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The map label for this gene is dnaX [H]

Identifier: 77458032

GI number: 77458032

Start: 2017476

End: 2019566

Strand: Direct

Name: dnaX [H]

Synonym: Pfl01_1805

Alternate gene names: 77458032

Gene position: 2017476-2019566 (Clockwise)

Preceding gene: 77458030

Following gene: 77458033

Centisome position: 31.34

GC content: 65.38

Gene sequence:

>2091_bases
ATGAGTTATCAGGTTCTTGCACGTAAATGGCGTCCGCGCTCGTTCCGCGAAATGGTCGGCCAGACCCATGTGCTCAAGGC
TCTGATCAATGCCTTGGACAGCCAGCGCCTGCACCACGCCTACCTCTTCACGGGTACGCGGGGCGTCGGCAAGACCACGA
TTGCGCGGATCATCGCCAAATGCCTGAACTGTGAAACAGGTATCACTTCAAGCCCGTGCGGCGAGTGTTCGGTGTGCCGC
GAGATCGATGAAGGCCGTTTCGTCGACCTGATCGAGATCGACGCCGCGAGCCGGACCAAGGTCGAGGACACCCGCGAGCT
GCTCGACAACGTGCAGTACGCCCCGAGCCGTGGGCGCTTCAAGGTCTACCTGATCGACGAAGTGCACATGCTCTCCAGCC
ATTCCTTCAATGCGCTGCTCAAAACCCTCGAAGAGCCGCCGCCCTACGTCAAGTTCATCCTGGCGACCACCGACCCGCAG
AAACTTCCGGCAACGATTTTGTCGCGTTGCCTGCAGTTCTCCCTGAAGAACATGACGCCTGAGCGGGTCGTCGAGCATCT
GACCCACGTTCTGGGCGCCGAAAATGTCCCGTTCGAAGACGACGCCCTGTGGCTGCTCGGCCGCGCGGCCGACGGTTCGA
TGCGTGACGCCATGAGCCTGACCGACCAGGCCATCGCCTTCGGTGAAGGCAAGGTGTTGGCCGCCGACGTGCGGGCGATG
CTCGGTACGCTGGATCACGGCCAGGTCTACGACGTGCTGCACGCGCTGATCGAAGGCGACGCCAAGGCGTTGCTCGAAGC
GGTGCGTCATCTCGCTGAACAGGGGCCGGACTGGAACGGCGTGCTCTCGGAAATTCTCAACGTGCTGCACCGCGTCGCCA
TCGCCCAGGCCTTGCCGGAAGGTGTCGACAACGGCCACGGCGACCGTGACCGGGTGCTGGCACTGGCCCAGGCCTTGCCG
GCCGAAGACGTGCAGTTCTATTACCAGATGGGCCTGATCGGTCGCCGCGACTTGCCGCTGGCGCCGGACCCGCGAGGCGG
TTTCGAGATGGTGCTGCTGCGGATGCTGGCCTTCCGGCCAGCAGACACGGCGGACGCCCCGAGGCAACCGCTAAAGCCAG
TGGGGATCAGCCAGGCCACAGTTGATTCCGCAAACTCAGTGGCTGCCGCGCCGAAACCTGCGCCGGTAGTTGCTGTGGCT
GTTGCGCCGGCGCCAGCGCCGGTGGTTGCACCTGCGCCGGCTCCCGAGCCTGCACCGGTTGCCCCGGTGATTGCGCCTGA
ACCCGTTCCTGAGCCCGAGGCCGAGCCCGAGCCGGTCGCCGTCGAAGAAGTCGTCGATCTGCCGTGGAATGACCCGGTAG
AGCCGGCGCCTGTGCAGCAGCCAGCGGTAGAACCGGTGCTGGAAACCACCGCCGAACAGCCTGACCTGCCGCCCATGCCG
CTGCCGACTCCGGACAGCGTCGTACCGGACGCGCCGGAGTGGGCCGCCGCGCCGATCCCCGAGCCATCAGTGGCCGACGT
CGATGCCGCCACACCGGGCATGGACATGGACGACGAGCCGCCGCTCGACGAGGATTACATCGAGCCGGACATGGATTCGG
CCTACAGTTACCTCGACGATCTGGCCAGCGAACACGCCGCAGAACCGGCTCCCGAGCCCGAGCCGGAACCCGCCGCCGCG
CCGGCCACCGGTCTGGCCCTGCAATGGCTGGAGCTGTTCCCGCAACTGCCGATCTCCGGGATGACCGGCAGCATCGCCGC
CAACTGCACGCTGATCGCAGTCGATGGCGACAACTGGCTGATGCACCTGGACCCGGCCCACAGCGCCTTGTTCAACGCCA
CCCAGCAGCGTCGTCTGAACGATGCGCTGAACCAGTTCCACGGGCGCACGCTGACCCTGACCATCGAGCTGATCAAGCCC
GAGCAGGAAACTCCTGCCCAGGCGGCGTCCCGGCGCCGTGCCAACCGTCAGCGCGAGGCGGAGGAATCGATCCACGGCGA
TCCGTTCATCCAGCAGATGGTCCAACAGTTCGGTGCGGTCGTGCGACACGATACTATTGAACCTGTCGACGCCCTGGTCA
GTCAGGGCTAA

Upstream 100 bases:

>100_bases
TCATGCAGCTTAGCCAGAATAGACGAGCACACCGGATGCAATTTTGCCCTTGCTCCGCTAGCATTAGCCGCTTCTGCTTC
CTTTGCCGCGACGGTTTTCG

Downstream 100 bases:

>100_bases
TAACTGAGGGCGTCCGGCCTGTCTGGCCGGGCGCTGTTTTGATCCAAGTACTTTTGAGGTGATTCCCATGATGAAAGGTG
GCATGGCCGGCCTGATGAAG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MSYQVLARKWRPRSFREMVGQTHVLKALINALDSQRLHHAYLFTGTRGVGKTTIARIIAKCLNCETGITSSPCGECSVCR
EIDEGRFVDLIEIDAASRTKVEDTRELLDNVQYAPSRGRFKVYLIDEVHMLSSHSFNALLKTLEEPPPYVKFILATTDPQ
KLPATILSRCLQFSLKNMTPERVVEHLTHVLGAENVPFEDDALWLLGRAADGSMRDAMSLTDQAIAFGEGKVLAADVRAM
LGTLDHGQVYDVLHALIEGDAKALLEAVRHLAEQGPDWNGVLSEILNVLHRVAIAQALPEGVDNGHGDRDRVLALAQALP
AEDVQFYYQMGLIGRRDLPLAPDPRGGFEMVLLRMLAFRPADTADAPRQPLKPVGISQATVDSANSVAAAPKPAPVVAVA
VAPAPAPVVAPAPAPEPAPVAPVIAPEPVPEPEAEPEPVAVEEVVDLPWNDPVEPAPVQQPAVEPVLETTAEQPDLPPMP
LPTPDSVVPDAPEWAAAPIPEPSVADVDAATPGMDMDDEPPLDEDYIEPDMDSAYSYLDDLASEHAAEPAPEPEPEPAAA
PATGLALQWLELFPQLPISGMTGSIAANCTLIAVDGDNWLMHLDPAHSALFNATQQRRLNDALNQFHGRTLTLTIELIKP
EQETPAQAASRRRANRQREAEESIHGDPFIQQMVQQFGAVVRHDTIEPVDALVSQG

Sequences:

>Translated_696_residues
MSYQVLARKWRPRSFREMVGQTHVLKALINALDSQRLHHAYLFTGTRGVGKTTIARIIAKCLNCETGITSSPCGECSVCR
EIDEGRFVDLIEIDAASRTKVEDTRELLDNVQYAPSRGRFKVYLIDEVHMLSSHSFNALLKTLEEPPPYVKFILATTDPQ
KLPATILSRCLQFSLKNMTPERVVEHLTHVLGAENVPFEDDALWLLGRAADGSMRDAMSLTDQAIAFGEGKVLAADVRAM
LGTLDHGQVYDVLHALIEGDAKALLEAVRHLAEQGPDWNGVLSEILNVLHRVAIAQALPEGVDNGHGDRDRVLALAQALP
AEDVQFYYQMGLIGRRDLPLAPDPRGGFEMVLLRMLAFRPADTADAPRQPLKPVGISQATVDSANSVAAAPKPAPVVAVA
VAPAPAPVVAPAPAPEPAPVAPVIAPEPVPEPEAEPEPVAVEEVVDLPWNDPVEPAPVQQPAVEPVLETTAEQPDLPPMP
LPTPDSVVPDAPEWAAAPIPEPSVADVDAATPGMDMDDEPPLDEDYIEPDMDSAYSYLDDLASEHAAEPAPEPEPEPAAA
PATGLALQWLELFPQLPISGMTGSIAANCTLIAVDGDNWLMHLDPAHSALFNATQQRRLNDALNQFHGRTLTLTIELIKP
EQETPAQAASRRRANRQREAEESIHGDPFIQQMVQQFGAVVRHDTIEPVDALVSQG
>Mature_695_residues
SYQVLARKWRPRSFREMVGQTHVLKALINALDSQRLHHAYLFTGTRGVGKTTIARIIAKCLNCETGITSSPCGECSVCRE
IDEGRFVDLIEIDAASRTKVEDTRELLDNVQYAPSRGRFKVYLIDEVHMLSSHSFNALLKTLEEPPPYVKFILATTDPQK
LPATILSRCLQFSLKNMTPERVVEHLTHVLGAENVPFEDDALWLLGRAADGSMRDAMSLTDQAIAFGEGKVLAADVRAML
GTLDHGQVYDVLHALIEGDAKALLEAVRHLAEQGPDWNGVLSEILNVLHRVAIAQALPEGVDNGHGDRDRVLALAQALPA
EDVQFYYQMGLIGRRDLPLAPDPRGGFEMVLLRMLAFRPADTADAPRQPLKPVGISQATVDSANSVAAAPKPAPVVAVAV
APAPAPVVAPAPAPEPAPVAPVIAPEPVPEPEAEPEPVAVEEVVDLPWNDPVEPAPVQQPAVEPVLETTAEQPDLPPMPL
PTPDSVVPDAPEWAAAPIPEPSVADVDAATPGMDMDDEPPLDEDYIEPDMDSAYSYLDDLASEHAAEPAPEPEPEPAAAP
ATGLALQWLELFPQLPISGMTGSIAANCTLIAVDGDNWLMHLDPAHSALFNATQQRRLNDALNQFHGRTLTLTIELIKPE
QETPAQAASRRRANRQREAEESIHGDPFIQQMVQQFGAVVRHDTIEPVDALVSQG

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=288, Percent_Identity=24.6527777777778, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI194306571, Length=294, Percent_Identity=24.4897959183673, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI194306567, Length=294, Percent_Identity=24.4897959183673, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786676, Length=379, Percent_Identity=60.6860158311346, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1787119, Length=230, Percent_Identity=25.2173913043478, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1787341, Length=149, Percent_Identity=30.2013422818792, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=305, Percent_Identity=21.9672131147541, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859927, Length=276, Percent_Identity=23.9130434782609, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17647857, Length=294, Percent_Identity=21.7687074829932, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 75367; Mature: 75236

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPRSFREMVGQTHVLKALINALDSQRLHHAYLFTGTRGVGKTTIARIIAK
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
CLNCETGITSSPCGECSVCREIDEGRFVDLIEIDAASRTKVEDTRELLDNVQYAPSRGRF
HHCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCE
KVYLIDEVHMLSSHSFNALLKTLEEPPPYVKFILATTDPQKLPATILSRCLQFSLKNMTP
EEEEECHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCH
ERVVEHLTHVLGAENVPFEDDALWLLGRAADGSMRDAMSLTDQAIAFGEGKVLAADVRAM
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
LGTLDHGQVYDVLHALIEGDAKALLEAVRHLAEQGPDWNGVLSEILNVLHRVAIAQALPE
HHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVDNGHGDRDRVLALAQALPAEDVQFYYQMGLIGRRDLPLAPDPRGGFEMVLLRMLAFRP
HCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
ADTADAPRQPLKPVGISQATVDSANSVAAAPKPAPVVAVAVAPAPAPVVAPAPAPEPAPV
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
APVIAPEPVPEPEAEPEPVAVEEVVDLPWNDPVEPAPVQQPAVEPVLETTAEQPDLPPMP
CCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
LPTPDSVVPDAPEWAAAPIPEPSVADVDAATPGMDMDDEPPLDEDYIEPDMDSAYSYLDD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHH
LASEHAAEPAPEPEPEPAAAPATGLALQWLELFPQLPISGMTGSIAANCTLIAVDGDNWL
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCEEEEEEECCCEE
MHLDPAHSALFNATQQRRLNDALNQFHGRTLTLTIELIKPEQETPAQAASRRRANRQREA
EEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
EESIHGDPFIQQMVQQFGAVVRHDTIEPVDALVSQG
HHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
>Mature Secondary Structure 
SYQVLARKWRPRSFREMVGQTHVLKALINALDSQRLHHAYLFTGTRGVGKTTIARIIAK
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
CLNCETGITSSPCGECSVCREIDEGRFVDLIEIDAASRTKVEDTRELLDNVQYAPSRGRF
HHCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCE
KVYLIDEVHMLSSHSFNALLKTLEEPPPYVKFILATTDPQKLPATILSRCLQFSLKNMTP
EEEEECHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCH
ERVVEHLTHVLGAENVPFEDDALWLLGRAADGSMRDAMSLTDQAIAFGEGKVLAADVRAM
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
LGTLDHGQVYDVLHALIEGDAKALLEAVRHLAEQGPDWNGVLSEILNVLHRVAIAQALPE
HHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVDNGHGDRDRVLALAQALPAEDVQFYYQMGLIGRRDLPLAPDPRGGFEMVLLRMLAFRP
HCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
ADTADAPRQPLKPVGISQATVDSANSVAAAPKPAPVVAVAVAPAPAPVVAPAPAPEPAPV
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
APVIAPEPVPEPEAEPEPVAVEEVVDLPWNDPVEPAPVQQPAVEPVLETTAEQPDLPPMP
CCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
LPTPDSVVPDAPEWAAAPIPEPSVADVDAATPGMDMDDEPPLDEDYIEPDMDSAYSYLDD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHH
LASEHAAEPAPEPEPEPAAAPATGLALQWLELFPQLPISGMTGSIAANCTLIAVDGDNWL
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCEEEEEEECCCEE
MHLDPAHSALFNATQQRRLNDALNQFHGRTLTLTIELIKPEQETPAQAASRRRANRQREA
EEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
EESIHGDPFIQQMVQQFGAVVRHDTIEPVDALVSQG
HHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]