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The map label for this gene is recQ [H]

Identifier: 77457695

GI number: 77457695

Start: 1647794

End: 1649923

Strand: Direct

Name: recQ [H]

Synonym: Pfl01_1468

Alternate gene names: 77457695

Gene position: 1647794-1649923 (Clockwise)

Preceding gene: 77457690

Following gene: 77457696

Centisome position: 25.59

GC content: 64.84

Gene sequence:

>2130_bases
ATGCTCGAACAGGCTCAACGCGTCCTCAAGGACATCTTCGGCTACGACAGTTTCCGTGGCCGTCAGGGTGCAATCATTGA
GCGCGTGGCCAGTGGCGGTGATGCCCTTGTCCTGATGCCGACCGGCGGCGGCAAGTCCCTGTGCTTCCAGGTGCCGGCGC
TGCTGCGCGATGGCCTGGCGGTGGTGGTATCGCCGTTGATCGCGCTGATGGACGATCAGGTCGCCACCCTCGAAGAGCTG
GGTGTGGCCGCCGCCGCGTTGAACTCCACCCTGAGCGCCGAACAACAGCGCGACCTCGCCAACCGGATCAAGCGCGGCGA
AGTGAAGATGCTGTATCTGGCGCCGGAGCGGCTGGTTCAGCCGCGCATGCTGTCGTTCCTGCAAGGCTTGAACATTGCGC
TGTTCGCCATCGACGAAGCGCACTGCGTGTCGCAATGGGGCCATGACTTCCGCCCGGAATACCTGCAACTGGGGCAGTTG
GCGGAAATGTTCCCCGACGTGCCGCGCATCGCCCTGACCGCCACCGCCGACAAACGCACCCGCGAAGAGATCGTCACTCG
CCTGCATTTGCAAAACGCCGAGCGTTTCCTGTCGAGCTTCGACCGGCCGAACATCTTCTACCGCATCGTGCCCAAGGAGC
AGCCGCGCAAGCAGTTGCTGGCGTTCCTCGCCGAACGGCGCAGCGACGCCGGCATCGTCTACTGCCTGTCGCGCAAGAAG
GTGGAAGAGGTGGCCGCGTTTCTCACCGAACAGGGCTTCCCGGCGCTGCCTTACCACGCCGGTCTGCCCAACGATCTGCG
CGCCTATCACCAGAAGCGCTTCCTCAACGAGGAAGGGCTGATCATGGTCGCCACGGTGGCGTTCGGCATGGGCATCGACA
AACCCAATGTGCGCTTCGTCGCTCACCTCGATCTGCCGAAATCCCTTGAGGCGTATTACCAGGAAACCGGGCGCGGCGGC
CGTGACGGCCTACCGGCGGACGCGTGGATGGCCTACGGTCTGCAAGACGTGGTGATGCTCAAGCAGATGCTGCAGAACTC
CGAGGGCGACGAGCGTCACAAGCGTCTGGAGCAGCACAAACTCGACGCCATGCTTTCGCTCTGCGAAGAAACCCGCTGCC
GCCGTCAGGCGCTGCTGGCGTACTTCGACGAGGACATGCCCGAGCCGTGCGGCCACTGCGACAACTGCACCGACGGCGTG
CAGACCTGGGACGCCACCGAGCCTGCGCGTCAGGCGCTGTCGGCGATCTATCGCACCGGCCAGCGTTATGGCGTCGGCCA
TCTGGTGGACGTGCTGCTGGGCAAGGACAACGAAAAGGTCCGCAGCTTCGGCCATCAGCACCTGTCGGTGTACGGCGTCG
GCAAGGCGTTGAGCGAGAGCGAATGGCGCTCGCTGTTCCGTCAGCTGGTTGCCCGCGGTCTGGCCGATGTCGATCACGAA
GGTTATGGCGGGCTGCGCCTGAGCGACACCTGCCGGCCGCTGCTCAAGGGGGAAGTGAGCCTGGAGCTGCGCCGCGACCT
CAAGCCGCAAGTCAGCGCCAAGAGCGGCAGCAAGAGCCCGGCCAGCCAACTCGTGCGCGGCGAAGAGCGCGAACAGTGGG
AAGCGTTGCGTGCCCTGCGGCGCAAACTGGCGGAAGAACATGGCGTGCCGCCGTATGTCATCTTCCCCGACTCGACCCTG
CTGGAAATGCTCCGCAGCCAGCCGACCTCGCTGGCGGACATGGCCCGGGTCAGCGGCGTCGGTGCGCGCAAGCTGGAGCG
GTACGGCGAGGCCTTTCTCGAAGTGCTCGGCGGCGAGGCCGAGGCGCCGAAAGTGGTGGCCGACGTGCGCCACGAACTGA
TCACCCTGGCCCGTGCCGGCATGACGCCGTTGCAGATCTCCGGTCAGCTGCAATGCTCGGAAAAGAACGTCTACACCATG
CTCGCCGAAGCCATCGGCAAGCAGCAGCTGTCGCTGGAACAGGCGCTGGATCTGCCGGAAGACCTGATGGGCGAAGTCCA
GGATGCGTTCCTCGACGGCGAAGGCGAGTTGCCGTCGGTCGCCGAAGTGGCCGAGCTGTTTGCCGGTCGTGTACCGGAAG
GCGTGCTTTACTGCGTGCGGGCTGCGCTGCAATCCGAGTTTGAAATGTAA

Upstream 100 bases:

>100_bases
TACGGCGCGATGCAATGCGCGCTTACGTTTTGTTTAAAGCAGCCTCGGCTGTCTTGAACCAGCCTGTGCAGGGATGTTTC
GGTGGATTTTTGGAGTTTTT

Downstream 100 bases:

>100_bases
GAGGGTGTTTGTGCCAACCGTTATACGGTTGTAACGATTCAGTACAGGACGCCTCTTGCCTATAGGCAAATGTCATGCTT
AGCTGACTAATAATTAGTTT

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MLEQAQRVLKDIFGYDSFRGRQGAIIERVASGGDALVLMPTGGGKSLCFQVPALLRDGLAVVVSPLIALMDDQVATLEEL
GVAAAALNSTLSAEQQRDLANRIKRGEVKMLYLAPERLVQPRMLSFLQGLNIALFAIDEAHCVSQWGHDFRPEYLQLGQL
AEMFPDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLAERRSDAGIVYCLSRKK
VEEVAAFLTEQGFPALPYHAGLPNDLRAYHQKRFLNEEGLIMVATVAFGMGIDKPNVRFVAHLDLPKSLEAYYQETGRGG
RDGLPADAWMAYGLQDVVMLKQMLQNSEGDERHKRLEQHKLDAMLSLCEETRCRRQALLAYFDEDMPEPCGHCDNCTDGV
QTWDATEPARQALSAIYRTGQRYGVGHLVDVLLGKDNEKVRSFGHQHLSVYGVGKALSESEWRSLFRQLVARGLADVDHE
GYGGLRLSDTCRPLLKGEVSLELRRDLKPQVSAKSGSKSPASQLVRGEEREQWEALRALRRKLAEEHGVPPYVIFPDSTL
LEMLRSQPTSLADMARVSGVGARKLERYGEAFLEVLGGEAEAPKVVADVRHELITLARAGMTPLQISGQLQCSEKNVYTM
LAEAIGKQQLSLEQALDLPEDLMGEVQDAFLDGEGELPSVAEVAELFAGRVPEGVLYCVRAALQSEFEM

Sequences:

>Translated_709_residues
MLEQAQRVLKDIFGYDSFRGRQGAIIERVASGGDALVLMPTGGGKSLCFQVPALLRDGLAVVVSPLIALMDDQVATLEEL
GVAAAALNSTLSAEQQRDLANRIKRGEVKMLYLAPERLVQPRMLSFLQGLNIALFAIDEAHCVSQWGHDFRPEYLQLGQL
AEMFPDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLAERRSDAGIVYCLSRKK
VEEVAAFLTEQGFPALPYHAGLPNDLRAYHQKRFLNEEGLIMVATVAFGMGIDKPNVRFVAHLDLPKSLEAYYQETGRGG
RDGLPADAWMAYGLQDVVMLKQMLQNSEGDERHKRLEQHKLDAMLSLCEETRCRRQALLAYFDEDMPEPCGHCDNCTDGV
QTWDATEPARQALSAIYRTGQRYGVGHLVDVLLGKDNEKVRSFGHQHLSVYGVGKALSESEWRSLFRQLVARGLADVDHE
GYGGLRLSDTCRPLLKGEVSLELRRDLKPQVSAKSGSKSPASQLVRGEEREQWEALRALRRKLAEEHGVPPYVIFPDSTL
LEMLRSQPTSLADMARVSGVGARKLERYGEAFLEVLGGEAEAPKVVADVRHELITLARAGMTPLQISGQLQCSEKNVYTM
LAEAIGKQQLSLEQALDLPEDLMGEVQDAFLDGEGELPSVAEVAELFAGRVPEGVLYCVRAALQSEFEM
>Mature_709_residues
MLEQAQRVLKDIFGYDSFRGRQGAIIERVASGGDALVLMPTGGGKSLCFQVPALLRDGLAVVVSPLIALMDDQVATLEEL
GVAAAALNSTLSAEQQRDLANRIKRGEVKMLYLAPERLVQPRMLSFLQGLNIALFAIDEAHCVSQWGHDFRPEYLQLGQL
AEMFPDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLAERRSDAGIVYCLSRKK
VEEVAAFLTEQGFPALPYHAGLPNDLRAYHQKRFLNEEGLIMVATVAFGMGIDKPNVRFVAHLDLPKSLEAYYQETGRGG
RDGLPADAWMAYGLQDVVMLKQMLQNSEGDERHKRLEQHKLDAMLSLCEETRCRRQALLAYFDEDMPEPCGHCDNCTDGV
QTWDATEPARQALSAIYRTGQRYGVGHLVDVLLGKDNEKVRSFGHQHLSVYGVGKALSESEWRSLFRQLVARGLADVDHE
GYGGLRLSDTCRPLLKGEVSLELRRDLKPQVSAKSGSKSPASQLVRGEEREQWEALRALRRKLAEEHGVPPYVIFPDSTL
LEMLRSQPTSLADMARVSGVGARKLERYGEAFLEVLGGEAEAPKVVADVRHELITLARAGMTPLQISGQLQCSEKNVYTM
LAEAIGKQQLSLEQALDLPEDLMGEVQDAFLDGEGELPSVAEVAELFAGRVPEGVLYCVRAALQSEFEM

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=644, Percent_Identity=34.6273291925466, Blast_Score=352, Evalue=6e-97,
Organism=Homo sapiens, GI14591902, Length=466, Percent_Identity=36.480686695279, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI14591904, Length=466, Percent_Identity=36.480686695279, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI148612816, Length=418, Percent_Identity=39.9521531100478, Blast_Score=292, Evalue=9e-79,
Organism=Homo sapiens, GI110735439, Length=713, Percent_Identity=29.45301542777, Blast_Score=290, Evalue=4e-78,
Organism=Homo sapiens, GI169218196, Length=713, Percent_Identity=29.45301542777, Blast_Score=290, Evalue=4e-78,
Organism=Homo sapiens, GI51242943, Length=394, Percent_Identity=39.8477157360406, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI51242947, Length=394, Percent_Identity=39.8477157360406, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI284005309, Length=383, Percent_Identity=36.2924281984334, Blast_Score=194, Evalue=2e-49,
Organism=Escherichia coli, GI48994977, Length=596, Percent_Identity=48.3221476510067, Blast_Score=569, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI25145561, Length=654, Percent_Identity=33.3333333333333, Blast_Score=332, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI32564293, Length=671, Percent_Identity=31.1475409836066, Blast_Score=295, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI71987997, Length=437, Percent_Identity=39.3592677345538, Blast_Score=294, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71987993, Length=438, Percent_Identity=39.7260273972603, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17552866, Length=444, Percent_Identity=37.6126126126126, Blast_Score=285, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17555296, Length=373, Percent_Identity=24.9329758713137, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71995718, Length=343, Percent_Identity=23.9067055393586, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=537, Percent_Identity=34.2644320297952, Blast_Score=326, Evalue=9e-90,
Organism=Saccharomyces cerevisiae, GI6324217, Length=338, Percent_Identity=23.0769230769231, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320224, Length=329, Percent_Identity=22.4924012158055, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323947, Length=349, Percent_Identity=23.7822349570201, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646066, Length=633, Percent_Identity=37.1248025276461, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI24664226, Length=424, Percent_Identity=39.1509433962264, Blast_Score=282, Evalue=6e-76,
Organism=Drosophila melanogaster, GI62472181, Length=421, Percent_Identity=38.9548693586698, Blast_Score=279, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24664230, Length=421, Percent_Identity=38.9548693586698, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI21358123, Length=348, Percent_Identity=37.9310344827586, Blast_Score=211, Evalue=2e-54,
Organism=Drosophila melanogaster, GI28574962, Length=352, Percent_Identity=25, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 78870; Mature: 78870

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQAQRVLKDIFGYDSFRGRQGAIIERVASGGDALVLMPTGGGKSLCFQVPALLRDGLA
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCHH
VVVSPLIALMDDQVATLEELGVAAAALNSTLSAEQQRDLANRIKRGEVKMLYLAPERLVQ
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHC
PRMLSFLQGLNIALFAIDEAHCVSQWGHDFRPEYLQLGQLAEMFPDVPRIALTATADKRT
HHHHHHHCCCCEEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHH
REEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLAERRSDAGIVYCLSRKK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECHHH
VEEVAAFLTEQGFPALPYHAGLPNDLRAYHQKRFLNEEGLIMVATVAFGMGIDKPNVRFV
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCCCCEEE
AHLDLPKSLEAYYQETGRGGRDGLPADAWMAYGLQDVVMLKQMLQNSEGDERHKRLEQHK
EECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LDAMLSLCEETRCRRQALLAYFDEDMPEPCGHCDNCTDGVQTWDATEPARQALSAIYRTG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCC
QRYGVGHLVDVLLGKDNEKVRSFGHQHLSVYGVGKALSESEWRSLFRQLVARGLADVDHE
CCCCHHHHHHHHHCCCCHHHHHHCHHHEEEEECCHHCCHHHHHHHHHHHHHHHHHCCCCC
GYGGLRLSDTCRPLLKGEVSLELRRDLKPQVSAKSGSKSPASQLVRGEEREQWEALRALR
CCCCCEECHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
RKLAEEHGVPPYVIFPDSTLLEMLRSQPTSLADMARVSGVGARKLERYGEAFLEVLGGEA
HHHHHHCCCCCEEECCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
EAPKVVADVRHELITLARAGMTPLQISGQLQCSEKNVYTMLAEAIGKQQLSLEQALDLPE
CCCHHHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHHHHHCHHHHHHHHHHCCCH
DLMGEVQDAFLDGEGELPSVAEVAELFAGRVPEGVLYCVRAALQSEFEM
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLEQAQRVLKDIFGYDSFRGRQGAIIERVASGGDALVLMPTGGGKSLCFQVPALLRDGLA
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCHH
VVVSPLIALMDDQVATLEELGVAAAALNSTLSAEQQRDLANRIKRGEVKMLYLAPERLVQ
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHC
PRMLSFLQGLNIALFAIDEAHCVSQWGHDFRPEYLQLGQLAEMFPDVPRIALTATADKRT
HHHHHHHCCCCEEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHH
REEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLAERRSDAGIVYCLSRKK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECHHH
VEEVAAFLTEQGFPALPYHAGLPNDLRAYHQKRFLNEEGLIMVATVAFGMGIDKPNVRFV
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCCCCEEE
AHLDLPKSLEAYYQETGRGGRDGLPADAWMAYGLQDVVMLKQMLQNSEGDERHKRLEQHK
EECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LDAMLSLCEETRCRRQALLAYFDEDMPEPCGHCDNCTDGVQTWDATEPARQALSAIYRTG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCC
QRYGVGHLVDVLLGKDNEKVRSFGHQHLSVYGVGKALSESEWRSLFRQLVARGLADVDHE
CCCCHHHHHHHHHCCCCHHHHHHCHHHEEEEECCHHCCHHHHHHHHHHHHHHHHHCCCCC
GYGGLRLSDTCRPLLKGEVSLELRRDLKPQVSAKSGSKSPASQLVRGEEREQWEALRALR
CCCCCEECHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
RKLAEEHGVPPYVIFPDSTLLEMLRSQPTSLADMARVSGVGARKLERYGEAFLEVLGGEA
HHHHHHCCCCCEEECCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
EAPKVVADVRHELITLARAGMTPLQISGQLQCSEKNVYTMLAEAIGKQQLSLEQALDLPE
CCCHHHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHHHHHCHHHHHHHHHHCCCH
DLMGEVQDAFLDGEGELPSVAEVAELFAGRVPEGVLYCVRAALQSEFEM
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]