Click here to switch to the map view.

The map label for this gene is gpwA [H]

Identifier: 77457881

GI number: 77457881

Start: 1843117

End: 1843677

Strand: Direct

Name: gpwA [H]

Synonym: Pfl01_1654

Alternate gene names: 77457881

Gene position: 1843117-1843677 (Clockwise)

Preceding gene: 77457880

Following gene: 77457885

Centisome position: 28.63

GC content: 59.54

Gene sequence:

>561_bases
ATGCTCAAGCGCTGGTGTGCTGTTCCCGCGTTGCTGATGGCGTTGACCGGACTGGCTCAGGCCGCGGATTGTCCGGATCT
GTTGCAAGGTTCGTTGCCCAAGTTGCGGGCCAAGGAATCCATCGACCTGTGTCAGCGTTACGCCGACAAACCGCTGGTAG
TGATCAACACGGCCAGCTTCTGTGGTTTCGCGCCGCAGTTCGAGGGGCTGGAGGCGCTCAATCAGCGCTACAAGGCCCAG
GGCCTGGAAATGCTCGGCGTACCGTCCAATGACTTCAAGCAGGAGTCCAAGGACAGCGCCGAGACCGCCAAGGTCTGCTA
CGCCAACTACGGCGTGACGTTCACCATGACCGAGCCGCAGAAGGTTCGGGGTGACGATGCGACTCACTTGTTCCAGGTGC
TGGCCAGGCAGAGCAGCGCGCCGAAGTGGAATTTCTACAAGTACGTCATCGACCGCCAGGGCAAGGTGATTGCCAACTTC
TCCAGCCTGACCAAACCGGATGATCCGGAATTTCTGGCAGCCATCGAGAAAGCCATTGCCTCCCAGTCGCTGAAACCCTG
A

Upstream 100 bases:

>100_bases
CAGGGCGGGCTGGCGCTGATGCAGTTGGGCATGGGTGCTTGCTAGATCGGCGGGAGGGCGAGTAACGTCGAGGTCTGACG
ATTGCTCAAGGATGCCCGAC

Downstream 100 bases:

>100_bases
TAGACACCCATCAAAAAGCCCCGCCTCTGTGAAGAGAGCGGGGCTTTTTATGGCGAGGGGTTAGCCTCGCCGTGCAGCAT
CAGAAGCGGTAGGTTGCGCC

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MLKRWCAVPALLMALTGLAQAADCPDLLQGSLPKLRAKESIDLCQRYADKPLVVINTASFCGFAPQFEGLEALNQRYKAQ
GLEMLGVPSNDFKQESKDSAETAKVCYANYGVTFTMTEPQKVRGDDATHLFQVLARQSSAPKWNFYKYVIDRQGKVIANF
SSLTKPDDPEFLAAIEKAIASQSLKP

Sequences:

>Translated_186_residues
MLKRWCAVPALLMALTGLAQAADCPDLLQGSLPKLRAKESIDLCQRYADKPLVVINTASFCGFAPQFEGLEALNQRYKAQ
GLEMLGVPSNDFKQESKDSAETAKVCYANYGVTFTMTEPQKVRGDDATHLFQVLARQSSAPKWNFYKYVIDRQGKVIANF
SSLTKPDDPEFLAAIEKAIASQSLKP
>Mature_186_residues
MLKRWCAVPALLMALTGLAQAADCPDLLQGSLPKLRAKESIDLCQRYADKPLVVINTASFCGFAPQFEGLEALNQRYKAQ
GLEMLGVPSNDFKQESKDSAETAKVCYANYGVTFTMTEPQKVRGDDATHLFQVLARQSSAPKWNFYKYVIDRQGKVIANF
SSLTKPDDPEFLAAIEKAIASQSLKP

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI192455698, Length=128, Percent_Identity=30.46875, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI15618997, Length=140, Percent_Identity=30.7142857142857, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1788003, Length=166, Percent_Identity=31.3253012048193, Blast_Score=86, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17535473, Length=130, Percent_Identity=32.3076923076923, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17506887, Length=131, Percent_Identity=32.824427480916, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322228, Length=124, Percent_Identity=41.9354838709677, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319721, Length=124, Percent_Identity=40.3225806451613, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322826, Length=125, Percent_Identity=36, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI85726443, Length=138, Percent_Identity=29.7101449275362, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656772, Length=135, Percent_Identity=31.8518518518519, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656777, Length=135, Percent_Identity=31.8518518518519, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24656767, Length=135, Percent_Identity=31.8518518518519, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 20542; Mature: 20542

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRWCAVPALLMALTGLAQAADCPDLLQGSLPKLRAKESIDLCQRYADKPLVVINTASF
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECHHH
CGFAPQFEGLEALNQRYKAQGLEMLGVPSNDFKQESKDSAETAKVCYANYGVTFTMTEPQ
HCCCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCHHHHHHHHHCCCCEEEEECCCH
KVRGDDATHLFQVLARQSSAPKWNFYKYVIDRQGKVIANFSSLTKPDDPEFLAAIEKAIA
HHCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEECHHHCCCCCCHHHHHHHHHHHH
SQSLKP
HCCCCC
>Mature Secondary Structure
MLKRWCAVPALLMALTGLAQAADCPDLLQGSLPKLRAKESIDLCQRYADKPLVVINTASF
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECHHH
CGFAPQFEGLEALNQRYKAQGLEMLGVPSNDFKQESKDSAETAKVCYANYGVTFTMTEPQ
HCCCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCHHHHHHHHHCCCCEEEEECCCH
KVRGDDATHLFQVLARQSSAPKWNFYKYVIDRQGKVIANFSSLTKPDDPEFLAAIEKAIA
HHCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEECHHHCCCCCCHHHHHHHHHHHH
SQSLKP
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA