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The map label for this gene is lgrB [H]

Identifier: 77458493

GI number: 77458493

Start: 2607835

End: 2611944

Strand: Direct

Name: lgrB [H]

Synonym: Pfl01_2266

Alternate gene names: 77458493

Gene position: 2607835-2611944 (Clockwise)

Preceding gene: 77458492

Following gene: 77458494

Centisome position: 40.5

GC content: 64.7

Gene sequence:

>4110_bases
ATGAATGCCGATCAATTGCTGGCGTTGTTCGCTCGCCATGGCGTGGTGCTCGAAGTGGACGGTGACAGGCTGCGCTGCAA
GGCGCCGCGCGGGTTTCTCACCGAAGAACTGACCCAGGCGCTCAAGCGTCACAAACAGGAACTGATCGCCTTGCTCGGCG
GGCACGATGACGCGGTAATTCCGCGCCGTGCTGGCGCGCACGGGTCCTGGCCGTTGTCGTTCTCGCAGCGGCAACTGTGG
TTTCTCGATCAATTGGAACCCGGCAACCCGTTCTACAACGTGCCCACGGCGGTAACGCTCAAAGGGCAGTTGAACGTCGC
GCAGCTGGAACGAGCGCTGAACCAACTGGTGGCCCGCCACGAAGTCCTGCGCACGACGTTTGGCAGCGTGGACGGAGAAC
CGCGTCAGGTGGTGCATCCGTCGATGCCGCTGTCGTTGTCGGTGACGGATCTGCGCCAGTTGCCTGGCGACGAGCGTGAG
CAGCAAGTGCGATTTGCCGTCGAACAGGACGCACGGGCGCCATTCGATCTGGCCACCGGCCCATTGTTGCGGGCGTCGTT
ACTGCGCGTGGCTGACGATGAATACCTGTGGCTGTACAGCGTGCATCACATCATCGCCGACGGCTGGTCGATGGGCGTGA
TCCTGCACGAAGTCGCCACGTTGTACGGCGATTATCTGCGTGGTGAAACCCCGACGCTTGCGCCGTTGCCGGTGCAATAC
GCCGACTACGCCTGCTGGCAGCAGCGCATCGGCGGTGCGGCGCTGGACGCTCAGCTCGATTACTGGCGTCGCACCCTGGA
CGACGCGCCGCTGTTGTCGACCCTGCCTGCCGACCGGCCGCGACCGCTGGTGCAGCGTTATGTCGGCGCCACGTTCAGTT
CCTCCGTCGATGGCGACACTTTGCGTGAACTCACGGCGCTGGCCCGGCAGACCCAGGGCACGCTGTTCAACGTGCTGCTC
GGTGCTTTAGCGGTGCTGCTGTGGCGCCACAGCGGTCAGCAGGACTTGTGCGTCGGCACGCCGTTCGCCAACCGCAATCG
TCCGGAAGTCGAGCCGCTGATCGGCCATTTCGTCAATACGTTGGTGCTGCGCCAGCGCCTGAATCCGCAGCAAACCTTCG
CCGAGCTGCTGCGCGAGGTGCGGGGTCAGATGCTCGACGTCCACGCCCATCAGGACGTGCCATTCGACCGCGTGGTCGAG
GCCGTCAACCCGCAGCGCGATCCCGGCCATTCGCCGTTGTTCCAGGTGATGCTGGTGTTGCAGAACACACCGGGCAACGC
GGTGCAGATGCCCGGCCTGGAACTGGCGCCGTACGGCACCAGCAGTGCCACGGCCAAGTTCGATCTGGCGTTCGAGTGGG
TCGAGCGGGCAGGGCGGCTGGACTTGCTGGTGGAATACAACACGGACCTCTACGACGTTGCGACCATTGAACGCCTGAGC
GGGCACTACCGCCACCTGCTCGAACAGATCGCCGCCGACGCCAAGCAACCGATCAATGCCTTGCCGCTGATGAATGAGGC
CGAGCGACAGCAGGTGCTGGTCGACTTCAACCGCGCCGCGCCGCTGACGCAAGCGGCGCCCTGCGTGCATCAACTGGTCG
AAGCGCAGGTCGCGAGCAATCCTCAGGCCTGCGCGGTGATATTTGAAGGCCAGTCGCTGAGCTATGCCGAGCTCAATGCA
CGGGCCAACCGACTGGCGCGGCATTTGCGCACCTTGGGCGTCGGTCCGGACGTGCGCGTGGCGGTGTGCATCGAGCGTTC
GCTGGAATTGCCAGTGGCGCTGCTGGCGGTGCTCAAGGCCGGCGGCGCCTACGTGCCGCTGGACCCGGACTATCCGCTGG
GACGCCTGAGTCATATGCTCGGCGACAGCACGCCGGCGGTGCTGCTGACCCTTGGCTCGGCGCACGGAATCTTGCGTCAG
GCCGTGCAAGGCTCGACCTGGGAAGCGCCGATCCTCGACCTCGAAAAAGATGCGGGGAACTGGGCGTCGTTGCCGGCGGA
CAATCTCGATCCGCGCAATGTCGGCGTTACCCCTGACCATCTCGCCTATGTCATCTACACCTCCGGCACCACCGGCTTGC
CCAAGGGCGCGATGGTCGCCCACCGTGGCTTGAGCAATCTGCTGTTGTGGTGTTTGCAGGTCTGCGGCGAGGCGGGGGCG
ATGTTGCACAAGATCCCGTTCGGTTTCGATGCTTCGGCATGGGAGACCTTCTGGCCGCTGGCAACCGGCGGGCGGCTGGT
GATCGCACGGCCCGGCGGCCATTACGAACCGGCGTACCTGGCCCGCGAGGTGCGCGAGCAACAGGTCACGGCGCTGGTGT
TCGTGCCAGCGATGTTGCAGCTGTTTCTGGAGGTCGACGAGGTCAGCCAATGTGTGTCGCTGACCGATGTGTTCAGCGGC
GGCGGTGAACTGCCGCCGGCTCTGGCCCGGCGCTTCCAGGAGCGTCTGCCCCGTGCGCGGCTGCACAATGTCTACGGCCC
GACCGAAACCACGGTGATCAACAGCATCTGGACCCTGGAGCCCGGCGCCGAGGTGCCGGCCCGGCAATTGCCGATCGGCC
GGCCGATTGCCAACAACCGCTTTTATGTTCTTGATGACCGCGACCAGCCGGTGCCGGTGGGCGTGACCGGGCATCTGCAC
ATTGGTGGTGTGGGTGTGGCCCGGGGTTATCTGGGGCTGGCGCAACTGAGTGCCGAGCGCTTTATCGACAATCCGTTCGT
GGCAGGTGATCGGCTCTATCGCAGTGGCGATCTGGCGCGCTACCGCCCGGACGGTCAGCTGGAATTTCTCGGTCGCAACG
ACTTTCAGGTCAAGTTGCGTGGCGTGCGCCTGGAACTGGGCGAAATCGAAGCCCGGCTCGAAGCGTTTCCCGGCATCCGC
AGCGCCGTGGTGTTGATGGTCGGCGAAGCGGCACAGGATCAGCGGCTGGTGGCCTGCTGTGTGGTGGCCGAACCCGTTGA
CGAAGCAGCGGTGCACGCCCATCTGGCGACAACCCTGCCCAGAGCCGTAATCCCCGGCAGCTATCTGTGGCTCGACGCGC
TGCCGCTGACTGCCAATGGCAAGGTTGATCGCACTGCGCTGACGGCATTGGCGGACGAAGAATTGGTCAATCGTCAGGTC
AACCTGAGCAGCCCGCGCGATCACATCGAGCTGGCGCTGTACCAGATCTGGAAAAGCCTGTTGCTGGCGCCGCAGATCGG
CATTCGCGACAACTTCTTCAATGTCGGCGGCACCTCCATCGCCGCGATCAAAATGGCCCATGAAATCAGCCAGCAGTTTT
CGGTCGAAGTGCCGGTGCGCGTGGTGCTCAGCTACCCGACCATCGAAGCGCTGGGCGGCTGGCTGCGGGTCGGGGCCAAC
CCGGCGCTGGCCCAGAGCAACCTGATCGAATTCCGGCGCGGCAGCGGCCAGCACAACGTGGTGTGCATTCACCCGGCGGG
CGGCACGGCGTTCTGTTACCTGTCGCTGGCCAAGGTGCTGCCGGATGCAACTGGCGTCTACGGGGTGCAATCGCCGGGGT
TGAATCCGGGGGAGAGCACCGAGCCGACGGTCGAAGCGATGGCCGAGGCTTACTTGCGCCAGATCGAACCGCTGACGCGG
CAACCTTTGATCCTCACCGGGCTGTCGTTCGGTGGTCTGGTGGCCTATCAAATGGCGCAGCGGTTGACGGCGGCCGGGCA
TCGTCAGGTGACCGTGGTGCTGCTCGACACTCAGGGCAGCGACGATCCGGGTTTCCGCGAGCAGATCGGCACCGTGGACA
TGGCCGAGTTCCGCGACAAGCTGGTGCGTTTCAACGGCATGTACCCCGGCATCGAAGACGCCCAGGTCGAACGCTACTTC
AACATCTACAACCACAACCGCCTGGCCATGGCCGCCTATGAGTGCGCACCGCGCGCCGGTCGCGTGGTGCTGATCCAGGC
CCGGGAAGATTTCAGCCGCCATCAGTTGCATGAACTGCGTGGCTTCTGGCGGCGCCGCGCGGGTAGCGGCTATCTGGCGA
AACTGGTCAGCGGCGGGCACTGGGACATGCTCGAAAGCGCGGAAATCCACCGGGTCTCGCAAATCATCCGTCGGGAGCTG
CAACGCTTCGACGCGCAGGAGGCGAAATGA

Upstream 100 bases:

>100_bases
TGCGCACAGCCGATGAACAACACCGCGCGTCGGTCGAGGCGTTTGCCATCGAGCCTGTGCCCGCCAGCCTGGACGACGAA
GACATGGAGGAGTTCGAAGT

Downstream 100 bases:

>100_bases
TGAGTGCGTCCAAAGACATGCCGTTGCTCGCACGTTTTGCCGAGCAAGTGGCGTGTAATCCTCAAGCCCCGGCGGTGATC
GATCAATCGCTCACGTTGAC

Product: amino acid adenylation

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent alanine adenylase; AlaA; Alanine activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent alanine adenylase; AlaA; Alanine activase; ATP-dependent D-valine adenylase; D-ValA; D-valine activase; Valine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 1369; Mature: 1369

Protein sequence:

>1369_residues
MNADQLLALFARHGVVLEVDGDRLRCKAPRGFLTEELTQALKRHKQELIALLGGHDDAVIPRRAGAHGSWPLSFSQRQLW
FLDQLEPGNPFYNVPTAVTLKGQLNVAQLERALNQLVARHEVLRTTFGSVDGEPRQVVHPSMPLSLSVTDLRQLPGDERE
QQVRFAVEQDARAPFDLATGPLLRASLLRVADDEYLWLYSVHHIIADGWSMGVILHEVATLYGDYLRGETPTLAPLPVQY
ADYACWQQRIGGAALDAQLDYWRRTLDDAPLLSTLPADRPRPLVQRYVGATFSSSVDGDTLRELTALARQTQGTLFNVLL
GALAVLLWRHSGQQDLCVGTPFANRNRPEVEPLIGHFVNTLVLRQRLNPQQTFAELLREVRGQMLDVHAHQDVPFDRVVE
AVNPQRDPGHSPLFQVMLVLQNTPGNAVQMPGLELAPYGTSSATAKFDLAFEWVERAGRLDLLVEYNTDLYDVATIERLS
GHYRHLLEQIAADAKQPINALPLMNEAERQQVLVDFNRAAPLTQAAPCVHQLVEAQVASNPQACAVIFEGQSLSYAELNA
RANRLARHLRTLGVGPDVRVAVCIERSLELPVALLAVLKAGGAYVPLDPDYPLGRLSHMLGDSTPAVLLTLGSAHGILRQ
AVQGSTWEAPILDLEKDAGNWASLPADNLDPRNVGVTPDHLAYVIYTSGTTGLPKGAMVAHRGLSNLLLWCLQVCGEAGA
MLHKIPFGFDASAWETFWPLATGGRLVIARPGGHYEPAYLAREVREQQVTALVFVPAMLQLFLEVDEVSQCVSLTDVFSG
GGELPPALARRFQERLPRARLHNVYGPTETTVINSIWTLEPGAEVPARQLPIGRPIANNRFYVLDDRDQPVPVGVTGHLH
IGGVGVARGYLGLAQLSAERFIDNPFVAGDRLYRSGDLARYRPDGQLEFLGRNDFQVKLRGVRLELGEIEARLEAFPGIR
SAVVLMVGEAAQDQRLVACCVVAEPVDEAAVHAHLATTLPRAVIPGSYLWLDALPLTANGKVDRTALTALADEELVNRQV
NLSSPRDHIELALYQIWKSLLLAPQIGIRDNFFNVGGTSIAAIKMAHEISQQFSVEVPVRVVLSYPTIEALGGWLRVGAN
PALAQSNLIEFRRGSGQHNVVCIHPAGGTAFCYLSLAKVLPDATGVYGVQSPGLNPGESTEPTVEAMAEAYLRQIEPLTR
QPLILTGLSFGGLVAYQMAQRLTAAGHRQVTVVLLDTQGSDDPGFREQIGTVDMAEFRDKLVRFNGMYPGIEDAQVERYF
NIYNHNRLAMAAYECAPRAGRVVLIQAREDFSRHQLHELRGFWRRRAGSGYLAKLVSGGHWDMLESAEIHRVSQIIRREL
QRFDAQEAK

Sequences:

>Translated_1369_residues
MNADQLLALFARHGVVLEVDGDRLRCKAPRGFLTEELTQALKRHKQELIALLGGHDDAVIPRRAGAHGSWPLSFSQRQLW
FLDQLEPGNPFYNVPTAVTLKGQLNVAQLERALNQLVARHEVLRTTFGSVDGEPRQVVHPSMPLSLSVTDLRQLPGDERE
QQVRFAVEQDARAPFDLATGPLLRASLLRVADDEYLWLYSVHHIIADGWSMGVILHEVATLYGDYLRGETPTLAPLPVQY
ADYACWQQRIGGAALDAQLDYWRRTLDDAPLLSTLPADRPRPLVQRYVGATFSSSVDGDTLRELTALARQTQGTLFNVLL
GALAVLLWRHSGQQDLCVGTPFANRNRPEVEPLIGHFVNTLVLRQRLNPQQTFAELLREVRGQMLDVHAHQDVPFDRVVE
AVNPQRDPGHSPLFQVMLVLQNTPGNAVQMPGLELAPYGTSSATAKFDLAFEWVERAGRLDLLVEYNTDLYDVATIERLS
GHYRHLLEQIAADAKQPINALPLMNEAERQQVLVDFNRAAPLTQAAPCVHQLVEAQVASNPQACAVIFEGQSLSYAELNA
RANRLARHLRTLGVGPDVRVAVCIERSLELPVALLAVLKAGGAYVPLDPDYPLGRLSHMLGDSTPAVLLTLGSAHGILRQ
AVQGSTWEAPILDLEKDAGNWASLPADNLDPRNVGVTPDHLAYVIYTSGTTGLPKGAMVAHRGLSNLLLWCLQVCGEAGA
MLHKIPFGFDASAWETFWPLATGGRLVIARPGGHYEPAYLAREVREQQVTALVFVPAMLQLFLEVDEVSQCVSLTDVFSG
GGELPPALARRFQERLPRARLHNVYGPTETTVINSIWTLEPGAEVPARQLPIGRPIANNRFYVLDDRDQPVPVGVTGHLH
IGGVGVARGYLGLAQLSAERFIDNPFVAGDRLYRSGDLARYRPDGQLEFLGRNDFQVKLRGVRLELGEIEARLEAFPGIR
SAVVLMVGEAAQDQRLVACCVVAEPVDEAAVHAHLATTLPRAVIPGSYLWLDALPLTANGKVDRTALTALADEELVNRQV
NLSSPRDHIELALYQIWKSLLLAPQIGIRDNFFNVGGTSIAAIKMAHEISQQFSVEVPVRVVLSYPTIEALGGWLRVGAN
PALAQSNLIEFRRGSGQHNVVCIHPAGGTAFCYLSLAKVLPDATGVYGVQSPGLNPGESTEPTVEAMAEAYLRQIEPLTR
QPLILTGLSFGGLVAYQMAQRLTAAGHRQVTVVLLDTQGSDDPGFREQIGTVDMAEFRDKLVRFNGMYPGIEDAQVERYF
NIYNHNRLAMAAYECAPRAGRVVLIQAREDFSRHQLHELRGFWRRRAGSGYLAKLVSGGHWDMLESAEIHRVSQIIRREL
QRFDAQEAK
>Mature_1369_residues
MNADQLLALFARHGVVLEVDGDRLRCKAPRGFLTEELTQALKRHKQELIALLGGHDDAVIPRRAGAHGSWPLSFSQRQLW
FLDQLEPGNPFYNVPTAVTLKGQLNVAQLERALNQLVARHEVLRTTFGSVDGEPRQVVHPSMPLSLSVTDLRQLPGDERE
QQVRFAVEQDARAPFDLATGPLLRASLLRVADDEYLWLYSVHHIIADGWSMGVILHEVATLYGDYLRGETPTLAPLPVQY
ADYACWQQRIGGAALDAQLDYWRRTLDDAPLLSTLPADRPRPLVQRYVGATFSSSVDGDTLRELTALARQTQGTLFNVLL
GALAVLLWRHSGQQDLCVGTPFANRNRPEVEPLIGHFVNTLVLRQRLNPQQTFAELLREVRGQMLDVHAHQDVPFDRVVE
AVNPQRDPGHSPLFQVMLVLQNTPGNAVQMPGLELAPYGTSSATAKFDLAFEWVERAGRLDLLVEYNTDLYDVATIERLS
GHYRHLLEQIAADAKQPINALPLMNEAERQQVLVDFNRAAPLTQAAPCVHQLVEAQVASNPQACAVIFEGQSLSYAELNA
RANRLARHLRTLGVGPDVRVAVCIERSLELPVALLAVLKAGGAYVPLDPDYPLGRLSHMLGDSTPAVLLTLGSAHGILRQ
AVQGSTWEAPILDLEKDAGNWASLPADNLDPRNVGVTPDHLAYVIYTSGTTGLPKGAMVAHRGLSNLLLWCLQVCGEAGA
MLHKIPFGFDASAWETFWPLATGGRLVIARPGGHYEPAYLAREVREQQVTALVFVPAMLQLFLEVDEVSQCVSLTDVFSG
GGELPPALARRFQERLPRARLHNVYGPTETTVINSIWTLEPGAEVPARQLPIGRPIANNRFYVLDDRDQPVPVGVTGHLH
IGGVGVARGYLGLAQLSAERFIDNPFVAGDRLYRSGDLARYRPDGQLEFLGRNDFQVKLRGVRLELGEIEARLEAFPGIR
SAVVLMVGEAAQDQRLVACCVVAEPVDEAAVHAHLATTLPRAVIPGSYLWLDALPLTANGKVDRTALTALADEELVNRQV
NLSSPRDHIELALYQIWKSLLLAPQIGIRDNFFNVGGTSIAAIKMAHEISQQFSVEVPVRVVLSYPTIEALGGWLRVGAN
PALAQSNLIEFRRGSGQHNVVCIHPAGGTAFCYLSLAKVLPDATGVYGVQSPGLNPGESTEPTVEAMAEAYLRQIEPLTR
QPLILTGLSFGGLVAYQMAQRLTAAGHRQVTVVLLDTQGSDDPGFREQIGTVDMAEFRDKLVRFNGMYPGIEDAQVERYF
NIYNHNRLAMAAYECAPRAGRVVLIQAREDFSRHQLHELRGFWRRRAGSGYLAKLVSGGHWDMLESAEIHRVSQIIRREL
QRFDAQEAK

Specific function: Activates the 3rd to 6th amino acids (Ala, D-Leu, Ala and D-Val) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 4th (D-Leu) and the 6th (D-Val) amino acids [H

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=575, Percent_Identity=24.695652173913, Blast_Score=122, Evalue=3e-27,
Organism=Homo sapiens, GI156151445, Length=558, Percent_Identity=23.6559139784946, Blast_Score=78, Evalue=7e-14,
Organism=Escherichia coli, GI1786801, Length=1349, Percent_Identity=29.8739807264641, Blast_Score=423, Evalue=1e-119,
Organism=Escherichia coli, GI1786810, Length=502, Percent_Identity=27.6892430278884, Blast_Score=107, Evalue=5e-24,
Organism=Escherichia coli, GI145693145, Length=519, Percent_Identity=24.0847784200385, Blast_Score=91, Evalue=5e-19,
Organism=Escherichia coli, GI221142682, Length=503, Percent_Identity=23.0616302186879, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1790505, Length=592, Percent_Identity=23.4797297297297, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17550940, Length=1233, Percent_Identity=21.735604217356, Blast_Score=194, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17556356, Length=1208, Percent_Identity=23.6754966887417, Blast_Score=189, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI32563687, Length=523, Percent_Identity=23.9005736137667, Blast_Score=98, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=622, Percent_Identity=21.5434083601286, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994703, Length=542, Percent_Identity=21.9557195571956, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994694, Length=542, Percent_Identity=21.9557195571956, Blast_Score=81, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI32564422, Length=356, Percent_Identity=24.7191011235955, Blast_Score=77, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI32564420, Length=356, Percent_Identity=24.7191011235955, Blast_Score=77, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319591, Length=967, Percent_Identity=24.8190279214064, Blast_Score=239, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319699, Length=563, Percent_Identity=22.0248667850799, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648676, Length=613, Percent_Identity=29.2006525285481, Blast_Score=195, Evalue=2e-49,
Organism=Drosophila melanogaster, GI18859661, Length=523, Percent_Identity=24.282982791587, Blast_Score=84, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20130357, Length=496, Percent_Identity=24.3951612903226, Blast_Score=79, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581924, Length=560, Percent_Identity=23.2142857142857, Blast_Score=79, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24582852, Length=598, Percent_Identity=22.4080267558528, Blast_Score=77, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356947, Length=496, Percent_Identity=20.1612903225806, Blast_Score=72, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 150785; Mature: 150785

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNADQLLALFARHGVVLEVDGDRLRCKAPRGFLTEELTQALKRHKQELIALLGGHDDAVI
CCHHHHHHHHHHCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PRRAGAHGSWPLSFSQRQLWFLDQLEPGNPFYNVPTAVTLKGQLNVAQLERALNQLVARH
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
EVLRTTFGSVDGEPRQVVHPSMPLSLSVTDLRQLPGDEREQQVRFAVEQDARAPFDLATG
HHHHHHHCCCCCCCCEEECCCCCCEEEHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
PLLRASLLRVADDEYLWLYSVHHIIADGWSMGVILHEVATLYGDYLRGETPTLAPLPVQY
HHHHHHHHHHCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
ADYACWQQRIGGAALDAQLDYWRRTLDDAPLLSTLPADRPRPLVQRYVGATFSSSVDGDT
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHCCCCCCCCCHHH
LRELTALARQTQGTLFNVLLGALAVLLWRHSGQQDLCVGTPFANRNRPEVEPLIGHFVNT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
LVLRQRLNPQQTFAELLREVRGQMLDVHAHQDVPFDRVVEAVNPQRDPGHSPLFQVMLVL
HHHHHCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHH
QNTPGNAVQMPGLELAPYGTSSATAKFDLAFEWVERAGRLDLLVEYNTDLYDVATIERLS
CCCCCCEEECCCCEECCCCCCCCCEEEHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHH
GHYRHLLEQIAADAKQPINALPLMNEAERQQVLVDFNRAAPLTQAAPCVHQLVEAQVASN
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHCC
PQACAVIFEGQSLSYAELNARANRLARHLRTLGVGPDVRVAVCIERSLELPVALLAVLKA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHC
GGAYVPLDPDYPLGRLSHMLGDSTPAVLLTLGSAHGILRQAVQGSTWEAPILDLEKDAGN
CCCEECCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCEECCCCCCC
WASLPADNLDPRNVGVTPDHLAYVIYTSGTTGLPKGAMVAHRGLSNLLLWCLQVCGEAGA
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHCHHCH
MLHKIPFGFDASAWETFWPLATGGRLVIARPGGHYEPAYLAREVREQQVTALVFVPAMLQ
HHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFLEVDEVSQCVSLTDVFSGGGELPPALARRFQERLPRARLHNVYGPTETTVINSIWTLE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHEEEEC
PGAEVPARQLPIGRPIANNRFYVLDDRDQPVPVGVTGHLHIGGVGVARGYLGLAQLSAER
CCCCCCHHHCCCCCCCCCCEEEEECCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHH
FIDNPFVAGDRLYRSGDLARYRPDGQLEFLGRNDFQVKLRGVRLELGEIEARLEAFPGIR
HCCCCCCCCCHHCCCCCCCEECCCCCEEEECCCCEEEEEEEEEEEHHHHHHHHHHCCCHH
SAVVLMVGEAAQDQRLVACCVVAEPVDEAAVHAHLATTLPRAVIPGSYLWLDALPLTANG
HEEHEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHCCCCEEEEECEEECCCC
KVDRTALTALADEELVNRQVNLSSPRDHIELALYQIWKSLLLAPQIGIRDNFFNVGGTSI
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
AAIKMAHEISQQFSVEVPVRVVLSYPTIEALGGWLRVGANPALAQSNLIEFRRGSGQHNV
HHHHHHHHHHHHCCCCCCEEEEEECCCHHHCCCHHEECCCHHHHHHHHHHHHCCCCCCCE
VCIHPAGGTAFCYLSLAKVLPDATGVYGVQSPGLNPGESTEPTVEAMAEAYLRQIEPLTR
EEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
QPLILTGLSFGGLVAYQMAQRLTAAGHRQVTVVLLDTQGSDDPGFREQIGTVDMAEFRDK
CCEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHCCCCHHHHHHH
LVRFNGMYPGIEDAQVERYFNIYNHNRLAMAAYECAPRAGRVVLIQAREDFSRHQLHELR
HHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHCCCCCCCEEEEEECCCHHHHHHHHHH
GFWRRRAGSGYLAKLVSGGHWDMLESAEIHRVSQIIRRELQRFDAQEAK
HHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNADQLLALFARHGVVLEVDGDRLRCKAPRGFLTEELTQALKRHKQELIALLGGHDDAVI
CCHHHHHHHHHHCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PRRAGAHGSWPLSFSQRQLWFLDQLEPGNPFYNVPTAVTLKGQLNVAQLERALNQLVARH
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
EVLRTTFGSVDGEPRQVVHPSMPLSLSVTDLRQLPGDEREQQVRFAVEQDARAPFDLATG
HHHHHHHCCCCCCCCEEECCCCCCEEEHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
PLLRASLLRVADDEYLWLYSVHHIIADGWSMGVILHEVATLYGDYLRGETPTLAPLPVQY
HHHHHHHHHHCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
ADYACWQQRIGGAALDAQLDYWRRTLDDAPLLSTLPADRPRPLVQRYVGATFSSSVDGDT
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHCCCCCCCCCHHH
LRELTALARQTQGTLFNVLLGALAVLLWRHSGQQDLCVGTPFANRNRPEVEPLIGHFVNT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
LVLRQRLNPQQTFAELLREVRGQMLDVHAHQDVPFDRVVEAVNPQRDPGHSPLFQVMLVL
HHHHHCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHH
QNTPGNAVQMPGLELAPYGTSSATAKFDLAFEWVERAGRLDLLVEYNTDLYDVATIERLS
CCCCCCEEECCCCEECCCCCCCCCEEEHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHH
GHYRHLLEQIAADAKQPINALPLMNEAERQQVLVDFNRAAPLTQAAPCVHQLVEAQVASN
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHCC
PQACAVIFEGQSLSYAELNARANRLARHLRTLGVGPDVRVAVCIERSLELPVALLAVLKA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHC
GGAYVPLDPDYPLGRLSHMLGDSTPAVLLTLGSAHGILRQAVQGSTWEAPILDLEKDAGN
CCCEECCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCEECCCCCCC
WASLPADNLDPRNVGVTPDHLAYVIYTSGTTGLPKGAMVAHRGLSNLLLWCLQVCGEAGA
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHCHHCH
MLHKIPFGFDASAWETFWPLATGGRLVIARPGGHYEPAYLAREVREQQVTALVFVPAMLQ
HHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFLEVDEVSQCVSLTDVFSGGGELPPALARRFQERLPRARLHNVYGPTETTVINSIWTLE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHEEEEC
PGAEVPARQLPIGRPIANNRFYVLDDRDQPVPVGVTGHLHIGGVGVARGYLGLAQLSAER
CCCCCCHHHCCCCCCCCCCEEEEECCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHH
FIDNPFVAGDRLYRSGDLARYRPDGQLEFLGRNDFQVKLRGVRLELGEIEARLEAFPGIR
HCCCCCCCCCHHCCCCCCCEECCCCCEEEECCCCEEEEEEEEEEEHHHHHHHHHHCCCHH
SAVVLMVGEAAQDQRLVACCVVAEPVDEAAVHAHLATTLPRAVIPGSYLWLDALPLTANG
HEEHEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHCCCCEEEEECEEECCCC
KVDRTALTALADEELVNRQVNLSSPRDHIELALYQIWKSLLLAPQIGIRDNFFNVGGTSI
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
AAIKMAHEISQQFSVEVPVRVVLSYPTIEALGGWLRVGANPALAQSNLIEFRRGSGQHNV
HHHHHHHHHHHHCCCCCCEEEEEECCCHHHCCCHHEECCCHHHHHHHHHHHHCCCCCCCE
VCIHPAGGTAFCYLSLAKVLPDATGVYGVQSPGLNPGESTEPTVEAMAEAYLRQIEPLTR
EEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
QPLILTGLSFGGLVAYQMAQRLTAAGHRQVTVVLLDTQGSDDPGFREQIGTVDMAEFRDK
CCEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHCCCCHHHHHHH
LVRFNGMYPGIEDAQVERYFNIYNHNRLAMAAYECAPRAGRVVLIQAREDFSRHQLHELR
HHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHCCCCCCCEEEEEECCCHHHHHHHHHH
GFWRRRAGSGYLAKLVSGGHWDMLESAEIHRVSQIIRRELQRFDAQEAK
HHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA