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The map label for this gene is mmlH [H]

Identifier: 77459023

GI number: 77459023

Start: 3223930

End: 3225219

Strand: Reverse

Name: mmlH [H]

Synonym: Pfl01_2798

Alternate gene names: 77459023

Gene position: 3225219-3223930 (Counterclockwise)

Preceding gene: 77459024

Following gene: 77459022

Centisome position: 50.09

GC content: 57.98

Gene sequence:

>1290_bases
ATGTTCAGCTGGTATCGCCAAATCACTCCTCGGGAGCGCAAAACGTTTTGGGCCTGCTTCGGCGGATGGTCCCTCGACGC
ACTGGAAGTACAAATGTTTGGCCTGGCGATTCCGGCTTTGATCGCCGCGTTCGCCTTGACCAAGGGCGATGCGGGGTTGA
TCAGCGGAGTGACTCTGGTCACGTCAGCTATCGGCGGTTGGGTAGGGGGGACATTGTCCGACCGCTACGGCCGGGTGCGT
ACGCTGCAGTGGATGATTGTGTGGTTCTCCTTTTTTACTTTTCTCTCCGCGTTTGTCACCGGTTTTAACCAGCTCTTGAT
CGTCAAGGCGCTCCAGGGTTTCGGCATCGGCGGCGAGTGGGCAGCGGGTGCAGTATTGATGGCCGAAACCATCAATCCGC
AGTATCGCGGCAAAGTGATGGGCACCGTACAAAGTGCCTGGGCCGTGGGTTGGGGGCTGGCGGTCGGAGTGTTCACACTG
ATTTATTCCCTCGTGCCGCAGGACATGGCGTGGCGCGTGATGTTCCTGGTCGGGCTGCTACCGTCGTTTCTGATTATCTG
GGTGCGTCGTAATGTCGAGGAGCCCGACAGCTTCCAGCGTCTGCAAAAAGAAAACGCCATCCCGCAAAGTTTCTTCAAAT
CCCTGGCCGGCATCTTCCGCCCCGATTTGATCCGCGTAACGCTGTTCGGCGGTCTATTGGGGCTGGGTGCGCACGGTGGT
TATCACGCGGTGATGACCTGGCTGCCAACGTTCCTCAAGACTGAGCGCAATCTGTCCGTACTGAATTCTGGTGGCTACCT
GGCGGTGATCATTTTTGCGTTCTGGTGCGGATGTGTCGTCAGTGGCTTTTTGATCGATCGGATTGGCCGGCGCAAAAACA
TCGTCCTGTTCGCGCTTTGCTGTGTCGTCACGGTGCAGAGTTATGTGTTCTTGCCGCTGACCAATACCCAGATGCTGTTC
CTGGGGTTCCCGCTCGGCTTTTTTGCGGCCGGTATTCCCGCAAGCCTTGGCGCGTTATTCAACGAGCTATACCCGGCAGA
CGTGCGCGGTGCCGGCGTCGGCTTCTGCTACAACTTTGGCCGAGTGCTTTCCGCGGTGTTCCCGTTCCTCGTCGGTCACA
TGAGCGACTCCATGTCCCTTGGATCTGCGATTGGTATCGACGCAGGGATTGCCTATGGCGTTGCGGTGATTGCGGCACTT
TGTCTGCCGGAAACCCGTGGACGCAGCCTCGAAGCTTCGAATACATCGGTGACAGTCACGATCAACGGCAACGAGAGTGC
GCGGGCCTGA

Upstream 100 bases:

>100_bases
CGGTCGCCGCTGGTTTGATCGTTTTGTTTGAGATGACTGGCCCCGAAGCGGCGCGGTTCGCGCTCGGCTGCCTCACGTTC
CGCCTATAAGGATAAGAATC

Downstream 100 bases:

>100_bases
TGCCCATTACCTTCTATTAGATGAACGCTATGACTGATACCTGCTCTACACCGATCACCGGCATCGACTCCCATGCTCAT
GTGTTCAGCCGTGATCTGAA

Product: general substrate transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MFSWYRQITPRERKTFWACFGGWSLDALEVQMFGLAIPALIAAFALTKGDAGLISGVTLVTSAIGGWVGGTLSDRYGRVR
TLQWMIVWFSFFTFLSAFVTGFNQLLIVKALQGFGIGGEWAAGAVLMAETINPQYRGKVMGTVQSAWAVGWGLAVGVFTL
IYSLVPQDMAWRVMFLVGLLPSFLIIWVRRNVEEPDSFQRLQKENAIPQSFFKSLAGIFRPDLIRVTLFGGLLGLGAHGG
YHAVMTWLPTFLKTERNLSVLNSGGYLAVIIFAFWCGCVVSGFLIDRIGRRKNIVLFALCCVVTVQSYVFLPLTNTQMLF
LGFPLGFFAAGIPASLGALFNELYPADVRGAGVGFCYNFGRVLSAVFPFLVGHMSDSMSLGSAIGIDAGIAYGVAVIAAL
CLPETRGRSLEASNTSVTVTINGNESARA

Sequences:

>Translated_429_residues
MFSWYRQITPRERKTFWACFGGWSLDALEVQMFGLAIPALIAAFALTKGDAGLISGVTLVTSAIGGWVGGTLSDRYGRVR
TLQWMIVWFSFFTFLSAFVTGFNQLLIVKALQGFGIGGEWAAGAVLMAETINPQYRGKVMGTVQSAWAVGWGLAVGVFTL
IYSLVPQDMAWRVMFLVGLLPSFLIIWVRRNVEEPDSFQRLQKENAIPQSFFKSLAGIFRPDLIRVTLFGGLLGLGAHGG
YHAVMTWLPTFLKTERNLSVLNSGGYLAVIIFAFWCGCVVSGFLIDRIGRRKNIVLFALCCVVTVQSYVFLPLTNTQMLF
LGFPLGFFAAGIPASLGALFNELYPADVRGAGVGFCYNFGRVLSAVFPFLVGHMSDSMSLGSAIGIDAGIAYGVAVIAAL
CLPETRGRSLEASNTSVTVTINGNESARA
>Mature_429_residues
MFSWYRQITPRERKTFWACFGGWSLDALEVQMFGLAIPALIAAFALTKGDAGLISGVTLVTSAIGGWVGGTLSDRYGRVR
TLQWMIVWFSFFTFLSAFVTGFNQLLIVKALQGFGIGGEWAAGAVLMAETINPQYRGKVMGTVQSAWAVGWGLAVGVFTL
IYSLVPQDMAWRVMFLVGLLPSFLIIWVRRNVEEPDSFQRLQKENAIPQSFFKSLAGIFRPDLIRVTLFGGLLGLGAHGG
YHAVMTWLPTFLKTERNLSVLNSGGYLAVIIFAFWCGCVVSGFLIDRIGRRKNIVLFALCCVVTVQSYVFLPLTNTQMLF
LGFPLGFFAAGIPASLGALFNELYPADVRGAGVGFCYNFGRVLSAVFPFLVGHMSDSMSLGSAIGIDAGIAYGVAVIAAL
CLPETRGRSLEASNTSVTVTINGNESARA

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=446, Percent_Identity=23.7668161434978, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI213021148, Length=444, Percent_Identity=21.8468468468468, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87082404, Length=388, Percent_Identity=24.2268041237113, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082231, Length=203, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790550, Length=401, Percent_Identity=24.9376558603491, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081723, Length=376, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082159, Length=367, Percent_Identity=25.8855585831063, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788942, Length=314, Percent_Identity=24.8407643312102, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788292, Length=340, Percent_Identity=23.8235294117647, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789152, Length=377, Percent_Identity=24.1379310344828, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789941, Length=388, Percent_Identity=27.0618556701031, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46547; Mature: 46547

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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ECCCCCCCC
>Mature Secondary Structure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ECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]