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The map label for this gene is rtcA [H]

Identifier: 77458175

GI number: 77458175

Start: 2223145

End: 2224173

Strand: Direct

Name: rtcA [H]

Synonym: Pfl01_1948

Alternate gene names: 77458175

Gene position: 2223145-2224173 (Clockwise)

Preceding gene: 77458174

Following gene: 77458176

Centisome position: 34.53

GC content: 62.1

Gene sequence:

>1029_bases
ATGAAACAGGACGTGATTGAACTGGACGGCGCCATCGGCGGTGGCCAGGTGTTGCGCAGTGCGCTGAGTCTGTCGATGGT
GACGGGCCAGGCGTTTCGAATAGTGCGGATTCGGGCCCGGCGCAGTCGTCCCGGCCTGTTGCGCCAGCACCTGACCGCCG
TGATGGCGGCGGCGCAGGTCTGCGGTGCAAAGATCCAGGGGGCTGAACTGGGCTCGCAGACATTGAGCTTCGAGCCGGGG
CCGATTCGTGGCGGCGATTATCGCTTTGCCATTGGCACCGCCGGCAGTTGCACCCTGGTGTTGCAGACCTTGCTGCCCGC
CTTGTTACTGGCGCCGCAAGCCAGCCGCGTGCGGATCAGCGGCGGCACGCATAATCCGCTGGCGCCACCGACCGATTTTC
TCAGCCGCAGCTGGTTGCCGCTGCTGCGACGGATGGGCGCGGAGGTTGAACTGACGTTGCTGCGCCACGGGTTTGTACCG
GCCGGCGGCGGTGAAATTGACGTCAGGGTGCAACCATCGAAACTGTCAGCACTGCACCTGTGTGAGCGCGGCTTGCCGCT
CTCGCAACAGGCGTTTGCGCTAACGGCCGGACTGGCGCCGAGTGTCGGTGTCCGCGAGCTCGAAAGGGTGGCCCAGCGAT
TGAACATGGCGTCAGCAGAATTGAACACCGTCATCCTTGATCCGGCCTGTGGCCCGGGCAATGTGCTGCTGCTGGAATAT
TCGTTCGAACACGTCACGGAGGTTTTCAGCGCTTTCGGTCAAGCCTCACTGCGTTCGGAGAAGGTTGCGGACGCCGCGAT
CGATCAAGCGACCGATTGGCTGCACAGCGGTGCGGCGGTGGCAGAGCATCTGGCCGACCAGTTGCTGTTGCCGATGGTGC
TGGCCGGAGGTGGATCGTTCACCACACCCAGGATGACCGAGCATTTGCACAGCAACATTTTGGTCATCGAGCGTTTTGTA
CCGATAACGATCCAGTGTGAGGAAGAAGGTGCAGACCGGTTGAGGGTTGAAGTTCGAACCAAGGAGTAA

Upstream 100 bases:

>100_bases
TTGAGCGTGCGGTGCCGACATTGCCCAGAACCCGGGAGGATTCGCGGCAGCTCGATCGATACCTGCGGGAAACCGTTGGT
TTGTATGCCTAAGGAAAAAA

Downstream 100 bases:

>100_bases
CAGGCGGCAAATTGCTGGCCCCCGAATGTTTCAAGTCCCGGCAAACTCGCTTTTTTTCAAAAGGTTAGGTGGGCTATATG
CGGACGATTGTCATCACCGT

Product: RNA 3'-terminal-phosphate cyclase

Products: NA

Alternate protein names: RNA cyclase; RNA-3'-phosphate cyclase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKQDVIELDGAIGGGQVLRSALSLSMVTGQAFRIVRIRARRSRPGLLRQHLTAVMAAAQVCGAKIQGAELGSQTLSFEPG
PIRGGDYRFAIGTAGSCTLVLQTLLPALLLAPQASRVRISGGTHNPLAPPTDFLSRSWLPLLRRMGAEVELTLLRHGFVP
AGGGEIDVRVQPSKLSALHLCERGLPLSQQAFALTAGLAPSVGVRELERVAQRLNMASAELNTVILDPACGPGNVLLLEY
SFEHVTEVFSAFGQASLRSEKVADAAIDQATDWLHSGAAVAEHLADQLLLPMVLAGGGSFTTPRMTEHLHSNILVIERFV
PITIQCEEEGADRLRVEVRTKE

Sequences:

>Translated_342_residues
MKQDVIELDGAIGGGQVLRSALSLSMVTGQAFRIVRIRARRSRPGLLRQHLTAVMAAAQVCGAKIQGAELGSQTLSFEPG
PIRGGDYRFAIGTAGSCTLVLQTLLPALLLAPQASRVRISGGTHNPLAPPTDFLSRSWLPLLRRMGAEVELTLLRHGFVP
AGGGEIDVRVQPSKLSALHLCERGLPLSQQAFALTAGLAPSVGVRELERVAQRLNMASAELNTVILDPACGPGNVLLLEY
SFEHVTEVFSAFGQASLRSEKVADAAIDQATDWLHSGAAVAEHLADQLLLPMVLAGGGSFTTPRMTEHLHSNILVIERFV
PITIQCEEEGADRLRVEVRTKE
>Mature_342_residues
MKQDVIELDGAIGGGQVLRSALSLSMVTGQAFRIVRIRARRSRPGLLRQHLTAVMAAAQVCGAKIQGAELGSQTLSFEPG
PIRGGDYRFAIGTAGSCTLVLQTLLPALLLAPQASRVRISGGTHNPLAPPTDFLSRSWLPLLRRMGAEVELTLLRHGFVP
AGGGEIDVRVQPSKLSALHLCERGLPLSQQAFALTAGLAPSVGVRELERVAQRLNMASAELNTVILDPACGPGNVLLLEY
SFEHVTEVFSAFGQASLRSEKVADAAIDQATDWLHSGAAVAEHLADQLLLPMVLAGGGSFTTPRMTEHLHSNILVIERFV
PITIQCEEEGADRLRVEVRTKE

Specific function: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A;

COG id: COG0430

COG function: function code A; RNA 3'-terminal phosphate cyclase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4506589, Length=343, Percent_Identity=31.4868804664723, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI195927044, Length=356, Percent_Identity=30.3370786516854, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI48994937, Length=339, Percent_Identity=50.7374631268437, Blast_Score=313, Evalue=1e-86,
Organism=Drosophila melanogaster, GI18543269, Length=356, Percent_Identity=31.1797752808989, Blast_Score=154, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013791
- InterPro:   IPR000228
- InterPro:   IPR020719
- InterPro:   IPR013796
- InterPro:   IPR020723
- InterPro:   IPR017770
- InterPro:   IPR013792 [H]

Pfam domain/function: PF01137 RTC; PF05189 RTC_insert [H]

EC number: =6.5.1.4 [H]

Molecular weight: Translated: 36593; Mature: 36593

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS01287 RTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDVIELDGAIGGGQVLRSALSLSMVTGQAFRIVRIRARRSRPGLLRQHLTAVMAAAQV
CCCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
CGAKIQGAELGSQTLSFEPGPIRGGDYRFAIGTAGSCTLVLQTLLPALLLAPQASRVRIS
HCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEC
GGTHNPLAPPTDFLSRSWLPLLRRMGAEVELTLLRHGFVPAGGGEIDVRVQPSKLSALHL
CCCCCCCCCCHHHHHCCHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCHHHHHHHH
CERGLPLSQQAFALTAGLAPSVGVRELERVAQRLNMASAELNTVILDPACGPGNVLLLEY
HHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEE
SFEHVTEVFSAFGQASLRSEKVADAAIDQATDWLHSGAAVAEHLADQLLLPMVLAGGGSF
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
TTPRMTEHLHSNILVIERFVPITIQCEEEGADRLRVEVRTKE
CCCHHHHHHHCCEEEEEEEEEEEEEECCCCCCEEEEEEEECC
>Mature Secondary Structure
MKQDVIELDGAIGGGQVLRSALSLSMVTGQAFRIVRIRARRSRPGLLRQHLTAVMAAAQV
CCCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
CGAKIQGAELGSQTLSFEPGPIRGGDYRFAIGTAGSCTLVLQTLLPALLLAPQASRVRIS
HCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEC
GGTHNPLAPPTDFLSRSWLPLLRRMGAEVELTLLRHGFVPAGGGEIDVRVQPSKLSALHL
CCCCCCCCCCHHHHHCCHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCHHHHHHHH
CERGLPLSQQAFALTAGLAPSVGVRELERVAQRLNMASAELNTVILDPACGPGNVLLLEY
HHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEE
SFEHVTEVFSAFGQASLRSEKVADAAIDQATDWLHSGAAVAEHLADQLLLPMVLAGGGSF
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
TTPRMTEHLHSNILVIERFVPITIQCEEEGADRLRVEVRTKE
CCCHHHHHHHCCEEEEEEEEEEEEEECCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA