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The map label for this gene is pcaK [H]

Identifier: 77458480

GI number: 77458480

Start: 2585720

End: 2586949

Strand: Reverse

Name: pcaK [H]

Synonym: Pfl01_2253

Alternate gene names: 77458480

Gene position: 2586949-2585720 (Counterclockwise)

Preceding gene: 77458485

Following gene: 77458478

Centisome position: 40.18

GC content: 63.82

Gene sequence:

>1230_bases
ATGCGTGGGGAAACAGCGCTCGAACGCCTGAGCGGCACGCCATCGACCACTTCGCCGTGGTGGGTGATCGGGCTGTGCAT
GCTGTTCAACGTGATCGACGGGCTTGATGTGATGGCCATGGCCTTCACCGCCAGCCGGGTTGCGGCGGAGTGGGCGTTGA
GCGGCGCGCAACTGGGCCTGTTGCTGAGCGCAAGTCTGGTCGGGATGGCGCTTGGTTCGCTGCTGGCCGCGCCCAGGGCC
GACCGCTTCGGGCGCAGGCCTTTGCTGCTTGGCGGTCTGCTGCTCAGCGGCCTGAGCATGTTGCTGTCGTTCTGGAGCCC
GGATCACCACGTATTGATGCTTCTGCGATTGCTGACCGGCATCGGCACCGGGGCGGTGCTGGTGGGGGCGAATGTGCTGA
CGTTCGAACACGCCAGCCCGCTACGGCGCAATCTGGCCATCGCATTGCAATCCCTCGCCTTTGCCATGGGCGCCAGTCTG
GGCGGTGTGCTGGCGCATGTACTGAATGAATCCGTTGGCTGGCGGTATGTCTTTCTTGCCGGAGGTTGCATCACGCTGGC
GGCCGCGCTTGCCGGCGTCTTTTGGCTGCGAGAGTCGCCGTCATTTCTGGCACTCGAACGCCGCACGCCAATCGCTACAG
CGTCGCCTGACAACCCCAGCCGACCGCTTTTGCCCGGTCAGTGGCAACAGACCACATCGCTGGCACTGGCACTCTTTCTG
TTGATGTTCTGCTTTTACTTCGTCATGAGCTGGACCCCGAGCCTGCTGGTCCACAACGGCTTTACTGATCGGCAAGGCGC
ACGTATCGGGGTGCTGTTGGCTTCTGGAGGTATGCTCGGCGCGCTGCTGCTGGGGCTGGCAGCCAATCGTTTCGGCTGCC
GGCGATTGTTGTCGGGTTTTCTGCTGCTCAACGCCGCCCTGCTGCCCCTGATGGTGCCGGCCTCTCACGTACCCGGTGTG
GCTGCGCTCGTGGCGGTTACGCTCGGCCTGATGCTCAACGGTGCAGTCGCCGCCCTGTATGTCCTGGCTCCTCAAGCGTT
CTGCACCTCGGTTCGTACGACCGGTGTCGGCGTGGTGCTGGGGATGGGGCGTCTGGGGGCGATCATTTCGCCGCTGGTCG
CCGGTTTTCTGCTGGATGCCGGATGGACCGCACAACACCTGTTCACGTTTTTCGCCGGTAGCCAGGTGTTGGCGGCCCTG
CTGATCTGGCGTGGCACTAAGGGACGATGA

Upstream 100 bases:

>100_bases
CCCGGCGCGCAAAATCGCGCTCGAACTCAGCAGCGGTTAACGGGCAGAATGCGGCGGGGAAAAGACCCATTTGAATCACA
GAGCGGAACAAGGATTGCGA

Downstream 100 bases:

>100_bases
TCAGCTTGCCCGTCGTGTTGCGCGACTCGATATCAATATGGGCCTGTTGTGCTTCGTCCAGCGAATAACGCTTGCCGATG
AAGGTTTTCAGTTTGCCGGT

Product: general substrate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRGETALERLSGTPSTTSPWWVIGLCMLFNVIDGLDVMAMAFTASRVAAEWALSGAQLGLLLSASLVGMALGSLLAAPRA
DRFGRRPLLLGGLLLSGLSMLLSFWSPDHHVLMLLRLLTGIGTGAVLVGANVLTFEHASPLRRNLAIALQSLAFAMGASL
GGVLAHVLNESVGWRYVFLAGGCITLAAALAGVFWLRESPSFLALERRTPIATASPDNPSRPLLPGQWQQTTSLALALFL
LMFCFYFVMSWTPSLLVHNGFTDRQGARIGVLLASGGMLGALLLGLAANRFGCRRLLSGFLLLNAALLPLMVPASHVPGV
AALVAVTLGLMLNGAVAALYVLAPQAFCTSVRTTGVGVVLGMGRLGAIISPLVAGFLLDAGWTAQHLFTFFAGSQVLAAL
LIWRGTKGR

Sequences:

>Translated_409_residues
MRGETALERLSGTPSTTSPWWVIGLCMLFNVIDGLDVMAMAFTASRVAAEWALSGAQLGLLLSASLVGMALGSLLAAPRA
DRFGRRPLLLGGLLLSGLSMLLSFWSPDHHVLMLLRLLTGIGTGAVLVGANVLTFEHASPLRRNLAIALQSLAFAMGASL
GGVLAHVLNESVGWRYVFLAGGCITLAAALAGVFWLRESPSFLALERRTPIATASPDNPSRPLLPGQWQQTTSLALALFL
LMFCFYFVMSWTPSLLVHNGFTDRQGARIGVLLASGGMLGALLLGLAANRFGCRRLLSGFLLLNAALLPLMVPASHVPGV
AALVAVTLGLMLNGAVAALYVLAPQAFCTSVRTTGVGVVLGMGRLGAIISPLVAGFLLDAGWTAQHLFTFFAGSQVLAAL
LIWRGTKGR
>Mature_409_residues
MRGETALERLSGTPSTTSPWWVIGLCMLFNVIDGLDVMAMAFTASRVAAEWALSGAQLGLLLSASLVGMALGSLLAAPRA
DRFGRRPLLLGGLLLSGLSMLLSFWSPDHHVLMLLRLLTGIGTGAVLVGANVLTFEHASPLRRNLAIALQSLAFAMGASL
GGVLAHVLNESVGWRYVFLAGGCITLAAALAGVFWLRESPSFLALERRTPIATASPDNPSRPLLPGQWQQTTSLALALFL
LMFCFYFVMSWTPSLLVHNGFTDRQGARIGVLLASGGMLGALLLGLAANRFGCRRLLSGFLLLNAALLPLMVPASHVPGV
AALVAVTLGLMLNGAVAALYVLAPQAFCTSVRTTGVGVVLGMGRLGAIISPLVAGFLLDAGWTAQHLFTFFAGSQVLAAL
LIWRGTKGR

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081723, Length=362, Percent_Identity=32.8729281767956, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI87082404, Length=359, Percent_Identity=22.2841225626741, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788068, Length=345, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082159, Length=368, Percent_Identity=23.0978260869565, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=171, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19922616, Length=385, Percent_Identity=24.6753246753247, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19922874, Length=405, Percent_Identity=24.9382716049383, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42956; Mature: 42956

Theoretical pI: Translated: 11.30; Mature: 11.30

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGETALERLSGTPSTTSPWWVIGLCMLFNVIDGLDVMAMAFTASRVAAEWALSGAQLGL
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHH
LLSASLVGMALGSLLAAPRADRFGRRPLLLGGLLLSGLSMLLSFWSPDHHVLMLLRLLTG
HHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
IGTGAVLVGANVLTFEHASPLRRNLAIALQSLAFAMGASLGGVLAHVLNESVGWRYVFLA
CCCCHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
GGCITLAAALAGVFWLRESPSFLALERRTPIATASPDNPSRPLLPGQWQQTTSLALALFL
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LMFCFYFVMSWTPSLLVHNGFTDRQGARIGVLLASGGMLGALLLGLAANRFGCRRLLSGF
HHHHHHHHHHCCCHHEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LLLNAALLPLMVPASHVPGVAALVAVTLGLMLNGAVAALYVLAPQAFCTSVRTTGVGVVL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
GMGRLGAIISPLVAGFLLDAGWTAQHLFTFFAGSQVLAALLIWRGTKGR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRGETALERLSGTPSTTSPWWVIGLCMLFNVIDGLDVMAMAFTASRVAAEWALSGAQLGL
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHH
LLSASLVGMALGSLLAAPRADRFGRRPLLLGGLLLSGLSMLLSFWSPDHHVLMLLRLLTG
HHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
IGTGAVLVGANVLTFEHASPLRRNLAIALQSLAFAMGASLGGVLAHVLNESVGWRYVFLA
CCCCHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
GGCITLAAALAGVFWLRESPSFLALERRTPIATASPDNPSRPLLPGQWQQTTSLALALFL
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LMFCFYFVMSWTPSLLVHNGFTDRQGARIGVLLASGGMLGALLLGLAANRFGCRRLLSGF
HHHHHHHHHHCCCHHEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LLLNAALLPLMVPASHVPGVAALVAVTLGLMLNGAVAALYVLAPQAFCTSVRTTGVGVVL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
GMGRLGAIISPLVAGFLLDAGWTAQHLFTFFAGSQVLAALLIWRGTKGR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]