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The map label for this gene is fadA [H]

Identifier: 77457966

GI number: 77457966

Start: 1930907

End: 1932112

Strand: Direct

Name: fadA [H]

Synonym: Pfl01_1739

Alternate gene names: 77457966

Gene position: 1930907-1932112 (Clockwise)

Preceding gene: 77457964

Following gene: 77457967

Centisome position: 29.99

GC content: 65.51

Gene sequence:

>1206_bases
ATGACCCAAGCTTTGATTTTCGACGCGTTACGCACGCCCCGTGGCAAGGGCAAGGCCGACGGTTCGCTGCACAGCGTCAA
ACCGGTGAACCTGGTGGCAGGGCTGCTGACCGCTTTGCAAGCGCGCACTGCGCTGGACACCAGCCAGGTCGATGACGTGG
TGCTGGGTTGTGTCACGCCGATCGGCGATCAGGGCTCGGACATCGCCAAGACCGCGGTGCAGGTGGCCGATTGGGACGTC
AGCGTCGCGGGCGTGCAGATCAACCGCTTCTGCGCCTCGGGACTGGAAGCGGTGAACCTGGGGGCGATGAAAGTGCGCTC
CGGGTTTGAAGAGCTGGTGGTGGTCGGCGGCGTCGAATCCATGTCCCGCGTGCCGATGGGCAGCGACGGTGGCGCCTGGG
CGCTGGACCCGCAAACCAACCTGCACAGCCATTTCACGCCACAAGGCGTCGGCGCCGACCTGATCGCCACCCTGGAAGGC
TTCAGCCGTCAGGACGTCGATGCCTACGCGCTGCACTCGCAACAGAAAGCCGCTCGCGCCCGGGCCGACGGTTCGTTCAA
CAAGTCGTTGGTGCCGGTGCAGGACCAGAACGGCATCATCCTGCTCGATCACGATGAGTTCATTCGCGCCGAGTCGACCC
TTGAAGGCCTGGGCAAGCTCAAGCCGAGTTTCGAGATGATCGGCCAGCTGGGCTTCGACGCCACGGCGCTGCGTGTCTAC
AGCCATGTCGAGCGGATCAACCATGTGCACACGCCGGGCAACAGCTCGGGGATCGTCGATGGCGCGGCGCTGATGTTGAT
CGGCTCCGAAGCCAAGGGGCGCGCGTTGGGCCTGCAACCCCGGGCGCGGATCGTCGCCACGGCGGTCACCAGCACCGATC
CGACGATCATGCTCACCGGCCCGGCGCCGGCCACTCGCAAGGCATTGGCCAAGGCCGGGCTGCGGGTGGAAGACATCGAC
CTTTTCGAGGTCAACGAGGCATTCGCCTCGGTGGTGCTGAAATTCATCAAGGACATGGCCGTCGACCCGGACAAGGTCAA
CGTCAATGGCGGCTCGATCGCCATCGGCCACCCGTTGGGGGCCACCGGTTGCGCGATCCTCGGCACCTTGCTCGATGAAC
TGGAAGCCCGACGCCTGCGCTACGGCCTGGCGACGCTGTGCGTCGGCGGCGGCATGGGCATCGCCACCATCATCGAACGC
CTCTGA

Upstream 100 bases:

>100_bases
GCGCGTCAACGTCATTGAGCGCTGTGGTCATTGAATCCATGACGGGTGAAGACAACAGTGGCAGCACGAATTTCACTCAC
CGCACAGGTTCGAGGACGTC

Downstream 100 bases:

>100_bases
TCCCAAGGAATCCTGTCATGACCCAAGCCATTCGTTACGAAAAAGGCCAGGACGGCATCGTCCTCCTGACCATCGACATG
CCGGGCCAGAGCGCCAACAC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTQALIFDALRTPRGKGKADGSLHSVKPVNLVAGLLTALQARTALDTSQVDDVVLGCVTPIGDQGSDIAKTAVQVADWDV
SVAGVQINRFCASGLEAVNLGAMKVRSGFEELVVVGGVESMSRVPMGSDGGAWALDPQTNLHSHFTPQGVGADLIATLEG
FSRQDVDAYALHSQQKAARARADGSFNKSLVPVQDQNGIILLDHDEFIRAESTLEGLGKLKPSFEMIGQLGFDATALRVY
SHVERINHVHTPGNSSGIVDGAALMLIGSEAKGRALGLQPRARIVATAVTSTDPTIMLTGPAPATRKALAKAGLRVEDID
LFEVNEAFASVVLKFIKDMAVDPDKVNVNGGSIAIGHPLGATGCAILGTLLDELEARRLRYGLATLCVGGGMGIATIIER
L

Sequences:

>Translated_401_residues
MTQALIFDALRTPRGKGKADGSLHSVKPVNLVAGLLTALQARTALDTSQVDDVVLGCVTPIGDQGSDIAKTAVQVADWDV
SVAGVQINRFCASGLEAVNLGAMKVRSGFEELVVVGGVESMSRVPMGSDGGAWALDPQTNLHSHFTPQGVGADLIATLEG
FSRQDVDAYALHSQQKAARARADGSFNKSLVPVQDQNGIILLDHDEFIRAESTLEGLGKLKPSFEMIGQLGFDATALRVY
SHVERINHVHTPGNSSGIVDGAALMLIGSEAKGRALGLQPRARIVATAVTSTDPTIMLTGPAPATRKALAKAGLRVEDID
LFEVNEAFASVVLKFIKDMAVDPDKVNVNGGSIAIGHPLGATGCAILGTLLDELEARRLRYGLATLCVGGGMGIATIIER
L
>Mature_400_residues
TQALIFDALRTPRGKGKADGSLHSVKPVNLVAGLLTALQARTALDTSQVDDVVLGCVTPIGDQGSDIAKTAVQVADWDVS
VAGVQINRFCASGLEAVNLGAMKVRSGFEELVVVGGVESMSRVPMGSDGGAWALDPQTNLHSHFTPQGVGADLIATLEGF
SRQDVDAYALHSQQKAARARADGSFNKSLVPVQDQNGIILLDHDEFIRAESTLEGLGKLKPSFEMIGQLGFDATALRVYS
HVERINHVHTPGNSSGIVDGAALMLIGSEAKGRALGLQPRARIVATAVTSTDPTIMLTGPAPATRKALAKAGLRVEDIDL
FEVNEAFASVVLKFIKDMAVDPDKVNVNGGSIAIGHPLGATGCAILGTLLDELEARRLRYGLATLCVGGGMGIATIIERL

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=36.1809045226131, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI4501853, Length=388, Percent_Identity=37.3711340206186, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI167614485, Length=417, Percent_Identity=34.5323741007194, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4557237, Length=416, Percent_Identity=29.8076923076923, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4504327, Length=442, Percent_Identity=31.2217194570136, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI194353979, Length=111, Percent_Identity=45.045045045045, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI48994986, Length=408, Percent_Identity=39.2156862745098, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1787663, Length=423, Percent_Identity=39.0070921985816, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI1788554, Length=416, Percent_Identity=39.1826923076923, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI87082165, Length=414, Percent_Identity=40.0966183574879, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1788683, Length=441, Percent_Identity=27.6643990929705, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI133906874, Length=371, Percent_Identity=34.2318059299191, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI25147385, Length=412, Percent_Identity=31.0679611650485, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17535921, Length=414, Percent_Identity=31.1594202898551, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17551802, Length=447, Percent_Identity=27.9642058165548, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17535917, Length=408, Percent_Identity=27.9411764705882, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322031, Length=403, Percent_Identity=32.258064516129, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=427, Percent_Identity=30.9133489461358, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24655093, Length=422, Percent_Identity=36.7298578199052, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI17648125, Length=401, Percent_Identity=33.1670822942643, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24640423, Length=417, Percent_Identity=33.0935251798561, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI17137578, Length=443, Percent_Identity=29.7968397291196, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 41974; Mature: 41842

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQALIFDALRTPRGKGKADGSLHSVKPVNLVAGLLTALQARTALDTSQVDDVVLGCVTP
CCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
IGDQGSDIAKTAVQVADWDVSVAGVQINRFCASGLEAVNLGAMKVRSGFEELVVVGGVES
CCCCCCHHHHHHHHHCCCCEEEECEEHHHHHHCCCCHHCCCHHHHHCCHHHEEEECCHHH
MSRVPMGSDGGAWALDPQTNLHSHFTPQGVGADLIATLEGFSRQDVDAYALHSQQKAARA
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
RADGSFNKSLVPVQDQNGIILLDHDEFIRAESTLEGLGKLKPSFEMIGQLGFDATALRVY
HCCCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHH
SHVERINHVHTPGNSSGIVDGAALMLIGSEAKGRALGLQPRARIVATAVTSTDPTIMLTG
HHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCEECCCCCCEEEEEEEECCCCEEEEEC
PAPATRKALAKAGLRVEDIDLFEVNEAFASVVLKFIKDMAVDPDKVNVNGGSIAIGHPLG
CCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCC
ATGCAILGTLLDELEARRLRYGLATLCVGGGMGIATIIERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
>Mature Secondary Structure 
TQALIFDALRTPRGKGKADGSLHSVKPVNLVAGLLTALQARTALDTSQVDDVVLGCVTP
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
IGDQGSDIAKTAVQVADWDVSVAGVQINRFCASGLEAVNLGAMKVRSGFEELVVVGGVES
CCCCCCHHHHHHHHHCCCCEEEECEEHHHHHHCCCCHHCCCHHHHHCCHHHEEEECCHHH
MSRVPMGSDGGAWALDPQTNLHSHFTPQGVGADLIATLEGFSRQDVDAYALHSQQKAARA
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
RADGSFNKSLVPVQDQNGIILLDHDEFIRAESTLEGLGKLKPSFEMIGQLGFDATALRVY
HCCCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHH
SHVERINHVHTPGNSSGIVDGAALMLIGSEAKGRALGLQPRARIVATAVTSTDPTIMLTG
HHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCEECCCCCCEEEEEEEECCCCEEEEEC
PAPATRKALAKAGLRVEDIDLFEVNEAFASVVLKFIKDMAVDPDKVNVNGGSIAIGHPLG
CCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCC
ATGCAILGTLLDELEARRLRYGLATLCVGGGMGIATIIERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]