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The map label for this gene is fkpA [H]

Identifier: 77457898

GI number: 77457898

Start: 1864537

End: 1865259

Strand: Direct

Name: fkpA [H]

Synonym: Pfl01_1671

Alternate gene names: 77457898

Gene position: 1864537-1865259 (Clockwise)

Preceding gene: 77457892

Following gene: 77457899

Centisome position: 28.96

GC content: 58.64

Gene sequence:

>723_bases
ATGAAACAGCATCGGTTGGCGGCGGCGGTTGCCCTGGTTAGCCTGGTCCTCGCGGGTTGTGATTCGCAGACCAGCGTAGA
GCTGAAAACCCCGGCGCAAAAAGCTTCCTACGGTATCGGCCTGAACATGGGCAAGAGCCTTGCTCAGGAAGGCATGGATG
ATCTGGACTCCAAAGCGGTAGCCCAGGGCATCGAAGATGCCGTCGGCAAGAAAGAACAGAAGCTGAAAGATGAAGAACTG
GTCGAAGCTTTCGCCGCGCTGCAAAAGCGTGCCGAAGAGCGTATGGCCAAGATGAGCGAAGAGTCGGCAGCCGCCGGCAA
GAAATTCCTCGAAGAAAACGGCAAGAAGGCTGGCGTGACCACCACCGCTTCCGGTCTGCAGTACGAAGTGGTCAAGAAAG
CCGACGGCCCACAACCCAAGCCTACCGATGTCGTGACCGTTCACTACACCGGCAAGCTGACCAACGGCACCGTTTTCGAC
AGCTCCGTCGAGCGCGGAAGCCCGATCGATCTGCCGGTCAGCGGTGTGATCCCGGGTTGGGTCGAAGGCCTGCAACTGAT
GCACGTTGGCGAGAAGTACAAGCTGTACATCCCTAGCGATCTGGCTTACGGCGCACAATCGCCAAGCCCGGCAATCCCGG
CCAACTCGGTCCTGGTTTTCGACCTGGAACTGCTGGCCATCAAGGATCCAGCCAAAGAAGACGCCGCTGCCGCCAAGCAA
TAA

Upstream 100 bases:

>100_bases
GAAGATTCCTGCTCTCATGCCGGTAGCCATTGGTCGTGGCGGCCTGATAAGCTCGCGGCTTTACTCGATTGCCCTTTCGG
CGCATGAACAAGGAAATAGC

Downstream 100 bases:

>100_bases
ACTTCGGCACCGGTTTCACCAACAACGCCTCGCTTATGCGGGGCGTTGTTGCATCTGGACGATGGTCGGCGTAAACAGAC
CGAACCGATGCTGGTCATGG

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKQHRLAAAVALVSLVLAGCDSQTSVELKTPAQKASYGIGLNMGKSLAQEGMDDLDSKAVAQGIEDAVGKKEQKLKDEEL
VEAFAALQKRAEERMAKMSEESAAAGKKFLEENGKKAGVTTTASGLQYEVVKKADGPQPKPTDVVTVHYTGKLTNGTVFD
SSVERGSPIDLPVSGVIPGWVEGLQLMHVGEKYKLYIPSDLAYGAQSPSPAIPANSVLVFDLELLAIKDPAKEDAAAAKQ

Sequences:

>Translated_240_residues
MKQHRLAAAVALVSLVLAGCDSQTSVELKTPAQKASYGIGLNMGKSLAQEGMDDLDSKAVAQGIEDAVGKKEQKLKDEEL
VEAFAALQKRAEERMAKMSEESAAAGKKFLEENGKKAGVTTTASGLQYEVVKKADGPQPKPTDVVTVHYTGKLTNGTVFD
SSVERGSPIDLPVSGVIPGWVEGLQLMHVGEKYKLYIPSDLAYGAQSPSPAIPANSVLVFDLELLAIKDPAKEDAAAAKQ
>Mature_240_residues
MKQHRLAAAVALVSLVLAGCDSQTSVELKTPAQKASYGIGLNMGKSLAQEGMDDLDSKAVAQGIEDAVGKKEQKLKDEEL
VEAFAALQKRAEERMAKMSEESAAAGKKFLEENGKKAGVTTTASGLQYEVVKKADGPQPKPTDVVTVHYTGKLTNGTVFD
SSVERGSPIDLPVSGVIPGWVEGLQLMHVGEKYKLYIPSDLAYGAQSPSPAIPANSVLVFDLELLAIKDPAKEDAAAAKQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=107, Percent_Identity=45.7943925233645, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI17149844, Length=107, Percent_Identity=45.7943925233645, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI17149842, Length=107, Percent_Identity=45.7943925233645, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=42.9906542056075, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=42.9906542056075, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI224809329, Length=103, Percent_Identity=39.8058252427184, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI224809327, Length=103, Percent_Identity=39.8058252427184, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4758384, Length=103, Percent_Identity=39.8058252427184, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7706131, Length=106, Percent_Identity=39.622641509434, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4503727, Length=109, Percent_Identity=40.3669724770642, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI224809331, Length=137, Percent_Identity=36.4963503649635, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI192448443, Length=91, Percent_Identity=36.2637362637363, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI87082390, Length=204, Percent_Identity=46.5686274509804, Blast_Score=183, Evalue=8e-48,
Organism=Escherichia coli, GI1789745, Length=218, Percent_Identity=39.9082568807339, Blast_Score=141, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=42.0560747663551, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17540882, Length=112, Percent_Identity=41.9642857142857, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17561782, Length=116, Percent_Identity=38.7931034482759, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561778, Length=117, Percent_Identity=38.4615384615385, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324194, Length=92, Percent_Identity=52.1739130434783, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=55.3191489361702, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323566, Length=132, Percent_Identity=37.1212121212121, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323482, Length=120, Percent_Identity=38.3333333333333, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=42.9906542056075, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583150, Length=107, Percent_Identity=37.3831775700935, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=46.1538461538462, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=46.1538461538462, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356629, Length=89, Percent_Identity=48.314606741573, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24647110, Length=95, Percent_Identity=40, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 25382; Mature: 25382

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQHRLAAAVALVSLVLAGCDSQTSVELKTPAQKASYGIGLNMGKSLAQEGMDDLDSKAV
CCHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHCCCCCHHHHHHHHHCHHHHHHHHH
AQGIEDAVGKKEQKLKDEELVEAFAALQKRAEERMAKMSEESAAAGKKFLEENGKKAGVT
HHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
TTASGLQYEVVKKADGPQPKPTDVVTVHYTGKLTNGTVFDSSVERGSPIDLPVSGVIPGW
ECCCCCEEEEEECCCCCCCCCCCEEEEEEECEECCCEEECCCCCCCCCCCCCHHCCCHHH
VEGLQLMHVGEKYKLYIPSDLAYGAQSPSPAIPANSVLVFDLELLAIKDPAKEDAAAAKQ
HHHHHHHCCCCEEEEEECCHHCCCCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHCCC
>Mature Secondary Structure
MKQHRLAAAVALVSLVLAGCDSQTSVELKTPAQKASYGIGLNMGKSLAQEGMDDLDSKAV
CCHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHCCCCCHHHHHHHHHCHHHHHHHHH
AQGIEDAVGKKEQKLKDEELVEAFAALQKRAEERMAKMSEESAAAGKKFLEENGKKAGVT
HHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
TTASGLQYEVVKKADGPQPKPTDVVTVHYTGKLTNGTVFDSSVERGSPIDLPVSGVIPGW
ECCCCCEEEEEECCCCCCCCCCCEEEEEEECEECCCEEECCCCCCCCCCCCCHHCCCHHH
VEGLQLMHVGEKYKLYIPSDLAYGAQSPSPAIPANSVLVFDLELLAIKDPAKEDAAAAKQ
HHHHHHHCCCCEEEEEECCHHCCCCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]