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The map label for this gene is hmgA

Identifier: 77457137

GI number: 77457137

Start: 1060280

End: 1061575

Strand: Direct

Name: hmgA

Synonym: Pfl01_0910

Alternate gene names: 77457137

Gene position: 1060280-1061575 (Clockwise)

Preceding gene: 77457135

Following gene: 77457138

Centisome position: 16.47

GC content: 64.04

Gene sequence:

>1296_bases
ATGAACCTCGATTCAGCCCTGGCTTACCAGTCCGGTTTCGGCAACGAATTCAGCTCGGAAGCGTTGCCCGGCGCACTGCC
CGTCGGCCAGAACTCCCCGCAGAAAGCCCCGTACGGTCTGTACACCGAACTGTTCTCCGGCACCGCGTTCACCATGACCC
GCAGCGAAGCGCGGCGTACGTGGATGTACCGGATCCAGCCGTCGGCCAATCACCCGGCATTCGTCAAACTGGAGCGGCAA
CTGGCGGGCGGCCCGTTGGGTGAAGTGACCCCCAATCGCCTGCGCTGGAACCCGCTGGACCTCCCGACCGAACCGACCGA
CTTCATCGACGGTCTGGTGAGCATGGCGGCCAACTCCGGCGCCGACAAACCGGCCGGCATCAGCATCTATCACTATGGCG
CCAACCGTTCGATGGAGCGCGTGTTCTTCAACGCCGACGGCGAGCTGCTGCTGGTACCGCAACTGGGTCGCTTGCGCATC
GCCACCGAACTGGGTGTGCTGGACGTGGCGCCGCTGGAAATCGCCGTGTTGCCACGGGGCCTGAAATTCCGCGTCGAACT
GCTCGACCCGCAAGCACGCGGGTACGTCGCCGAGAACCATGGCGCGCCACTGCGCCTGCCGGACCTGGGGCCGATCGGCA
GCAACGGCCTGGCCAATCCACGGGATTTCCTGACCCCGGTCGCCGCCTACGAAAACCTGCAACAACCGACCACCCTGGTG
CAGAAATTCCTCGGCCAGTTGTGGGGTACCGAACTCAATCACTCGCCGCTGAACGTGGTCGCCTGGCACGGCAACAACGT
GCCGTACAAGTATGACCTGCGCCGCTTCAACACCATCGGCACCGTCAGTTTCGATCACCCGGACCCATCGATCTTCACCG
TGCTGACCTCGCCGACCAGCGTCCACGGTCTGGCCAACCTCGACTTCGTGATCTTCCCGCCGCGCTGGATGGTGGCCGAG
AACACCTTCCGTCCGCCGTGGTTCCACCGCAACCTGATGAATGAATTCATGGGCCTGATCCAGGGCGAATACGACGCCAA
GGCCGAAGGTTTCGTGCCCGGCGGCGCGTCCCTGCACAGCTGCATGAGCGCCCACGGCCCGGACGGCGAGACTTGCACCA
AAGCCATCAACGCGGACCTCAAACCGGCGAAGATCGACAACACCATGGCCTTCATGTTCGAGACCAGCCAGGTGCTGCGC
CCAAGCCGCTTCGCCCTCGACTGCCCGCAATTGCAATCCACTTACGACGCCTGCTGGGCCACGCTGCCCGCCACGTTCGA
TCCGACCCGGAGATAA

Upstream 100 bases:

>100_bases
TACGTTATGCGTAATTGAATTACGATAAAAATAACCCCGGCGTGCCAAGACCTCTGATCCAGAGCGTCCGGCCATGCCGA
CGCCCTGTTCAGGAGGCTCC

Downstream 100 bases:

>100_bases
CCCATGACTCAGAATTCCATCACCCGCAGTTGGGTCGCCTCGGCCAACGGTCACGCGGATTTCCCATTGCAGAACCTGCC
GCTGGGCGTATTCAGCACCA

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNLDSALAYQSGFGNEFSSEALPGALPVGQNSPQKAPYGLYTELFSGTAFTMTRSEARRTWMYRIQPSANHPAFVKLERQ
LAGGPLGEVTPNRLRWNPLDLPTEPTDFIDGLVSMAANSGADKPAGISIYHYGANRSMERVFFNADGELLLVPQLGRLRI
ATELGVLDVAPLEIAVLPRGLKFRVELLDPQARGYVAENHGAPLRLPDLGPIGSNGLANPRDFLTPVAAYENLQQPTTLV
QKFLGQLWGTELNHSPLNVVAWHGNNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTSVHGLANLDFVIFPPRWMVAE
NTFRPPWFHRNLMNEFMGLIQGEYDAKAEGFVPGGASLHSCMSAHGPDGETCTKAINADLKPAKIDNTMAFMFETSQVLR
PSRFALDCPQLQSTYDACWATLPATFDPTRR

Sequences:

>Translated_431_residues
MNLDSALAYQSGFGNEFSSEALPGALPVGQNSPQKAPYGLYTELFSGTAFTMTRSEARRTWMYRIQPSANHPAFVKLERQ
LAGGPLGEVTPNRLRWNPLDLPTEPTDFIDGLVSMAANSGADKPAGISIYHYGANRSMERVFFNADGELLLVPQLGRLRI
ATELGVLDVAPLEIAVLPRGLKFRVELLDPQARGYVAENHGAPLRLPDLGPIGSNGLANPRDFLTPVAAYENLQQPTTLV
QKFLGQLWGTELNHSPLNVVAWHGNNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTSVHGLANLDFVIFPPRWMVAE
NTFRPPWFHRNLMNEFMGLIQGEYDAKAEGFVPGGASLHSCMSAHGPDGETCTKAINADLKPAKIDNTMAFMFETSQVLR
PSRFALDCPQLQSTYDACWATLPATFDPTRR
>Mature_431_residues
MNLDSALAYQSGFGNEFSSEALPGALPVGQNSPQKAPYGLYTELFSGTAFTMTRSEARRTWMYRIQPSANHPAFVKLERQ
LAGGPLGEVTPNRLRWNPLDLPTEPTDFIDGLVSMAANSGADKPAGISIYHYGANRSMERVFFNADGELLLVPQLGRLRI
ATELGVLDVAPLEIAVLPRGLKFRVELLDPQARGYVAENHGAPLRLPDLGPIGSNGLANPRDFLTPVAAYENLQQPTTLV
QKFLGQLWGTELNHSPLNVVAWHGNNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTSVHGLANLDFVIFPPRWMVAE
NTFRPPWFHRNLMNEFMGLIQGEYDAKAEGFVPGGASLHSCMSAHGPDGETCTKAINADLKPAKIDNTMAFMFETSQVLR
PSRFALDCPQLQSTYDACWATLPATFDPTRR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family

Homologues:

Organism=Homo sapiens, GI115527117, Length=439, Percent_Identity=49.2027334851936, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17507969, Length=429, Percent_Identity=50.1165501165501, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24583650, Length=438, Percent_Identity=48.6301369863014, Blast_Score=396, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HGD_PSEPF (Q3KHV3)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_346642.1
- STRING:   Q3KHV3
- GeneID:   3715813
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_0910
- eggNOG:   COG3508
- HOGENOM:   HBG293508
- OMA:   RNCMSEF
- ProtClustDB:   PRK05341
- BioCyc:   PFLU205922:PFL_0910-MONOMER
- HAMAP:   MF_00334
- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950
- PANTHER:   PTHR11056
- TIGRFAMs:   TIGR01015

Pfam domain/function: PF04209 HgmA; SSF51182 RmlC_like_cupin

EC number: =1.13.11.5

Molecular weight: Translated: 47490; Mature: 47490

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDSALAYQSGFGNEFSSEALPGALPVGQNSPQKAPYGLYTELFSGTAFTMTRSEARRT
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEHHHHCCE
WMYRIQPSANHPAFVKLERQLAGGPLGEVTPNRLRWNPLDLPTEPTDFIDGLVSMAANSG
EEEEECCCCCCCEEEEEEHHHCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCC
ADKPAGISIYHYGANRSMERVFFNADGELLLVPQLGRLRIATELGVLDVAPLEIAVLPRG
CCCCCCEEEEEECCCCCEEEEEECCCCCEEEECCCCCEEEEECCCCEEECCEEEEEECCC
LKFRVELLDPQARGYVAENHGAPLRLPDLGPIGSNGLANPRDFLTPVAAYENLQQPTTLV
CEEEEEEECCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
QKFLGQLWGTELNHSPLNVVAWHGNNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTS
HHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEEEECEEEEEEECCCCCCEEEEEECCCC
VHGLANLDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLIQGEYDAKAEGFVPGGASLHS
CCCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
CMSAHGPDGETCTKAINADLKPAKIDNTMAFMFETSQVLRPSRFALDCPQLQSTYDACWA
HHHCCCCCHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHCCCCHHCCCCHHHHHHHHHHHH
TLPATFDPTRR
HCCCCCCCCCC
>Mature Secondary Structure
MNLDSALAYQSGFGNEFSSEALPGALPVGQNSPQKAPYGLYTELFSGTAFTMTRSEARRT
CCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEHHHHCCE
WMYRIQPSANHPAFVKLERQLAGGPLGEVTPNRLRWNPLDLPTEPTDFIDGLVSMAANSG
EEEEECCCCCCCEEEEEEHHHCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCC
ADKPAGISIYHYGANRSMERVFFNADGELLLVPQLGRLRIATELGVLDVAPLEIAVLPRG
CCCCCCEEEEEECCCCCEEEEEECCCCCEEEECCCCCEEEEECCCCEEECCEEEEEECCC
LKFRVELLDPQARGYVAENHGAPLRLPDLGPIGSNGLANPRDFLTPVAAYENLQQPTTLV
CEEEEEEECCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
QKFLGQLWGTELNHSPLNVVAWHGNNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTS
HHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEEEECEEEEEEECCCCCCEEEEEECCCC
VHGLANLDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLIQGEYDAKAEGFVPGGASLHS
CCCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
CMSAHGPDGETCTKAINADLKPAKIDNTMAFMFETSQVLRPSRFALDCPQLQSTYDACWA
HHHCCCCCHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHCCCCHHCCCCHHHHHHHHHHHH
TLPATFDPTRR
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA