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The map label for this gene is argH1

Identifier: 77459077

GI number: 77459077

Start: 3290101

End: 3291528

Strand: Direct

Name: argH1

Synonym: Pfl01_2852

Alternate gene names: 77459077

Gene position: 3290101-3291528 (Clockwise)

Preceding gene: 77459075

Following gene: 77459078

Centisome position: 51.1

GC content: 66.04

Gene sequence:

>1428_bases
ATGTCTCAAACCACCGACCGTCTCTGGGGTGCCCGTTTCAAAAGCGGCCCGTCCGCTGCCCTGGCGGCCCTGTCCCGTTG
CCCCGAGCGCTATTTCCGCCTGACGCCGTACGATCTGGCCGGCTCCAAGGCCCACGCCGGGGAACTGCAACGTGCCGGTC
TGCTGGACGAGCAGGAAACCCGCACGATGATCGAAGCCCTGGACGGCATCGGTGCCGATTTCGCTGCCGGGCGCATCGCC
CCGACGCTGGACGACGAAGACGTTCACACCTTCATCGAGCGCCTGCTGACCGAACGCCTCGGCGCACTGGGCGGCAAGCT
GCGCGCCGGCCGTTCACGCAACGACCAGACCGCCAACGACCTGCGCCTGTTCCTGCGTGATCACGTGCGCACCCTGGCCG
TGGAAGTGCTGGCCCTGCAAACGGCGCTAGTTGATCAGGCCGAGCAGCACGTCGAAAGCATCTGCCCGGGCTTCACCCAC
TTGCAGCAAGCGCAACCGATCGTGTTCGCCCATCACCTGTTGGCCCACGCGCAATCGATGCTGCGTGACGTGCAGCGACT
GATGGACTGGGACGCCCGCACTTCGCTGTCGCCCCTCGGTGCCGCAGCCATGGCCGGCTCCGCGATCGCTCGTCAGCCGC
AACAATCGGCCAAGGAAATGGGCTATGCCGGGGTCTGCGAAAACTCCATCGACGCCGTGGCCAGCCGCGATCACGTCGCC
GAATTCCTGTTCATCGCCAGCATGCTCGGGATCAACATCTCGCGTCTGGCCGAAGAATTCTGCCTGTGGTCGTCGCGCCA
GTTCCGCTGGGTCGATCTGGACGATGCCTACGCCACCGGCAGCTCGATCATGCCGCAGAAGAAAAACCCCGACATCGCCG
AACTGGCCCGGGGCAAGGCTGGCCGTCTGATCGGCAACCTGACCGGCCTGCTGTCGACGCTCAAATCCCTGCCGCTGTCG
TACAACCGCGACCTGAGCGAAGACAAGAACGGCGTGCTCGACAGCGTCGACACCCTGCTGCTGGTGCTGCCGGCGATGGC
CGGGATGGTCGCGACCATGACCGTCAACGTCGAGGAACTGCGGCGTCAGGCGCCGCTGGGCTTTACCCTCGCCACCGAAG
TCGCCGACTGGCTGGCCGTGCGCGGCGTGCCGTTCAAGGAAGCCCACGAAATCACTGGCGCACTGGTTCAGGCCTGCGAA
AAACACGACCTTGAATTGTGGGAAGCCTCGCCGGCATTGCTGGCCGAGATCGACCCACGCCTCACGGCAGACGTGCGTGA
CAGCCTGACCCTGGAAGCCGCCATCGCGGCCCGCAGCGGCTGGGGCGGCACCGCGCCGCAACAGGTGCGCGAGCAGATCG
GCCGCCTGAAAACCGCCCTCGCCGCGCAGCAGCAGTGGACCGAAAACTACCAGGGCTTCCGCCTCTAA

Upstream 100 bases:

>100_bases
AAACTGCTTTGGCCTGATTCCGTCTGCCGATTGTTCGGCACGTTTTTTCAGGGCCATGCACACCGATTTCAGTTCGCGTT
ACCGACGAGGAAAACAACAA

Downstream 100 bases:

>100_bases
GCCGGGTCCCCCTCCCACCGGGAGGGGGTTGATCGAAAAGTACAGTGTACGGAGAAACACCATGAGCCAGACTCAGGCAG
AACGACTCCAGGCGGAGCGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 1; Arginosuccinase 1

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSQTTDRLWGARFKSGPSAALAALSRCPERYFRLTPYDLAGSKAHAGELQRAGLLDEQETRTMIEALDGIGADFAAGRIA
PTLDDEDVHTFIERLLTERLGALGGKLRAGRSRNDQTANDLRLFLRDHVRTLAVEVLALQTALVDQAEQHVESICPGFTH
LQQAQPIVFAHHLLAHAQSMLRDVQRLMDWDARTSLSPLGAAAMAGSAIARQPQQSAKEMGYAGVCENSIDAVASRDHVA
EFLFIASMLGINISRLAEEFCLWSSRQFRWVDLDDAYATGSSIMPQKKNPDIAELARGKAGRLIGNLTGLLSTLKSLPLS
YNRDLSEDKNGVLDSVDTLLLVLPAMAGMVATMTVNVEELRRQAPLGFTLATEVADWLAVRGVPFKEAHEITGALVQACE
KHDLELWEASPALLAEIDPRLTADVRDSLTLEAAIAARSGWGGTAPQQVREQIGRLKTALAAQQQWTENYQGFRL

Sequences:

>Translated_475_residues
MSQTTDRLWGARFKSGPSAALAALSRCPERYFRLTPYDLAGSKAHAGELQRAGLLDEQETRTMIEALDGIGADFAAGRIA
PTLDDEDVHTFIERLLTERLGALGGKLRAGRSRNDQTANDLRLFLRDHVRTLAVEVLALQTALVDQAEQHVESICPGFTH
LQQAQPIVFAHHLLAHAQSMLRDVQRLMDWDARTSLSPLGAAAMAGSAIARQPQQSAKEMGYAGVCENSIDAVASRDHVA
EFLFIASMLGINISRLAEEFCLWSSRQFRWVDLDDAYATGSSIMPQKKNPDIAELARGKAGRLIGNLTGLLSTLKSLPLS
YNRDLSEDKNGVLDSVDTLLLVLPAMAGMVATMTVNVEELRRQAPLGFTLATEVADWLAVRGVPFKEAHEITGALVQACE
KHDLELWEASPALLAEIDPRLTADVRDSLTLEAAIAARSGWGGTAPQQVREQIGRLKTALAAQQQWTENYQGFRL
>Mature_474_residues
SQTTDRLWGARFKSGPSAALAALSRCPERYFRLTPYDLAGSKAHAGELQRAGLLDEQETRTMIEALDGIGADFAAGRIAP
TLDDEDVHTFIERLLTERLGALGGKLRAGRSRNDQTANDLRLFLRDHVRTLAVEVLALQTALVDQAEQHVESICPGFTHL
QQAQPIVFAHHLLAHAQSMLRDVQRLMDWDARTSLSPLGAAAMAGSAIARQPQQSAKEMGYAGVCENSIDAVASRDHVAE
FLFIASMLGINISRLAEEFCLWSSRQFRWVDLDDAYATGSSIMPQKKNPDIAELARGKAGRLIGNLTGLLSTLKSLPLSY
NRDLSEDKNGVLDSVDTLLLVLPAMAGMVATMTVNVEELRRQAPLGFTLATEVADWLAVRGVPFKEAHEITGALVQACEK
HDLELWEASPALLAEIDPRLTADVRDSLTLEAAIAARSGWGGTAPQQVREQIGRLKTALAAQQQWTENYQGFRL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=464, Percent_Identity=39.4396551724138, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI68303542, Length=464, Percent_Identity=39.4396551724138, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI68303549, Length=464, Percent_Identity=37.2844827586207, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI68303547, Length=464, Percent_Identity=36.8534482758621, Blast_Score=293, Evalue=3e-79,
Organism=Escherichia coli, GI1790398, Length=453, Percent_Identity=40.1766004415011, Blast_Score=311, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6321806, Length=464, Percent_Identity=37.7155172413793, Blast_Score=306, Evalue=4e-84,
Organism=Drosophila melanogaster, GI221473854, Length=458, Percent_Identity=37.5545851528384, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI78706858, Length=458, Percent_Identity=37.5545851528384, Blast_Score=313, Evalue=1e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY1_PSEPF (Q3KCB2)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_348583.1
- ProteinModelPortal:   Q3KCB2
- SMR:   Q3KCB2
- STRING:   Q3KCB2
- GeneID:   3712172
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_2852
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MPGRTHL
- ProtClustDB:   PRK00855
- BioCyc:   PFLU205922:PFL_2852-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51913; Mature: 51781

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTTDRLWGARFKSGPSAALAALSRCPERYFRLTPYDLAGSKAHAGELQRAGLLDEQET
CCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHH
RTMIEALDGIGADFAAGRIAPTLDDEDVHTFIERLLTERLGALGGKLRAGRSRNDQTAND
HHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHH
LRLFLRDHVRTLAVEVLALQTALVDQAEQHVESICPGFTHLQQAQPIVFAHHLLAHAQSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHH
LRDVQRLMDWDARTSLSPLGAAAMAGSAIARQPQQSAKEMGYAGVCENSIDAVASRDHVA
HHHHHHHHCCCHHCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
EFLFIASMLGINISRLAEEFCLWSSRQFRWVDLDDAYATGSSIMPQKKNPDIAELARGKA
HHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCCCCCHHHHHCCCH
GRLIGNLTGLLSTLKSLPLSYNRDLSEDKNGVLDSVDTLLLVLPAMAGMVATMTVNVEEL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECHHHH
RRQAPLGFTLATEVADWLAVRGVPFKEAHEITGALVQACEKHDLELWEASPALLAEIDPR
HHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHCCCC
LTADVRDSLTLEAAIAARSGWGGTAPQQVREQIGRLKTALAAQQQWTENYQGFRL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SQTTDRLWGARFKSGPSAALAALSRCPERYFRLTPYDLAGSKAHAGELQRAGLLDEQET
CCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHH
RTMIEALDGIGADFAAGRIAPTLDDEDVHTFIERLLTERLGALGGKLRAGRSRNDQTAND
HHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHH
LRLFLRDHVRTLAVEVLALQTALVDQAEQHVESICPGFTHLQQAQPIVFAHHLLAHAQSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHH
LRDVQRLMDWDARTSLSPLGAAAMAGSAIARQPQQSAKEMGYAGVCENSIDAVASRDHVA
HHHHHHHHCCCHHCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
EFLFIASMLGINISRLAEEFCLWSSRQFRWVDLDDAYATGSSIMPQKKNPDIAELARGKA
HHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCCCCCHHHHHCCCH
GRLIGNLTGLLSTLKSLPLSYNRDLSEDKNGVLDSVDTLLLVLPAMAGMVATMTVNVEEL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECHHHH
RRQAPLGFTLATEVADWLAVRGVPFKEAHEITGALVQACEKHDLELWEASPALLAEIDPR
HHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHCCCC
LTADVRDSLTLEAAIAARSGWGGTAPQQVREQIGRLKTALAAQQQWTENYQGFRL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA