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The map label for this gene is xanP [H]

Identifier: 77458798

GI number: 77458798

Start: 2949196

End: 2950662

Strand: Reverse

Name: xanP [H]

Synonym: Pfl01_2573

Alternate gene names: 77458798

Gene position: 2950662-2949196 (Counterclockwise)

Preceding gene: 77458799

Following gene: 77458797

Centisome position: 45.83

GC content: 62.3

Gene sequence:

>1467_bases
ATGACCGTCTCTGAAAAAGCCCCGCGCAACAACGATCTGATCTACGGCCTCAACGACCGTCCGCACTTCACCGCAACGGT
GTTTGCCGCCCTGCAACATGTGCTGGCCAGCTTCGTCGGCATCATCACCCCGACCCTGATCATGGGCGGTGCCCTCGGCC
TGCAAAGTGAAATCCCGTACCTGATCAGCATGGCGCTGTTCGTCTCGGGCCTCGGCACCTTCGTTCAGGCCAAGCGCTTC
GGCCCGGTCGGTTCGGGGCTGCTGTGCCTGCAAGGCACCAGTTTTTCCTTTATCAGCGTGATTCTCAGCGCCGGTTTCAT
GGTCAAGGCCCGGGGCGGCGGCACCGATGAGATTCTGTCGACGATCTTCGGCGTATGCTTCTTTGCCGCCTTCATCGAAG
TGGTGCTGAGCCAGTTCATCGGCAAATTGCGCATGCTGATCACCCCGGTGGTGACCGGCACCATCATTACTCTGATGGGC
CTGTCGCTGATCAAGGTGGCGATGACCGACATTGCCGGCGGCTTCGGCGCGGCGGATCTGGGCGCGGCCAGCCATGTGTT
CCTGGCGGCGCTGGTGCTGGGCACCATTGTGGTGTTGAACCGGGTTGACGTGCCGTTCCTGCGCCTGGGGGCGATTGTCA
TCGGCCTGACCCTCGGCTACGTGGTGGCGTGGCTGATGGGCACCGTTGATTTCGCCAACCTGCCCGAAGTGCCGGTGGTC
AGCGTGCCGGTGCCGTTCAAATACGGTTTCAACTTTGATTGGGTGGCGTTCGTGCCGGTAGCGGTGATTTTCCTGGTGTC
GCCGCTGGAGGCTGCCGGTGACCTGACCGCCAACTCGATGATTTCCCGGCAACCGGTGAAAGGCCCGCTGTACATCCGCC
GGATCAAGTCCGGGCTGCTCGCCGATGGTCTCAACTCGGCCATGGCCGCCGTGTTCAACAGCATGCCGATGGTGACTTTC
GCCCAGAACAACGGGGTGATACAGCTCACCGGCGTGGCCAGCCGCTACGTGGCGTTCTTCATCGCCGGCCTGCTGGTGCT
GCTGGGGCTGTTCCCGATGATCGGCGCGGTGCTGCAACTGATGCCGAAACCGGTACTCGGCGGCGCAGAGCTGGTGATGT
TCGGCACCGTGGCCGTCGCCGGGATCAAGATCCTCGCCGAGGCCGGCCTGCATCGGCGCAACATGCTCATCGTGGCGATT
TCCGTGGGCATGGGCCTGGGCATCGCCGCCGTGCCGGAAGTGCTGCGTGAACTGCCGCAGGCGCTGCGCAACATCTTCGA
ATCGCCGATCACCGTCGGTGCGCTGTGCGCCATCGTGCTGAATATCTTCCTGCCGGAAGAATTCATCGAACTGGAAGAAG
ATGACTTCGACCCGGAAGCCTCTATCCTTCAGGTCATGGAAAACCCCGACCTGCCGGCCAAAGCTGAACCCGCAACCAAG
GCCGCTGTCGCACAGTTGAACCGTTGA

Upstream 100 bases:

>100_bases
CAGAGCGTGGGAACGATCATGCGTTGCCCTCGCCCCTCGCTTACGGCATCCTGCGCACCCATTTTCCGACCCGGCCCCGC
ATTGCGGCACGCAAACCACC

Downstream 100 bases:

>100_bases
TCCTGTCCGCTCGATGAAAAAAGGGCTGATACCGGCGACGGTTCAGCCCTTTTTCAATGAGAGAGCATCAATGCGCCGTA
TCCAAGCCGTCATCCTGTCC

Product: xanthine/uracil permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTVSEKAPRNNDLIYGLNDRPHFTATVFAALQHVLASFVGIITPTLIMGGALGLQSEIPYLISMALFVSGLGTFVQAKRF
GPVGSGLLCLQGTSFSFISVILSAGFMVKARGGGTDEILSTIFGVCFFAAFIEVVLSQFIGKLRMLITPVVTGTIITLMG
LSLIKVAMTDIAGGFGAADLGAASHVFLAALVLGTIVVLNRVDVPFLRLGAIVIGLTLGYVVAWLMGTVDFANLPEVPVV
SVPVPFKYGFNFDWVAFVPVAVIFLVSPLEAAGDLTANSMISRQPVKGPLYIRRIKSGLLADGLNSAMAAVFNSMPMVTF
AQNNGVIQLTGVASRYVAFFIAGLLVLLGLFPMIGAVLQLMPKPVLGGAELVMFGTVAVAGIKILAEAGLHRRNMLIVAI
SVGMGLGIAAVPEVLRELPQALRNIFESPITVGALCAIVLNIFLPEEFIELEEDDFDPEASILQVMENPDLPAKAEPATK
AAVAQLNR

Sequences:

>Translated_488_residues
MTVSEKAPRNNDLIYGLNDRPHFTATVFAALQHVLASFVGIITPTLIMGGALGLQSEIPYLISMALFVSGLGTFVQAKRF
GPVGSGLLCLQGTSFSFISVILSAGFMVKARGGGTDEILSTIFGVCFFAAFIEVVLSQFIGKLRMLITPVVTGTIITLMG
LSLIKVAMTDIAGGFGAADLGAASHVFLAALVLGTIVVLNRVDVPFLRLGAIVIGLTLGYVVAWLMGTVDFANLPEVPVV
SVPVPFKYGFNFDWVAFVPVAVIFLVSPLEAAGDLTANSMISRQPVKGPLYIRRIKSGLLADGLNSAMAAVFNSMPMVTF
AQNNGVIQLTGVASRYVAFFIAGLLVLLGLFPMIGAVLQLMPKPVLGGAELVMFGTVAVAGIKILAEAGLHRRNMLIVAI
SVGMGLGIAAVPEVLRELPQALRNIFESPITVGALCAIVLNIFLPEEFIELEEDDFDPEASILQVMENPDLPAKAEPATK
AAVAQLNR
>Mature_487_residues
TVSEKAPRNNDLIYGLNDRPHFTATVFAALQHVLASFVGIITPTLIMGGALGLQSEIPYLISMALFVSGLGTFVQAKRFG
PVGSGLLCLQGTSFSFISVILSAGFMVKARGGGTDEILSTIFGVCFFAAFIEVVLSQFIGKLRMLITPVVTGTIITLMGL
SLIKVAMTDIAGGFGAADLGAASHVFLAALVLGTIVVLNRVDVPFLRLGAIVIGLTLGYVVAWLMGTVDFANLPEVPVVS
VPVPFKYGFNFDWVAFVPVAVIFLVSPLEAAGDLTANSMISRQPVKGPLYIRRIKSGLLADGLNSAMAAVFNSMPMVTFA
QNNGVIQLTGVASRYVAFFIAGLLVLLGLFPMIGAVLQLMPKPVLGGAELVMFGTVAVAGIKILAEAGLHRRNMLIVAIS
VGMGLGIAAVPEVLRELPQALRNIFESPITVGALCAIVLNIFLPEEFIELEEDDFDPEASILQVMENPDLPAKAEPATKA
AVAQLNR

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=549, Percent_Identity=24.9544626593807, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI40316845, Length=549, Percent_Identity=24.9544626593807, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790087, Length=444, Percent_Identity=45.4954954954955, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI87082178, Length=450, Percent_Identity=46.4444444444444, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI87082181, Length=419, Percent_Identity=32.2195704057279, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1788843, Length=462, Percent_Identity=27.0562770562771, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87081818, Length=451, Percent_Identity=25.0554323725055, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=486, Percent_Identity=25.1028806584362, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17541904, Length=481, Percent_Identity=22.6611226611227, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=395, Percent_Identity=24.5569620253165, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 51508; Mature: 51377

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCC
>Mature Secondary Structure 
TVSEKAPRNNDLIYGLNDRPHFTATVFAALQHVLASFVGIITPTLIMGGALGLQSEIPY
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH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HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]