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The map label for this gene is phhA [H]

Identifier: 77457726

GI number: 77457726

Start: 1677327

End: 1678118

Strand: Reverse

Name: phhA [H]

Synonym: Pfl01_1499

Alternate gene names: 77457726

Gene position: 1678118-1677327 (Counterclockwise)

Preceding gene: 77457780

Following gene: 77457725

Centisome position: 26.06

GC content: 59.22

Gene sequence:

>792_bases
ATGAAGCAGACGCAATACGTGGCCCGCGAGCCCGATGCGCAAGGTTTTATCGACTACCCCGCCGAAGAACACGCGGTGTG
GAACACGCTGATCACCCGCCAGTTGAAAGTGATCGAGGGTCGTGCGTGCCAGGAATACCTGGACGGTATCGAAAAACTCG
GTCTGCCCCACGACCGCATTCCGCAACTGGGCGAGATCAACAAGGTGCTCGGCGAGACCACCGGTTGGCAGGTTGCCCGC
GTCCCGGCGCTGATCCCTTTCCAGACCTTTTTCGAATTGCTCGCCAGCAAGCAGTTTCCGGTGGCCACGTTCATTCGTAC
CCGTGAAGAACTGGACTACCTGCAGGAGCCGGACATTTTCCACGAGATCTTTGGCCACTGCCCGCTGCTGACCAACCCGT
GGTTCGCCGAATTCACCCACACCTACGGCAAACTCGGCCTGCAGGCGACCAAGGAAGAACGCGTTTATCTGGCGCGTCTG
TACTGGATGACCATCGAGTTCGGCCTGGTCGACACCCCGCAAGGCAAACGCATCTACGGCGGCGGCATCCTGTCTTCGCC
GAAAGAAACTGTTTATTCGCTGTCGGATGAGCCCGAGCATCAGGCCTTCGATCCGCTGGAAGCGATGCGCACGCCGTACC
GCATCGACATCCTGCAACCGCTGTATTTTGTCCTGCCGAACCTCAAGCGCCTGTTCGACCTGGCCCACGAAGACATCATG
GCCATGGTCAAGCAAGGCATGCAGCTGGGTCTGCACGCACCGAAGTTTCCGCCAAAACCGAAAGCCGCGTGA

Upstream 100 bases:

>100_bases
CAACCAGTCTTCAACCTGCTGCAACAACAAACGTTCCGGGGTATTTCTCAGTCCATCGCAGGACATAACAAGAACGAAAT
TCCCCTCGCAGGAGAGCAGT

Downstream 100 bases:

>100_bases
CCCGCGACTTTTGCTTACAAGTGAGTCTGTCCGTCGTCGCCACTTTGGTTTAGCGTGGCGACATTGACCGCCAATATAAA
AAAACACCTTCAGATTTCAG

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKQTQYVAREPDAQGFIDYPAEEHAVWNTLITRQLKVIEGRACQEYLDGIEKLGLPHDRIPQLGEINKVLGETTGWQVAR
VPALIPFQTFFELLASKQFPVATFIRTREELDYLQEPDIFHEIFGHCPLLTNPWFAEFTHTYGKLGLQATKEERVYLARL
YWMTIEFGLVDTPQGKRIYGGGILSSPKETVYSLSDEPEHQAFDPLEAMRTPYRIDILQPLYFVLPNLKRLFDLAHEDIM
AMVKQGMQLGLHAPKFPPKPKAA

Sequences:

>Translated_263_residues
MKQTQYVAREPDAQGFIDYPAEEHAVWNTLITRQLKVIEGRACQEYLDGIEKLGLPHDRIPQLGEINKVLGETTGWQVAR
VPALIPFQTFFELLASKQFPVATFIRTREELDYLQEPDIFHEIFGHCPLLTNPWFAEFTHTYGKLGLQATKEERVYLARL
YWMTIEFGLVDTPQGKRIYGGGILSSPKETVYSLSDEPEHQAFDPLEAMRTPYRIDILQPLYFVLPNLKRLFDLAHEDIM
AMVKQGMQLGLHAPKFPPKPKAA
>Mature_263_residues
MKQTQYVAREPDAQGFIDYPAEEHAVWNTLITRQLKVIEGRACQEYLDGIEKLGLPHDRIPQLGEINKVLGETTGWQVAR
VPALIPFQTFFELLASKQFPVATFIRTREELDYLQEPDIFHEIFGHCPLLTNPWFAEFTHTYGKLGLQATKEERVYLARL
YWMTIEFGLVDTPQGKRIYGGGILSSPKETVYSLSDEPEHQAFDPLEAMRTPYRIDILQPLYFVLPNLKRLFDLAHEDIM
AMVKQGMQLGLHAPKFPPKPKAA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=212, Percent_Identity=37.7358490566038, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI88900505, Length=212, Percent_Identity=37.7358490566038, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI88900501, Length=212, Percent_Identity=37.7358490566038, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI31795563, Length=212, Percent_Identity=35.377358490566, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4759248, Length=212, Percent_Identity=33.4905660377358, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI4557819, Length=215, Percent_Identity=35.3488372093023, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71980736, Length=221, Percent_Identity=32.579185520362, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17531391, Length=213, Percent_Identity=38.0281690140845, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI115533973, Length=230, Percent_Identity=31.304347826087, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI115532103, Length=230, Percent_Identity=31.304347826087, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71980731, Length=155, Percent_Identity=30.3225806451613, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136774, Length=213, Percent_Identity=34.2723004694836, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17136776, Length=213, Percent_Identity=34.2723004694836, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24660393, Length=212, Percent_Identity=33.0188679245283, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI62472054, Length=212, Percent_Identity=33.0188679245283, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24654994, Length=212, Percent_Identity=32.0754716981132, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 30217; Mature: 30217

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTQYVAREPDAQGFIDYPAEEHAVWNTLITRQLKVIEGRACQEYLDGIEKLGLPHDRI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHCC
PQLGEINKVLGETTGWQVARVPALIPFQTFFELLASKQFPVATFIRTREELDYLQEPDIF
CCHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHH
HEIFGHCPLLTNPWFAEFTHTYGKLGLQATKEERVYLARLYWMTIEFGLVDTPQGKRIYG
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEECCEECCCCCEEEC
GGILSSPKETVYSLSDEPEHQAFDPLEAMRTPYRIDILQPLYFVLPNLKRLFDLAHEDIM
CCCCCCCHHHHHCCCCCCCCHHCCHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AMVKQGMQLGLHAPKFPPKPKAA
HHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKQTQYVAREPDAQGFIDYPAEEHAVWNTLITRQLKVIEGRACQEYLDGIEKLGLPHDRI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHCC
PQLGEINKVLGETTGWQVARVPALIPFQTFFELLASKQFPVATFIRTREELDYLQEPDIF
CCHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHH
HEIFGHCPLLTNPWFAEFTHTYGKLGLQATKEERVYLARLYWMTIEFGLVDTPQGKRIYG
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEECCEECCCCCEEEC
GGILSSPKETVYSLSDEPEHQAFDPLEAMRTPYRIDILQPLYFVLPNLKRLFDLAHEDIM
CCCCCCCHHHHHCCCCCCCCHHCCHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AMVKQGMQLGLHAPKFPPKPKAA
HHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]