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The map label for this gene is dctA [H]

Identifier: 77458998

GI number: 77458998

Start: 3198114

End: 3199421

Strand: Reverse

Name: dctA [H]

Synonym: Pfl01_2773

Alternate gene names: 77458998

Gene position: 3199421-3198114 (Counterclockwise)

Preceding gene: 77458999

Following gene: 77458997

Centisome position: 49.69

GC content: 53.13

Gene sequence:

>1308_bases
GTGGAAACTTCCAAGTCCCGCTGGTATAGCCAGCTGTATGTGCAGGTGCTGATCGGTATCGTGATCGGTGCAGCAATCGG
TTACTTCGTGCCTGATATTGGAGCCAAGCTCCAACCCTTCGCCGATGGTTTCATCAAGCTGATAAAAATGCTGCTGGCCC
CCATTATCTTCGGTACGGTCGTCGTCGGTATCGCGAAAATGGGCAGTATCAAGGAGGTCGGACGGATTGGCGTAAAAGCG
CTGATCTACTTTGAAATTCTATCGACTATCGCCTTGGTCGTAGGCCTTATCGTGGTGAACATCGTCAAGCCTGGCGTCGG
GATGAACATTAACGTCAACGCGCTCGATGGAAATGCTATCAGCAAGTACAGCCAGGCCGCGAGTGAACAAGGCGGTACAA
TTGATTTCTTCCTTAATATCATTCCCCACACGTTCCTCGGCGCATTCTCCAACGGCGTCATGCTGCAGGTCATTCTGCTT
TCGGTCTTGATGGGAGTTGCCCTGGTTCAGATGGGCGAAACCAGCAAGCCGCTGATCAACACTATTGATTTGTTCCTGCA
AGGCCTGTTCAAGATCGTTGCAATGGTCATGCGCTTGGCGCCGATTGGTGCGGGTGCAGGTATGGCGTTCACTATCGGCA
AGTACGGGATTGGCACCTTGCTGTCACTCGGTCAGTTGCTGATCGCGCTCTACATTACAACCTTGATTTTCATTGTGGTG
GTGCTAGGCACGGTGGCCAGATGGTCAGGCATGCCACTCATGCAGTTTCTCCGTTATTTCAAGGACGAAATTCTCATCAC
TCTTGGCACCTGCTCAACCGAAGCAGTGCTGCCACGCATGATGGTGAAACTTGAAAAACTTGGCTGCAAGAAATCTGTAG
TGGGCATGGTGCTGCCAACGGGATACACCTTCAACGCAGACGGCACCTGCATCTACCTCACCATGGCCGCGATCTTCATC
GCCCAGGCGACCAACACGCCACTGACCTTCGTTGATCAGATGATCCTGCTAGGCGTATTCCTGCTGACATCCAAAGGGTC
AGCTGGTGTCGCGGGTGCGGGGTTTGTCACGCTGGCTGCAACACTCACGACCATCCACTCCATTCCTCTGGTCGGACTCG
TTTTGCTTTTGGGCATTGATCGTTTCTTGAACGAAGCGCGGGCCGTGACCAATCTGATCGGCAATGGCATCGGCACCATC
GCCATTGCCAAGTGGGACAACTCGTTCGATGTCGAGGCTTGCGAACGTGAGATCGCCGCAATGAAGCAAGAAAAGGCGGC
AAGCAAGGCATCGCTGGCGCATAAATAA

Upstream 100 bases:

>100_bases
TTCCTCTATCTGTGGCCTCCTTCAGGGAGGCCGCAGAGTCAGGCGTCACCCACTGATGCCAAGCCACATGCCCATCACAA
AAATAAAATGAGGTGCTTCC

Downstream 100 bases:

>100_bases
ACTACAAAGCGATCCGGTCATTCCCATCTAAACGGTTATGACCGGTAGTGTTTTCCATGCCTTCTTCCGCGTGGAGAGAC
CTGATTGGAAAGATTGATGG

Product: Sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
METSKSRWYSQLYVQVLIGIVIGAAIGYFVPDIGAKLQPFADGFIKLIKMLLAPIIFGTVVVGIAKMGSIKEVGRIGVKA
LIYFEILSTIALVVGLIVVNIVKPGVGMNINVNALDGNAISKYSQAASEQGGTIDFFLNIIPHTFLGAFSNGVMLQVILL
SVLMGVALVQMGETSKPLINTIDLFLQGLFKIVAMVMRLAPIGAGAGMAFTIGKYGIGTLLSLGQLLIALYITTLIFIVV
VLGTVARWSGMPLMQFLRYFKDEILITLGTCSTEAVLPRMMVKLEKLGCKKSVVGMVLPTGYTFNADGTCIYLTMAAIFI
AQATNTPLTFVDQMILLGVFLLTSKGSAGVAGAGFVTLAATLTTIHSIPLVGLVLLLGIDRFLNEARAVTNLIGNGIGTI
AIAKWDNSFDVEACEREIAAMKQEKAASKASLAHK

Sequences:

>Translated_435_residues
METSKSRWYSQLYVQVLIGIVIGAAIGYFVPDIGAKLQPFADGFIKLIKMLLAPIIFGTVVVGIAKMGSIKEVGRIGVKA
LIYFEILSTIALVVGLIVVNIVKPGVGMNINVNALDGNAISKYSQAASEQGGTIDFFLNIIPHTFLGAFSNGVMLQVILL
SVLMGVALVQMGETSKPLINTIDLFLQGLFKIVAMVMRLAPIGAGAGMAFTIGKYGIGTLLSLGQLLIALYITTLIFIVV
VLGTVARWSGMPLMQFLRYFKDEILITLGTCSTEAVLPRMMVKLEKLGCKKSVVGMVLPTGYTFNADGTCIYLTMAAIFI
AQATNTPLTFVDQMILLGVFLLTSKGSAGVAGAGFVTLAATLTTIHSIPLVGLVLLLGIDRFLNEARAVTNLIGNGIGTI
AIAKWDNSFDVEACEREIAAMKQEKAASKASLAHK
>Mature_435_residues
METSKSRWYSQLYVQVLIGIVIGAAIGYFVPDIGAKLQPFADGFIKLIKMLLAPIIFGTVVVGIAKMGSIKEVGRIGVKA
LIYFEILSTIALVVGLIVVNIVKPGVGMNINVNALDGNAISKYSQAASEQGGTIDFFLNIIPHTFLGAFSNGVMLQVILL
SVLMGVALVQMGETSKPLINTIDLFLQGLFKIVAMVMRLAPIGAGAGMAFTIGKYGIGTLLSLGQLLIALYITTLIFIVV
VLGTVARWSGMPLMQFLRYFKDEILITLGTCSTEAVLPRMMVKLEKLGCKKSVVGMVLPTGYTFNADGTCIYLTMAAIFI
AQATNTPLTFVDQMILLGVFLLTSKGSAGVAGAGFVTLAATLTTIHSIPLVGLVLLLGIDRFLNEARAVTNLIGNGIGTI
AIAKWDNSFDVEACEREIAAMKQEKAASKASLAHK

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=470, Percent_Identity=25.1063829787234, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI169790839, Length=423, Percent_Identity=28.3687943262411, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI194239697, Length=509, Percent_Identity=23.7721021611002, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI40254478, Length=450, Percent_Identity=24.8888888888889, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI21314632, Length=433, Percent_Identity=26.0969976905312, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI66773030, Length=403, Percent_Identity=25.3101736972705, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI223468564, Length=285, Percent_Identity=27.0175438596491, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI223468566, Length=285, Percent_Identity=27.0175438596491, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI5032093, Length=285, Percent_Identity=27.719298245614, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI262359914, Length=380, Percent_Identity=28.4210526315789, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI301601644, Length=201, Percent_Identity=31.3432835820896, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789947, Length=406, Percent_Identity=55.4187192118227, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1790514, Length=431, Percent_Identity=37.8190255220418, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1788024, Length=412, Percent_Identity=20.631067961165, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=454, Percent_Identity=27.7533039647577, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=449, Percent_Identity=25.1670378619154, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71983106, Length=469, Percent_Identity=24.7334754797441, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=469, Percent_Identity=24.7334754797441, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193206505, Length=405, Percent_Identity=25.4320987654321, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17541374, Length=427, Percent_Identity=25.2927400468384, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193206654, Length=437, Percent_Identity=21.9679633867277, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583025, Length=459, Percent_Identity=21.5686274509804, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137668, Length=459, Percent_Identity=21.5686274509804, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24583023, Length=459, Percent_Identity=21.5686274509804, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI281360481, Length=471, Percent_Identity=22.5053078556263, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI281360483, Length=471, Percent_Identity=22.5053078556263, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17137666, Length=471, Percent_Identity=22.5053078556263, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46251; Mature: 46251

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]