTTCAA
GTGGGTGACACGGCAAGGCGCCGGTTGCGGACTGGATACTTCAAGCATTGCAGTCGCAGGAGGTGGTTCAGGAGGCGGGA
TGGCCGCCGTCATCAGCCAGCGCGACGCCGAATGTGACGAACCATGCATCTGCTTTCAGCTGCTGCTTTACCCTTTGCTC
GACTGCAACACTCGCCGCAGCTCCCACACGAGATTCGGGCAAGGACATGGACTGACTGTCGATCTGCTCGAATGGTACCT
CGGTCACTACCTGCCGCCCGGTACATCGCGCGTGGACAGACGGCTGTCGCCCCTGCTCAGTGACTCGCTGCATGGACTGC
CCCGAACGTTGATCATCACCTGCGGACTTGACGTTCTTCGTGATGAGGGACGTGCCTACGCCAAGCGATTGCGAGCAGCA
AATGTCACTGTCGAACACAAAGAGTTTTCGGGGATGCGTCACGGTTTCATGAACTACCCTGCCGCCCATGAAGAGGCCAG
ACGCGCCCTGCTGCTTTGCGCCCGGACCCTTCAGGCACAGCTTCGCGGCGAATGA

Upstream 100 bases:

>100_bases
CATCCACCGACGACAATGTTGCTGGAAGTCTCTCGACTGGTCAGCCCTGAATACGTTATCGAGATCGAGGCAGAGGCCCG
TTCGGGCAGAGGCTGCGGCC

Downstream 100 bases:

>100_bases
TGGCCGGGACTGGAATCAACGTCTGCGAGCGGCTTTCCAGACAAGGCAAAAATGCAGACAGCCCGTGCACATATCCCCGT
TGTACACGGCAAATTTGCAC

Product: esterase/lipase/thioesterase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MDETSLTVEDARTALRQAQVTCVHDLAIESHGRSLPLRLYTPPGKGPFPVLVFFHGGGWVTGDLDTHDGFCRLMCEWAGC
AVVAVDFARPPEHLFPAALEDCWTAFKWVTRQGAGCGLDTSSIAVAGGGSGGGMAAVISQRDAECDEPCICFQLLLYPLL
DCNTRRSSHTRFGQGHGLTVDLLEWYLGHYLPPGTSRVDRRLSPLLSDSLHGLPRTLIITCGLDVLRDEGRAYAKRLRAA
NVTVEHKEFSGMRHGFMNYPAAHEEARRALLLCARTLQAQLRGE

Sequences:

>Translated_284_residues
MDETSLTVEDARTALRQAQVTCVHDLAIESHGRSLPLRLYTPPGKGPFPVLVFFHGGGWVTGDLDTHDGFCRLMCEWAGC
AVVAVDFARPPEHLFPAALEDCWTAFKWVTRQGAGCGLDTSSIAVAGGGSGGGMAAVISQRDAECDEPCICFQLLLYPLL
DCNTRRSSHTRFGQGHGLTVDLLEWYLGHYLPPGTSRVDRRLSPLLSDSLHGLPRTLIITCGLDVLRDEGRAYAKRLRAA
NVTVEHKEFSGMRHGFMNYPAAHEEARRALLLCARTLQAQLRGE
>Mature_284_residues
MDETSLTVEDARTALRQAQVTCVHDLAIESHGRSLPLRLYTPPGKGPFPVLVFFHGGGWVTGDLDTHDGFCRLMCEWAGC
AVVAVDFARPPEHLFPAALEDCWTAFKWVTRQGAGCGLDTSSIAVAGGGSGGGMAAVISQRDAECDEPCICFQLLLYPLL
DCNTRRSSHTRFGQGHGLTVDLLEWYLGHYLPPGTSRVDRRLSPLLSDSLHGLPRTLIITCGLDVLRDEGRAYAKRLRAA
NVTVEHKEFSGMRHGFMNYPAAHEEARRALLLCARTLQAQLRGE

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=293, Percent_Identity=29.6928327645051, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI157041239, Length=130, Percent_Identity=33.8461538461538, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI61966717, Length=284, Percent_Identity=23.943661971831, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI21328446, Length=131, Percent_Identity=29.7709923664122, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786682, Length=249, Percent_Identity=30.9236947791165, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71996133, Length=319, Percent_Identity=26.9592476489028, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17567059, Length=286, Percent_Identity=27.2727272727273, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI72001146, Length=124, Percent_Identity=32.258064516129, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540028, Length=160, Percent_Identity=27.5, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 31116; Mature: 31116

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDETSLTVEDARTALRQAQVTCVHDLAIESHGRSLPLRLYTPPGKGPFPVLVFFHGGGWV
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEEEECCCEE
TGDLDTHDGFCRLMCEWAGCAVVAVDFARPPEHLFPAALEDCWTAFKWVTRQGAGCGLDT
ECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SSIAVAGGGSGGGMAAVISQRDAECDEPCICFQLLLYPLLDCNTRRSSHTRFGQGHGLTV
CCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
DLLEWYLGHYLPPGTSRVDRRLSPLLSDSLHGLPRTLIITCGLDVLRDEGRAYAKRLRAA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHH
NVTVEHKEFSGMRHGFMNYPAAHEEARRALLLCARTLQAQLRGE
CCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDETSLTVEDARTALRQAQVTCVHDLAIESHGRSLPLRLYTPPGKGPFPVLVFFHGGGWV
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEEEECCCEE
TGDLDTHDGFCRLMCEWAGCAVVAVDFARPPEHLFPAALEDCWTAFKWVTRQGAGCGLDT
ECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SSIAVAGGGSGGGMAAVISQRDAECDEPCICFQLLLYPLLDCNTRRSSHTRFGQGHGLTV
CCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
DLLEWYLGHYLPPGTSRVDRRLSPLLSDSLHGLPRTLIITCGLDVLRDEGRAYAKRLRAA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHH
NVTVEHKEFSGMRHGFMNYPAAHEEARRALLLCARTLQAQLRGE
CCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]